NO960225D0 - AZA spiro forbindelser som virker på det cholinergiske system med muscarinisk agonist aktivitet - Google Patents
AZA spiro forbindelser som virker på det cholinergiske system med muscarinisk agonist aktivitetInfo
- Publication number
- NO960225D0 NO960225D0 NO960225A NO960225A NO960225D0 NO 960225 D0 NO960225 D0 NO 960225D0 NO 960225 A NO960225 A NO 960225A NO 960225 A NO960225 A NO 960225A NO 960225 D0 NO960225 D0 NO 960225D0
- Authority
- NO
- Norway
- Prior art keywords
- image
- act
- agonist activity
- spiro compounds
- muscarinic agonist
- Prior art date
Links
- 150000008627 azaspiro compounds Chemical class 0.000 title 1
- 230000001713 cholinergic effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000000472 muscarinic agonist Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 210000001428 peripheral nervous system Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D497/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/094,855 US5534520A (en) | 1990-04-10 | 1993-07-20 | Spiro compounds containing five-membered rings |
PCT/GB1994/001543 WO1995003303A2 (en) | 1993-07-20 | 1994-07-15 | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
Publications (3)
Publication Number | Publication Date |
---|---|
NO960225D0 true NO960225D0 (no) | 1996-01-18 |
NO960225L NO960225L (no) | 1996-03-12 |
NO310075B1 NO310075B1 (no) | 2001-05-14 |
Family
ID=22247578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO960225A NO310075B1 (no) | 1993-07-20 | 1996-01-18 | AZA spiroforbindelser som virker på det cholinergiske system med muscarinisk agonistaktivitet, anvendelse av samme for fremstilling av medikament, farmasöytisk sammensetning omfattende samme samt kjemisk forbindelse til bruk som medikament |
Country Status (25)
Country | Link |
---|---|
US (1) | US5534520A (no) |
EP (1) | EP0711292B1 (no) |
JP (1) | JP3802050B2 (no) |
KR (1) | KR100341683B1 (no) |
CN (1) | CN1129942B (no) |
AT (1) | ATE212347T1 (no) |
AU (1) | AU696530B2 (no) |
BG (1) | BG62774B1 (no) |
BR (1) | BR9407088A (no) |
CA (1) | CA2167584C (no) |
CZ (1) | CZ295929B6 (no) |
DE (1) | DE69429724T2 (no) |
DK (1) | DK0711292T3 (no) |
ES (1) | ES2171458T3 (no) |
FI (1) | FI113777B (no) |
HU (1) | HU224638B1 (no) |
IL (1) | IL110340A (no) |
NO (1) | NO310075B1 (no) |
NZ (1) | NZ268637A (no) |
PL (1) | PL178931B1 (no) |
PT (1) | PT711292E (no) |
RO (1) | RO117851B1 (no) |
RU (1) | RU2129555C1 (no) |
WO (1) | WO1995003303A2 (no) |
ZA (1) | ZA945284B (no) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
HUT67539A (en) * | 1991-11-25 | 1995-04-28 | American Home Prod | 1-amino-2-[(benzothiazolyl)-methyl]-spiro-[isoquinoline-4(1h),-3'-pyrrolidine]-1,2',3,5'(2h)-tetrones, analogs thereof, process for producing them and pharmaceutical compositions containing them |
PL183933B1 (pl) * | 1994-08-24 | 2002-08-30 | Astra Ab | Związki spiroazabicyklo, sposób wytwarzania związku spiroazabicyklo i kompozycja farmaceutyczna |
FR2725206B1 (fr) * | 1994-09-29 | 1996-12-06 | Roussel Uclaf | Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
EP0854869B1 (en) | 1995-09-29 | 2004-08-25 | Eli Lilly And Company | Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation |
US6140358A (en) | 1996-04-02 | 2000-10-31 | Bayer Aktiengesellschaft | Substituted phenyl keto enols as pesticides and herbicides |
EP0932401A1 (en) * | 1996-07-01 | 1999-08-04 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using enantiomerically enriched (r,r)-glycopyrrolate |
US8048875B1 (en) * | 1997-02-24 | 2011-11-01 | S.L.A. Pharma Ag | Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker |
AU733047C (en) | 1997-02-24 | 2002-05-16 | S.L.A. Pharma Ag | Pharmaceutical composition |
NZ500643A (en) | 1997-05-30 | 2001-12-21 | Neurosearch As | Spiro-quinuclidine derivatives and their use in treating conditions responsive to nicotinic ACh receptor modulators |
TW402591B (en) | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
EP1086066A4 (en) * | 1998-06-08 | 2001-08-08 | Advanced Medicine Inc | MUSCARINIC RECEPTOR ANTAGONISTS |
ATE234302T1 (de) * | 1998-06-12 | 2003-03-15 | Hoffmann La Roche | Di- oder triazaspiro(4,5)decanderivate |
ES2181336T3 (es) * | 1998-06-12 | 2003-02-16 | Hoffmann La Roche | Espiro(piperidin-4,1'-pirrolo(3,4-c)pirrol). |
US6353006B1 (en) | 1999-01-14 | 2002-03-05 | Bayer Corporation | Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents |
US6693202B1 (en) * | 1999-02-16 | 2004-02-17 | Theravance, Inc. | Muscarinic receptor antagonists |
AU2001241056A1 (en) * | 2000-03-09 | 2001-09-17 | Mitsubishi Pharma Corporation | Spiro compounds, process for preparing the same and use thereof as drugs |
DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
CN101050215A (zh) * | 2001-12-28 | 2007-10-10 | 阿卡蒂亚药品公司 | 作为单胺受体调节剂的螺氮杂环化合物 |
DE10210195B4 (de) * | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
NZ560368A (en) * | 2002-05-03 | 2008-11-28 | Israel Inst Biolog Res | Methods and compostions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor |
GB0323204D0 (en) * | 2003-10-03 | 2003-11-05 | Novartis Ag | Organic compounds |
