MD3523310T2 - Poliforme cristaline ale unui agonist al receptorului muscarinic al acetilcolinei - Google Patents
Poliforme cristaline ale unui agonist al receptorului muscarinic al acetilcolineiInfo
- Publication number
- MD3523310T2 MD3523310T2 MDE20190908T MDE20190908T MD3523310T2 MD 3523310 T2 MD3523310 T2 MD 3523310T2 MD E20190908 T MDE20190908 T MD E20190908T MD E20190908 T MDE20190908 T MD E20190908T MD 3523310 T2 MD3523310 T2 MD 3523310T2
- Authority
- MD
- Moldova
- Prior art keywords
- acetylcholine receptor
- muscarinic acetylcholine
- receptor agonist
- crystalline polymorphs
- crystalline
- Prior art date
Links
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 title abstract 3
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 title abstract 3
- 229940122578 Acetylcholine receptor agonist Drugs 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- PHOZOHFUXHPOCK-QMMMGPOBSA-N (2s)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one Chemical compound N1C(=O)[C@H](CC)SC11CCN(C)CC1 PHOZOHFUXHPOCK-QMMMGPOBSA-N 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003413 spiro compounds Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
Sunt furnizate forme cristaline noi ale unui compus spiro care acţionează ca un agonist muscarinic al receptorului de acetilcolină. În special, sunt descrise forme polimorfe cristaline izolate de (S)-2-etil-8-metil-1-tia-4,8-diazaspiro[4,5]decan-3-onă care au proprietăţi favorabile în fabricarea farmaceutică. De asemenea, sunt furnizate metode de preparare a polimorfilor cristalini menţionaţi şi de transformare a acestora unul în altul, precum şi metode de preparare a medicamentelor care le conţin, care sunt adecvate pentru utilizare în tratamentul bolilor şi tulburărilor care răspund la modularea receptorului muscarnic al acetilcolinei.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16192494 | 2016-10-05 | ||
| PCT/EP2017/075373 WO2018065529A1 (en) | 2016-10-05 | 2017-10-05 | Crystalline polymorphs of a muscarinic acetylcholine receptor agonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MD3523310T2 true MD3523310T2 (ro) | 2022-10-31 |
Family
ID=57083221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MDE20190908T MD3523310T2 (ro) | 2016-10-05 | 2017-10-05 | Poliforme cristaline ale unui agonist al receptorului muscarinic al acetilcolinei |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US11008342B2 (ro) |
| EP (1) | EP3523310B1 (ro) |
| JP (3) | JP7163280B2 (ro) |
| KR (1) | KR20190056398A (ro) |
| CN (1) | CN109790180A (ro) |
| AU (1) | AU2017341088B2 (ro) |
| BR (1) | BR112019005450A2 (ro) |
| CA (1) | CA3036134A1 (ro) |
| CL (1) | CL2019000532A1 (ro) |
| CO (1) | CO2019003003A2 (ro) |
| DK (1) | DK3523310T3 (ro) |
| EA (1) | EA201990376A1 (ro) |
| ES (1) | ES2924432T3 (ro) |
| HR (1) | HRP20220962T1 (ro) |
| HU (1) | HUE059720T2 (ro) |
| IL (2) | IL265747B2 (ro) |
| LT (1) | LT3523310T (ro) |
| MA (1) | MA46464B1 (ro) |
| MD (1) | MD3523310T2 (ro) |
| MX (1) | MX2019003748A (ro) |
| PE (1) | PE20191003A1 (ro) |
| PH (1) | PH12019550048A1 (ro) |
| PL (1) | PL3523310T3 (ro) |
| PT (1) | PT3523310T (ro) |
| RS (1) | RS63438B1 (ro) |
| SG (1) | SG11201901612TA (ro) |
| SI (1) | SI3523310T1 (ro) |
| WO (1) | WO2018065529A1 (ro) |
