MX360290B - Cis-(e)-4-(3-fluorofenil)-2',3',4,9'-tetrahidro-n,n-dimetil-2'-(1 -oxo-3-fenil-2-propenil)-espiro[ciclohexan-1,1'[1h]-pirido[3,4-b] indol]-4-amina cristalina. - Google Patents

Cis-(e)-4-(3-fluorofenil)-2',3',4,9'-tetrahidro-n,n-dimetil-2'-(1 -oxo-3-fenil-2-propenil)-espiro[ciclohexan-1,1'[1h]-pirido[3,4-b] indol]-4-amina cristalina.

Info

Publication number
MX360290B
MX360290B MX2015011797A MX2015011797A MX360290B MX 360290 B MX360290 B MX 360290B MX 2015011797 A MX2015011797 A MX 2015011797A MX 2015011797 A MX2015011797 A MX 2015011797A MX 360290 B MX360290 B MX 360290B
Authority
MX
Mexico
Prior art keywords
pyrido
indol
spiro
propenyl
fluorophenyl
Prior art date
Application number
MX2015011797A
Other languages
English (en)
Other versions
MX2015011797A (es
Inventor
Gruss Michael
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of MX2015011797A publication Critical patent/MX2015011797A/es
Publication of MX360290B publication Critical patent/MX360290B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona con formas cristalinas de cis-(E)-4-(3-fluorofenil)-2´,3´,4´,9´- tetrahidro-N,N-dimetil-2´-( 1-oxo-3-fenil-2-propenil)-spiro[ciclohexan-1.1´[1H]-pirido[3,4-b] indol]-4-amina, las composiciones farmacéuticas y medicamentos que comprenden estas modificaciones, el uso de estas modificaciones así como con un proceso para preparar las formas cristalinas.
MX2015011797A 2013-03-15 2014-03-14 Cis-(e)-4-(3-fluorofenil)-2',3',4,9'-tetrahidro-n,n-dimetil-2'-(1 -oxo-3-fenil-2-propenil)-espiro[ciclohexan-1,1'[1h]-pirido[3,4-b] indol]-4-amina cristalina. MX360290B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13001331 2013-03-15
PCT/EP2014/000682 WO2014139681A1 (en) 2013-03-15 2014-03-14 Crystalline cis-(e)-4-(3-fluorophenyl)-2',3',4',9'-tetrahydro-n,n-dimethyl-2'-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1'[1h]-pyrido[3,4-b]indol]-4-amine

Publications (2)

Publication Number Publication Date
MX2015011797A MX2015011797A (es) 2016-01-08
MX360290B true MX360290B (es) 2018-10-29

Family

ID=47900478

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011797A MX360290B (es) 2013-03-15 2014-03-14 Cis-(e)-4-(3-fluorofenil)-2',3',4,9'-tetrahidro-n,n-dimetil-2'-(1 -oxo-3-fenil-2-propenil)-espiro[ciclohexan-1,1'[1h]-pirido[3,4-b] indol]-4-amina cristalina.

Country Status (15)

Country Link
US (1) US9296749B2 (es)
EP (1) EP2970284B1 (es)
CN (1) CN105246892B (es)
AR (1) AR095574A1 (es)
BR (1) BR112015022509A2 (es)
CA (1) CA2898335A1 (es)
ES (1) ES2658193T3 (es)
HK (1) HK1213263A1 (es)
HU (1) HUE037195T2 (es)
IL (1) IL241362B (es)
MX (1) MX360290B (es)
PL (1) PL2970284T3 (es)
PT (1) PT2970284T (es)
SI (1) SI2970284T1 (es)
WO (1) WO2014139681A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI582092B (zh) * 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
TW201832765A (zh) * 2017-02-24 2018-09-16 德商歌林達有限公司 膀胱內投藥用於治療膀胱痛之組合物
JP2019073493A (ja) * 2017-10-17 2019-05-16 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヴルヴォディニアの治療

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102007009319A1 (de) 2007-02-22 2008-08-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
TWI582092B (zh) 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物

Also Published As

Publication number Publication date
CN105246892B (zh) 2019-05-03
IL241362B (en) 2020-04-30
HUE037195T2 (hu) 2018-08-28
AR095574A1 (es) 2015-10-28
SI2970284T1 (en) 2018-02-28
US9296749B2 (en) 2016-03-29
CA2898335A1 (en) 2014-09-18
BR112015022509A2 (pt) 2017-07-18
WO2014139681A1 (en) 2014-09-18
IL241362A0 (en) 2015-11-30
HK1213263A1 (zh) 2016-06-30
PT2970284T (pt) 2018-02-08
EP2970284A1 (en) 2016-01-20
MX2015011797A (es) 2016-01-08
PL2970284T3 (pl) 2018-03-30
EP2970284B1 (en) 2017-11-01
ES2658193T3 (es) 2018-03-08
CN105246892A (zh) 2016-01-13
US20140288307A1 (en) 2014-09-25

Similar Documents

Publication Publication Date Title
UA122773C2 (uk) Спосіб одержання (4s)-4-(4-ціано-2-метоксифеніл)-5-етокси-2,8-диметил-1,4-дигідро-1,6-нафтиридин-3-карбоксаміду і його очищення для застосування як фармацевтичного активного інгредієнта
PH12015501289A1 (en) Novel benzimidazole derivatives as ep4 antagonists
PH12014502540A1 (en) Benzimidazole-proline derivatives
SG10201804817TA (en) Delayed release compositions of linaclotide
MD20150023A2 (ro) Piridinone biciclice noi
MX345926B (es) Nuevas composiciones, producción de las mismas y uso de las mismas para la producción de poliamidas coladas.
PH12017500089B1 (en) Aldosterone synthase inhibitors
MX2014010433A (es) Nueva forma cristalina de sulfato de sitagliptina.
AU2012283449A8 (en) Crystalline (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine
MX360290B (es) Cis-(e)-4-(3-fluorofenil)-2',3',4,9'-tetrahidro-n,n-dimetil-2'-(1 -oxo-3-fenil-2-propenil)-espiro[ciclohexan-1,1'[1h]-pirido[3,4-b] indol]-4-amina cristalina.
MX2015017541A (es) Derivados de espiro [2.4] heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx.
MX2019011265A (es) Derivados del acido acetico azaindol y su uso como moduladores de receptor de prostaglandina d2.
MX2013013436A (es) Derivados de indol sustituidos para el tratamiento de transtornos inmunologicos.
MX2014009084A (es) Derivados de pirimidooxazocina como inhibidores de mtor.
WO2015087343A3 (en) An improved process for the preparation of nilotinib and pharmaceutically acceptable salts thereof
WO2014115169A3 (en) Crizotinib solid dispersion
MX2016011900A (es) Derivados de acido azaindol-acetico y su uso como moduladores del receptor de prostaglandina d2.
WO2015102017A8 (en) Processes for the preparation of lorcaserin
WO2013114397A3 (en) Pharmaceutically acceptable salt of brinzolamide and composition thereof
WO2014122671A3 (en) Solid oral compositions of saxagliptin
MD20160115A2 (ro) Combinaţie nouă dintre 8-ciclopropil-3-[2-(3-fluorofenil)etil]-7,8-dihidro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazin-4,9-dionă şi un inhibitor al acetilcolinesterazei şi compoziţii farmaceutice care o conţin
GB2527958A (en) Pregnane-oximino-aminoalkylethers and process for preparation thereof, useful as antidiabetic and antidyslipidemic agents

Legal Events

Date Code Title Description
FG Grant or registration