HK1250029A1 - 具有雙環結構的多巴胺d3受體拮抗劑 - Google Patents
具有雙環結構的多巴胺d3受體拮抗劑Info
- Publication number
- HK1250029A1 HK1250029A1 HK18109519.3A HK18109519A HK1250029A1 HK 1250029 A1 HK1250029 A1 HK 1250029A1 HK 18109519 A HK18109519 A HK 18109519A HK 1250029 A1 HK1250029 A1 HK 1250029A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- dopamine
- receptor antagonists
- bicyclo
- moiety
- bicyclo moiety
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Addiction (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1513871.2A GB201513871D0 (en) | 2015-08-05 | 2015-08-05 | Bicyclo dopamine D3 receptor antagonists |
| GBGB1518125.8A GB201518125D0 (en) | 2015-10-13 | 2015-10-13 | Dopamine D3 receptor antagonist having a bicyclo moiety |
| PCT/IB2016/054708 WO2017021920A1 (en) | 2015-08-05 | 2016-08-04 | Dopamine d3 receptor antagonists having a bicyclo moiety |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1250029A1 true HK1250029A1 (zh) | 2018-11-23 |
Family
ID=56801657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK18109519.3A HK1250029A1 (zh) | 2015-08-05 | 2018-07-23 | 具有雙環結構的多巴胺d3受體拮抗劑 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10273244B2 (zh) |
| EP (1) | EP3331886B1 (zh) |
| AU (1) | AU2016303558B2 (zh) |
| CA (1) | CA2992820C (zh) |
| DK (1) | DK3331886T3 (zh) |
| ES (1) | ES2821896T3 (zh) |
| HK (1) | HK1250029A1 (zh) |
| IL (1) | IL256914B (zh) |
| NZ (1) | NZ739139A (zh) |
| WO (1) | WO2017021920A1 (zh) |
| ZA (1) | ZA201800483B (zh) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016303558B2 (en) | 2015-08-05 | 2020-08-06 | Indivior Uk Limited | Dopamine D3 receptor antagonists having a bicyclo moiety |
| US10870660B2 (en) | 2016-07-28 | 2020-12-22 | Shionogi & Co., Ltd. | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect |
| WO2019084075A1 (en) * | 2017-10-24 | 2019-05-02 | The Trustees Of The University Of Pennsylvania | DOPAMINE RECEPTOR SELECTIVE ANTAGONISTS AND METHODS OF USING THE SAME |
| US11447484B2 (en) | 2018-01-26 | 2022-09-20 | Shionogi & Co., Ltd. | Cyclic compound having dopamine D3 receptor antagonistic effect |
| BR112020014875A2 (pt) | 2018-01-26 | 2020-12-08 | Shionogi & Co., Ltd. | Composto cíclico condensado tendo antagonismo de receptor de dopamina d3 |
| EP3758695A4 (en) | 2018-02-28 | 2021-10-06 | The Trustees Of The University Of Pennsylvania | POLY (AD-RIBOSE) DEPENDENT CYTOTOXIC AGENTS LOW AFFINITY POLYMERASE-1 |
| EP3608326A1 (en) | 2018-08-10 | 2020-02-12 | Irbm S.P.A. | Tricyclic inhibitors of hepatitis b virus |
| EP3741762A1 (en) | 2019-05-23 | 2020-11-25 | Irbm S.P.A. | Oxalamido-substituted tricyclic inhibitors of hepatitis b virus |
| EP3825318A1 (en) | 2019-11-25 | 2021-05-26 | Promidis S.r.l. | Oxalamido-substituted tricyclic inhibitors of hepatitis b virus |
| UY38705A (es) | 2019-05-23 | 2020-12-31 | Irbm S P A | Inhibidores tricíclicos sustituidos con oxalamido del virus de hepatitis b |
| CN110684028B (zh) * | 2019-10-28 | 2021-10-26 | 上海阿拉丁生化科技股份有限公司 | 一种2，6-二氮杂双环[3，3，0]辛烷类化合物的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4341403A1 (de) * | 1993-12-04 | 1995-06-08 | Basf Ag | N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung |
| US5541217A (en) | 1995-05-17 | 1996-07-30 | Ortho Pharmaceutical Corporation | 4-arylcyclopenta[c]pyrrole analgesics |
| KR101143718B1 (ko) * | 2004-02-23 | 2012-07-05 | 글락소 그룹 리미티드 | 도파민 ｄ3 수용체의 조절제로서 유용한 아자비시클로(3.1.0) 헥산 유도체 |
| GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
| US9540324B2 (en) * | 2013-09-26 | 2017-01-10 | Luc Therapeutics, Inc. | Selective octahydro-cyclopenta[C] pyrrole negative modulators of NR2B |
| CN106659715A (zh) * | 2013-12-20 | 2017-05-10 | 药物发现研究所 | 取代的氨基三唑及其使用方法 |
| AU2016303558B2 (en) | 2015-08-05 | 2020-08-06 | Indivior Uk Limited | Dopamine D3 receptor antagonists having a bicyclo moiety |
-
2016
- 2016-08-04 AU AU2016303558A patent/AU2016303558B2/en active Active
- 2016-08-04 CA CA2992820A patent/CA2992820C/en active Active
- 2016-08-04 ES ES16757355T patent/ES2821896T3/es active Active
- 2016-08-04 WO PCT/IB2016/054708 patent/WO2017021920A1/en active Application Filing
- 2016-08-04 US US15/750,128 patent/US10273244B2/en active Active
- 2016-08-04 NZ NZ739139A patent/NZ739139A/en unknown
- 2016-08-04 EP EP16757355.9A patent/EP3331886B1/en active Active
- 2016-08-04 DK DK16757355.9T patent/DK3331886T3/da active
-
2018
- 2018-01-14 IL IL256914A patent/IL256914B/en active IP Right Grant
- 2018-01-23 ZA ZA2018/00483A patent/ZA201800483B/en unknown
- 2018-07-23 HK HK18109519.3A patent/HK1250029A1/zh unknown
-
2019
- 2019-03-04 US US16/292,110 patent/US10584135B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL256914A (en) | 2018-03-29 |
| ZA201800483B (en) | 2019-07-31 |
| WO2017021920A1 (en) | 2017-02-09 |
| AU2016303558B2 (en) | 2020-08-06 |
| AU2016303558A1 (en) | 2018-02-08 |
| EP3331886B1 (en) | 2020-07-15 |
| US20190194225A1 (en) | 2019-06-27 |
| ES2821896T3 (es) | 2021-04-28 |
| DK3331886T3 (da) | 2020-08-24 |
| US20180222918A1 (en) | 2018-08-09 |
| US10273244B2 (en) | 2019-04-30 |
| CA2992820A1 (en) | 2017-02-09 |
| EP3331886A1 (en) | 2018-06-13 |
| US10584135B2 (en) | 2020-03-10 |
| IL256914B (en) | 2021-03-25 |
| CA2992820C (en) | 2022-08-16 |
| NZ739139A (en) | 2023-01-27 |
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