MX2007006776A - Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina. - Google Patents

Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina.

Info

Publication number
MX2007006776A
MX2007006776A MX2007006776A MX2007006776A MX2007006776A MX 2007006776 A MX2007006776 A MX 2007006776A MX 2007006776 A MX2007006776 A MX 2007006776A MX 2007006776 A MX2007006776 A MX 2007006776A MX 2007006776 A MX2007006776 A MX 2007006776A
Authority
MX
Mexico
Prior art keywords
modulation
chemokine receptor
receptor activity
methods
compounds
Prior art date
Application number
MX2007006776A
Other languages
English (en)
Inventor
Laval Chan Chun Kong
Christophe Moinet
Marc Courchesne
Louis Vaillancourt
Charles Blais
Monica Bubenik
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Publication of MX2007006776A publication Critical patent/MX2007006776A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Compuestos espiro de acuerdo con la formula (I): en donde el radical R1 representa NR7R9, R2, R3, R7, R8, R????8 son como se definieron en la presente, y en donde el anillo A representa un heteroanillo de 5 o 6 miembros sustituido una o dos veces con un sustituyente ceto. Estos compuestos y sus sales farmaceuticamente aceptables se utilizan en combinaciones o en composiciones farmaceuticas y son utiles en la modulacion de la actividad del receptor de quimioquina CCR5.
MX2007006776A 2004-12-09 2005-12-09 Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina. MX2007006776A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63426604P 2004-12-09 2004-12-09
US69305105P 2005-06-23 2005-06-23
PCT/CA2005/001878 WO2006060919A1 (en) 2004-12-09 2005-12-09 Novel spirotropane compounds and methods for the modulation of chemokine receptor activity

Publications (1)

Publication Number Publication Date
MX2007006776A true MX2007006776A (es) 2007-07-09

Family

ID=36577643

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007006776A MX2007006776A (es) 2004-12-09 2005-12-09 Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina.

Country Status (13)

Country Link
US (1) US7960403B2 (es)
EP (1) EP1831222A4 (es)
JP (1) JP2008522986A (es)
KR (1) KR20070095310A (es)
AP (1) AP2007004058A0 (es)
AU (1) AU2005313813B2 (es)
BR (1) BRPI0518859A2 (es)
CA (1) CA2587508A1 (es)
EA (1) EA200701248A1 (es)
MX (1) MX2007006776A (es)
NZ (1) NZ555624A (es)
SG (1) SG158111A1 (es)
WO (1) WO2006060919A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006000096A1 (en) 2004-06-25 2006-01-05 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
CA2587508A1 (en) 2004-12-09 2006-06-15 Virochem Pharma Inc. Novel spirotropane compounds and methods for the modulation of chemokine receptor activity
US8076349B2 (en) 2004-12-09 2011-12-13 Virochem Pharma Inc. Spirotropane compounds and methods for the modulation of chemokine receptor activity
WO2007143847A1 (en) * 2006-06-14 2007-12-21 Virochem Pharma Inc. Spirotropane compounds
RU2565766C1 (ru) * 2014-11-17 2015-10-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии и регенеративной медицины имени Е.Л. Гольдберга" 4-(3,4-дибромтиофенкарбонил)-2,6,8,12-тетраацетил-2,4,6,8,10,12-гексаазатетрацикло[5,5,0,03,11,05,9]додекан в качестве анальгетического средства и способ его получения
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US6166209A (en) 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
WO2001066546A1 (fr) 2000-03-09 2001-09-13 Mitsubishi Pharma Corporation Composes spiro, leur procede de preparation et leur utilisation comme medicaments
JP2004506013A (ja) 2000-08-17 2004-02-26 メルク　エンド　カムパニー　インコーポレーテッド シクロペンチル系ケモカイン受容体活性調節剤
US7247725B2 (en) 2002-10-30 2007-07-24 Merck & Co., Inc. Gamma-aminoamide modulators of chemokine receptor activity
EP1776362A1 (en) * 2003-07-18 2007-04-25 Virochem Pharma Inc. Spiro compounds and methods for the modulation of chemokine receptor activity
CA2579609A1 (en) 2003-09-10 2005-03-17 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
WO2005023809A1 (en) 2003-09-10 2005-03-17 Virochem Pharma Inc. Spiro compounds and methods for the modulation of chemokine receptor activity
WO2006000096A1 (en) 2004-06-25 2006-01-05 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
US8076349B2 (en) 2004-12-09 2011-12-13 Virochem Pharma Inc. Spirotropane compounds and methods for the modulation of chemokine receptor activity
CA2587508A1 (en) 2004-12-09 2006-06-15 Virochem Pharma Inc. Novel spirotropane compounds and methods for the modulation of chemokine receptor activity
WO2007143847A1 (en) 2006-06-14 2007-12-21 Virochem Pharma Inc. Spirotropane compounds

Also Published As

Publication number Publication date
EA200701248A1 (ru) 2007-12-28
US7960403B2 (en) 2011-06-14
JP2008522986A (ja) 2008-07-03
AP2007004058A0 (en) 2007-08-31
AU2005313813A1 (en) 2006-06-15
KR20070095310A (ko) 2007-09-28
EP1831222A4 (en) 2009-10-21
NZ555624A (en) 2009-09-25
CA2587508A1 (en) 2006-06-15
EP1831222A1 (en) 2007-09-12
US20080267906A1 (en) 2008-10-30
WO2006060919A1 (en) 2006-06-15
BRPI0518859A2 (pt) 2008-12-09
SG158111A1 (en) 2010-01-29
AU2005313813B2 (en) 2011-04-14

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