MA46464B1 - Polymorphes de l'agoniste de récepteur muscarinique - Google Patents
Polymorphes de l'agoniste de récepteur muscariniqueInfo
- Publication number
- MA46464B1 MA46464B1 MA46464A MA46464A MA46464B1 MA 46464 B1 MA46464 B1 MA 46464B1 MA 46464 A MA46464 A MA 46464A MA 46464 A MA46464 A MA 46464A MA 46464 B1 MA46464 B1 MA 46464B1
- Authority
- MA
- Morocco
- Prior art keywords
- polymorphs
- receptor agonist
- relates
- muscarinic receptor
- processes
- Prior art date
Links
- 229940121743 Muscarinic receptor agonist Drugs 0.000 title 1
- 239000000472 muscarinic agonist Substances 0.000 title 1
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 abstract 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- PHOZOHFUXHPOCK-QMMMGPOBSA-N (2s)-2-ethyl-8-methyl-1-thia-4,8-diazaspiro[4.5]decan-3-one Chemical compound N1C(=O)[C@H](CC)SC11CCN(C)CC1 PHOZOHFUXHPOCK-QMMMGPOBSA-N 0.000 abstract 1
- 229940122578 Acetylcholine receptor agonist Drugs 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000003413 spiro compounds Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A—HUMAN NECESSITIES
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Reproductive Health (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
Abstract
L'invention concerne de nouvelles formes cristallines d'un composé spiro qui agit en tant qu'agoniste du récepteur muscarinique de l'acétylcholine. En particulier, l'invention concerne des polymorphes cristallins isolés de (s)-2-éthyl-8-méthyl-1-thia -4,8-diazaspiro [4,5] décane-3-one qui ont des propriétés favorables dans la fabrication pharmaceutique. L'invention concerne également des procédés de préparation desdits polymorphes cristallins, et la conversion de ces derniers, les uns dans les autres, ainsi que des procédés de préparation de médicaments contenant ceux-ci, qui sont appropriés pour une utilisation dans le traitement de maladies et de troubles qui répondent à la modulation du récepteur d'acétylcholine muscarinique.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16192494 | 2016-10-05 | ||
| PCT/EP2017/075373 WO2018065529A1 (fr) | 2016-10-05 | 2017-10-05 | Polymorphes cristallins d'un agoniste du récepteur muscarinique de l'acétylcholine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MA46464A MA46464A (fr) | 2021-05-26 |
| MA46464B1 true MA46464B1 (fr) | 2022-10-31 |
Family
ID=57083221
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA46464A MA46464B1 (fr) | 2016-10-05 | 2017-10-05 | Polymorphes de l'agoniste de récepteur muscarinique |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US11008342B2 (fr) |
| EP (1) | EP3523310B1 (fr) |
| JP (3) | JP7163280B2 (fr) |
| KR (1) | KR102710640B1 (fr) |
| CN (1) | CN109790180A (fr) |
| AU (1) | AU2017341088B2 (fr) |
| BR (1) | BR112019005450A2 (fr) |
| CA (1) | CA3036134A1 (fr) |
| CL (1) | CL2019000532A1 (fr) |
| CO (1) | CO2019003003A2 (fr) |
| DK (1) | DK3523310T3 (fr) |
| EA (1) | EA201990376A1 (fr) |
| ES (1) | ES2924432T3 (fr) |
| HR (1) | HRP20220962T1 (fr) |
| HU (1) | HUE059720T2 (fr) |
| IL (2) | IL265747B2 (fr) |
| LT (1) | LT3523310T (fr) |
| MA (1) | MA46464B1 (fr) |
| MD (1) | MD3523310T2 (fr) |
| MX (1) | MX2019003748A (fr) |
| PE (1) | PE20191003A1 (fr) |
| PH (1) | PH12019550048A1 (fr) |
| PL (1) | PL3523310T3 (fr) |
| PT (1) | PT3523310T (fr) |
| RS (1) | RS63438B1 (fr) |
| SG (1) | SG11201901612TA (fr) |
| SI (1) | SI3523310T1 (fr) |
| WO (1) | WO2018065529A1 (fr) |
| ZA (1) | ZA201901695B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201901612TA (en) * | 2016-10-05 | 2019-03-28 | Nsc Therapeutics Gmbh | Crystalline polymorphs of a muscarinic acetylcholine receptor agonist |
