PT2970284T - Cis-(e)-4-(3-fluorofenil)-2',3',4',9'-tetra-hidro-n,n-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclo-hexano-1,1'[1h]-pirido[3,4-b]indol]-4-amina cristalina - Google Patents

Cis-(e)-4-(3-fluorofenil)-2',3',4',9'-tetra-hidro-n,n-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclo-hexano-1,1'[1h]-pirido[3,4-b]indol]-4-amina cristalina

Info

Publication number
PT2970284T
PT2970284T PT147122063T PT14712206T PT2970284T PT 2970284 T PT2970284 T PT 2970284T PT 147122063 T PT147122063 T PT 147122063T PT 14712206 T PT14712206 T PT 14712206T PT 2970284 T PT2970284 T PT 2970284T
Authority
PT
Portugal
Prior art keywords
pyrido
indol
spiro
propenyl
fluorophenyl
Prior art date
Application number
PT147122063T
Other languages
English (en)
Portuguese (pt)
Inventor
Gruss Michael
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of PT2970284T publication Critical patent/PT2970284T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT147122063T 2013-03-15 2014-03-14 Cis-(e)-4-(3-fluorofenil)-2',3',4',9'-tetra-hidro-n,n-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclo-hexano-1,1'[1h]-pirido[3,4-b]indol]-4-amina cristalina PT2970284T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13001331 2013-03-15

Publications (1)

Publication Number Publication Date
PT2970284T true PT2970284T (pt) 2018-02-08

Family

ID=47900478

Family Applications (1)

Application Number Title Priority Date Filing Date
PT147122063T PT2970284T (pt) 2013-03-15 2014-03-14 Cis-(e)-4-(3-fluorofenil)-2',3',4',9'-tetra-hidro-n,n-dimetil-2'-(1-oxo-3-fenil-2-propenil)-espiro[ciclo-hexano-1,1'[1h]-pirido[3,4-b]indol]-4-amina cristalina

Country Status (15)

Country Link
US (1) US9296749B2 (es)
EP (1) EP2970284B1 (es)
CN (1) CN105246892B (es)
AR (1) AR095574A1 (es)
BR (1) BR112015022509A2 (es)
CA (1) CA2898335A1 (es)
ES (1) ES2658193T3 (es)
HK (1) HK1213263A1 (es)
HU (1) HUE037195T2 (es)
IL (1) IL241362B (es)
MX (1) MX360290B (es)
PL (1) PL2970284T3 (es)
PT (1) PT2970284T (es)
SI (1) SI2970284T1 (es)
WO (1) WO2014139681A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI582092B (zh) * 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物
TW201832765A (zh) * 2017-02-24 2018-09-16 德商歌林達有限公司 膀胱內投藥用於治療膀胱痛之組合物
JP2019073493A (ja) * 2017-10-17 2019-05-16 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヴルヴォディニアの治療

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360792A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
DE102007009319A1 (de) 2007-02-22 2008-08-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
TWI582092B (zh) * 2010-07-28 2017-05-11 歌林達股份有限公司 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物

Also Published As

Publication number Publication date
MX2015011797A (es) 2016-01-08
HUE037195T2 (hu) 2018-08-28
MX360290B (es) 2018-10-29
WO2014139681A1 (en) 2014-09-18
SI2970284T1 (en) 2018-02-28
EP2970284B1 (en) 2017-11-01
IL241362B (en) 2020-04-30
BR112015022509A2 (pt) 2017-07-18
AR095574A1 (es) 2015-10-28
EP2970284A1 (en) 2016-01-20
US9296749B2 (en) 2016-03-29
PL2970284T3 (pl) 2018-03-30
HK1213263A1 (zh) 2016-06-30
CA2898335A1 (en) 2014-09-18
CN105246892B (zh) 2019-05-03
US20140288307A1 (en) 2014-09-25
IL241362A0 (en) 2015-11-30
CN105246892A (zh) 2016-01-13
ES2658193T3 (es) 2018-03-08

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