EA200701248A1 - Новые спиротропановые соединения и способы модуляции активности рецептора хемокина - Google Patents

Новые спиротропановые соединения и способы модуляции активности рецептора хемокина

Info

Publication number
EA200701248A1
EA200701248A1 EA200701248A EA200701248A EA200701248A1 EA 200701248 A1 EA200701248 A1 EA 200701248A1 EA 200701248 A EA200701248 A EA 200701248A EA 200701248 A EA200701248 A EA 200701248A EA 200701248 A1 EA200701248 A1 EA 200701248A1
Authority
EA
Eurasian Patent Office
Prior art keywords
spirotropane
chemokin
receptor
connections
new
Prior art date
Application number
EA200701248A
Other languages
English (en)
Inventor
Лаваль Чань Чунь Кун
Кристоф Муане
Марк Куршесн
Луи Вайанкур
Шарль Бле
Моника Бюбеник
Original Assignee
Вирокем Фарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Вирокем Фарма Инк. filed Critical Вирокем Фарма Инк.
Publication of EA200701248A1 publication Critical patent/EA200701248A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Предложены спиросоединения формулы (I), где радикал Rпредставляет собой NRR; R, R, R, R"имеют определенные в описании значения и где цикл А представляет собой 5- или 6-членный гетероцикл, замещенный одним или двумя кето-заместителями. Указанные соединения и их фармацевтически приемлемые соли могут быть использованы в комбинациях или в фармацевтических композициях и могут быть полезны при модуляции активности рецептора CCR5 хемокина.
EA200701248A 2004-12-09 2005-12-09 Новые спиротропановые соединения и способы модуляции активности рецептора хемокина EA200701248A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63426604P 2004-12-09 2004-12-09
US69305105P 2005-06-23 2005-06-23
PCT/CA2005/001878 WO2006060919A1 (en) 2004-12-09 2005-12-09 Novel spirotropane compounds and methods for the modulation of chemokine receptor activity

Publications (1)

Publication Number Publication Date
EA200701248A1 true EA200701248A1 (ru) 2007-12-28

Family

ID=36577643

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701248A EA200701248A1 (ru) 2004-12-09 2005-12-09 Новые спиротропановые соединения и способы модуляции активности рецептора хемокина

Country Status (13)

Country Link
US (1) US7960403B2 (ru)
EP (1) EP1831222A4 (ru)
JP (1) JP2008522986A (ru)
KR (1) KR20070095310A (ru)
AP (1) AP2007004058A0 (ru)
AU (1) AU2005313813B2 (ru)
BR (1) BRPI0518859A2 (ru)
CA (1) CA2587508A1 (ru)
EA (1) EA200701248A1 (ru)
MX (1) MX2007006776A (ru)
NZ (1) NZ555624A (ru)
SG (1) SG158111A1 (ru)
WO (1) WO2006060919A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006000096A1 (en) 2004-06-25 2006-01-05 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
US8076349B2 (en) 2004-12-09 2011-12-13 Virochem Pharma Inc. Spirotropane compounds and methods for the modulation of chemokine receptor activity
MX2007006776A (es) 2004-12-09 2007-07-09 Virochem Pharma Inc Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina.
US8124613B2 (en) 2006-06-14 2012-02-28 Virochem Pharma Inc. Spirotropane compounds
RU2565766C1 (ru) * 2014-11-17 2015-10-20 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии и регенеративной медицины имени Е.Л. Гольдберга" 4-(3,4-дибромтиофенкарбонил)-2,6,8,12-тетраацетил-2,4,6,8,10,12-гексаазатетрацикло[5,5,0,03,11,05,9]додекан в качестве анальгетического средства и способ его получения
US11116737B1 (en) 2020-04-10 2021-09-14 University Of Georgia Research Foundation, Inc. Methods of using probenecid for treatment of coronavirus infections

