NO931631D0 - Kompleksdannende midler og maalsoeking av radioaktive immunoreagenser nyttige innen terapeutiske og diagnostiske bildedannende sammensetninger og fremgangsmetoder - Google Patents
Kompleksdannende midler og maalsoeking av radioaktive immunoreagenser nyttige innen terapeutiske og diagnostiske bildedannende sammensetninger og fremgangsmetoderInfo
- Publication number
- NO931631D0 NO931631D0 NO931631A NO931631A NO931631D0 NO 931631 D0 NO931631 D0 NO 931631D0 NO 931631 A NO931631 A NO 931631A NO 931631 A NO931631 A NO 931631A NO 931631 D0 NO931631 D0 NO 931631D0
- Authority
- NO
- Norway
- Prior art keywords
- targeting
- immunore
- radioactive
- therapeutic
- agents
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1054—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from lung
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1063—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from stomach or intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61086190A | 1990-11-08 | 1990-11-08 | |
US07/784,333 US5367080A (en) | 1990-11-08 | 1991-10-29 | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
PCT/US1991/008253 WO1992008494A2 (en) | 1990-11-08 | 1991-11-07 | Targeting radioactive immunoreagents |
Publications (2)
Publication Number | Publication Date |
---|---|
NO931631D0 true NO931631D0 (no) | 1993-05-05 |
NO931631L NO931631L (no) | 1993-06-23 |
Family
ID=27086372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO93931631A NO931631L (no) | 1990-11-08 | 1993-05-05 | Kompleksdannende midler og maalsoeking av radioaktive immunoreagenser nyttige innen terapeutiske og diagnostiske bildedannende sammensetninger og fremgangsmetoder |
Country Status (21)
Country | Link |
---|---|
US (4) | US5367080A (no) |
EP (1) | EP0624097B1 (no) |
JP (1) | JP3292301B2 (no) |
KR (1) | KR930701974A (no) |
AT (1) | ATE164082T1 (no) |
AU (2) | AU667030B2 (no) |
BR (1) | BR9107074A (no) |
CA (1) | CA2095123A1 (no) |
DE (1) | DE69129127T2 (no) |
DK (1) | DK0624097T3 (no) |
ES (1) | ES2113892T3 (no) |
FI (1) | FI932083A (no) |
GR (1) | GR3026713T3 (no) |
HU (1) | HUT67298A (no) |
IE (1) | IE913907A1 (no) |
MX (1) | MX9101999A (no) |
NO (1) | NO931631L (no) |
NZ (1) | NZ240521A (no) |
PT (1) | PT99460B (no) |
TW (1) | TW201271B (no) |
WO (1) | WO1992008494A2 (no) |
Families Citing this family (87)
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US5367080A (en) * | 1990-11-08 | 1994-11-22 | Sterling Winthrop Inc. | Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods |
ATE203168T1 (de) * | 1992-05-07 | 2001-08-15 | Nycomed Imaging As | Komplexbildnermittel und zielimmunoreagenzien |
ES2105332T3 (es) * | 1992-10-14 | 1997-10-16 | Nycomed Imaging As | Polimeros quelantes. |
CA2152777A1 (en) * | 1992-12-28 | 1994-07-07 | Hirofusa Shirai | Pharmaceutical use of terpyridine derivatives |
US5760191A (en) * | 1993-02-05 | 1998-06-02 | Nycomed Imaging As | Macrocyclic complexing agents and targeting immunoreagents useful in therapeutic and diagnostic compositions and methods |
WO1994020523A1 (en) * | 1993-03-10 | 1994-09-15 | The Wellcome Foundation Limited | Tumor targeting with l-enantiomeric oligonucleotide conjugates of immunoreagents and of chelated radionuclides |
US5744119A (en) * | 1993-05-11 | 1998-04-28 | Sterling Winthrop | Preparation of a radioconjugate formulation |
