US20040076671A1 - Methods and compositions for topical wound treatment - Google Patents

Methods and compositions for topical wound treatment Download PDF

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Publication number
US20040076671A1
US20040076671A1 US10/367,393 US36739303A US2004076671A1 US 20040076671 A1 US20040076671 A1 US 20040076671A1 US 36739303 A US36739303 A US 36739303A US 2004076671 A1 US2004076671 A1 US 2004076671A1
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United States
Prior art keywords
wound
composition
lidocaine
dressing
safe
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Abandoned
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US10/367,393
Inventor
Aletha Tippett
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Aletha Tippett
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Publication date
Priority to US42000802P priority Critical
Application filed by Aletha Tippett filed Critical Aletha Tippett
Priority to US10/367,393 priority patent/US20040076671A1/en
Publication of US20040076671A1 publication Critical patent/US20040076671A1/en
Application status is Abandoned legal-status Critical

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/65Tetracyclines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Abstract

Compositions for improved treatment of wounds on a patient. A first composition having a safe and effective amount of lidocaine, wherein the composition is topically applied to a wound on a patient. A second composition having a safe and effective amount of lidocaine and a safe and effective amount of topical antibiotic, wherein the composition is topically applied to a wound on a patient. A method for treating a patient having a skin wound by locally administering a safe and effective amount of lidocaine and an antibiotic compound in the skin wound such that healing of the skin wound is enhanced.

Description

    RELATED APPLICATION
  • The present application claims priority under 35 U.S.C. § 19 of U.S. Provisional Application Serial No. 60/420008 filed Oct. 21, 2002.[0001]
  • TECHNICAL FIELD
  • The present invention relates generally to methods and compositions for treating patients, and more particularly to a method and composition for topical wound treatment. [0002]
  • BACKGROUND OF THE INVENTION
  • Wounds are commonplace from childhood to old age. Wounds are a significant problem among the geriatric and nursing home population, especially at the end of life. Pressure ulcers alone exact a -tremendous human and financial toll, costing on average more than $1,200 per patient per month to treat. The prevalence of pressure ulcers in 1997 was 16 of every 1,000 nursing home residents. A goal of a federal program, “Healthy People 2010” is a reduction of pressure ulcers to a prevalence of less than 8 per 1,000. Diabetic ulcers similarly result in significant morbidity and costs, with diabetics accounting for approximately 82,000 amputations annually in the U.S., averaging $30,000 per amputation. Other wounds plaguing the nursing home and end of life population are ulcers resulting from arterial and venous insufficiency, as well as traumatic wounds, and non-healing surgical wounds. [0003]
  • Most of the wounds treated are chronic wounds, often persisting for many months. Especially among the terminally ill, there is little expectation of healing a wound due to the population being malnourished, immobile and with many comorbidities that inhibit and delay wound healing. In addition, often the patient will not live long enough to heal a wound. In the terminally ill patient, the goal typically is palliation, including relief of pain, and prevention of infection. A chronic wound is any break, or ulceration, of the skin that is of long duration or recurs frequently and has not responded to conventional therapies. [0004]
  • Standard wound care involves debridement, cleansing and covering the wound with any of a variety of commercially available dressings. There are many special dressings available which are designed to keep wounds moist or absorb exudates. Some specialty dressings have silver impregnated in the dressing to prevent infection. Typically dressings are attached either with self-adhesive or tape, or in some cases are applied with a compression wrap. Recent high tech approaches are available for wound care using thermal wound treatments and vacuum pumps. While these can be effective, they are very expensive and healing times are still measured in weeks or months. As such, it is desired to have an inexpensive wound treatment method and composition which reduces the time required for wounds to heal. [0005]
  • SUMMARY OF THE INVENTION
  • Accordingly, it is an object of the present invention to provide novel methods and compositions for topical wound care which overcomes one or more disadvantages of the prior art. [0006]
  • It is a more specific object of the invention to provide novel methods and compositions for improved treatment of wounds on a patient utilizing lidocaine. [0007]
  • These additional objects and advantages are provided by the methods and compositions of improved treatment of wounds on a patient of the present invention. [0008]
  • More particularly, a method and composition are provided for improved treatment of wounds on a patient. The composition comprises a safe and effective amount of lidocaine in a carrier, wherein the composition is topically applied to a wound on a patient. [0009]
  • In another embodiment of the present invention, a composition for improved treatment of wounds on a patient is provided. The composition comprises a safe and effective amount of lidocaine in a carrier and a safe and effective amount of a topical antibiotic compound, wherein the composition is topically applied to a wound on a patient. [0010]
  • In another embodiment, the present invention is directed to a wound dressing comprising a bandage, a safe and effective amount of lidocaine in a carrier, wherein the wound dressing enhances healing of a wound. [0011]
  • Also provided is a method for treating a patient having a skin wound, including the steps of locally administering a safe and effective amount of lidocaine in a carrier to the skin wound such that the healing of the skin wound is enhanced. [0012]
  • Another aspect of the present invention is an article of manufacture comprising packaging material and a composition comprising a safe and effectiv