NO904119L - Trombolytisk materiale inneholdende vevstypeplasminogenaktivator eller derivat derav. - Google Patents

Trombolytisk materiale inneholdende vevstypeplasminogenaktivator eller derivat derav.

Info

Publication number
NO904119L
NO904119L NO90904119A NO904119A NO904119L NO 904119 L NO904119 L NO 904119L NO 90904119 A NO90904119 A NO 90904119A NO 904119 A NO904119 A NO 904119A NO 904119 L NO904119 L NO 904119L
Authority
NO
Norway
Prior art keywords
salt
derivative
plasminogen activator
tissue type
thrombolytic
Prior art date
Application number
NO90904119A
Other languages
English (en)
Other versions
NO904119D0 (no
Inventor
Yukio Shimazaki
Miyuki Kawashima
Masahiko Ishibashi
Ryo Tanaka
Kiyoshi Sakai
Hisahiro Ishiwari
Original Assignee
Mitsui Toatsu Chemicals
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals, Mochida Pharm Co Ltd filed Critical Mitsui Toatsu Chemicals
Publication of NO904119D0 publication Critical patent/NO904119D0/no
Publication of NO904119L publication Critical patent/NO904119L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49—Urokinase; Tissue plasminogen activator
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Fats And Perfumes (AREA)
  • Preliminary Treatment Of Fibers (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Trombolytisk blanding innehold- ende vevstype-plasminogenaktivator eller et derivat derav i kombinasjon med en anionisk polymer eller et salt derav og en aminforbindelse eller et salt derav eller i kombinasjon med en anionisk polymer eller et salt derav, en aminforbindelse og en syre eller et salt derav. Blandingen er en vandig løsning eller et lyofilisert preparat som kan løses stabilt ved fortynning ved nær nøytral pH i både farmasøytiske løsninger som har høy saltkonsentra- sjon, slik som fysiologisk saltvann, såvel som farmasøytiske løsninger som har lav saltkonsentrasjon, slik som en 5% glucoseløsning. Klinisk anvendelige produkter for infusjon eller injeksjon fremstilles for anvendelse ved en nær nøytral pH.
NO90904119A 1989-09-21 1990-09-20 Trombolytisk materiale inneholdende vevstypeplasminogenaktivator eller derivat derav. NO904119L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP24331089 1989-09-21

Publications (2)

Publication Number Publication Date
NO904119D0 NO904119D0 (no) 1990-09-20
NO904119L true NO904119L (no) 1991-03-22

Family

ID=17101932

Family Applications (1)

Application Number Title Priority Date Filing Date
NO90904119A NO904119L (no) 1989-09-21 1990-09-20 Trombolytisk materiale inneholdende vevstypeplasminogenaktivator eller derivat derav.

Country Status (15)

Country Link
US (1) US6051223A (no)
EP (1) EP0419252B1 (no)
JP (1) JP2520975B2 (no)
KR (1) KR930008908B1 (no)
CN (1) CN1041799C (no)
AT (1) ATE86867T1 (no)
BR (1) BR9004692A (no)
CA (1) CA2025317C (no)
DE (1) DE69001110T2 (no)
DK (1) DK0419252T3 (no)
ES (1) ES2054263T3 (no)
FI (1) FI104953B (no)
GR (1) GR3007396T3 (no)
NO (1) NO904119L (no)
NZ (1) NZ235298A (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207151B1 (en) * 1989-09-21 2001-03-27 Mitsui Chemicals Inc. Aqueous solution of t-PA
US5272076A (en) * 1991-06-13 1993-12-21 Eli Lilly And Company Compounds and methods for treatment of thromboembolic disorders using an adduct of t-PA
US6527979B2 (en) * 1999-08-27 2003-03-04 Corazon Technologies, Inc. Catheter systems and methods for their use in the treatment of calcified vascular occlusions
EP2604697B1 (en) * 2006-03-27 2015-07-01 Tokyo University of Agriculture and Technology TLO Triprenyl phenol compounds, process for their production and use as thrombolysis enhancer
EP3524235A1 (en) * 2012-06-11 2019-08-14 The Cleveland Clinic Foundation Treatment and prevention of cardiovascular disease and thrombosis
CN103191054B (zh) * 2013-04-19 2015-05-27 范克 一种肝素钠封管注射液及其制备方法

