EP1086066A4 - Muscarinic receptor antagonists - Google Patents
Muscarinic receptor antagonistsInfo
- Publication number
- EP1086066A4 EP1086066A4 EP99928444A EP99928444A EP1086066A4 EP 1086066 A4 EP1086066 A4 EP 1086066A4 EP 99928444 A EP99928444 A EP 99928444A EP 99928444 A EP99928444 A EP 99928444A EP 1086066 A4 EP1086066 A4 EP 1086066A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- receptor antagonists
- muscarinic receptor
- muscarinic
- antagonists
- receptor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/12—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8846698P | 1998-06-08 | 1998-06-08 | |
| US88466P | 1998-06-08 | ||
| US9293898P | 1998-07-15 | 1998-07-15 | |
| US92938P | 1998-07-15 | ||
| US12028799P | 1999-02-16 | 1999-02-16 | |
| US120287P | 1999-02-16 | ||
| PCT/US1999/012733 WO1999064043A1 (en) | 1998-06-08 | 1999-06-07 | Muscarinic receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1086066A1 EP1086066A1 (en) | 2001-03-28 |
| EP1086066A4 true EP1086066A4 (en) | 2001-08-08 |
Family
ID=27375975
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP99928444A Withdrawn EP1086066A4 (en) | 1998-06-08 | 1999-06-07 | Muscarinic receptor antagonists |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1086066A4 (en) |
| JP (1) | JP2002517464A (en) |
| AR (1) | AR018629A1 (en) |
| AU (1) | AU763638B2 (en) |
| CA (1) | CA2315883A1 (en) |
| NZ (1) | NZ505329A (en) |
| SG (1) | SG80041A1 (en) |
| WO (1) | WO1999064043A1 (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200800953A (en) | 2002-10-30 | 2008-01-01 | Theravance Inc | Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine |
| PE20040950A1 (en) | 2003-02-14 | 2005-01-01 | Theravance Inc | BIPHENYL DERIVATIVES AS AGONISTS OF ß2-ADRENERGIC RECEPTORS AND AS ANTAGONISTS OF MUSCARINAL RECEPTORS |
| EP1615881A2 (en) | 2003-04-01 | 2006-01-18 | Theravance, Inc. | Diarylmethyl and related compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| ES2329133T3 (en) | 2003-05-28 | 2009-11-23 | Theravance, Inc. | AZABICICLOALCANIC COMPOUNDS AS ANTAGONISTS OF MUSCARINIC RECEPTORS. |
| TW200510298A (en) | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
| JP2007524641A (en) | 2003-07-11 | 2007-08-30 | セラヴァンス， インコーポレーテッド | Substituted 4-amino-1-benzylpiperidine compounds |
| CA2543858C (en) | 2003-11-21 | 2014-04-15 | Theravance, Inc. | Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity |
| TW200538095A (en) | 2004-03-11 | 2005-12-01 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
| WO2005087735A1 (en) | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| WO2005087737A1 (en) | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| WO2005087736A1 (en) | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| WO2005087734A1 (en) | 2004-03-11 | 2005-09-22 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| EP1723108A1 (en) | 2004-03-11 | 2006-11-22 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| TWI341836B (en) | 2004-03-11 | 2011-05-11 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
| US7524962B2 (en) | 2004-03-11 | 2009-04-28 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| US7659403B2 (en) | 2005-03-10 | 2010-02-09 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| EP1866284A1 (en) | 2005-03-10 | 2007-12-19 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| JP2008537931A (en) | 2005-03-10 | 2008-10-02 | セラヴァンス， インコーポレーテッド | Biphenyl compounds useful as muscarinic receptor antagonists |
| TW200714587A (en) | 2005-03-10 | 2007-04-16 | Theravance Inc | Biphenyl compounds useful as muscarinic receptor antagonists |
| EP1856112A1 (en) | 2005-03-10 | 2007-11-21 | Theravance, Inc. | Biphenyl compounds useful as muscarinic receptor antagonists |
| JP2008546695A (en) | 2005-06-13 | 2008-12-25 | セラヴァンス， インコーポレーテッド | Biphenyl compounds useful as muscarinic receptor antagonists |
| GB0602778D0 (en) | 2006-02-10 | 2006-03-22 | Glaxo Group Ltd | Novel compound |
| US8389759B2 (en) * | 2007-03-12 | 2013-03-05 | Nektar Therapeutics | Oligomer-anticholinergic agent conjugates |
| WO2017107877A1 (en) * | 2015-12-25 | 2017-06-29 | 四川海思科制药有限公司 | Biphenyl derivative and preparation method and medical use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4587046A (en) * | 1982-05-18 | 1986-05-06 | The Regents Of The University Of California | Drug-carrier conjugates |
| DE3402060A1 (en) * | 1984-01-21 | 1985-08-01 | Dr. Karl Thomae Gmbh, 7950 Biberach | SUBSTITUTED 5,11-DIHYDRO-6H-DIBENZ (B, E) AZEPIN-6-ONE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| US4675326A (en) * | 1985-05-08 | 1987-06-23 | Gabriel Amitai | Bisquaternary antidotes |
