RS63438B1 - Kristalni polimorfi agonista muskarinskog acetilholinskog receptora - Google Patents

Kristalni polimorfi agonista muskarinskog acetilholinskog receptora

Info

Publication number
RS63438B1
RS63438B1 RS20220724A RSP20220724A RS63438B1 RS 63438 B1 RS63438 B1 RS 63438B1 RS 20220724 A RS20220724 A RS 20220724A RS P20220724 A RSP20220724 A RS P20220724A RS 63438 B1 RS63438 B1 RS 63438B1
Authority
RS
Serbia
Prior art keywords
receptor agonist
acetylcholine receptor
muscarinic acetylcholine
crystalline polymorphs
polymorphs
Prior art date
Application number
RS20220724A
Other languages
English (en)
Inventor
Abraham Fisher
Nira Bar-Ner
Manfred Windisch
Original Assignee
Nsc Therapeutics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nsc Therapeutics Gmbh filed Critical Nsc Therapeutics Gmbh
Publication of RS63438B1 publication Critical patent/RS63438B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10Spiro-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/429Thiazoles condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
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    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
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    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • AHUMAN NECESSITIES
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
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    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/10Ophthalmic agents for accommodation disorders, e.g. myopia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • AHUMAN NECESSITIES
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    • A61P3/04Anorexiants; Antiobesity agents
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
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    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Emergency Medicine (AREA)
RS20220724A 2016-10-05 2017-10-05 Kristalni polimorfi agonista muskarinskog acetilholinskog receptora RS63438B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16192494 2016-10-05
EP17788131.5A EP3523310B1 (en) 2016-10-05 2017-10-05 Crystalline polymorphs of a muscarinic acetylcholine receptor agonist
PCT/EP2017/075373 WO2018065529A1 (en) 2016-10-05 2017-10-05 Crystalline polymorphs of a muscarinic acetylcholine receptor agonist

Publications (1)

Publication Number Publication Date
RS63438B1 true RS63438B1 (sr) 2022-08-31

Family

ID=57083221

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20220724A RS63438B1 (sr) 2016-10-05 2017-10-05 Kristalni polimorfi agonista muskarinskog acetilholinskog receptora

Country Status (29)

Country Link
US (3) US11008342B2 (sr)
EP (1) EP3523310B1 (sr)
JP (3) JP7163280B2 (sr)
KR (1) KR20190056398A (sr)
CN (1) CN109790180A (sr)
AU (1) AU2017341088B2 (sr)
BR (1) BR112019005450A2 (sr)
CA (1) CA3036134A1 (sr)
CL (1) CL2019000532A1 (sr)
CO (1) CO2019003003A2 (sr)
DK (1) DK3523310T3 (sr)
EA (1) EA201990376A1 (sr)
ES (1) ES2924432T3 (sr)
HR (1) HRP20220962T1 (sr)
HU (1) HUE059720T2 (sr)
IL (2) IL265747B2 (sr)
LT (1) LT3523310T (sr)
MA (1) MA46464B1 (sr)
MD (1) MD3523310T2 (sr)
MX (1) MX2019003748A (sr)
PE (1) PE20191003A1 (sr)
PH (1) PH12019550048A1 (sr)
PL (1) PL3523310T3 (sr)
PT (1) PT3523310T (sr)
RS (1) RS63438B1 (sr)
SG (1) SG11201901612TA (sr)
SI (1) SI3523310T1 (sr)
WO (1) WO2018065529A1 (sr)
ZA (1) ZA201901695B (sr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3523310B1 (en) * 2016-10-05 2022-05-18 NSC THERAPEUTICS GmbH Crystalline polymorphs of a muscarinic acetylcholine receptor agonist

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855290A (en) 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US6797558B2 (en) 2001-04-24 2004-09-28 Micron Technology, Inc. Methods of forming a capacitor with substantially selective deposite of polysilicon on a substantially crystalline capacitor dielectric layer
BR0210391A (pt) * 2001-06-12 2004-06-15 Elan Pharm Inc Composto, métodos de tratar um paciente que tenha ou de prevenir um paciente de contrair uma doença ou condição e de preparar um composto, e, uso de um composto
MXPA04010921A (es) * 2002-05-03 2005-05-27 Israel Inst Biolog Res Metodos y composiciones para el tratamietno de trastornos del sistema nervioso central y periferico y compuestos novedosos utiles para los mismos.
EP3523310B1 (en) 2016-10-05 2022-05-18 NSC THERAPEUTICS GmbH Crystalline polymorphs of a muscarinic acetylcholine receptor agonist
EP3768261A1 (en) 2018-03-22 2021-01-27 NSC THERAPEUTICS GmbH Compounds and methods for use in the treatment of microglia-mediated disorders

Also Published As

Publication number Publication date
BR112019005450A2 (pt) 2019-06-18
IL265747B2 (en) 2023-12-01
IL265747A (en) 2019-06-30
KR20190056398A (ko) 2019-05-24
AU2017341088A1 (en) 2019-04-04
MA46464A (fr) 2021-05-26
US20210238195A1 (en) 2021-08-05
CL2019000532A1 (es) 2019-07-12
JP2019529389A (ja) 2019-10-17
PH12019550048A1 (en) 2019-07-24
SI3523310T1 (sl) 2022-10-28
SG11201901612TA (en) 2019-03-28
JP2022119840A (ja) 2022-08-17
ES2924432T3 (es) 2022-10-06
ZA201901695B (en) 2021-08-25
EA201990376A1 (ru) 2019-11-29
JP2024056724A (ja) 2024-04-23
US11866449B2 (en) 2024-01-09
JP7163280B2 (ja) 2022-10-31
EP3523310A1 (en) 2019-08-14
MA46464B1 (fr) 2022-10-31
US20200040007A1 (en) 2020-02-06
HRP20220962T1 (hr) 2022-10-28
PL3523310T3 (pl) 2022-08-29
CN109790180A (zh) 2019-05-21
DK3523310T3 (da) 2022-08-08
US11008342B2 (en) 2021-05-18
HUE059720T2 (hu) 2022-12-28
WO2018065529A1 (en) 2018-04-12
PE20191003A1 (es) 2019-07-15
MD3523310T2 (ro) 2022-10-31
CA3036134A1 (en) 2018-04-12
LT3523310T (lt) 2022-08-25
IL304126A (en) 2023-09-01
CO2019003003A2 (es) 2019-04-12
IL265747B1 (en) 2023-08-01
AU2017341088B2 (en) 2021-06-24
EP3523310B1 (en) 2022-05-18
MX2019003748A (es) 2019-08-12
PT3523310T (pt) 2022-08-04
US20240083914A1 (en) 2024-03-14

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