ATE212347T1 - Auf das cholinerge system mit muscarin agonisticher aktivität wirkende aza-spiro- verbindungen - Google Patents

Auf das cholinerge system mit muscarin agonisticher aktivität wirkende aza-spiro- verbindungen

Info

Publication number
ATE212347T1
ATE212347T1 AT94921036T AT94921036T ATE212347T1 AT E212347 T1 ATE212347 T1 AT E212347T1 AT 94921036 T AT94921036 T AT 94921036T AT 94921036 T AT94921036 T AT 94921036T AT E212347 T1 ATE212347 T1 AT E212347T1
Authority
AT
Austria
Prior art keywords
image
muscarine
aza
agonistic activity
spiro compounds
Prior art date
Application number
AT94921036T
Other languages
English (en)
Inventor
Abraham Fisher
Yishai Karton
Daniele Marciano
Dov Barak
Haim Meshulam
Original Assignee
Israel State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Israel State filed Critical Israel State
Application granted granted Critical
Publication of ATE212347T1 publication Critical patent/ATE212347T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
AT94921036T 1993-07-20 1994-07-15 Auf das cholinerge system mit muscarin agonisticher aktivität wirkende aza-spiro- verbindungen ATE212347T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/094,855 US5534520A (en) 1990-04-10 1993-07-20 Spiro compounds containing five-membered rings
PCT/GB1994/001543 WO1995003303A2 (en) 1993-07-20 1994-07-15 Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity

Publications (1)

Publication Number Publication Date
ATE212347T1 true ATE212347T1 (de) 2002-02-15

Family

ID=22247578

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94921036T ATE212347T1 (de) 1993-07-20 1994-07-15 Auf das cholinerge system mit muscarin agonisticher aktivität wirkende aza-spiro- verbindungen

Country Status (25)

Country Link
US (1) US5534520A (de)
EP (1) EP0711292B1 (de)
JP (1) JP3802050B2 (de)
KR (1) KR100341683B1 (de)
CN (1) CN1129942B (de)
AT (1) ATE212347T1 (de)
AU (1) AU696530B2 (de)
BG (1) BG62774B1 (de)
BR (1) BR9407088A (de)
CA (1) CA2167584C (de)
CZ (1) CZ295929B6 (de)
DE (1) DE69429724T2 (de)
DK (1) DK0711292T3 (de)
ES (1) ES2171458T3 (de)
FI (1) FI113777B (de)
HU (1) HU224638B1 (de)
IL (1) IL110340A (de)
NO (1) NO310075B1 (de)
NZ (1) NZ268637A (de)
PL (1) PL178931B1 (de)
PT (1) PT711292E (de)
RO (1) RO117851B1 (de)
RU (1) RU2129555C1 (de)
WO (1) WO1995003303A2 (de)
ZA (1) ZA945284B (de)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
ES2101291T3 (es) * 1991-11-25 1997-07-01 American Home Prod 1'-amino-2-((benzotiazolil)metil)espiro(isoquinolina-4(1h),3'-pirrolidina)-1,2',3,5'(2h)-tetronas y sus analogos utiles como inhibidores de aldosa reductasa.
PT777671E (pt) * 1994-08-24 2000-08-31 Astrazeneca Ab Compostos espiro-azabiciclicos uteis em terapia
FR2725206B1 (fr) * 1994-09-29 1996-12-06 Roussel Uclaf Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
WO1997011940A1 (en) 1995-09-29 1997-04-03 Eli Lilly And Company Spiro compounds as inhibitors of fibrinogen-dependent platelet aggregation
CA2250417A1 (en) 1996-04-02 1997-10-09 Bayer Aktiengesellschaft Substituted phenyl keto enols as pesticides and herbicides
EP0932401A1 (de) * 1996-07-01 1999-08-04 Sepracor, Inc. Methoden und zusammensetzungen zur behandlung von harninkontiniez mittels enantiomerishc angereichertem (r,r)-glycopyrrolat
CN1127333C (zh) 1997-02-24 2003-11-12 S.L.A.药业股份公司 含有胆碱能药物或钙通道阻滞剂的局部用医药组合物
US8048875B1 (en) * 1997-02-24 2011-11-01 S.L.A. Pharma Ag Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker
NZ500643A (en) 1997-05-30 2001-12-21 Neurosearch As Spiro-quinuclidine derivatives and their use in treating conditions responsive to nicotinic ACh receptor modulators
TW402591B (en) * 1997-07-11 2000-08-21 Janssen Pharmaceutica Nv Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives
JP2002517464A (ja) * 1998-06-08 2002-06-18 アドバンスド メディスン インコーポレーテッド ムスカリン性レセプターアンタゴニスト
PT963985E (pt) * 1998-06-12 2003-06-30 Hoffmann La Roche Derivados de di- ou triaza-espiro(4,5)decano
ATE222908T1 (de) * 1998-06-12 2002-09-15 Hoffmann La Roche Spiro(piperidin-4,1'-pyrrolo(3,4-c)pyrrole)
US6353006B1 (en) 1999-01-14 2002-03-05 Bayer Corporation Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents
US6693202B1 (en) 1999-02-16 2004-02-17 Theravance, Inc. Muscarinic receptor antagonists
GB9915625D0 (en) * 1999-07-02 1999-09-01 Cortendo Ab Method
AU2001241056A1 (en) * 2000-03-09 2001-09-17 Mitsubishi Pharma Corporation Spiro compounds, process for preparing the same and use thereof as drugs
AR035411A1 (es) * 2000-12-29 2004-05-26 Fujisawa Pharmaceutical Co Uso de un derivado de tacrolimus para fabricar un agente neurotrofico, composiciones y articulos de fabricacion o kits que lo comprenden, metodo para fabricar un agente que lo comprende y tejidos e injertos con una celula nerviosa tratada con este compuesto
DK1385515T3 (da) * 2001-04-18 2008-10-27 Euro Celtique Sa Spiropyrazole forbindelser
DE10130020A1 (de) 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
KR100974901B1 (ko) 2001-12-28 2010-08-10 아카디아 파마슈티칼스 인코포레이티드 모노아민 수용체 조정자로서의 스피로아자사이클릭 화합물
DE10210195B4 (de) * 2002-03-07 2005-12-15 Schwarz Pharma Ag Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz
US7439251B2 (en) * 2002-05-03 2008-10-21 Israel Institute For Biological Research Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
RU2238071C2 (ru) * 2002-11-27 2004-10-20 Маркарян Эдуард Георгиевич Способ лечения пострадавших с черепно-мозговой травмой в ранний посттравматический период
GB0323204D0 (en) 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US7592348B2 (en) 2003-12-15 2009-09-22 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7763609B2 (en) 2003-12-15 2010-07-27 Schering Corporation Heterocyclic aspartyl protease inhibitors
US7700603B2 (en) * 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
CA2583342A1 (en) * 2004-10-13 2006-04-27 Merck And Co., Inc. Spiropiperidine compounds useful as beta-secretase inhibitors for the treatment of alzhermer's disease
NZ555624A (en) * 2004-12-09 2009-09-25 Virochem Pharma Inc Spirotropane compounds and methods for the modulation of CCR5 chemokine receptor activity
EP1824853A4 (de) * 2004-12-09 2010-06-09 Virochem Pharma Inc Neue spirotropanverbindungen und verfahren zur modulation der aktivität des chemokinrezeptors