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2310133A2 (fr) * 1975-05-05 1976-12-03 Fabre Sa Pierre Nouveau medicament comportant un activateur du plasminogene perfectionne
JPS52145591A (en) * 1976-05-28 1977-12-03 Kanebo Ltd Stabilization of urokinase
JPS5467089A (en) * 1977-11-07 1979-05-30 Dainippon Pharmaceut Co Ltd Urokinase composition
JPS5568290A (en) * 1978-11-16 1980-05-22 Kanebo Ltd Stabilization of urokinase
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
JPS60158116A (ja) * 1984-01-30 1985-08-19 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPS60158117A (ja) * 1984-01-30 1985-08-19 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
JPS60181028A (ja) * 1984-02-29 1985-09-14 Asahi Chem Ind Co Ltd 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助法
JPS60184026A (ja) * 1984-03-01 1985-09-19 Asahi Chem Ind Co Ltd 組織プラスミノ−ゲン・アクチベ−タ−の溶解補助方法
GR860624B (en) * 1985-03-06 1986-07-08 Survival Technology T-pa composition and method of getting into blood steam
DE3512908A1 (de) * 1985-04-11 1986-10-23 Behringwerke Ag, 3550 Marburg Gewebe-plasminogenaktivator (t-pa) enthaltendes mittel
DE3512910A1 (de) * 1985-04-11 1986-10-16 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung von plasminogenaktivatoren
DE3512909A1 (de) * 1985-04-11 1986-10-23 Behringwerke Ag, 3550 Marburg Verfahren zur bestimmung von plasminogenaktivatoren (pa)
JPH0669960B2 (ja) * 1985-11-22 1994-09-07 エーザイ株式会社 水溶性を増加したｔＰＡ含有医薬組成物
DE3687255T2 (de) * 1985-09-10 1993-05-06 Eisai Co Ltd Einen gewebe-plasminogen-aktivator enthaltende zusammensetzung.
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法
JPS62120321A (ja) * 1985-11-20 1987-06-01 Eisai Co Ltd ｔＰＡ含有医薬組成物
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
JPH0678241B2 (ja) * 1986-04-02 1994-10-05 エーザイ株式会社 ｔＰＡ医薬組成物
JPS62292729A (ja) * 1986-06-12 1987-12-19 Toyobo Co Ltd ヒト子宮組織由来プラスミノ−ゲン活性化因子製剤
US4857320A (en) * 1987-02-19 1989-08-15 Monsanto Company Method of enhancing the solubility of tissue plasminogen activator
DE3718889A1 (de) * 1987-06-05 1988-12-22 Behringwerke Ag Verfahren zur herstellung einer loesung hoher spezifischer volumenaktivitaet von einem protein mit gewebe-plasminogenaktivator (t-pa)-aktivitaet, loesung, enthaltend protein mit t-pa-aktivitaet und verwendung der loesung in der human- und veterinaermedizin
JP2708749B2 (ja) * 1987-08-10 1998-02-04 エーザイ株式会社 修飾型ｔＰＡ含有注射用組成物
US4898826A (en) * 1987-12-10 1990-02-06 Invitron Corporation Method to solubilize tissue plasminogen activator
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
JPH06226234A (ja) * 1993-02-01 1994-08-16 Shojiro Takeuchi 産業廃棄物の炭化処理方法
JPH06236332A (ja) * 1993-02-09 1994-08-23 Oki Electric Ind Co Ltd プログラムローディング装置
JPH06259221A (ja) * 1993-03-05 1994-09-16 Tokyo Electric Co Ltd 画面表示器を備えた情報処理装置
JPH06281326A (ja) * 1993-03-30 1994-10-07 Shibaura Eng Works Co Ltd 洗浄物の乾燥方法

Also Published As

Publication number Publication date
FI104953B (fi) 2000-05-15
NZ235298A (en) 1992-12-23
JP2520975B2 (ja) 1996-07-31
GR3007396T3 (no) 1993-07-30
US6051223A (en) 2000-04-18
DK0419252T3 (da) 1993-04-19
CN1050321A (zh) 1991-04-03
CA2025317A1 (en) 1991-03-22
CN1041799C (zh) 1999-01-27
NO904119D0 (no) 1990-09-20
AU619697B2 (en) 1992-01-30
DE69001110T2 (de) 1993-06-24
AU6246790A (en) 1991-03-28
EP0419252B1 (en) 1993-03-17
ES2054263T3 (es) 1994-08-01
JPH0418032A (ja) 1992-01-22
FI904617A0 (fi) 1990-09-19
KR930008908B1 (ko) 1993-09-17
EP0419252A1 (en) 1991-03-27
DE69001110D1 (de) 1993-04-22
BR9004692A (pt) 1991-09-10
KR910005883A (ko) 1991-04-27
ATE86867T1 (de) 1993-04-15
CA2025317C (en) 1996-05-07

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