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EP1086066A4 - Muscarinic receptor antagonists - Google Patents

Muscarinic receptor antagonists

Info

Publication number
EP1086066A4
EP1086066A4 EP99928444A EP99928444A EP1086066A4 EP 1086066 A4 EP1086066 A4 EP 1086066A4 EP 99928444 A EP99928444 A EP 99928444A EP 99928444 A EP99928444 A EP 99928444A EP 1086066 A4 EP1086066 A4 EP 1086066A4
Authority
EP
European Patent Office
Prior art keywords
receptor antagonists
muscarinic receptor
muscarinic
antagonists
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99928444A
Other languages
German (de)
French (fr)
Other versions
EP1086066A1 (en
Inventor
Mathai Mammen
David Oare
John H Griffin
James Aggen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theravance Inc
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US8846698P priority Critical
Priority to US88466P priority
Priority to US9293898P priority
Priority to US92938P priority
Priority to US120287P priority
Priority to US12028799P priority
Application filed by Theravance Inc filed Critical Theravance Inc
Priority to PCT/US1999/012733 priority patent/WO1999064043A1/en
Publication of EP1086066A1 publication Critical patent/EP1086066A1/en
Publication of EP1086066A4 publication Critical patent/EP1086066A4/en
Application status is Withdrawn legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/12Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with only hydrogen atoms attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40Oxygen atoms
    • C07D211/44Oxygen atoms attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
EP99928444A 1998-06-08 1999-06-07 Muscarinic receptor antagonists Withdrawn EP1086066A4 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US8846698P true 1998-06-08 1998-06-08
US88466P 1998-06-08
US9293898P true 1998-07-15 1998-07-15
US92938P 1998-07-15
US12028799P true 1999-02-16 1999-02-16
US120287P 1999-02-16
PCT/US1999/012733 WO1999064043A1 (en) 1998-06-08 1999-06-07 Muscarinic receptor antagonists

Publications (2)

Publication Number Publication Date
EP1086066A1 EP1086066A1 (en) 2001-03-28
EP1086066A4 true EP1086066A4 (en) 2001-08-08

Family

ID=27375975

Family Applications (1)

Application Number Title Priority Date Filing Date
EP99928444A Withdrawn EP1086066A4 (en) 1998-06-08 1999-06-07 Muscarinic receptor antagonists

Country Status (8)

Country Link
EP (1) EP1086066A4 (en)
JP (1) JP2002517464A (en)
AR (1) AR018629A1 (en)
AU (1) AU763638B2 (en)
CA (1) CA2315883A1 (en)
NZ (1) NZ505329A (en)
SG (1) SG80041A1 (en)
WO (1) WO1999064043A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200800953A (en) 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
PE09502004A1 (en) 2003-02-14 2005-01-01 Theravance Inc Biphenyl derivatives as agonists beta2 adrenoceptor antagonists RECEIVERS AND muscarinic receptor
JP4767842B2 (en) 2003-04-01 2011-09-07 セラヴァンス, インコーポレーテッド Diarylmethyl compounds and related compounds having a β2 adrenergic receptor agonist activity and muscarinic receptor antagonist activity
US7358244B2 (en) 2003-05-28 2008-04-15 Theravance, Inc. Azabicycloalkane compounds
TW200510298A (en) 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
US7368463B2 (en) 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
US7345060B2 (en) 2003-11-21 2008-03-18 Theravance, Inc. Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
EP1723115A1 (en) 2004-03-11 2006-11-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
US7501442B2 (en) 2004-03-11 2009-03-10 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
WO2005087735A1 (en) 2004-03-11 2005-09-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
TWI341836B (en) 2004-03-11 2011-05-11 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
WO2005087736A1 (en) 2004-03-11 2005-09-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
WO2005087739A1 (en) 2004-03-11 2005-09-22 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
TW200538095A (en) 2004-03-11 2005-12-01 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
US7265133B2 (en) 2004-03-11 2007-09-04 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
US7479562B2 (en) 2005-03-10 2009-01-20 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
TW200714587A (en) 2005-03-10 2007-04-16 Theravance Inc Biphenyl compounds useful as muscarinic receptor antagonists
US7659403B2 (en) 2005-03-10 2010-02-09 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
WO2006099032A1 (en) 2005-03-10 2006-09-21 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
US7642355B2 (en) 2005-03-10 2010-01-05 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
EP1893577A1 (en) 2005-06-13 2008-03-05 Theravance, Inc. Biphenyl compounds useful as muscarinic receptor antagonists
GB0602778D0 (en) 2006-02-10 2006-03-22 Glaxo Group Ltd Novel compound
US8389759B2 (en) * 2007-03-12 2013-03-05 Nektar Therapeutics Oligomer-anticholinergic agent conjugates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4587046A (en) * 1982-05-18 1986-05-06 The Regents Of The University Of California Drug-carrier conjugates
DE3402060A1 (en) * 1984-01-21 1985-08-01 Thomae Gmbh Dr K Substituted 5,11-dihydro-6H-dibenz (b, e) azepin-6-one, process for their preparation and pharmaceutical compositions containing these compounds
US4675326A (en) * 1985-05-08 1987-06-23 Gabriel Amitai Bisquaternary antidotes
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
AT152917T (en) * 1990-09-28 1997-05-15 Neorx Corp Polymeric delivery vehicle of covalently bound active ingredients

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BACHRACH, A. ET AL: "Attachment of drugs to polydimethylsiloxanes", EUR. POLYM. J. (1984), 20(5), 493-500, XP000196583 *
CHEMICAL ABSTRACTS, vol. 84, no. 7, 16 February 1976, Columbus, Ohio, US; abstract no. 43492, BRAUDE, M. B. ET AL: "Chemical structure and anthelmintic activity. V. Analogs of the anthelmintics neftamon and difezil" XP002168882 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TOMIOKA, TATSUO: "Synthesis of hypotensive compounds. I. Synthesis of methoxy and ethoxycarbonyloxy benzoates", XP002168883, retrieved from STN Database accession no. 73:120260 *
ISHIHARA, YUJI ET AL: "Central cholinergic agents. III. Synthesis of 2-alkoxy-2,8- diazaspiro[4.5]decane-1,3-diones as muscarinic agonists", CHEM. PHARM. BULL. (1992), 40(5), 1177-85, XP000651676 *
KHIM.-FARM. ZH. (1975), 9(10), 12-14 *
KOSTENIS, E. ET AL: "Allosteric effect on muscarinic M2-receptors of derivatives of the alkane-bis-ammonium compound W84. Comparison with bispyridinium-type allosteric modulators", EUR. J. MED. CHEM. (1994), 29(12), 947-53, XP002168881 *
See also references of WO9964043A1 *
WEINER, BEN ZION ET AL: "Atropine attached to polyethylene glycols", EUR. J. MED. CHEM. - CHIM. THER. (1976), 11(6), 525-6, XP002140747 *
YAKUGAKU ZASSHI (1970), 90(8), 1048-51 *

Also Published As

Publication number Publication date
SG80041A1 (en) 2001-04-17
WO1999064043A9 (en) 2000-03-02
WO1999064043A1 (en) 1999-12-16
CA2315883A1 (en) 1999-12-16
AU763638B2 (en) 2003-07-31
JP2002517464A (en) 2002-06-18
AR018629A1 (en) 2001-11-28
EP1086066A1 (en) 2001-03-28
AU4550899A (en) 1999-12-30
NZ505329A (en) 2003-05-30

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Owner name: THERAVANCE, INC.

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Effective date: 20040402