US8211904B2 (en) * 2005-07-18 2012-07-03 Merck, Sharp & Dohme Corp. Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
ITMI20061279A1 (it) * 2006-06-30 2008-01-01 Consiglio Nazionale Ricerche Agonisti nicotinici selettivi per il sottotipo recettoriale alfa7,procedimento per la loro preparazione e relative composizioni farmaceutiche
AU2007293416A1 (en) * 2006-09-07 2008-03-13 Merck & Co., Inc. Spiropiperidine beta-secretase inhibitors for the treatment of Alzheimer's disease
EP2068872A1 (de) 2006-09-08 2009-06-17 Braincells, Inc. Kombinationen mit einem 4-acylaminopyridin-derivat
ATE538651T1 (de) * 2006-10-30 2012-01-15 Merck Sharp & Dohme Spiropiperidininhibitoren von beta-secretase zur behandlung von alzheimer-krankheit
JP2010512389A (ja) 2006-12-12 2010-04-22 シェーリング コーポレイション アスパルチルプロテアーゼ阻害剤
KR20090090364A (ko) * 2006-12-12 2009-08-25 쉐링 코포레이션 트리사이클릭 환 시스템을 함유하는 아스파르틸 프로테아제 억제제
US7863291B2 (en) * 2008-04-23 2011-01-04 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
CA2750777C (en) * 2009-01-26 2018-04-03 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
WO2011044184A1 (en) 2009-10-08 2011-04-14 Schering Corporation Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use
WO2011044185A2 (en) 2009-10-08 2011-04-14 Schering Corporation Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use
WO2011044187A1 (en) 2009-10-08 2011-04-14 Schering Corporation Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use
AU2009354790A1 (en) * 2009-10-29 2012-06-14 Bristol-Myers Squibb Company Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands
US9145426B2 (en) 2011-04-07 2015-09-29 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use
WO2012138734A1 (en) 2011-04-07 2012-10-11 Merck Sharp & Dohme Corp. C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
MX2013011947A (es) 2011-04-13 2014-01-16 Merck Sharp & Dohme Iminotiazinas 5-sustituidas y sus monoxidos y dioxidos como inhibidores de la enzima que encinde la proteina precursora amiloide en el sitio beta, composiciones y su uso.
KR20140054295A (ko) 2011-08-22 2014-05-08 머크 샤프 앤드 돔 코포레이션 Bace 억제제로서의 2-스피로-치환된 이미노티아진 및 그의 모노- 및 디옥시드, 조성물 및 그의 용도
JP6417324B2 (ja) 2012-07-13 2018-11-07 ペイン セラピューティクス インコーポレイテッド τリン酸化を阻害する方法
WO2014062553A1 (en) 2012-10-17 2014-04-24 Merck Sharp & Dohme Corp. Tricyclic substituted thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
EP2908825B1 (de) 2012-10-17 2018-04-18 Merck Sharp & Dohme Corp. Tricyclische substituierte thiadiazindioxidverbindungen als bace-hemmer, zusammensetzungen und deren verwendung
CA2894919A1 (en) 2012-12-20 2014-06-26 Merck Sharp & Dohme Corp. C5,c6 oxacyclic-fused iminothiazine dioxide compounds as bace inhibitors, compositions, and their use
US9489013B2 (en) 2012-12-20 2016-11-08 Merck Sharp & Dohme Corp. C6-azaspiro iminothiadiazine dioxides as bace inhibitors, compositions, and their use
EP2934534B1 (de) 2012-12-21 2017-12-13 Merck Sharp & Dohme Corp. C5-spiro-iminothiadiazindioxide als bace-inhibitoren
EP2968353B1 (de) 2013-03-15 2018-12-19 Merck Sharp & Dohme Corp. C2-azaspiro-iminothiadiazindioxide als bace-inhibitoren
US9433604B2 (en) 2013-10-08 2016-09-06 Pain Therapeutics Inc. Method for inhibiting growth of cancer cells
EP3083575B1 (de) 2013-12-18 2021-11-03 Merck Sharp & Dohme Corp. C-6-spirocarbocyclische iminothiadiazindioxide als bace-inhibitoren, zusammensetzungen daraus und deren verwendung
EP3265466A4 (de) * 2015-03-06 2018-12-26 Chase Pharmaceuticals Corporation Peripherale-anticholinergene muscarinagonistenkombination
US10307409B2 (en) 2015-03-06 2019-06-04 Chase Pharmaceuticals Corporation Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system
WO2017044693A1 (en) 2015-09-11 2017-03-16 Chase Pharmaceuticals Corporation Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system
SI3523310T1 (sl) 2016-10-05 2022-10-28 Nsc Therapeutics Gmbh Kristalinični polimorfi agonista muskarinskega acetilholinskega receptorja
US12201619B2 (en) * 2018-03-22 2025-01-21 Nsc Therapeutics Gmbh Compounds and methods for use in the treatment of microglia-mediated disorders
AU2021270664B2 (en) * 2020-05-12 2024-05-30 Beijing Greatway Pharmaceutical Technology Co., Ltd. Compound for adjusting activity of NMDA receptor, and pharmaceutical composition and use thereof
CA3213079A1 (en) 2021-04-13 2022-10-20 Kristin Lynne ANDREWS Amino-substituted heterocycles for treating cancers with egfr mutations

