NO991731L - Lokalanestetika for utvortes bruk - Google Patents

Lokalanestetika for utvortes bruk

Info

Publication number
NO991731L
NO991731L NO991731A NO991731A NO991731L NO 991731 L NO991731 L NO 991731L NO 991731 A NO991731 A NO 991731A NO 991731 A NO991731 A NO 991731A NO 991731 L NO991731 L NO 991731L
Authority
NO
Norway
Prior art keywords
external use
percutaneous absorption
ethanol
isopropyl alcohol
water
Prior art date
Application number
NO991731A
Other languages
English (en)
Other versions
NO991731D0 (no
Inventor
Toshio Inagi
Akira Mada
Original Assignee
Kowa Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kowa Co filed Critical Kowa Co
Publication of NO991731D0 publication Critical patent/NO991731D0/no
Publication of NO991731L publication Critical patent/NO991731L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • External Artificial Organs (AREA)
  • Cyclones (AREA)

Abstract

Lokalanestetikum for utvortes bruk fremstilles ved blanding av a) en aktiv bestanddel valgt fra lidokain, prilokain, og farmasøytisk akseptable salter derav, b) en perkutan absorpsjonsakselerator, c) etanol og/eller isopropylalkohol, og d) vann, slik at blandings-forholdet for etanol og/eller isopropylalkohol til vann fortrinnsvis er fra 0,5 til 1,2 beregnet på vekt, og pH-verdien justeres fortrinnsvis til å være i området fra 6,0 til 8,5. Det tilveiebringes således et lokalanestetikum av den perkutane absorpsjonstypen for utvortes bruk, og dette har hensiktsmessige bruksegenskaper ved påføring og fjerning, kan påføres på en bred hudoverflate, og har utmerket perkutan absorpsjon og hurtig effektivitet samt utmerket stabilitet.
NO991731A 1996-10-14 1999-04-13 Lokalanestetika for utvortes bruk NO991731L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP27081396 1996-10-14
PCT/JP1997/003567 WO1998016212A1 (en) 1996-10-14 1997-10-06 Local anesthetic for external use

Publications (2)

Publication Number Publication Date
NO991731D0 NO991731D0 (no) 1999-04-13
NO991731L true NO991731L (no) 1999-06-14

Family

ID=17491384

Family Applications (1)

Application Number Title Priority Date Filing Date
NO991731A NO991731L (no) 1996-10-14 1999-04-13 Lokalanestetika for utvortes bruk

Country Status (31)

Country Link
US (1) US6429228B1 (no)
EP (1) EP0957906B1 (no)
JP (1) JP2001503035A (no)
KR (1) KR20000049125A (no)
CN (1) CN1135104C (no)
AT (1) ATE214599T1 (no)
AU (1) AU731946B2 (no)
BG (1) BG103325A (no)
BR (1) BR9711911A (no)
CA (1) CA2268535A1 (no)
CZ (1) CZ129899A3 (no)
DE (1) DE69711237T2 (no)
DK (1) DK0957906T3 (no)
EA (1) EA001611B1 (no)
EE (1) EE03743B1 (no)
ES (1) ES2173485T3 (no)
HU (1) HUP9904109A3 (no)
ID (1) ID21773A (no)
IL (1) IL129335A (no)
LT (1) LT4585B (no)
MY (1) MY118301A (no)
NO (1) NO991731L (no)
NZ (1) NZ335056A (no)
PL (1) PL332724A1 (no)
PT (1) PT957906E (no)
RO (1) RO120604B1 (no)
SK (1) SK284332B6 (no)
TR (1) TR199900814T2 (no)
TW (1) TW450815B (no)
WO (1) WO1998016212A1 (no)
YU (1) YU19399A (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6528086B2 (en) * 1999-09-28 2003-03-04 Zars, Inc. Methods and apparatus for drug delivery involving phase changing formulations
US20020006435A1 (en) * 2000-01-27 2002-01-17 Samuels Paul J. Transdermal anesthetic and vasodilator composition and methods for topical administration
US6894078B2 (en) * 2001-09-17 2005-05-17 James G. Castillo Alcohol based topical anesthetic formulation and method
US20040077593A1 (en) * 2002-10-21 2004-04-22 Marron Susan M. Numbing gel for hair removal
US20040076671A1 (en) * 2002-10-21 2004-04-22 Aletha Tippett Methods and compositions for topical wound treatment
JP4667369B2 (ja) * 2003-03-21 2011-04-13 ネックスメド ホールディングス インコーポレイテッド 早漏を治療するための組成物および方法
US20050014823A1 (en) * 2003-07-17 2005-01-20 Soderlund Patrick L. Topical anesthetic composition and method of administration
WO2006018997A1 (ja) * 2004-08-18 2006-02-23 Medrx Co., Ltd. 外用剤
WO2007002304A2 (en) 2005-06-22 2007-01-04 Vnus Medical Technologies, Inc. Methods and apparatus for introducing tumescent fluid to body tissue
USRE46397E1 (en) 2007-11-07 2017-05-09 Svip5 Llc Slow release of organic salts of local anesthetics for pain relief
CA2738524C (en) 2008-10-02 2013-11-26 Mylan Inc. Method for making a multilayer adhesive laminate
DE102009007152A1 (de) * 2009-02-02 2010-08-05 Müller-Glewe, Gunter Ultraschall-Gel
EP2552409A1 (en) * 2010-04-01 2013-02-06 Pharmanest AB Bioadhesive compositions of local anaesthetics
CN102018696B (zh) * 2010-11-22 2013-07-03 北京泰德制药股份有限公司 一种含有利多卡因或其药用盐的皮肤外用制剂
JP5512891B2 (ja) * 2011-06-20 2014-06-04 久光製薬株式会社 リドカイン含有パップ剤
FR2983731B1 (fr) * 2011-12-07 2014-04-25 Univ Paris Descartes Emulsions topiques a base de melanges eutectiques d'anesthesiques locaux et d'acide gras
CN103505791A (zh) * 2012-06-28 2014-01-15 杨德普 透皮吸收局麻无痛注射穿刺酒精棉片
CN103550675A (zh) * 2013-09-04 2014-02-05 赵会霞 一种止痛贴
KR102080860B1 (ko) * 2018-04-11 2020-02-24 숭실대학교산학협력단 미세구조의 피부 흡수 증강제, 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제, 및 미세구조의 피부 흡수 증강제를 포함하는 국소 마취제를 이용한 마취 방법
CN110090197A (zh) * 2019-04-19 2019-08-06 广州芮一生物科技有限公司 一种可成膜的麻醉面膜膏

