NZ216763A - 6-alkylidenandrosta-1,4-diene-3,17-dione derivatives and pharmaceutical compositions - Google Patents

6-alkylidenandrosta-1,4-diene-3,17-dione derivatives and pharmaceutical compositions

Info

Publication number
NZ216763A
NZ216763A NZ216763A NZ21676386A NZ216763A NZ 216763 A NZ216763 A NZ 216763A NZ 216763 A NZ216763 A NZ 216763A NZ 21676386 A NZ21676386 A NZ 21676386A NZ 216763 A NZ216763 A NZ 216763A
Authority
NZ
New Zealand
Prior art keywords
dione
diene
compound
formula
hydrogen
Prior art date
Application number
NZ216763A
Other languages
English (en)
Inventor
F Buzzetti
N Barbugian
P Lombardi
Salle E Di
Original Assignee
Erba Farmitalia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10582036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NZ216763(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Erba Farmitalia filed Critical Erba Farmitalia
Publication of NZ216763A publication Critical patent/NZ216763A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
NZ216763A 1985-07-09 1986-07-07 6-alkylidenandrosta-1,4-diene-3,17-dione derivatives and pharmaceutical compositions NZ216763A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858517360A GB8517360D0 (en) 1985-07-09 1985-07-09 Substituted androsta-1,4-diene-3,17-diones

Publications (1)

Publication Number Publication Date
NZ216763A true NZ216763A (en) 1988-05-30

Family

ID=10582036

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ216763A NZ216763A (en) 1985-07-09 1986-07-07 6-alkylidenandrosta-1,4-diene-3,17-dione derivatives and pharmaceutical compositions

Country Status (38)

Country Link
US (2) US4808616A (bg)
JP (1) JPS6212797A (bg)
KR (1) KR950003614B1 (bg)
CN (1) CN86104664B (bg)
AT (1) AT395157B (bg)
AU (1) AU578840B2 (bg)
BE (1) BE905067A (bg)
BG (1) BG61370B2 (bg)
BR (1) BR1100240A (bg)
CA (1) CA1277656C (bg)
CH (1) CH668599A5 (bg)
CS (2) CS258498B2 (bg)
CZ (1) CZ413591A3 (bg)
DE (1) DE10199030I1 (bg)
DK (1) DK163520C (bg)
ES (2) ES8801304A1 (bg)
FI (1) FI83424C (bg)
FR (1) FR2584725B1 (bg)
GB (2) GB8517360D0 (bg)
GR (1) GR861780B (bg)
HK (1) HK94190A (bg)
HU (1) HU194274B (bg)
IE (1) IE58949B1 (bg)
IL (1) IL79336A (bg)
IT (1) IT1196436B (bg)
MY (1) MY102294A (bg)
NL (2) NL193616C (bg)
NO (2) NO165547C (bg)
NZ (1) NZ216763A (bg)
PH (1) PH21785A (bg)
PT (1) PT82944B (bg)
SE (1) SE468988B (bg)
SG (1) SG80490G (bg)
SK (1) SK413591A3 (bg)
SU (2) SU1442077A3 (bg)
UA (1) UA6046A1 (bg)
YU (2) YU44585B (bg)
ZA (1) ZA865079B (bg)