US5559214A (en) * | 1993-05-28 | 1996-09-24 | Sterling Winthrop Inc. | Unsymmetrical complexing agents and targeting immunoreagents useful in thearpeutic and diagnostic compositions and methods |
WO1994029333A1 (en) * | 1993-06-07 | 1994-12-22 | The Wellcome Foundation Limited | Immunoreactive reagents employing monoamine oxidase |
DE19505960A1 (de) * | 1995-02-21 | 1996-08-22 | Deutsches Krebsforsch | Konjugat zur individuellen Dosierung von Arzneimitteln |
US5562626A (en) * | 1995-09-11 | 1996-10-08 | Sanpietro; Joseph A. | Safety syringe |
AUPO066096A0 (en) * | 1996-06-26 | 1996-07-18 | Peptide Delivery Systems Pty Ltd | Oral delivery of peptides |
JP4033497B2 (ja) | 1996-09-06 | 2008-01-16 | 三菱化学株式会社 | ワクチン製剤 |
AU9452198A (en) * | 1997-10-15 | 1999-05-17 | Nycomed Imaging As | Complexing agents and targeting immunoreagents |
AU2530199A (en) * | 1998-02-06 | 1999-08-23 | Nycomed Imaging As | Targeting immunoreagents useful in therapeutic and diagnostic compositions and methods |
DE19911329A1 (de) * | 1998-03-27 | 2000-09-21 | Benes Ivan Friedrich | Humantherapeutisch anwendbares Radioimmunkonjugat und Verfahren zu seiner Herstellung |
AU3375599A (en) * | 1998-03-31 | 1999-10-18 | Trustees Of Boston University | Methods for designing molecular conjugates and compositions thereof |
US6314314B1 (en) | 1999-01-14 | 2001-11-06 | Seth J. Karp | Method for locating an internal bleeding site in a human body |
EP1203026A4 (en) * | 1999-07-29 | 2005-03-16 | Dyax Corp | FRACTIONS BINDING FIBRIN |
WO2001077145A2 (en) * | 2000-04-12 | 2001-10-18 | Amersham Health As | Integrin binding peptide derivatives |
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JP2024503637A (ja) | 2021-01-07 | 2024-01-26 | 3ベー ファーマシューティカルズ ゲーエムベーハー | 線維芽細胞活性化タンパク質リガンドを含む化合物およびその使用 |
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WO2024052431A1 (en) | 2022-09-07 | 2024-03-14 | 3B Pharmaceuticals Gmbh | Prostate specific membrane antigen (psma) ligands and use thereof |
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US4801722A (en) * | 1981-07-01 | 1989-01-31 | Eastman Kodak Company | Coumarin chelates |
US4859777A (en) * | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
US4837169A (en) * | 1981-07-01 | 1989-06-06 | Eastman Kodak Company | Polypyridine Fluorescent labels for immunoassay |
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DE3580420D1 (de) * | 1984-08-13 | 1990-12-13 | Hsc Res Dev Corp | 1,10-phenanthrolin-2,9-dicarbonsaeure-derivate und deren verwendung fuer fluoreszens-immunoassay. |
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DK365785A (da) * | 1984-09-17 | 1986-03-18 | Hoffmann La Roche | Metalcomplexer |
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SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
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AU8152887A (en) * | 1986-10-17 | 1988-05-06 | Cytogen Corporation | Method for preparation of protein-chelator-metal ion compositions suitable for injection |
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JPH082878B2 (ja) * | 1988-02-12 | 1996-01-17 | 富士写真フイルム株式会社 | 4’−アルコキシ−2,2’:6’,2〃−デルピリジン誘導体及びその金属錯体 |
SE8800613D0 (sv) * | 1988-02-23 | 1988-02-23 | Wallac Oy | A novel spectrofluorometric method and compounds that are of value for the method |
