BRPI0518859A2 - compostos de espirotropano e mÉtodos para a modulaÇço de atividade de receptor de quimiocina - Google Patents

compostos de espirotropano e mÉtodos para a modulaÇço de atividade de receptor de quimiocina

Info

Publication number
BRPI0518859A2
BRPI0518859A2 BRPI0518859-8A BRPI0518859A BRPI0518859A2 BR PI0518859 A2 BRPI0518859 A2 BR PI0518859A2 BR PI0518859 A BRPI0518859 A BR PI0518859A BR PI0518859 A2 BRPI0518859 A2 BR PI0518859A2
Authority
BR
Brazil
Prior art keywords
compounds
methods
chemokine receptor
receptor activity
spirotropan
Prior art date
Application number
BRPI0518859-8A
Other languages
English (en)
Inventor
Laval Chan Chun Kong
Chistophe Moinet
Marc Courchesne
Louis Vaillancourt
Charles Blais
Monica Bubenik
Original Assignee
Virochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Virochem Pharma Inc filed Critical Virochem Pharma Inc
Publication of BRPI0518859A2 publication Critical patent/BRPI0518859A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

COMPOSTOS DE ESPIROTROPANO E MÉTODOS PARA A MODULAÇçO DE ATIVIDADE DE RECEPTOR DE QUIMIOCINA. Compostos de spiro de acordo com a fórmula (I): em que o radical R~ 1~ representa NR~ 7~R~ 9~, R~ 2~, R~ 3~, R~ 7~, R~ 8~ , R"~ 8~ são como aqui dedinidos, e em que o anel A representa uma heteroação de 5 ou 6 membros substituida uma vez ou duas vezes com substituinte de ceto. Estes compostos e seus sais farmaceuticamente aceitáveis são usados em combinações ou em composições farmacêuticas e são úteis na modulação de atividade de receptor de quimiocina de CCR5
BRPI0518859-8A 2004-12-09 2005-12-09 compostos de espirotropano e mÉtodos para a modulaÇço de atividade de receptor de quimiocina BRPI0518859A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63426604P 2004-12-09 2004-12-09
US69305105P 2005-06-23 2005-06-23
PCT/CA2005/001878 WO2006060919A1 (en) 2004-12-09 2005-12-09 Novel spirotropane compounds and methods for the modulation of chemokine receptor activity

Publications (1)

Publication Number Publication Date
BRPI0518859A2 true BRPI0518859A2 (pt) 2008-12-09

Family

ID=36577643

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0518859-8A BRPI0518859A2 (pt) 2004-12-09 2005-12-09 compostos de espirotropano e mÉtodos para a modulaÇço de atividade de receptor de quimiocina

Country Status (13)

Country Link
US (1) US7960403B2 (pt)
EP (1) EP1831222A4 (pt)
JP (1) JP2008522986A (pt)
KR (1) KR20070095310A (pt)
AP (1) AP2007004058A0 (pt)
AU (1) AU2005313813B2 (pt)
BR (1) BRPI0518859A2 (pt)
CA (1) CA2587508A1 (pt)
EA (1) EA200701248A1 (pt)
MX (1) MX2007006776A (pt)
NZ (1) NZ555624A (pt)
SG (1) SG158111A1 (pt)
WO (1) WO2006060919A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006000096A1 (en) 2004-06-25 2006-01-05 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
US8076349B2 (en) 2004-12-09 2011-12-13 Virochem Pharma Inc. Spirotropane compounds and methods for the modulation of chemokine receptor activity
MX2007006776A (es) 2004-12-09 2007-07-09 Virochem Pharma Inc Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina.
US8124613B2 (en) 2006-06-14 2012-02-28 Virochem Pharma Inc. Spirotropane compounds
RU2565766C1 (ru) * 2014-11-17 2015-10-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии и регенеративной медицины имени Е.Л. Гольдберга" 4-(3,4-дибромтиофенкарбонил)-2,6,8,12-тетраацетил-2,4,6,8,10,12-гексаазатетрацикло[5,5,0,03,11,05,9]додекан в качестве анальгетического средства и способ его получения
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
WO2001066546A1 (fr) 2000-03-09 2001-09-13 Mitsubishi Pharma Corporation Composes spiro, leur procede de preparation et leur utilisation comme medicaments
AU2001283345B2 (en) 2000-08-17 2005-03-24 Merck Sharp & Dohme Corp. Cyclopentyl modulators of chemokine receptor activity
EP1558250A4 (en) * 2002-10-30 2006-11-02 Merck & Co Inc GAMMA AMINOAMIDE MODULATORS OF THE CHEMOKIN RECEPTOR ACTIVITY
CA2573951A1 (en) * 2003-07-18 2005-01-27 Virochem Pharma Inc. Spiro compounds and methods for the modulation of chemokine receptor activity
EP1786815B1 (en) 2003-09-10 2011-08-24 Virochem Pharma Inc. Spiro compounds and methods for the modulation of chemokine receptor activity
WO2005023810A1 (en) * 2003-09-10 2005-03-17 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
WO2006000096A1 (en) 2004-06-25 2006-01-05 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
MX2007006776A (es) 2004-12-09 2007-07-09 Virochem Pharma Inc Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina.
US8076349B2 (en) 2004-12-09 2011-12-13 Virochem Pharma Inc. Spirotropane compounds and methods for the modulation of chemokine receptor activity
US8124613B2 (en) 2006-06-14 2012-02-28 Virochem Pharma Inc. Spirotropane compounds

Also Published As

Publication number Publication date
EA200701248A1 (ru) 2007-12-28
EP1831222A1 (en) 2007-09-12
MX2007006776A (es) 2007-07-09
NZ555624A (en) 2009-09-25
WO2006060919A1 (en) 2006-06-15
EP1831222A4 (en) 2009-10-21
CA2587508A1 (en) 2006-06-15
KR20070095310A (ko) 2007-09-28
JP2008522986A (ja) 2008-07-03
US20080267906A1 (en) 2008-10-30
AU2005313813A1 (en) 2006-06-15
SG158111A1 (en) 2010-01-29
AU2005313813B2 (en) 2011-04-14
AP2007004058A0 (en) 2007-08-31
US7960403B2 (en) 2011-06-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 7A. ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2202 DE 19/03/2013.