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GB8617107D0 (en) * 1986-07-14 1986-08-20 Erba Farmitalia 6-/7-methylenandrosta-1 4-diene-3 17-dione derivatives
GB8622330D0 (en) * 1986-09-17 1986-10-22 Erba Farmitalia 4-substituted 6-alkylidenandrostene-3,17-dione derivatives
DE3715869A1 (de) * 1987-05-07 1988-11-17 Schering Ag Verfahren zur herstellung von 1-methyl-androsta-1,4-dien-3,17-dion und die neuen zwischenprodukte fuer dieses verfahren
GB8721384D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
GB8721383D0 (en) * 1987-09-11 1987-10-21 Erba Farmitalia Preparation of methylene derivatives
GB8801697D0 (en) * 1988-01-26 1988-02-24 Erba Farmitalia Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione
KR0180008B1 (ko) * 1991-03-28 1999-04-01 야마구찌 다까시 신규 옥사-또는 아자스테로이드 유체
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
US5539127A (en) * 1992-09-30 1996-07-23 Teikoku Hormone Mfg. Co., Ltd. 7-substituted oxa- or azasteroid compound
US6407082B1 (en) * 1996-09-13 2002-06-18 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a vitamin D compound
GB9313420D0 (en) * 1993-06-29 1993-08-11 Erba Carlo Spa Fluorinated 6-methylenandrosta-1,4-dien-3-one-derivatives and process for their preparations
US6028064A (en) 1996-09-13 2000-02-22 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of progestin products
US6034074A (en) 1996-09-13 2000-03-07 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of a Vitamin D compound
US6511970B1 (en) 1996-09-13 2003-01-28 New Life Pharmaceuticals Inc. Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6765002B2 (en) 2000-03-21 2004-07-20 Gustavo Rodriguez Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
WO2001004342A1 (en) * 1999-07-07 2001-01-18 Pharmacia & Upjohn Company Process to prepare exemestane
GB9930839D0 (en) * 1999-12-30 2000-02-16 Pharmacia & Upjohn Spa Process for treating gynecomastia
GB0005257D0 (en) * 2000-03-03 2000-04-26 Pharmacia & Upjohn Spa Breast cancer hormonal therapy
US20010044431A1 (en) * 2000-03-21 2001-11-22 Rodriguez Gustavo C. Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
GB0017635D0 (en) * 2000-07-18 2000-09-06 Pharmacia & Upjohn Spa Antitumor combined therapy
AU2001283964A1 (en) * 2000-08-09 2002-02-18 Pharmacia And Upjohn Company Composition for combined use of aromatase inhibitors
WO2002020020A1 (en) * 2000-09-08 2002-03-14 Pharmacia Italia S.P.A. Exemestane as chemopreventing agent
EP1377298B1 (en) * 2001-01-26 2006-08-30 Pfizer Italia S.r.l. Exemestane for treating hormono-dependent disorders
US20040082557A1 (en) * 2001-01-26 2004-04-29 Wajszczuk Charles Paul Methods for treating estrogen-dependent disorders
PT2762140T (pt) 2001-02-19 2017-07-04 Novartis Ag Resumo
MXPA03010401A (es) 2001-05-16 2004-03-09 Novartis Ag Combinacion que comprende n-[5-[4- (4-metil- piperazino-metil) -benzoilamido] -2-metilfenil] -4-(3-piridil)-2 -pirimidin-amina, y un agente quimioterapeutico.
GB0120147D0 (en) * 2001-08-17 2001-10-10 Metris Therapeutics Ltd Treatment method
US20040043938A1 (en) * 2001-11-06 2004-03-04 Dinesh Purandare Combination therapy for estrogen-dependent disorders
GB0128510D0 (en) * 2001-11-28 2002-01-23 Novartis Ag Organic compounds
DE60324416D1 (de) 2002-05-16 2008-12-11 Novartis Ag Verwendung von edg rezeptor bindenden wirkstoffen für die krebstherapie
CN1317293C (zh) * 2002-10-24 2007-05-23 南京长澳医药科技有限公司 一种依西美坦的合成工艺
CN1304413C (zh) * 2002-10-24 2007-03-14 上海华拓医药科技发展有限公司 一种抗癌药物依西美坦制备方法
US20040186160A1 (en) * 2002-12-13 2004-09-23 Sugen, Inc. Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors
WO2005027916A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and aromatase inhibitors
US20050101579A1 (en) * 2003-11-06 2005-05-12 Shippen Eugene R. Endometriosis treatment protocol
ATE548375T1 (de) 2004-01-16 2012-03-15 Cedarburg Pharmaceuticals Inc Exemestan und zwischenprodukte davon und verfahren zu dessen herstellung
US7435757B2 (en) * 2004-07-02 2008-10-14 Schering Ag 2-substituted D-homo-estra-1,3,5(10)-trienes as inhibitors of 17β-hydroxy steroid dehydrogenase type 1
US10174070B2 (en) 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
KR101484134B1 (ko) 2005-09-30 2015-01-21 엔디씨, 엘엘씨 (ｓ)-６-메틸옥사알킬 엑스메스탄 화합물 및 관련 사용방법
DE102006008074B4 (de) * 2006-02-22 2013-08-14 RUHR-UNIVERSITäT BOCHUM Behandlung von Krebs mit Geruchsrezeptor-Liganden
AU2007247112B2 (en) 2006-05-09 2010-08-26 Novartis Ag Combination comprising an iron chelator and an anti-neoplastic agent and use thereof
WO2008033466A2 (en) * 2006-09-14 2008-03-20 Combinatorx (Singapore) Pre. Ltd. Compositions and methods for treatment of viral diseases
US20080275259A1 (en) * 2007-05-04 2008-11-06 Scinopharm Taiwan, Ltd Process for preparing aromatase inhibitors
ES2718912T3 (es) 2007-10-16 2019-07-05 Repros Therapeutics Inc Trans-clomifeno para el tratamiento de la diabetes en hombres hipogonadales
EP2070943A1 (en) * 2007-12-14 2009-06-17 Crystal Pharma, S.A. Process for obtaining 6-Alkylidenandrost-1,4-diene-3one
CN101468023B (zh) * 2007-12-26 2011-02-02 上海复星医药（集团）股份有限公司 依西美坦片及其制备工艺
ES2461092T3 (es) * 2008-01-21 2014-05-16 Cadila Healthcare Limited Procedimiento para preparar el inhibidor de aromatasa Exemestano
GB0813628D0 (en) * 2008-07-25 2008-09-03 Arrow Int Ltd Stable coated anti-cancer agent
WO2010076811A2 (en) * 2008-12-30 2010-07-08 Ind-Swift Laboratories Limited Process for the preparation of exemestane
EP2429299B1 (en) 2009-05-01 2016-06-01 Celloxess Llc Treating male infertility secondary to sperm oxidative stress
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
CN102884072A (zh) 2010-04-08 2013-01-16 爱默蕾大学 被取代的雄甾-4-烯二酮
JP2013525296A (ja) 2010-04-16 2013-06-20 ノバルティス アーゲー 内分泌療法抵抗性乳癌の処置
ES2605960T3 (es) 2010-09-14 2017-03-17 Endece, Llc Derivados de desmetil-estradiol 6-sustituido como agonistas del RE-beta
US20150031656A1 (en) 2012-02-29 2015-01-29 Repros Therapeutics Inc. Combination therapy for treating androgen deficiency
BR112016014903A8 (pt) * 2014-02-11 2018-05-02 Novartis Ag combinações farmacêuticas que compreendem um inibidor de pi3k, seu uso, sua preparação combinada, e embalagem comercial
US11633382B2 (en) 2015-11-10 2023-04-25 Paracrine Therapeutics Ab Treatment of ER-negative breast cancer with an PDGF-CC inhibitor and anti-estrogen
CN112409432B (zh) * 2020-11-16 2023-07-07 陕西理工大学 一种依西美坦的合成方法

