WO2013132514A3 - Novel processes for preparation of (r)-5-[2-[(5,6-diethyl-2,3-dihydro-lh-rnden-2-yl)amino]-l- hydroxyethylj-8-hydroxy quinolin-2(lh)-one - Google Patents

Novel processes for preparation of (r)-5-[2-[(5,6-diethyl-2,3-dihydro-lh-rnden-2-yl)amino]-l- hydroxyethylj-8-hydroxy quinolin-2(lh)-one Download PDF

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Publication number
WO2013132514A3
WO2013132514A3 PCT/IN2013/000052 IN2013000052W WO2013132514A3 WO 2013132514 A3 WO2013132514 A3 WO 2013132514A3 IN 2013000052 W IN2013000052 W IN 2013000052W WO 2013132514 A3 WO2013132514 A3 WO 2013132514A3
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WO
WIPO (PCT)
Prior art keywords
preparation
rnden
hydroxyethylj
dihydro
diethyl
Prior art date
Application number
PCT/IN2013/000052
Other languages
French (fr)
Other versions
WO2013132514A2 (en
Inventor
Davuluri Ramamohan RAO
Ponnaiah Ravi
Praveen Kumar Neela
Bathani GURUSWAMY
Kallepally SUDEER
Mutyala SWETHA
Original Assignee
Rao Davuluri Ramamohan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Rao Davuluri Ramamohan filed Critical Rao Davuluri Ramamohan
Publication of WO2013132514A2 publication Critical patent/WO2013132514A2/en
Publication of WO2013132514A3 publication Critical patent/WO2013132514A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof

Abstract

Provided are novel processes for preparation of Indacaterol Maleate by employing novel intermediates of the formula IIIA and IΧΑ.
PCT/IN2013/000052 2012-03-09 2013-01-24 A novel process for the preparation of (r)-5-[2-[(5, 6-diethyl-2, 3-dihydro-1h-inden-2-yl) amino]-1-hydroxyethyl]-8-hydroxy quinolin-2(1h)-one WO2013132514A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN890/CHE/2012 2012-03-09
IN890CH2012 2012-03-09

Publications (2)

Publication Number Publication Date
WO2013132514A2 WO2013132514A2 (en) 2013-09-12
WO2013132514A3 true WO2013132514A3 (en) 2013-11-07

Family

ID=49117457

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2013/000052 WO2013132514A2 (en) 2012-03-09 2013-01-24 A novel process for the preparation of (r)-5-[2-[(5, 6-diethyl-2, 3-dihydro-1h-inden-2-yl) amino]-1-hydroxyethyl]-8-hydroxy quinolin-2(1h)-one

Country Status (1)

Country Link
WO (1) WO2013132514A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2626829T3 (en) * 2013-03-27 2017-07-26 Laboratorios Lesvi, S.L. Process for the manufacture of (R) -5 [2- (5,6-diethyl-indan-2-ylamino) -1-hydroxyethyl] -8-hydroxy- (1H) -quinolin-2-one
EP3092217B1 (en) 2014-01-09 2020-06-03 Davuluri, Ramamohan Rao A novel process for preparation of indacaterol or its pharmaceutically acceptable salts
US10227305B2 (en) 2014-08-22 2019-03-12 G. Pratap REDDY Process for preparing indacaterol and salts thereof
EP3247693B1 (en) * 2015-01-20 2019-09-04 OLON S.p.A. Process for the preparation of indanamine derivatives and new synthesis intermediates
CN108250140B (en) * 2016-12-28 2021-06-25 正大天晴药业集团股份有限公司 Preparation method of indacaterol maleate
CN110724095B (en) * 2019-09-12 2023-06-09 上海方予健康医药科技有限公司 Preparation method of indacaterol acetate
CN114751857A (en) * 2022-04-29 2022-07-15 梯尔希（南京）药物研发有限公司 Preparation method of indacaterol impurity

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075114A1 (en) * 1999-06-04 2000-12-14 Novartis Ag Beta2-adrenoceptor agonists
WO2002045703A2 (en) * 2000-12-04 2002-06-13 Novartis Ag Mixtures or organic compounds for the treatmentof airway diseases
WO2004076422A1 (en) * 2003-02-28 2004-09-10 Novartis Ag Process for preparing 5-‘(r)-2-(5,6-diethyl-indian-2-ylamino)-1-hydroxy-ethyl!-8-hydroxy-(1h)-quinolin-2-one salt, useful as an adrenoceptor agonist
WO2004087668A1 (en) * 2003-04-02 2004-10-14 Novartis Ag A process for the preparation of 5-(haloacetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075114A1 (en) * 1999-06-04 2000-12-14 Novartis Ag Beta2-adrenoceptor agonists
WO2002045703A2 (en) * 2000-12-04 2002-06-13 Novartis Ag Mixtures or organic compounds for the treatmentof airway diseases
WO2004076422A1 (en) * 2003-02-28 2004-09-10 Novartis Ag Process for preparing 5-‘(r)-2-(5,6-diethyl-indian-2-ylamino)-1-hydroxy-ethyl!-8-hydroxy-(1h)-quinolin-2-one salt, useful as an adrenoceptor agonist
WO2004087668A1 (en) * 2003-04-02 2004-10-14 Novartis Ag A process for the preparation of 5-(haloacetyl)-8-(substituted oxy)-(1h)-quinolin-2-ones

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