DE68919280T2 - Alpha-adrenergische Rezeptorantagonisten. - Google Patents

Alpha-adrenergische Rezeptorantagonisten.

Info

Publication number
DE68919280T2
DE68919280T2 DE68919280T DE68919280T DE68919280T2 DE 68919280 T2 DE68919280 T2 DE 68919280T2 DE 68919280 T DE68919280 T DE 68919280T DE 68919280 T DE68919280 T DE 68919280T DE 68919280 T2 DE68919280 T2 DE 68919280T2
Authority
DE
Germany
Prior art keywords
alpha
receptor antagonists
adrenergic receptor
antagonists
adrenoceptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68919280T
Other languages
English (en)
Other versions
DE68919280D1 (de
Inventor
John Joseph Lafferty
Robert Michael Demarinis
Dinubhai Himatlal Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of DE68919280D1 publication Critical patent/DE68919280D1/de
Application granted granted Critical
Publication of DE68919280T2 publication Critical patent/DE68919280T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
DE68919280T 1988-06-01 1989-05-26 Alpha-adrenergische Rezeptorantagonisten. Expired - Fee Related DE68919280T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20100488A 1988-06-01 1988-06-01

Publications (2)

Publication Number Publication Date
DE68919280D1 DE68919280D1 (de) 1994-12-15
DE68919280T2 true DE68919280T2 (de) 1995-03-23

Family

ID=22744083

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68919280T Expired - Fee Related DE68919280T2 (de) 1988-06-01 1989-05-26 Alpha-adrenergische Rezeptorantagonisten.

Country Status (13)

Country Link
EP (1) EP0344979B1 (de)
JP (1) JPH03504607A (de)
KR (1) KR900701797A (de)
CN (1) CN1039810A (de)
AT (1) ATE113949T1 (de)
AU (1) AU629224B2 (de)
CA (1) CA1320953C (de)
DE (1) DE68919280T2 (de)
NZ (1) NZ229300A (de)
PT (1) PT90719B (de)
WO (1) WO1989012054A1 (de)
ZA (1) ZA894098B (de)
ZW (1) ZW6789A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470845A (en) * 1992-10-28 1995-11-28 Bristol-Myers Squibb Company Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia
CA2107644A1 (en) * 1992-10-28 1994-04-29 David R. Magnin .alpha.-phosphonosulfonae squalene synthetase inhibitors and methd
US5447922A (en) * 1994-08-24 1995-09-05 Bristol-Myers Squibb Company α-phosphonosulfinic squalene synthetase inhibitors
EP1939180A1 (de) * 2006-12-20 2008-07-02 sanofi-aventis Heteroarylacrylamide und ihre Verwendung als Arzneimittel für die Stimulation der Expression der endothelialen NO-Synthase
EP2824106B1 (de) * 2012-03-06 2016-11-23 Takeda Pharmaceutical Company Limited Tricyclische verbindung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856910A (en) * 1950-01-10 1974-12-24 Roussel Uclaf Novel thienobenzazepines as anti-depressants
US3649644A (en) * 1969-08-08 1972-03-14 Warner Lambert Co 1 2 3 4 4a 5 6 6a-octahydrobenzofuro (3 2-c)indoles
BE795451A (fr) * 1972-02-23 1973-08-16 Pfizer Agents hypoglycemiants aza indoliques tricycliques
US3950343A (en) * 1973-11-06 1976-04-13 Ayerst, Mckenna And Harrison Ltd. Pyrroloisoquinoline derivatives
JPS57144286A (en) * 1981-03-02 1982-09-06 Takeda Chem Ind Ltd Azepinoindole derivative and its preparation
US4833244A (en) * 1985-04-22 1989-05-23 Hoechst-Rouseel Pharmaceuticals Inc. Ethanobenzazepines
DE3525564A1 (de) * 1985-07-15 1987-02-05 Schering Ag Tricyclische verbindungen mit indolstruktur, verfahren zu ihrer herstellung und deren verwendung als arzneimittel
US4769368A (en) * 1986-02-10 1988-09-06 Smithkline Beckman Corporation 2,3,4,8,9,9A-Hexahydro-4-aryl-1H-indeno(1,7-CD)azepines
DE3630539A1 (de) * 1986-09-08 1988-03-10 Madaus & Co Dr Derivate von 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonin (bzw. -1,4-benzoxazonin), verfahren zu ihrer herstellung und arzneimittel, die diese verbindung enthalten

Also Published As

Publication number Publication date
KR900701797A (ko) 1990-12-04
ZW6789A1 (en) 1989-08-30
EP0344979A2 (de) 1989-12-06
PT90719A (pt) 1989-12-29
PT90719B (pt) 1994-11-30
WO1989012054A1 (en) 1989-12-14
CA1320953C (en) 1993-08-03
NZ229300A (en) 1991-04-26
JPH03504607A (ja) 1991-10-09
DE68919280D1 (de) 1994-12-15
ZA894098B (en) 1990-06-27
EP0344979A3 (de) 1991-05-15
CN1039810A (zh) 1990-02-21
AU629224B2 (en) 1992-10-01
EP0344979B1 (de) 1994-11-09
ATE113949T1 (de) 1994-11-15
AU3857289A (en) 1990-01-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee