IL116209A0 - Metal complexes and complexing agents as x-ray contrast media - Google Patents

Metal complexes and complexing agents as x-ray contrast media

Info

Publication number
IL116209A0
IL116209A0 IL11620995A IL11620995A IL116209A0 IL 116209 A0 IL116209 A0 IL 116209A0 IL 11620995 A IL11620995 A IL 11620995A IL 11620995 A IL11620995 A IL 11620995A IL 116209 A0 IL116209 A0 IL 116209A0
Authority
IL
Israel
Prior art keywords
metal complexes
complexing agents
contrast media
ray contrast
ray
Prior art date
Application number
IL11620995A
Other languages
English (en)
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of IL116209A0 publication Critical patent/IL116209A0/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
IL11620995A 1994-11-30 1995-11-30 Metal complexes and complexing agents as x-ray contrast media IL116209A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35108694A 1994-11-30 1994-11-30
US38740895A 1995-02-13 1995-02-13

Publications (1)

Publication Number Publication Date
IL116209A0 true IL116209A0 (en) 1996-01-31

Family

ID=26996938

Family Applications (3)

Application Number Title Priority Date Filing Date
IL11620695A IL116206A0 (en) 1994-11-30 1995-11-30 Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic compositions containing the same
IL11620995A IL116209A0 (en) 1994-11-30 1995-11-30 Metal complexes and complexing agents as x-ray contrast media
IL11620895A IL116208A0 (en) 1994-11-30 1995-11-30 Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic agents containing the same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
IL11620695A IL116206A0 (en) 1994-11-30 1995-11-30 Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic compositions containing the same

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL11620895A IL116208A0 (en) 1994-11-30 1995-11-30 Metal complexes of diethylenetriaminepentaacetic acid derivatives and pharmaceutical and diagnostic agents containing the same

Country Status (15)

Country Link
US (4) US5672335A (xx)
EP (3) EP0794938A1 (xx)
JP (3) JPH10509961A (xx)
CN (1) CN1167444A (xx)
AU (3) AU4254696A (xx)
CA (3) CA2206522A1 (xx)
CZ (1) CZ166897A3 (xx)
FI (3) FI972288A0 (xx)
HU (1) HUT77284A (xx)
IL (3) IL116206A0 (xx)
MX (1) MX9703880A (xx)
NO (3) NO972457L (xx)
PL (1) PL320462A1 (xx)
SK (1) SK68997A3 (xx)
WO (3) WO1996016928A1 (xx)

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GB9501560D0 (en) * 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
CN1177357A (zh) * 1995-01-26 1998-03-25 耐克麦德英梅金公司 铋化合物
US6403055B1 (en) 1996-08-02 2002-06-11 Dibra S.P.A. Diagnostic imaging contrast agent with improved in serum relaxivity
US6458337B1 (en) 1996-08-02 2002-10-01 Dibra S.P.A Diagnostic imaging contrast agent with improved in serum relaxivity
IT1290417B1 (it) * 1996-08-02 1998-12-03 Bracco Spa Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed
IT1283650B1 (it) * 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
US7521531B2 (en) 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
US6060040A (en) * 1996-12-23 2000-05-09 Bracco Research S.A. Cross-linked polymeric compositions for increasing the MRI contrast in visualising the digestive tract of patients
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6767741B1 (en) 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
MXPA03007392A (es) * 2001-02-20 2003-12-04 Enzon Inc Enlazantes polimericos ramificados terminalmente y conjugados polimericos que contienen los mismos.
DE10127126A1 (de) * 2001-06-05 2002-12-19 Forschungszentrum Juelich Gmbh Geschützte Tyrosinderivate, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von O-(2-[·18·F]-Fluorethyl)-L-tyrosin
US6627394B2 (en) 2001-07-19 2003-09-30 Common Sense Ltd. Diagnostic pad
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
GB0423506D0 (en) * 2004-10-22 2004-11-24 Univ Belfast Light emitting complex salts
EP2717934A4 (en) * 2011-06-06 2015-01-14 Oregon State X-RAY CONTRACTS FROM WISMUT PARTICLES
US20150132229A1 (en) * 2012-05-18 2015-05-14 Bayer Pharma Aktiengesellschaft Bis azainositol heavy metal complexes for x-ray imaging
BR102013023479B1 (pt) * 2013-09-12 2022-07-26 Uniao Brasileira De Educação E Assistência Processo de síntese de compostos de coordenação à base de lantanídeo
CN105277656B (zh) 2014-07-01 2018-12-25 科蒙森斯公司 用于鉴定羊水的诊断组合物
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
EP3544964B1 (en) 2016-11-28 2020-06-17 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
JP7120802B2 (ja) 2017-07-20 2022-08-17 株式会社神戸製鋼所 流体流通装置及びその流通異常検知方法
JP6836471B2 (ja) 2017-07-20 2021-03-03 株式会社神戸製鋼所 流体流通装置
CN107573291A (zh) * 2017-10-27 2018-01-12 上海司太立制药有限公司 一种钆塞酸二钠配体杂质的制备方法和用途
JOP20210114A1 (ar) 2018-11-23 2023-01-30 Bayer Ag تركيبة وسط تباين وعملية لتحضيرها
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging

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US3994966A (en) * 1972-09-28 1976-11-30 The Board Of Trustees Of The Leland Stanford Junior University Chelating agents
US4622420A (en) * 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US4339426A (en) * 1980-03-18 1982-07-13 Regents Of The University Of California Bleomycin analog
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US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
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DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
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US5137711A (en) * 1988-07-19 1992-08-11 Mallickrodt Medical, Inc. Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
NZ231180A (en) * 1988-10-31 1994-11-25 Dow Chemical Co Bifunctional chelants;complexes,conjugates and pharmaceutical compositions thereof
US5342604A (en) * 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
US5101041A (en) * 1989-04-26 1992-03-31 The Curators Of The University Of Missouri Triamines and their derivatives as bifunctional chelating agents
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US5695739A (en) * 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
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Also Published As

Publication number Publication date
SK68997A3 (en) 1997-11-05
WO1996016677A2 (de) 1996-06-06
WO1996016928A1 (de) 1996-06-06
PL320462A1 (en) 1997-09-29
AU4254696A (en) 1996-06-19
FI972288A (fi) 1997-05-29
IL116206A0 (en) 1996-01-31
US5885548A (en) 1999-03-23
AU3922795A (en) 1996-06-19
NO972460D0 (no) 1997-05-29
NO972459D0 (no) 1997-05-29
FI972288A0 (fi) 1997-05-29
FI972286A (fi) 1997-05-29
CA2206397A1 (en) 1996-06-06
NO972457L (no) 1997-07-30
US5746995A (en) 1998-05-05
WO1996016929A1 (de) 1996-06-06
HUT77284A (hu) 1998-03-30
IL116208A0 (en) 1996-01-31
US5672335A (en) 1997-09-30
JPH10509961A (ja) 1998-09-29
NO972460L (no) 1997-05-29
US5853699A (en) 1998-12-29
CA2206576A1 (en) 1996-06-06
MX9703880A (es) 1997-08-30
JPH11503405A (ja) 1999-03-26
EP0794799A2 (de) 1997-09-17
NO972457D0 (no) 1997-05-29
NO972459L (no) 1997-07-29
FI972287A0 (fi) 1997-05-29
CA2206522A1 (en) 1996-06-06
FI972286A0 (fi) 1997-05-29
WO1996016677A3 (de) 1996-09-12
EP0794939A1 (de) 1997-09-17
FI972287A (fi) 1997-05-29
AU4299496A (en) 1996-06-19
JPH10511934A (ja) 1998-11-17
CN1167444A (zh) 1997-12-10
EP0794938A1 (de) 1997-09-17
CZ166897A3 (en) 1997-09-17

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