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954487A (en) * 1979-01-08 1990-09-04 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
CA1165240A (en) * 1980-07-09 1984-04-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
JPS57142913A (en) * 1981-02-27 1982-09-03 Nitto Electric Ind Co Ltd Donor of physiologically active substance
US4748022A (en) 1985-03-25 1988-05-31 Busciglio John A Topical composition
US4764381A (en) * 1985-12-06 1988-08-16 Key Pharmaceuticals, Inc. Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol
US5209724A (en) 1988-04-11 1993-05-11 Dhaliwal Avtar S Composite anesthetic article and method of use
PT90784A (pt) * 1988-06-09 1989-12-29 Alza Corp Processo para a preparacao de uma composicao de materiais para aplicacao sobre uma superficie corporal ou membral
US5378730A (en) * 1988-06-09 1995-01-03 Alza Corporation Permeation enhancer comprising ethanol and monoglycerides
JPH0755167B2 (ja) * 1988-09-21 1995-06-14 松下電器産業株式会社 移動体
US4892737A (en) * 1988-09-22 1990-01-09 University Of Florida Composition and method for enhancing permeability of topical drugs
GB9101986D0 (en) 1991-01-30 1991-03-13 Smith & Nephew Pharmaceutical compositions
JPH04261119A (ja) * 1991-02-13 1992-09-17 Lintec Corp 経皮吸収型貼付剤
JP3115625B2 (ja) * 1991-03-30 2000-12-11 帝國製薬株式会社 リドカイン含有外用貼付剤
JP2775203B2 (ja) 1991-05-11 1998-07-16 久光製薬株式会社 吸収促進組成物
JPH0640947A (ja) 1992-07-28 1994-02-15 T T S Gijutsu Kenkyusho:Kk 経皮吸収製剤用組成物および経皮吸収製剤
JPH0694891A (ja) 1992-09-10 1994-04-08 Kawasaki Heavy Ind Ltd 使用済燃料貯蔵・輸送容器
JPH08286701A (ja) 1995-04-11 1996-11-01 Nissan Motor Co Ltd 複数ロボット制御方法およびシステム

Also Published As

Publication number Publication date
PL332724A1 (en) 1999-10-11
ID21773A (id) 1999-07-22
MY118301A (en) 2004-09-30
YU19399A (sh) 2001-09-28
SK284332B6 (sk) 2005-01-03
IL129335A (en) 2004-08-31
EA001611B1 (ru) 2001-06-25
US6429228B1 (en) 2002-08-06
HUP9904109A2 (hu) 2000-04-28
HUP9904109A3 (en) 2000-11-28
AU731946B2 (en) 2001-04-05
AU4399697A (en) 1998-05-11
LT4585B (lt) 1999-12-27
ATE214599T1 (de) 2002-04-15
LT99036A (en) 1999-07-26
TW450815B (en) 2001-08-21
CN1240353A (zh) 2000-01-05
BR9711911A (pt) 2000-01-18
RO120604B1 (ro) 2006-05-30
SK48299A3 (en) 2000-01-18
CZ129899A3 (cs) 1999-09-15
PT957906E (pt) 2002-07-31
CN1135104C (zh) 2004-01-21
TR199900814T2 (xx) 1999-07-21
BG103325A (en) 2000-01-31
DK0957906T3 (da) 2002-05-27
EE03743B1 (et) 2002-06-17
DE69711237D1 (de) 2002-04-25
WO1998016212A1 (en) 1998-04-23
EA199900376A1 (ru) 1999-10-28
EP0957906A1 (en) 1999-11-24
CA2268535A1 (en) 1998-04-23
EP0957906B1 (en) 2002-03-20
DE69711237T2 (de) 2002-10-17
NZ335056A (en) 2000-08-25
KR20000049125A (ko) 2000-07-25
EE9900144A (et) 1999-12-15
NO991731D0 (no) 1999-04-13
ES2173485T3 (es) 2002-10-16
IL129335A0 (en) 2000-02-17
JP2001503035A (ja) 2001-03-06

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