| WO2022098700A1 (fr) * | 2020-11-03 | 2022-05-12 | Cassava Sciences, Inc. | Inhibition d'une réponse immunitaire induite par un ou plusieurs composants parmi tlr2, rage, ccr5, cxcr4 et cd4 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4855290A (en) | 1985-05-10 | 1989-08-08 | State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research | Derivatives of quinuclidine |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| US6797558B2 (en) | 2001-04-24 | 2004-09-28 | Micron Technology, Inc. | Methods of forming a capacitor with substantially selective deposite of polysilicon on a substantially crystalline capacitor dielectric layer |
| CA2450167A1 (fr) * | 2001-06-12 | 2002-12-19 | Elan Pharmaceuticals, Inc. | Macrocycles utiles dans le traitement de la maladie d'alzheimer |
| KR100998804B1 (ko) * | 2002-05-03 | 2010-12-06 | 이스라엘 인스티튜트 포 바이올로지컬 리서치 | 중추 및 말초 신경계 장애의 치료를 위한 방법 및 조성물,및 그에 유용한 신규 화합물 |
| SG11201901612TA (en) * | 2016-10-05 | 2019-03-28 | Nsc Therapeutics Gmbh | Crystalline polymorphs of a muscarinic acetylcholine receptor agonist |
| WO2019180224A1 (fr) | 2018-03-22 | 2019-09-26 | Nsc Therapeutics Gmbh | Composés et procédés destinés à être utilisés dans le traitement de troubles médiés par la microglie |
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2017
- 2017-10-05 SG SG11201901612TA patent/SG11201901612TA/en unknown
- 2017-10-05 MX MX2019003748A patent/MX2019003748A/es unknown
- 2017-10-05 EA EA201990376A patent/EA201990376A1/ru unknown
- 2017-10-05 CN CN201780060800.4A patent/CN109790180A/zh active Pending
- 2017-10-05 PT PT177881315T patent/PT3523310T/pt unknown
- 2017-10-05 BR BR112019005450A patent/BR112019005450A2/pt active Search and Examination
- 2017-10-05 WO PCT/EP2017/075373 patent/WO2018065529A1/fr active Application Filing
- 2017-10-05 EP EP17788131.5A patent/EP3523310B1/fr active Active
- 2017-10-05 JP JP2019512714A patent/JP7163280B2/ja active Active
- 2017-10-05 RS RS20220724A patent/RS63438B1/sr unknown
- 2017-10-05 ES ES17788131T patent/ES2924432T3/es active Active
- 2017-10-05 AU AU2017341088A patent/AU2017341088B2/en active Active
- 2017-10-05 HU HUE17788131A patent/HUE059720T2/hu unknown
- 2017-10-05 HR HRP20220962TT patent/HRP20220962T1/hr unknown
- 2017-10-05 PL PL17788131.5T patent/PL3523310T3/pl unknown
- 2017-10-05 LT LTEPPCT/EP2017/075373T patent/LT3523310T/lt unknown
- 2017-10-05 MD MDE20190908T patent/MD3523310T2/ro unknown
- 2017-10-05 DK DK17788131.5T patent/DK3523310T3/da active
- 2017-10-05 US US16/338,930 patent/US11008342B2/en active Active
- 2017-10-05 KR KR1020197010921A patent/KR102710640B1/ko active IP Right Grant
- 2017-10-05 MA MA46464A patent/MA46464B1/fr unknown
- 2017-10-05 SI SI201731206T patent/SI3523310T1/sl unknown
- 2017-10-05 IL IL265747A patent/IL265747B2/en unknown
- 2017-10-05 PE PE2019000719A patent/PE20191003A1/es unknown
- 2017-10-05 CA CA3036134A patent/CA3036134A1/fr active Pending
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2019
- 2019-02-28 CL CL2019000532A patent/CL2019000532A1/es unknown
- 2019-03-19 ZA ZA2019/01695A patent/ZA201901695B/en unknown
- 2019-03-26 PH PH12019550048A patent/PH12019550048A1/en unknown
- 2019-03-28 CO CONC2019/0003003A patent/CO2019003003A2/es unknown
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2020
- 2020-12-22 US US17/130,564 patent/US11866449B2/en active Active
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2022
- 2022-05-18 JP JP2022081233A patent/JP2022119840A/ja active Pending
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2023
- 2023-06-28 IL IL304126A patent/IL304126A/en unknown
- 2023-11-21 US US18/516,585 patent/US20240083914A1/en active Pending
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2024
- 2024-01-24 JP JP2024008595A patent/JP2024056724A/ja active Pending
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