BRPI0518859A2 - compostos de espirotropano e mÉtodos para a modulaÇço de atividade de receptor de quimiocina - Google Patents
compostos de espirotropano e mÉtodos para a modulaÇço de atividade de receptor de quimiocinaInfo
- Publication number
- BRPI0518859A2 BRPI0518859A2 BRPI0518859-8A BRPI0518859A BRPI0518859A2 BR PI0518859 A2 BRPI0518859 A2 BR PI0518859A2 BR PI0518859 A BRPI0518859 A BR PI0518859A BR PI0518859 A2 BRPI0518859 A2 BR PI0518859A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- methods
- chemokine receptor
- receptor activity
- spirotropan
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
COMPOSTOS DE ESPIROTROPANO E MÉTODOS PARA A MODULAÇçO DE ATIVIDADE DE RECEPTOR DE QUIMIOCINA. Compostos de spiro de acordo com a fórmula (I): em que o radical R~ 1~ representa NR~ 7~R~ 9~, R~ 2~, R~ 3~, R~ 7~, R~ 8~ , R"~ 8~ são como aqui dedinidos, e em que o anel A representa uma heteroação de 5 ou 6 membros substituida uma vez ou duas vezes com substituinte de ceto. Estes compostos e seus sais farmaceuticamente aceitáveis são usados em combinações ou em composições farmacêuticas e são úteis na modulação de atividade de receptor de quimiocina de CCR5
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63426604P | 2004-12-09 | 2004-12-09 | |
US69305105P | 2005-06-23 | 2005-06-23 | |
PCT/CA2005/001878 WO2006060919A1 (en) | 2004-12-09 | 2005-12-09 | Novel spirotropane compounds and methods for the modulation of chemokine receptor activity |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0518859A2 true BRPI0518859A2 (pt) | 2008-12-09 |
Family
ID=36577643
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0518859-8A BRPI0518859A2 (pt) | 2004-12-09 | 2005-12-09 | compostos de espirotropano e mÉtodos para a modulaÇço de atividade de receptor de quimiocina |
Country Status (13)
Country | Link |
---|---|
US (1) | US7960403B2 (pt) |
EP (1) | EP1831222A4 (pt) |
JP (1) | JP2008522986A (pt) |
KR (1) | KR20070095310A (pt) |
AP (1) | AP2007004058A0 (pt) |
AU (1) | AU2005313813B2 (pt) |
BR (1) | BRPI0518859A2 (pt) |
CA (1) | CA2587508A1 (pt) |
EA (1) | EA200701248A1 (pt) |
MX (1) | MX2007006776A (pt) |
NZ (1) | NZ555624A (pt) |
SG (1) | SG158111A1 (pt) |
WO (1) | WO2006060919A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7709642B2 (en) | 2004-06-25 | 2010-05-04 | Virochem Pharma, Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
MX2007006776A (es) | 2004-12-09 | 2007-07-09 | Virochem Pharma Inc | Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina. |
WO2006060918A1 (en) | 2004-12-09 | 2006-06-15 | Virochem Pharma Inc. | Novel spirotropane compounds and methods for the modulation of chemokine receptor activity |
CA2655203A1 (en) * | 2006-06-14 | 2007-12-21 | Virochem Pharma Inc. | Spirotropane compounds |
RU2565766C1 (ru) * | 2014-11-17 | 2015-10-20 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии и регенеративной медицины имени Е.Л. Гольдберга" | 4-(3,4-дибромтиофенкарбонил)-2,6,8,12-тетраацетил-2,4,6,8,10,12-гексаазатетрацикло[5,5,0,03,11,05,9]додекан в качестве анальгетического средства и способ его получения |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5534520A (en) | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
US5852029A (en) * | 1990-04-10 | 1998-12-22 | Israel Institute For Biological Research | Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity |
US5407938A (en) * | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
US6166209A (en) * | 1997-12-11 | 2000-12-26 | Hoffmann-La Roche Inc. | Piperidine derivatives |
AU2001241056A1 (en) | 2000-03-09 | 2001-09-17 | Mitsubishi Pharma Corporation | Spiro compounds, process for preparing the same and use thereof as drugs |
EP1318811B1 (en) | 2000-08-17 | 2006-08-30 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
CA2503720A1 (en) | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Gamma-aminoamide modulators of chemokine receptor activity |
WO2005007656A1 (en) * | 2003-07-18 | 2005-01-27 | Virochem Pharma Inc. | Spiro compounds and methods for the modulation of chemokine receptor activity |
CA2579608A1 (en) | 2003-09-10 | 2005-03-17 | Virochem Pharma Inc. | Spiro compounds and methods for the modulation of chemokine receptor activity |
EP1786816A4 (en) * | 2003-09-10 | 2009-11-04 | Virochem Pharma Inc | SPIROHYDANTOIN COMPOUNDS AND METHODS FOR MODULATING CHEMOKINE RECEPTOR ACTIVITY |
US7709642B2 (en) | 2004-06-25 | 2010-05-04 | Virochem Pharma, Inc. | Spirohydantoin compounds and methods for the modulation of chemokine receptor activity |
WO2006060918A1 (en) | 2004-12-09 | 2006-06-15 | Virochem Pharma Inc. | Novel spirotropane compounds and methods for the modulation of chemokine receptor activity |
MX2007006776A (es) | 2004-12-09 | 2007-07-09 | Virochem Pharma Inc | Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina. |
CA2655203A1 (en) | 2006-06-14 | 2007-12-21 | Virochem Pharma Inc. | Spirotropane compounds |
-
2005
- 2005-12-09 MX MX2007006776A patent/MX2007006776A/es active IP Right Grant
- 2005-12-09 KR KR1020077015147A patent/KR20070095310A/ko not_active Application Discontinuation
- 2005-12-09 EA EA200701248A patent/EA200701248A1/ru unknown
- 2005-12-09 WO PCT/CA2005/001878 patent/WO2006060919A1/en active Application Filing
- 2005-12-09 US US11/792,581 patent/US7960403B2/en not_active Expired - Fee Related
- 2005-12-09 AU AU2005313813A patent/AU2005313813B2/en not_active Ceased
- 2005-12-09 SG SG200908088-8A patent/SG158111A1/en unknown
- 2005-12-09 EP EP05819431A patent/EP1831222A4/en not_active Withdrawn
- 2005-12-09 CA CA002587508A patent/CA2587508A1/en not_active Abandoned
- 2005-12-09 NZ NZ555624A patent/NZ555624A/en not_active IP Right Cessation
- 2005-12-09 BR BRPI0518859-8A patent/BRPI0518859A2/pt not_active IP Right Cessation
- 2005-12-09 AP AP2007004058A patent/AP2007004058A0/xx unknown
- 2005-12-09 JP JP2007544710A patent/JP2008522986A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2008522986A (ja) | 2008-07-03 |
EP1831222A1 (en) | 2007-09-12 |
US7960403B2 (en) | 2011-06-14 |
AU2005313813B2 (en) | 2011-04-14 |
EP1831222A4 (en) | 2009-10-21 |
US20080267906A1 (en) | 2008-10-30 |
AP2007004058A0 (en) | 2007-08-31 |
AU2005313813A1 (en) | 2006-06-15 |
NZ555624A (en) | 2009-09-25 |
KR20070095310A (ko) | 2007-09-28 |
SG158111A1 (en) | 2010-01-29 |
MX2007006776A (es) | 2007-07-09 |
WO2006060919A1 (en) | 2006-06-15 |
CA2587508A1 (en) | 2006-06-15 |
EA200701248A1 (ru) | 2007-12-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 7A. ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2202 DE 19/03/2013. |