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GB929985A (bg) *
US2744120A (en) * 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US3112305A (en) * 1960-11-07 1963-11-26 British Drug Houses Ltd 6-methylene-3-oxo-delta4-steroids and process for their preparation
GB1042291A (en) * 1961-11-08 1966-09-14 Organon Labor Ltd í¸-6ª‡-amino steroids and the preparation thereof
DK120154B (da) * 1968-02-29 1971-04-19 Schering Ag Fremgangsmåde til fremstilling af N-substituerede 4-amino-3-oxosteroid-4,6-diener af androstan- eller pregnanrækken eller deres ammoniumsalte.
BE759143A (fr) * 1969-11-19 1971-05-19 Upjohn Co Procede de preparation d'un nouveau compose steroide
US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
DE3004508C2 (de) * 1980-02-05 1981-12-10 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur Herstellung von 6-Methylensteroiden
DE3322285A1 (de) * 1983-06-18 1984-12-20 Schering AG, 1000 Berlin und 4709 Bergkamen 1-alkyl-androsta-1,4-dien-3,17-dione, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US4512986A (en) * 1983-07-26 1985-04-23 Research Triangle Institute Progrestationally active steroids
GB8517360D0 (en) * 1985-07-09 1985-08-14 Erba Farmitalia Substituted androsta-1,4-diene-3,17-diones

