NO972457L - Anvendelse av metallkomplekser som lever- og galleröntgendiagnostika i datatomografien - Google Patents

Anvendelse av metallkomplekser som lever- og galleröntgendiagnostika i datatomografien

Info

Publication number
NO972457L
NO972457L NO972457A NO972457A NO972457L NO 972457 L NO972457 L NO 972457L NO 972457 A NO972457 A NO 972457A NO 972457 A NO972457 A NO 972457A NO 972457 L NO972457 L NO 972457L
Authority
NO
Norway
Prior art keywords
liver
metal complexes
biliary
computer tomography
ray diagnostics
Prior art date
Application number
NO972457A
Other languages
English (en)
Norwegian (no)
Other versions
NO972457D0 (no
Inventor
Franz-Karl Maier
Michael Bauer
Werner Krause
Ulrich Speck
Gabriele Schuhmann-Giampieri
Andreas Muehler
Thomas Balzer
Wolf-Ruediger Press
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of NO972457D0 publication Critical patent/NO972457D0/no
Publication of NO972457L publication Critical patent/NO972457L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
NO972457A 1994-11-30 1997-05-29 Anvendelse av metallkomplekser som lever- og galleröntgendiagnostika i datatomografien NO972457L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35108694A 1994-11-30 1994-11-30
US38740895A 1995-02-13 1995-02-13
PCT/DE1995/001644 WO1996016677A2 (de) 1994-11-30 1995-11-20 Verwendung von metallkomplexen als leber- und gallen-röntgendiagnostika in der computertomographie

Publications (2)

Publication Number Publication Date
NO972457D0 NO972457D0 (no) 1997-05-29
NO972457L true NO972457L (no) 1997-07-30

Family

ID=26996938

Family Applications (3)

Application Number Title Priority Date Filing Date
NO972460A NO972460L (no) 1994-11-30 1997-05-29 Nye substituerte DTPA-derivater, deres metallkomplekser, farmasöytiske midler inneholdende metallkompleksene samt deres anvendelse ved diagnostikk og terapi
NO972459A NO972459L (no) 1994-11-30 1997-05-29 Nye flersubst DTPA-derivater og deres metallkomplekser, farmasöytiske preparater inneh slike komplekser, deres anv ved diagnostikk og terapi, fremg for fremst av de kompleksdannende midler og komplekser, samt fremg for frems av de farmasöytiske
NO972457A NO972457L (no) 1994-11-30 1997-05-29 Anvendelse av metallkomplekser som lever- og galleröntgendiagnostika i datatomografien

Family Applications Before (2)

Application Number Title Priority Date Filing Date
NO972460A NO972460L (no) 1994-11-30 1997-05-29 Nye substituerte DTPA-derivater, deres metallkomplekser, farmasöytiske midler inneholdende metallkompleksene samt deres anvendelse ved diagnostikk og terapi
NO972459A NO972459L (no) 1994-11-30 1997-05-29 Nye flersubst DTPA-derivater og deres metallkomplekser, farmasöytiske preparater inneh slike komplekser, deres anv ved diagnostikk og terapi, fremg for fremst av de kompleksdannende midler og komplekser, samt fremg for frems av de farmasöytiske

Country Status (15)