| US5534520A (en) * | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
| DE69126124T2 (en) * | 1990-09-28 | 1997-08-28 | Neorx Corp | POLYMERS CARRIER FOR RELEASING COVALENT-RELATED ACTIVE SUBSTANCES |
-
1999
- 1999-06-07 AU AU45508/99A patent/AU763638B2/en not_active Expired
- 1999-06-07 JP JP2000553111A patent/JP2002517464A/en active Pending
- 1999-06-07 SG SG9902762A patent/SG80041A1/en unknown
- 1999-06-07 CA CA002315883A patent/CA2315883A1/en not_active Abandoned
- 1999-06-07 WO PCT/US1999/012733 patent/WO1999064043A1/en not_active Application Discontinuation
- 1999-06-07 EP EP99928444A patent/EP1086066A4/en not_active Withdrawn
- 1999-06-07 NZ NZ505329A patent/NZ505329A/en not_active IP Right Cessation
- 1999-06-08 AR ARP990102700A patent/AR018629A1/en unknown
Non-Patent Citations (9)
| Title |
|---|
| BACHRACH, A. ET AL: "Attachment of drugs to polydimethylsiloxanes", EUR. POLYM. J. (1984), 20(5), 493-500, XP000196583 * |
| CHEMICAL ABSTRACTS, vol. 84, no. 7, 16 February 1976, Columbus, Ohio, US; abstract no. 43492, BRAUDE, M. B. ET AL: "Chemical structure and anthelmintic activity. V. Analogs of the anthelmintics neftamon and difezil" XP002168882 * |
| DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TOMIOKA, TATSUO: "Synthesis of hypotensive compounds. I. Synthesis of methoxy and ethoxycarbonyloxy benzoates", XP002168883, retrieved from STN Database accession no. 73:120260 * |
| ISHIHARA, YUJI ET AL: "Central cholinergic agents. III. Synthesis of 2-alkoxy-2,8- diazaspiro[4.5]decane-1,3-diones as muscarinic agonists", CHEM. PHARM. BULL. (1992), 40(5), 1177-85, XP000651676 * |
| KHIM.-FARM. ZH. (1975), 9(10), 12-14 * |
| KOSTENIS, E. ET AL: "Allosteric effect on muscarinic M2-receptors of derivatives of the alkane-bis-ammonium compound W84. Comparison with bispyridinium-type allosteric modulators", EUR. J. MED. CHEM. (1994), 29(12), 947-53, XP002168881 * |
| See also references of WO9964043A1 * |
| WEINER, BEN ZION ET AL: "Atropine attached to polyethylene glycols", EUR. J. MED. CHEM. - CHIM. THER. (1976), 11(6), 525-6, XP002140747 * |
| YAKUGAKU ZASSHI (1970), 90(8), 1048-51 * |
Also Published As
| Publication number | Publication date |
|---|---|
| SG80041A1 (en) | 2001-04-17 |
| JP2002517464A (en) | 2002-06-18 |
| WO1999064043A1 (en) | 1999-12-16 |
| AU4550899A (en) | 1999-12-30 |
| WO1999064043A9 (en) | 2000-03-02 |
| AU763638B2 (en) | 2003-07-31 |
| AR018629A1 (en) | 2001-11-28 |
| CA2315883A1 (en) | 1999-12-16 |
| NZ505329A (en) | 2003-05-30 |
| EP1086066A1 (en) | 2001-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL348375A1 (en) | Pyrrolidine derivatives-ccr-3 receptor antagonists | |
| SG80041A1 (en) | Muscarinic receptor antagonists | |
| IL128409A0 (en) | Muscarinic antagonists | |
| EP1100506A4 (en) | Integrin receptor antagonists | |
| EP1105389A4 (en) | Integrin receptor antagonists | |
| GB2343891B (en) | 4-Aroyl-piperidine CCR-3 receptor antagonists | |
| IL140249A0 (en) | Muscarinic antagonists | |
| PL342881A1 (en) | Vitronectin receptor antagonists | |
| ZA971513B (en) | Oxa-and thia-diazole muscarinic receptor antagonists | |
| IL142045A0 (en) | Naphthalenecarboxamides as tachykinin receptor antagonists | |
| HK1043590A1 (en) | Muscarinic antagonists | |
| EP1084142A4 (en) | Gpr35a receptor | |
| GB9820014D0 (en) | Receptor antagonists and uses thereof | |
| EP1039903A4 (en) | Il-8 receptor antagonists | |
| EP1047424A4 (en) | Il-8 receptor antagonists | |
| IL141163A0 (en) | Vitronectin receptor antagonists | |
| EP1131335A4 (en) | 7tm receptor hlwar77 | |
| EP1083909A4 (en) | hCEPR RECEPTOR | |
| ZA200003475B (en) | Muscarinic receptor antagonists. | |
| GB9811283D0 (en) | Vironectin receptor antagonists | |
| EP1109565A4 (en) | Gabab1aa receptor | |
| GB9822701D0 (en) | Intergrin receptor antagonists | |
| GB9814737D0 (en) | Fibrinogen receptor antagonists | |
| GB9810182D0 (en) | Vitronectin receptor antagonists | |
| GB9810882D0 (en) | Vitronectin receptor antagonists |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 20000616 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| RIC1 | Information provided on ipc code assigned before grant |
Free format text: 7C 07B 61/00 A, 7A 61K 38/00 B, 7A 61K 39/00 B, 7A 61K 39/44 B, 7A 61K 39/395 B, 7A 61K 51/00 B, 7G 01N 33/53 B, 7G 01N 33/543 B, 7G 01N 33/566 B, 7C 07D 209/00 B, 7C 07D 211/00 B, 7C 07D 221/24 B |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20010625 |
|
| AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: THERAVANCE, INC. |
|
| 17Q | First examination report despatched |
Effective date: 20031121 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20040402 |