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SE8802575D0 (sv) * | 1988-07-08 | 1988-07-08 | Wallac Oy | Terpyridine derivatives |
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GB8927503D0 (en) * | 1989-12-04 | 1990-02-07 | Kronem Systems Inc | Enzyme-amplified lanthanide chelate luminescence |
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-
1991
- 1991-10-29 US US07/784,333 patent/US5367080A/en not_active Expired - Lifetime
- 1991-11-07 BR BR919107074A patent/BR9107074A/pt not_active Application Discontinuation
- 1991-11-07 DK DK91920573T patent/DK0624097T3/da active
- 1991-11-07 AT AT91920573T patent/ATE164082T1/de active
- 1991-11-07 AU AU90291/91A patent/AU667030B2/en not_active Expired
- 1991-11-07 ES ES91920573T patent/ES2113892T3/es not_active Expired - Lifetime
- 1991-11-07 JP JP50016592A patent/JP3292301B2/ja not_active Expired - Lifetime
- 1991-11-07 HU HU9301328A patent/HUT67298A/hu unknown
- 1991-11-07 EP EP91920573A patent/EP0624097B1/en not_active Expired - Lifetime
- 1991-11-07 WO PCT/US1991/008253 patent/WO1992008494A2/en active IP Right Grant
- 1991-11-07 CA CA002095123A patent/CA2095123A1/en not_active Abandoned
- 1991-11-07 DE DE69129127T patent/DE69129127T2/de not_active Expired - Lifetime
- 1991-11-07 KR KR1019930701386A patent/KR930701974A/ko not_active IP Right Cessation
- 1991-11-08 NZ NZ240521A patent/NZ240521A/en unknown
- 1991-11-08 MX MX9101999A patent/MX9101999A/es unknown
- 1991-11-08 IE IE390791A patent/IE913907A1/en unknown
- 1991-11-08 PT PT99460A patent/PT99460B/pt not_active IP Right Cessation
-
1992
- 1992-01-07 TW TW081100086A patent/TW201271B/zh active
-
1993
- 1993-05-05 NO NO93931631A patent/NO931631L/no unknown
- 1993-05-07 FI FI932083A patent/FI932083A/fi not_active Application Discontinuation
-
1994
- 1994-08-08 US US08/287,381 patent/US5523402A/en not_active Expired - Lifetime
-
1995
- 1995-01-19 US US08/375,276 patent/US5707603A/en not_active Expired - Lifetime
- 1995-12-15 US US08/573,377 patent/US5677445A/en not_active Expired - Lifetime
-
1996
- 1996-06-07 AU AU55835/96A patent/AU5583596A/en not_active Abandoned
-
1998
- 1998-04-23 GR GR980400901T patent/GR3026713T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DE69129127T2 (de) | 1998-10-08 |
DE69129127D1 (de) | 1998-04-23 |
NZ240521A (en) | 1995-01-27 |
WO1992008494A3 (en) | 1993-07-08 |
KR930701974A (ko) | 1993-09-08 |
AU5583596A (en) | 1996-08-01 |
ATE164082T1 (de) | 1998-04-15 |
PT99460B (pt) | 1999-02-26 |
US5707603A (en) | 1998-01-13 |
US5523402A (en) | 1996-06-04 |
MX9101999A (es) | 1992-06-01 |
NO931631L (no) | 1993-06-23 |
TW201271B (no) | 1993-03-01 |
FI932083A (fi) | 1993-07-02 |
EP0624097A1 (en) | 1994-11-17 |
DK0624097T3 (da) | 1998-10-19 |
WO1992008494A2 (en) | 1992-05-29 |
AU9029191A (en) | 1992-06-11 |
ES2113892T3 (es) | 1998-05-16 |
HUT67298A (en) | 1995-03-28 |
JPH06501703A (ja) | 1994-02-24 |
CA2095123A1 (en) | 1992-05-09 |
GR3026713T3 (en) | 1998-07-31 |
JP3292301B2 (ja) | 2002-06-17 |
FI932083A0 (fi) | 1993-05-07 |
BR9107074A (pt) | 1993-09-21 |
HU9301328D0 (en) | 1993-10-28 |
IE913907A1 (en) | 1992-05-20 |
AU667030B2 (en) | 1996-03-07 |
PT99460A (pt) | 1992-09-30 |
US5677445A (en) | 1997-10-14 |
EP0624097B1 (en) | 1998-03-18 |
US5367080A (en) | 1994-11-22 |
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