Country Link
US (4) US5672335A (de)
EP (3) EP0794938A1 (de)
JP (3) JPH11503405A (de)
CN (1) CN1167444A (de)
AU (3) AU4299496A (de)
CA (3) CA2206576A1 (de)
CZ (1) CZ166897A3 (de)
FI (3) FI972286A0 (de)
HU (1) HUT77284A (de)
IL (3) IL116209A0 (de)
MX (1) MX9703880A (de)
NO (3) NO972460L (de)
PL (1) PL320462A1 (de)
SK (1) SK68997A3 (de)
WO (3) WO1996016929A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
DE69620582T2 (de) * 1995-01-26 2002-11-07 Nycomed Imaging As Verwendung von WISMUTVERBINDUNGEN zur Herstellung eines Arzneimittels zur Behandlung von Magenverstimmungen, die durch Helicobacter pylori verursacht werden
US6403055B1 (en) 1996-08-02 2002-06-11 Dibra S.P.A. Diagnostic imaging contrast agent with improved in serum relaxivity
IT1290417B1 (it) * 1996-08-02 1998-12-03 Bracco Spa Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed
US6458337B1 (en) 1996-08-02 2002-10-01 Dibra S.P.A Diagnostic imaging contrast agent with improved in serum relaxivity
IT1283650B1 (it) * 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US7521531B2 (en) 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
JP4432000B2 (ja) 1996-12-23 2010-03-17 ブラッコ・リサーチ・ソシエテ・アノニム 患者の消化管の視覚化におけるｍｒｉ造影の増加用組成物
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6767741B1 (en) 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
DK1362053T3 (da) * 2001-02-20 2008-03-10 Enzon Inc Terminalt forgrenede polymere linkere og polymere konjugater indeholdende disse
DE10127126A1 (de) * 2001-06-05 2002-12-19 Forschungszentrum Juelich Gmbh Geschützte Tyrosinderivate, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von O-(2-[·18·F]-Fluorethyl)-L-tyrosin
US6627394B2 (en) 2001-07-19 2003-09-30 Common Sense Ltd. Diagnostic pad
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
GB0423506D0 (en) * 2004-10-22 2004-11-24 Univ Belfast Light emitting complex salts
US10071174B2 (en) 2011-06-06 2018-09-11 Portland State University Bismuth particle X-ray contrast agents
CA2873652A1 (en) * 2012-05-18 2013-11-21 Markus Berger Bis azainositol heavy metal complexes for x-ray imaging
BR102013023479B1 (pt) * 2013-09-12 2022-07-26 Uniao Brasileira De Educação E Assistência Processo de síntese de compostos de coordenação à base de lantanídeo
CN105277656B (zh) 2014-07-01 2018-12-25 科蒙森斯公司 用于鉴定羊水的诊断组合物
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
JP7120802B2 (ja) 2017-07-20 2022-08-17 株式会社神戸製鋼所 流体流通装置及びその流通異常検知方法
JP6836471B2 (ja) 2017-07-20 2021-03-03 株式会社神戸製鋼所 流体流通装置
CN107573291A (zh) * 2017-10-27 2018-01-12 上海司太立制药有限公司 一种钆塞酸二钠配体杂质的制备方法和用途
SG11202104657RA (en) 2018-11-23 2021-06-29 Bayer Ag Formulation of contrast media and process of preparation thereof
EP4059925A1 (de) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft Neues kontrastmittel zur verwendung in der magnetresonanzbildgebung
EP4335840A1 (de) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft Neue kontrastmittel zur verwendung in der diagnostischen bildgebung
EP4335462A1 (de) 2022-09-09 2024-03-13 Bayer AG Kontrastmittel zur verwendung in der diagnostischen bildgebung mittels computertomografie

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1374979A (en) * 1970-12-21 1974-11-20 Nat Res Dev 3,5-dioxopiperazine derivatives
US3994966A (en) * 1972-09-28 1976-11-30 The Board Of Trustees Of The Leland Stanford Junior University Chelating agents
US4339426A (en) * 1980-03-18 1982-07-13 Regents Of The University Of California Bleomycin analog
US4622420A (en) * 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
US5482700A (en) * 1987-03-31 1996-01-09 Schering Aktiengesellschaft Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
ES2033433T3 (es) * 1987-07-16 1993-03-16 Nycomed As Procedimiento para preparar acidos aminopolicarboxilicos y sus derivados.
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5399340A (en) * 1987-09-24 1995-03-21 Schering Aktiengesellschaft Use of amide complex compounds
US5137711A (en) * 1988-07-19 1992-08-11 Mallickrodt Medical, Inc. Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
NZ231180A (en) * 1988-10-31 1994-11-25 Dow Chemical Co Bifunctional chelants;complexes,conjugates and pharmaceutical compositions thereof
US5342604A (en) * 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
US5101041A (en) * 1989-04-26 1992-03-31 The Curators Of The University Of Missouri Triamines and their derivatives as bifunctional chelating agents
DE3922005A1 (de) * 1989-06-30 1991-01-10 Schering Ag Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
US5695739A (en) * 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
GB9122984D0 (en) * 1991-10-30 1991-12-18 Salutar Inc Contrast media
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
EP0703790B1 (de) * 1993-06-02 2000-08-16 BRACCO S.p.A. Iodierte paramagnetische chelaten, und deren verwendung als kontrastmittel
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
DE69420581T2 (de) * 1993-12-03 2000-01-20 Bracco Spa Paramagnetische chelate für magnetische kernresonant-diagnose