| ZA (1) | ZA201901695B (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3523310B1 (en) * | 2016-10-05 | 2022-05-18 | NSC THERAPEUTICS GmbH | Crystalline polymorphs of a muscarinic acetylcholine receptor agonist |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855290A (en) | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| US6797558B2 (en) | 2001-04-24 | 2004-09-28 | Micron Technology, Inc. | Methods of forming a capacitor with substantially selective deposite of polysilicon on a substantially crystalline capacitor dielectric layer |
| BR0210391A (pt) * | 2001-06-12 | 2004-06-15 | Elan Pharm Inc | Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto |
| MXPA04010921A (es) * | 2002-05-03 | 2005-05-27 | Israel Inst Biolog Res | Metodos y composiciones para el tratamietno de trastornos del sistema nervioso central y periferico y compuestos novedosos utiles para los mismos. |
| EP3523310B1 (en) | 2016-10-05 | 2022-05-18 | NSC THERAPEUTICS GmbH | Crystalline polymorphs of a muscarinic acetylcholine receptor agonist |
| EP3768261A1 (en) | 2018-03-22 | 2021-01-27 | NSC THERAPEUTICS GmbH | Compounds and methods for use in the treatment of microglia-mediated disorders |
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2017
- 2017-10-05 EP EP17788131.5A patent/EP3523310B1/en active Active
- 2017-10-05 CN CN201780060800.4A patent/CN109790180A/zh active Pending
- 2017-10-05 HU HUE17788131A patent/HUE059720T2/hu unknown
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- 2017-10-05 MX MX2019003748A patent/MX2019003748A/es unknown
- 2017-10-05 MA MA46464A patent/MA46464B1/fr unknown
- 2017-10-05 PL PL17788131.5T patent/PL3523310T3/pl unknown
- 2017-10-05 US US16/338,930 patent/US11008342B2/en active Active
- 2017-10-05 BR BR112019005450A patent/BR112019005450A2/pt active Search and Examination
- 2017-10-05 AU AU2017341088A patent/AU2017341088B2/en active Active
- 2017-10-05 SI SI201731206T patent/SI3523310T1/sl unknown
- 2017-10-05 RS RS20220724A patent/RS63438B1/sr unknown
- 2017-10-05 WO PCT/EP2017/075373 patent/WO2018065529A1/en unknown
- 2017-10-05 SG SG11201901612TA patent/SG11201901612TA/en unknown
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- 2017-10-05 JP JP2019512714A patent/JP7163280B2/ja active Active
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- 2017-10-05 CA CA3036134A patent/CA3036134A1/en active Pending
- 2017-10-05 HR HRP20220962TT patent/HRP20220962T1/hr unknown
- 2017-10-05 KR KR1020197010921A patent/KR20190056398A/ko not_active Application Discontinuation
- 2017-10-05 PT PT177881315T patent/PT3523310T/pt unknown
- 2017-10-05 MD MDE20190908T patent/MD3523310T2/ro unknown
- 2017-10-05 DK DK17788131.5T patent/DK3523310T3/da active
- 2017-10-05 EA EA201990376A patent/EA201990376A1/ru unknown
- 2017-10-05 PE PE2019000719A patent/PE20191003A1/es unknown
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2019
- 2019-02-28 CL CL2019000532A patent/CL2019000532A1/es unknown
- 2019-03-19 ZA ZA2019/01695A patent/ZA201901695B/en unknown
- 2019-03-26 PH PH12019550048A patent/PH12019550048A1/en unknown
- 2019-03-28 CO CONC2019/0003003A patent/CO2019003003A2/es unknown
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2020
- 2020-12-22 US US17/130,564 patent/US11866449B2/en active Active
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2022
- 2022-05-18 JP JP2022081233A patent/JP2022119840A/ja active Pending
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2023
- 2023-06-28 IL IL304126A patent/IL304126A/en unknown
- 2023-11-21 US US18/516,585 patent/US20240083914A1/en active Pending
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2024
- 2024-01-24 JP JP2024008595A patent/JP2024056724A/ja active Pending
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