US7763609B2 (en) | 2003-12-15 | 2010-07-27 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
US7592348B2 (en) | 2003-12-15 | 2009-09-22 | Schering Corporation | Heterocyclic aspartyl protease inhibitors |
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AU2005295814A1 (en) * | 2004-10-13 | 2006-04-27 | Merck & Co., Inc. | Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of Alzhermer's disease |
WO2006060918A1 (en) * | 2004-12-09 | 2006-06-15 | Virochem Pharma Inc. | Novel spirotropane compounds and methods for the modulation of chemokine receptor activity |
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ATE550338T1 (de) * | 2005-07-18 | 2012-04-15 | Merck Sharp & Dohme | Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit |
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ITMI20061279A1 (it) * | 2006-06-30 | 2008-01-01 | Consiglio Nazionale Ricerche | Agonisti nicotinici selettivi per il sottotipo recettoriale alfa7,procedimento per la loro preparazione e relative composizioni farmaceutiche |
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US7863291B2 (en) * | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
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US9034891B2 (en) | 2009-01-26 | 2015-05-19 | Israel Institute For Biological Research | Bicyclic heterocyclic spiro compounds |
UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування | |
US8569310B2 (en) | 2009-10-08 | 2013-10-29 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use |
US8557826B2 (en) | 2009-10-08 | 2013-10-15 | Merck Sharp & Dohme Corp. | Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions, and their use |
US8563543B2 (en) | 2009-10-08 | 2013-10-22 | Merck Sharp & Dohme Corp. | Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
KR20120099060A (ko) * | 2009-10-29 | 2012-09-06 | 브리스톨-마이어스 스큅 컴퍼니 | 알파-7 니코틴성 아세틸콜린 수용체 리간드로서의 퀴누클리딘 화합물 |
WO2012138734A1 (en) | 2011-04-07 | 2012-10-11 | Merck Sharp & Dohme Corp. | C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use |
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US3161644A (en) * | 1962-06-22 | 1964-12-15 | Res Lab Dr C Janssen N V | 1-benzyl-4-substituted piperidines |
JPS4917534B1 (no) * | 1970-10-06 | 1974-05-01 | ||
BE790675A (fr) * | 1971-10-29 | 1973-04-27 | Science Union & Cie | Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane |
EP0189370A3 (de) * | 1985-01-16 | 1988-01-27 | Sandoz Ag | Spiro-dioxolane, -dithiolane und -oxothiolane |
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JPH02164882A (ja) * | 1988-12-20 | 1990-06-25 | Yamanouchi Pharmaceut Co Ltd | スピロ化合物及びその中間体 |
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IL97726A (en) * | 1990-04-10 | 1994-12-29 | Israel Inst Biolog Res | Pharmaceutical preparations containing compounds with bridged and unbridged heterocyclic groups connected via spiro-atop with oxazoline and thiazoline groups, and sharp compounds |
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TW201312B (en) * | 1991-04-09 | 1993-03-01 | Israel State | Spiro bridged and unbridged heterocyclic compounds |
-
1993
- 1993-07-20 US US08/094,855 patent/US5534520A/en not_active Expired - Lifetime
-
1994
- 1994-07-15 EP EP94921036A patent/EP0711292B1/en not_active Expired - Lifetime
- 1994-07-15 AT AT94921036T patent/ATE212347T1/de not_active IP Right Cessation
- 1994-07-15 PT PT94921036T patent/PT711292E/pt unknown
- 1994-07-15 HU HU9600126A patent/HU224638B1/hu not_active IP Right Cessation
- 1994-07-15 JP JP50499595A patent/JP3802050B2/ja not_active Expired - Fee Related
- 1994-07-15 DE DE69429724T patent/DE69429724T2/de not_active Expired - Lifetime
- 1994-07-15 CZ CZ1996182A patent/CZ295929B6/cs not_active IP Right Cessation
- 1994-07-15 PL PL94312684A patent/PL178931B1/pl not_active IP Right Cessation
- 1994-07-15 DK DK94921036T patent/DK0711292T3/da active
- 1994-07-15 WO PCT/GB1994/001543 patent/WO1995003303A2/en active IP Right Grant
- 1994-07-15 RU RU96103370A patent/RU2129555C1/ru not_active IP Right Cessation
- 1994-07-15 ES ES94921036T patent/ES2171458T3/es not_active Expired - Lifetime
- 1994-07-15 RO RO96-00099A patent/RO117851B1/ro unknown
- 1994-07-15 BR BR9407088A patent/BR9407088A/pt not_active Application Discontinuation
- 1994-07-15 NZ NZ268637A patent/NZ268637A/en not_active IP Right Cessation
- 1994-07-15 AU AU71915/94A patent/AU696530B2/en not_active Ceased
- 1994-07-15 CN CN94192839XA patent/CN1129942B/zh not_active Expired - Fee Related
- 1994-07-15 CA CA002167584A patent/CA2167584C/en not_active Expired - Fee Related
- 1994-07-15 IL IL11034094A patent/IL110340A/xx not_active IP Right Cessation
- 1994-07-15 KR KR1019960700296A patent/KR100341683B1/ko not_active IP Right Cessation
- 1994-07-19 ZA ZA945284A patent/ZA945284B/xx unknown
-
1996
- 1996-01-17 FI FI960238A patent/FI113777B/fi active
- 1996-01-18 NO NO960225A patent/NO310075B1/no not_active IP Right Cessation
- 1996-02-19 BG BG100370A patent/BG62774B1/bg unknown
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