Also Published As

Publication number Publication date
AU4254696A (en) 1996-06-19
US5672335A (en) 1997-09-30
AU3922795A (en) 1996-06-19
NO972459L (no) 1997-07-29
CZ166897A3 (en) 1997-09-17
FI972288A (fi) 1997-05-29
SK68997A3 (en) 1997-11-05
JPH11503405A (ja) 1999-03-26
HUT77284A (hu) 1998-03-30
NO972459D0 (no) 1997-05-29
JPH10509961A (ja) 1998-09-29
AU4299496A (en) 1996-06-19
CA2206576A1 (en) 1996-06-06
JPH10511934A (ja) 1998-11-17
IL116208A0 (en) 1996-01-31
NO972460D0 (no) 1997-05-29
WO1996016677A2 (de) 1996-06-06
FI972287A (fi) 1997-05-29
FI972288A0 (fi) 1997-05-29
US5853699A (en) 1998-12-29
WO1996016928A1 (de) 1996-06-06
CA2206522A1 (en) 1996-06-06
WO1996016677A3 (de) 1996-09-12
CN1167444A (zh) 1997-12-10
CA2206397A1 (en) 1996-06-06
EP0794799A2 (de) 1997-09-17
PL320462A1 (en) 1997-09-29
FI972286A (fi) 1997-05-29
US5885548A (en) 1999-03-23
EP0794938A1 (de) 1997-09-17
WO1996016929A1 (de) 1996-06-06
IL116206A0 (en) 1996-01-31
IL116209A0 (en) 1996-01-31
NO972457D0 (no) 1997-05-29
EP0794939A1 (de) 1997-09-17
NO972460L (no) 1997-05-29
US5746995A (en) 1998-05-05
FI972286A0 (fi) 1997-05-29
FI972287A0 (fi) 1997-05-29
MX9703880A (es) 1997-08-30

Similar Documents

Publication Publication Date Title
NO972457L (no) Anvendelse av metallkomplekser som lever- og galleröntgendiagnostika i datatomografien
IL150258A0 (en) Cascade polymer complexes
MY113079A (en) Estrogen agonists as remedies for cardiovascular diseases
NO931631D0 (no) Kompleksdannende midler og maalsoeking av radioaktive immunoreagenser nyttige innen terapeutiske og diagnostiske bildedannende sammensetninger og fremgangsmetoder
CY1111863T1 (el) Αντισωματα εναντιον υποδοχεα θανατου 4 (dr4) και χρησεις αυτων
AU8188987A (en) Improved metal complex-containing pharmaceutical agents
DE69107504D1 (de) Härtungsmittel für geschädigte Gewebe im Verdauungssystem.
SE9704186D0 (sv) New composition of matter
NO307325B1 (no) Middel for transdermal applikasjon inneholdende 3- ketodesogestrel
NZ233784A (en) Pharmaceutical composition comprising an inclusion compound of imipramine or derivative in cyclodextrin
NO944838L (no) Arabinogalaktanderivater og anvendelser derav
DE69512924T2 (de) Röntgenstrahlenempfindliche photoleitfähige zusammensetzungen für röntgenradiographie
ATE140219T1 (de) Chelatbildende mittel
NO972458L (no) Anvendelse av metallkomplekser som lever- og galleröntgendiagnostika
RS49734B (sr) Primena intravenoznih kontrastnih sredstava za projekcionu mamografiju
DE69407057D1 (de) 1,3.5 (10) - estratriene derivate mit oraler wirkung
DK0468258T3 (da) Substituerede pyridooxaziner
ATE134988T1 (de) Neue vorangeordnete sechszähnige liganden verwendbar in röntgenologischen bildformenden wirkstoffen
DK0457127T3 (da) Spermicidt belægningsmiddel
RU96108676A (ru) Способ рентгенологического исследования желчных протоков
AU5093993A (en) Nonionic X-ray contrast agents compositions and methods
DE60212424D1 (de) Radiopharmazeutishes mittel zur behandlung von krebs im frühstadium
IL103696A0 (en) Contrast agents and compositions for radiological imaging,and radiological imaging method utilizing same
UA31289A (uk) Спосіб лікування запальних захворювань щелепо-лицевої ділянки
IT9047682A0 (it) Composizione sterilizzatrice e procedimento per il suo impiego.