Also Published As

Publication number Publication date
DK163520C (da) 1992-07-27
KR950003614B1 (ko) 1995-04-17
HK94190A (en) 1990-11-23
PT82944B (pt) 1989-01-30
SG80490G (en) 1990-11-23
SU1501923A3 (ru) 1989-08-15
BE905067A (fr) 1987-01-08
YU103687A (en) 1988-08-31
NL300017I2 (nl) 2001-01-02
CS257794B2 (en) 1988-06-15
SE8603046D0 (sv) 1986-07-08
BR1100240A (pt) 1999-12-28
DK324386A (da) 1987-01-10
IE58949B1 (en) 1993-12-01
AT395157B (de) 1992-10-12
JPH0443919B2 (bg) 1992-07-20
ES557466A0 (es) 1988-06-01
SE468988B (sv) 1993-04-26
YU44585B (en) 1990-10-31
DE10199030I1 (de) 2001-10-04
PH21785A (en) 1988-02-24
MY102294A (en) 1992-05-15
ES8801304A1 (es) 1987-12-16
ZA865079B (en) 1987-03-25
ATA181986A (de) 1992-02-15
FI83424C (fi) 1991-07-10
IT1196436B (it) 1988-11-16
NO862753D0 (no) 1986-07-08
AU578840B2 (en) 1988-11-03
UA6046A1 (uk) 1994-12-29
FI862871A (fi) 1987-01-10
AU5979986A (en) 1987-01-15
FI83424B (fi) 1991-03-28
DK324386D0 (da) 1986-07-08
YU120186A (en) 1988-02-29
NL193616C (nl) 2000-04-04
NL193616B (nl) 1999-12-01
FI862871A0 (fi) 1986-07-07
CA1277656C (en) 1990-12-11
GB8517360D0 (en) 1985-08-14
IL79336A0 (en) 1986-10-31
US4904650A (en) 1990-02-27
CN86104664B (zh) 1988-06-29
ES8802429A1 (es) 1988-06-01
CN86104664A (zh) 1987-02-18
GR861780B (en) 1986-11-11
DK163520B (da) 1992-03-09
NO165547C (no) 1991-02-27
NL300017I1 (nl) 2000-11-01
JPS6212797A (ja) 1987-01-21
PT82944A (en) 1986-08-01
NO165547B (no) 1990-11-19
GB2177700B (en) 1988-12-07
US4808616A (en) 1989-02-28
CZ413591A3 (en) 1994-03-16
SK413591A3 (en) 1995-07-11
IL79336A (en) 1991-06-10
NL8601785A (nl) 1987-02-02
NO2000009I1 (no) 2000-10-05
ES556550A0 (es) 1987-12-16
IE861821L (en) 1987-01-09
HU194274B (en) 1988-01-28
YU44628B (en) 1990-10-31
BG61370B2 (bg) 1997-06-30
NO862753L (no) 1987-01-12
CH668599A5 (de) 1989-01-13
GB2177700A (en) 1987-01-28
CS258498B2 (en) 1988-08-16
FR2584725A1 (fr) 1987-01-16
IT8621004A0 (it) 1986-07-02
SU1442077A3 (ru) 1988-11-30
CS521486A2 (en) 1987-09-17
GB8616585D0 (en) 1986-08-13
SE8603046L (sv) 1987-01-10
HUT42780A (en) 1987-08-28
KR870001140A (ko) 1987-03-11
FR2584725B1 (fr) 1988-05-13

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