NO943319L - Forbedrede promedikamenter for enzymformidlet aktivering - Google Patents

Forbedrede promedikamenter for enzymformidlet aktivering

Info

Publication number
NO943319L
NO943319L NO943319A NO943319A NO943319L NO 943319 L NO943319 L NO 943319L NO 943319 A NO943319 A NO 943319A NO 943319 A NO943319 A NO 943319A NO 943319 L NO943319 L NO 943319L
Authority
NO
Norway
Prior art keywords
prodrugs
enhanced
mediated activation
enzyme mediated
enzyme
Prior art date
Application number
NO943319A
Other languages
English (en)
Other versions
NO943319D0 (no
NO313126B1 (no
Inventor
Klaus Bosslet
Jorg Czech
Dieter Hoffmann
Andrea Vasella
Roland Hoos
Francois Tillequin
Jean-Claude Florent
Michel Azoulay
Claude Monneret
Jean-Claude Jacquesy
Jean-Pierre Gesson
Michel Koch
Original Assignee
Behringwerke Ag
Hoechst Sa Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Behringwerke Ag, Hoechst Sa Lab filed Critical Behringwerke Ag
Publication of NO943319D0 publication Critical patent/NO943319D0/no
Publication of NO943319L publication Critical patent/NO943319L/no
Publication of NO313126B1 publication Critical patent/NO313126B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO19943319A 1993-09-09 1994-09-08 Forbedrede promedikamenter for enzym-formidlet aktivering og farmasöytiske preparater inneholdende disse NO313126B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93114475A EP0647450A1 (en) 1993-09-09 1993-09-09 Improved prodrugs for enzyme mediated activation

Publications (3)

Publication Number Publication Date
NO943319D0 NO943319D0 (no) 1994-09-08
NO943319L true NO943319L (no) 1995-03-10
NO313126B1 NO313126B1 (no) 2002-08-19

Family

ID=8213248

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19943319A NO313126B1 (no) 1993-09-09 1994-09-08 Forbedrede promedikamenter for enzym-formidlet aktivering og farmasöytiske preparater inneholdende disse

Country Status (13)

Country Link
US (1) US5621002A (no)
EP (2) EP0647450A1 (no)
JP (1) JP3773120B2 (no)
KR (1) KR100385830B1 (no)
AT (1) ATE208213T1 (no)
AU (1) AU678494B2 (no)
CA (1) CA2131662C (no)
DE (1) DE69428957T2 (no)
DK (1) DK0642799T3 (no)
ES (1) ES2167343T3 (no)
NO (1) NO313126B1 (no)
PT (1) PT642799E (no)
ZA (1) ZA946920B (no)

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CA2131662C (en) 2008-09-02
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EP0642799B1 (en) 2001-11-07
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DK0642799T3 (da) 2002-02-25
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ZA946920B (en) 1995-04-12
KR100385830B1 (ko) 2003-08-19
US5621002A (en) 1997-04-15
EP0647450A1 (en) 1995-04-12
AU678494B2 (en) 1997-05-29
AU7169994A (en) 1995-03-23
ATE208213T1 (de) 2001-11-15
DE69428957D1 (de) 2001-12-13
DE69428957T2 (de) 2002-06-06
KR950007874A (ko) 1995-04-15
JPH07149667A (ja) 1995-06-13
PT642799E (pt) 2002-04-29

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