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US6166209A (en) * 1997-12-11 2000-12-26 Hoffmann-La Roche Inc. Piperidine derivatives
WO2001066546A1 (fr) 2000-03-09 2001-09-13 Mitsubishi Pharma Corporation Composes spiro, leur procede de preparation et leur utilisation comme medicaments
AU2001283345B2 (en) 2000-08-17 2005-03-24 Merck Sharp & Dohme Corp. Cyclopentyl modulators of chemokine receptor activity
EP1558250A4 (en) * 2002-10-30 2006-11-02 Merck & Co Inc GAMMA AMINOAMIDE MODULATORS OF THE CHEMOKIN RECEPTOR ACTIVITY
CA2573951A1 (en) * 2003-07-18 2005-01-27 Virochem Pharma Inc. Spiro compounds and methods for the modulation of chemokine receptor activity
EP1786815B1 (en) 2003-09-10 2011-08-24 Virochem Pharma Inc. Spiro compounds and methods for the modulation of chemokine receptor activity
WO2005023810A1 (en) * 2003-09-10 2005-03-17 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
WO2006000096A1 (en) 2004-06-25 2006-01-05 Virochem Pharma Inc. Spirohydantoin compounds and methods for the modulation of chemokine receptor activity
MX2007006776A (es) 2004-12-09 2007-07-09 Virochem Pharma Inc Compuestos de espirotropano novedosos y metodos para la modulacion de la actividad del receptor de quimioquina.
US8076349B2 (en) 2004-12-09 2011-12-13 Virochem Pharma Inc. Spirotropane compounds and methods for the modulation of chemokine receptor activity
US8124613B2 (en) 2006-06-14 2012-02-28 Virochem Pharma Inc. Spirotropane compounds

Also Published As

Publication number Publication date
EP1831222A1 (en) 2007-09-12
MX2007006776A (es) 2007-07-09
NZ555624A (en) 2009-09-25
WO2006060919A1 (en) 2006-06-15
EP1831222A4 (en) 2009-10-21
CA2587508A1 (en) 2006-06-15
KR20070095310A (ko) 2007-09-28
JP2008522986A (ja) 2008-07-03
US20080267906A1 (en) 2008-10-30
AU2005313813A1 (en) 2006-06-15
BRPI0518859A2 (pt) 2008-12-09
SG158111A1 (en) 2010-01-29
AU2005313813B2 (en) 2011-04-14
AP2007004058A0 (en) 2007-08-31
US7960403B2 (en) 2011-06-14

Similar Documents

Publication Publication Date Title
ATE402174T1 (de) Imidazopyridinderivate als kinaseinhibitoren
TR200000520A2 (tr) 4-Fenil-piridin türevleri.
SE0202463D0 (sv) Novel compounds
HRP20080052T3 (en) Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation
EA200501009A1 (ru) Замещённые пирролопиразольные производные в качестве ингибиторов киназы
EA200701248A1 (ru) Новые спиротропановые соединения и способы модуляции активности рецептора хемокина
EA200400953A1 (ru) Замещённые пиридиноны в качестве модуляторов map-киназы p38
EA200300919A1 (ru) N-замещенные неарильные гетероциклические антагонисты nmda/nr2b
ATE327977T1 (de) Tetrahydrochinolin-derivate als crth2 antagonisten
NO20062239L (no) Nye tetrahydrospiro[piperidin-2,7&#39;-pyrrolo[3,2-b]pyridinderivater og nye indolderivater nyttige i behandlingen av 5-HT6 reseptorrelaterte forstyrrelser
EA200501332A1 (ru) Производные пиримидин-4-она и их применение в качестве модуляторов киназы p38
SE0401345D0 (sv) Therapeutic compounds: Pyridine as scaffold
AP1564A (en) Piperazinyl sulfonic acid derivatives, their pharmaceutical compositions and methods of use.
SE0300908D0 (sv) Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
NO20013409L (no) Anvendelse av pyrimidin-derivater for forhindring og behandling av cerebral ischemi
DK1242410T3 (da) Nye forbindelser
SE0302570D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
SE0302572D0 (sv) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
ATE297926T1 (de) Hexahydropyrazino(1&#39;2&#39;:1,6)-pyrido(3,4-b)indole 1,4-dion-derivate zur behandlung von cardiovaskulären erkrankungen und erektionsstörungen
SE0301445D0 (sv) Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
DK0508955T3 (da) Anvendelse af 2-iminothiazolidin-4-onderivater som nye lægemidler
DE602005010725D1 (de) Indolin-2-one-pyridin-derivate, herstellung und therapeutische verwendung dafür
EA200400877A1 (ru) 2&#39;-гало-3&#39;,5&#39;-диалкоксифен-1&#39;-илимино-2-имидазолидиновые производные и их применение для лечения недержания мочи
SE0300104D0 (sv) Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
DE68919280T2 (de) Alpha-adrenergische Rezeptorantagonisten.