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3161644A (en) * 1962-06-22 1964-12-15 Res Lab Dr C Janssen N V 1-benzyl-4-substituted piperidines
JPS4917534B1 (de) * 1970-10-06 1974-05-01
BE790675A (fr) * 1971-10-29 1973-04-27 Science Union & Cie Nouveaux derives de l'oxa-1 diaza-3,8 spiro (4,5) decane
EP0189370A3 (de) * 1985-01-16 1988-01-27 Sandoz Ag Spiro-dioxolane, -dithiolane und -oxothiolane
US4855290A (en) * 1985-05-10 1989-08-08 State Of Israel, Represented By Prime Minister's Office, Israel Institute For Biological Research Derivatives of quinuclidine
EP0273659A1 (de) * 1986-12-27 1988-07-06 Takeda Chemical Industries, Ltd. Azaspiroverbindungen, ihre Herstellung und Verwendung
JPS63208590A (ja) * 1987-02-24 1988-08-30 Yamanouchi Pharmaceut Co Ltd ヘテロ環式スピロ化合物及びその製造法
IL87234A (en) * 1987-08-13 1992-02-16 Israel Inst Biolog Res Optical isomers of 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine,their preparation and pharmaceutical compositions containing them
ATE122353T1 (de) * 1987-10-05 1995-05-15 Yamanouchi Pharma Co Ltd Heterozyklische spiroverbindungen und ihre herstellung.
US4876260A (en) * 1987-10-28 1989-10-24 State Of Israel, Israel Institute Of Biological Research Oxathiolanes
JPH02164882A (ja) * 1988-12-20 1990-06-25 Yamanouchi Pharmaceut Co Ltd スピロ化合物及びその中間体
JPH02247183A (ja) * 1989-03-20 1990-10-02 Yamanouchi Pharmaceut Co Ltd ヘテロ環スピロ化合物
YU150489A (sh) * 1989-08-10 1992-12-21 W.L. Gore & Co. Gmbh. Uređaj za ispitivanje odevnih predmeta na nepromočivost
IL97726A (en) * 1990-04-10 1994-12-29 Israel Inst Biolog Res Pharmaceutical compositions containing compounds with bridged and unbridged heterocyclic groups, spiro-connected with oxazoline and thiazoline groups, and some new such compounds
US5073560A (en) * 1990-07-20 1991-12-17 Fisons Corporation Spiro-isoxazolidine derivatives as cholinergic agents
TW201312B (en) * 1991-04-09 1993-03-01 Israel State Spiro bridged and unbridged heterocyclic compounds

Also Published As

Publication number Publication date
HU224638B1 (hu) 2005-12-28
HU9600126D0 (en) 1996-03-28
FI960238A7 (fi) 1996-03-18
CN1129942B (zh) 2011-08-10
CN1129942A (zh) 1996-08-28
PT711292E (pt) 2002-07-31
BR9407088A (pt) 1996-08-13
WO1995003303A3 (en) 1995-03-02
PL312684A1 (en) 1996-05-13
AU7191594A (en) 1995-02-20
DE69429724T2 (de) 2002-08-29
IL110340A0 (en) 1994-10-21
AU696530B2 (en) 1998-09-10
JPH09503491A (ja) 1997-04-08
RU2129555C1 (ru) 1999-04-27
JP3802050B2 (ja) 2006-07-26
DE69429724D1 (de) 2002-03-14
BG100370A (bg) 1996-11-29
RO117851B1 (ro) 2002-08-30
ES2171458T3 (es) 2002-09-16
FI113777B (fi) 2004-06-15
CZ18296A3 (en) 1996-07-17
IL110340A (en) 1999-06-20
CA2167584C (en) 2006-10-24
EP0711292B1 (de) 2002-01-23
PL178931B1 (pl) 2000-06-30
NO310075B1 (no) 2001-05-14
NO960225D0 (no) 1996-01-18
CZ295929B6 (cs) 2005-12-14
KR100341683B1 (ko) 2002-11-30
ZA945284B (en) 1995-10-12
HUT74588A (en) 1997-01-28
NO960225L (no) 1996-03-12
US5534520A (en) 1996-07-09
NZ268637A (en) 1998-01-26
DK0711292T3 (da) 2002-05-06
WO1995003303A2 (en) 1995-02-02
KR960703914A (ko) 1996-08-31
EP0711292A1 (de) 1996-05-15
FI960238A0 (fi) 1996-01-17
BG62774B1 (bg) 2000-07-31
CA2167584A1 (en) 1995-02-02

Similar Documents

Publication Publication Date Title
DE69429724D1 (de) Auf das cholinerge system mit muscarin agonisticher aktivität wirkende aza-spiro-verbindungen
MX9102407A (es) 4 arilpiperazinas y 4-arilpiperidinas novedosas.
ES2160114T3 (es) Derivados opticamente activos de 2-imidazolin-5-onas como fungicidas.
IL104489A0 (en) Carbamates and crop protection agents containing them
NO953462L (no) Heterosykliske forbindelser og deres fremstilling og anvendelse
DE68915653D1 (de) Organosiloxan-Olefin-Copolymere.
EP0522082A4 (en) Multi-functional pharmaceutical compounds and methods of use
TW275615B (de)
ES2064487T3 (es) Nuevos inhibidores de glicosidasa.
NZ334848A (en) Use of 1-hydroxy-2-pyridones for the treatment of skin diseases caused by fungi and bacteria
ES2163401T3 (es) 5,8-dihidrodiazaantracenos con actividad antitumoral.
AP8800109A0 (en) "Heterocyclic insecticides".
ATE55907T1 (de) Oktahydroindolizine brauchbar als analgetika.
AU6826887A (en) 5-substituted octahydroindolizine analgesics compounds and 7-keto intermediates
EP0532629A4 (de)
MY106979A (en) Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents.
UA41915C2 (uk) Засіб для інгібування проліферації і міграції клітин васкулярних гладенькіх м`язів у ссавців
DE69015411D1 (de) 5,11-Dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one und -thione und deren Verwendung bei der Vorbeugung und und Behandlung von AIDS.
CA2148593A1 (en) Use of piperazine derivatives for the treatment of cognitive disorders
IL111246A0 (en) Tricyclic compounds and pharmaceutical compositions containing them
DE69113318D1 (de) Platte für Distillationskolonne, Distillationskolonne mit einer derartigen Platte und Anwendung einer derartigen Kolonne.
ATE137227T1 (de) 2-tbutyl-4-chlor-5-(4-ibutoxymethylcyclohexyl)- methylthio-3(h)-pyridazinon mit insektizider und akarizider aktivität
UA7778A1 (uk) 13-[(2s) 2-аміно-4-карбоксибутаноіл]-1, 4, 7, 10 тетраокса-13-азаціклопентадекан гідрохлорід, який має антиамнестичну і антигіпоксичну дію
UA7931A1 (uk) N,n '-біс-(теофілін-7-ілметилен)-піперазин, що володіє противірусною та протимікробною активністю

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee