NO802352L - Fremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater. - Google Patents

Fremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater.

Info

Publication number
NO802352L
NO802352L NO802352A NO802352A NO802352L NO 802352 L NO802352 L NO 802352L NO 802352 A NO802352 A NO 802352A NO 802352 A NO802352 A NO 802352A NO 802352 L NO802352 L NO 802352L
Authority
NO
Norway
Prior art keywords
hydrogen
carbon atoms
preparation
compounds
procedure
Prior art date
Application number
NO802352A
Other languages
English (en)
Other versions
NO153220B (no
NO153220C (no
Inventor
Arto Johannes Karjalainen
Kauko Oiva Antero Kurkela
Original Assignee
Farmos Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Oy filed Critical Farmos Oy
Publication of NO802352L publication Critical patent/NO802352L/no
Publication of NO153220B publication Critical patent/NO153220B/no
Publication of NO153220C publication Critical patent/NO153220C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/313—Compounds having groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/30—Compounds having groups
    • C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/258—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO802352A 1979-08-07 1980-08-06 Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolinderivater. NO153220C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6457579A 1979-08-07 1979-08-07

Publications (3)

Publication Number Publication Date
NO802352L true NO802352L (no) 1981-02-09
NO153220B NO153220B (no) 1985-10-28
NO153220C NO153220C (no) 1986-02-05

Family

ID=22056899

Family Applications (1)

Application Number Title Priority Date Filing Date
NO802352A NO153220C (no) 1979-08-07 1980-08-06 Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolinderivater.

Country Status (21)

Country Link
US (1) US4443466A (no)
EP (1) EP0024829B1 (no)
JP (1) JPS5632463A (no)
AT (1) ATE7226T1 (no)
AU (1) AU518569B2 (no)
BG (1) BG60426B2 (no)
CA (1) CA1154780A (no)
DD (1) DD152548A1 (no)
DE (1) DE3067618D1 (no)
DK (2) DK155794C (no)
FI (1) FI70709C (no)
HK (1) HK68587A (no)
HU (1) HU184809B (no)
IE (1) IE50080B1 (no)
IL (1) IL60723A (no)
NO (1) NO153220C (no)
NZ (1) NZ194536A (no)
SG (1) SG34987G (no)
SU (2) SU997607A3 (no)
UA (1) UA5559A1 (no)
ZA (1) ZA804787B (no)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2069481B (en) * 1980-02-13 1983-07-27 Farmos Oy Substituted imidazole derivatives
US4374843A (en) * 1980-10-14 1983-02-22 Pfizer Inc. 2-Guanidino-4-heteroarylthiazoles
GB2092569B (en) * 1981-02-05 1984-09-19 Farmos Oy Substituted imidazole derivatives and their preparation and use
GB2101114B (en) * 1981-07-10 1985-05-22 Farmos Group Ltd Substituted imidazole derivatives and their preparation and use
GB2110663B (en) * 1981-12-04 1985-08-07 Farmos Group Ltd Imidazole derivatives
FI833794A0 (fi) * 1983-10-18 1983-10-18 Farmos Oy Substituerade 2-merkapto-imidazoler
JPH0658947B2 (ja) * 1984-02-24 1994-08-03 株式会社日立製作所 半導体メモリ装置の製法
DE3539629A1 (de) * 1985-11-08 1987-05-14 Basf Ag Dialkoxyketone und ein verfahren zu ihrer herstellung
GB8626287D0 (en) * 1986-11-04 1986-12-03 Ucb Sa Substituted 1h-imidazoles
JPS63150266A (ja) * 1986-12-12 1988-06-22 Mitsui Petrochem Ind Ltd ベンジルイミダゾ−ル誘導体
GB2206880B (en) * 1987-07-16 1991-04-24 Farmos Oy Optical isomers of an imidazole derivative
GB8810067D0 (en) * 1988-04-28 1988-06-02 Ucb Sa Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides
US5255225A (en) * 1989-04-05 1993-10-19 Hitachi, Ltd. Semiconductor integrated circuit device and memory consisting of semiconductor integrated circuit
US5073566A (en) * 1989-11-30 1991-12-17 Eli Lilly And Company Angiotensin ii antagonist 1,3-imidazoles and use thereas
US5086064A (en) * 1990-03-27 1992-02-04 Warner-Lambert Company 3,5-di-tertiary-butyl-4-hydroxyphenyl thiazolyl, oxazolyl, and imidazolyl methanones and related compounds as antiinflammatory agents
GB2256135B (en) 1991-05-31 1995-01-18 Orion Yhtymae Oy Transdermal administration of 4-substituted imidazoles
US5401851A (en) * 1992-06-03 1995-03-28 Eli Lilly And Company Angiotensin II antagonists
ES2076085B1 (es) * 1993-06-15 1997-03-01 Lilly Co Eli Antagonistas de angiotensina ii.
ES2188649T3 (es) * 1993-11-15 2003-07-01 Schering Corp Fenil-alquil-imidazoles como antagonistas del receptor h3.
US5922751A (en) * 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
KR100385095B1 (ko) * 1997-07-15 2003-08-19 주식회사 엘지생명과학 파네실전이효소저해효능을갖는2환또는3환방향족화합물
US6841684B2 (en) 1997-12-04 2005-01-11 Allergan, Inc. Imidiazoles having reduced side effects
US6329369B1 (en) 1997-12-04 2001-12-11 Allergan Sales, Inc. Methods of treating pain and other conditions
US6503935B1 (en) 1998-08-07 2003-01-07 Abbott Laboratories Imidazoles and related compounds as α1A agonists
JP2002544258A (ja) * 1999-05-12 2002-12-24 ニューロサーチ、アクティーゼルスカブ イオンチャネル調節剤
TWI283669B (en) * 1999-06-10 2007-07-11 Allergan Inc Compounds and method of treatment having agonist-like activity selective at alpha 2B or 2B/2C adrenergic receptors
JP2002262119A (ja) * 2001-02-28 2002-09-13 Sharp Corp 画像処理装置、画像処理方法、画像処理プログラムを記録した機械読取可能な記録媒体および画像処理プログラム
US7777035B2 (en) * 2005-06-22 2010-08-17 Chemocentryx, Inc. Azaindazole compounds and methods of use
ZA200800309B (en) * 2005-06-22 2009-10-28 Chemocentryx Inc Azaindazole compounds and methods of use
JP2009524616A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ疾患のための４−イミダゾール誘導体の使用
US20090252779A1 (en) * 2006-06-22 2009-10-08 Chemocentryx, Inc. Azaindazole compounds and methods of use
CN101528710B (zh) 2006-10-19 2012-11-07 弗·哈夫曼-拉罗切有限公司 氨基甲基-4-咪唑类
EP2086959B1 (en) 2006-11-02 2011-11-16 F. Hoffmann-La Roche AG Substituted 2-imidazoles as modulators of the trace amine associated receptors
CA2669112A1 (en) 2006-11-16 2008-05-22 F. Hoffmann-La Roche Ag Substituted 4-imidazoles
ATE509628T1 (de) 2006-12-13 2011-06-15 Hoffmann La Roche Neue 2-imidazole als liganden für trace amine associated receptors (taar)
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
US7868020B2 (en) 2007-01-12 2011-01-11 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
US8013169B2 (en) 2007-01-12 2011-09-06 Allergan, Inc Naphthylmethylimidizoles as therapeutic agents
US8119807B2 (en) 2007-01-12 2012-02-21 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
BRPI0806940A2 (pt) 2007-02-02 2014-05-06 Hoffmann La Roche 2-amino-oxazolinas como ligantes taar1 para distúrbios do snc
CA2676944C (en) 2007-02-15 2016-01-19 F. Hoffmann-La Roche Ag 2-aminooxazolines as taar1 ligands
EA015529B1 (ru) * 2007-05-22 2011-08-30 Кемосентрикс, Инк. 3-(имидазолил)пиразоло[3,4-b]пиридины
CA2691082A1 (en) 2007-07-02 2009-01-08 F. Hoffmann-La Roche Ag 2 -imidazolines having a good affinity to the trace amine associated receptors (taars)
WO2009003867A1 (en) 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
BRPI0813837A2 (pt) 2007-07-27 2015-01-06 Hoffmann La Roche 2-azetidinametanoaminas e 2-pirrolidinametanoaminas como ligantes de taar
KR101167773B1 (ko) 2007-08-03 2012-07-24 에프. 호프만-라 로슈 아게 Ｔａａｒ１ 리간드로서의 피리딘카복스아마이드 및 벤즈아마이드 유도체
EP2296648A1 (en) * 2008-05-13 2011-03-23 Allergan, Inc. Naphthylmethylimidizoles for the treatment of stress urinary incontinence
AU2009246601A1 (en) * 2008-05-13 2009-11-19 Allergan, Inc. Quinolynylmethylimidizoles as therapeutic agents
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
DK2323663T3 (en) * 2008-09-11 2015-06-01 Chemocentryx Inc 4-amino-3- (imidazolyl) pyrazolo [3,4-d] pyrimidines
CN101747280B (zh) * 2008-11-28 2011-11-09 上海迪赛诺医药发展有限公司 制备地托咪定及其中间体的方法
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
CN101941944A (zh) * 2010-09-07 2011-01-12 江阴希迪医药科技有限公司 兽药麻醉剂盐酸地托咪啶盐的合成方法
RU2448095C1 (ru) * 2010-12-09 2012-04-20 Олег Геннадьевич Еремин Способ получения детомидина или его нетоксичных фармацевтически приемлемых солей
RU2448094C1 (ru) * 2010-12-09 2012-04-20 Олег Геннадьевич Еремин Улучшенный способ получения медетомидина или его нетоксичных фармацевтически приемлемых солей
CA2860099A1 (en) * 2012-02-13 2013-08-22 Johannes Aebi Imidazolylketone derivatives asd aldosterone synthase inhibitors
RU2478622C1 (ru) * 2012-02-16 2013-04-10 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) (1-гидрокси-4,5-диметил-1н-имидазол-2-ил)(фенил)метаноноксим, проявляющий антиаритмические свойства
CN107922399A (zh) 2015-07-16 2018-04-17 内布拉斯加大学董事委员会 吡咯霉素及其使用方法
MY196907A (en) * 2015-12-25 2023-05-09 Otsuka Pharma Factory Inc Phenylimidazole compound
KR102537050B1 (ko) 2016-03-17 2023-05-26 에프. 호프만-라 로슈 아게 Taar의 작용제로서 활성을 갖는 5-에틸-4-메틸-피라졸-3-카복스아미드 유도체
CN107814771A (zh) * 2017-11-14 2018-03-20 安徽诺全药业有限公司 一种盐酸地托咪定的制备方法
WO2020016827A1 (en) * 2018-07-18 2020-01-23 Clexio Biosciences Ltd. Purified crystalline detomidine hydrochloride monohydrate, anhydrate and free base with low amounts of iso-detomidine and other impurities by recrystallisation in water

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE553516A (no) * 1955-12-19
US2946804A (en) * 1958-12-29 1960-07-26 Abbott Lab (5-methyl-4-imidazolyl)-diphenyl carbinol salts and lower alkyl quaternaries
US3177223A (en) * 1961-12-22 1965-04-06 Air Prod & Chem Preparation of substituted imidazoles
AU1643776A (en) * 1975-07-31 1978-02-02 Wellcome Found Anti-inflammatory compositions

Also Published As

Publication number Publication date
SG34987G (en) 1988-03-04
DK157491C (da) 1990-06-25
HU184809B (en) 1984-10-29
AU6107180A (en) 1981-02-12
BG60426B2 (bg) 1995-03-31
ZA804787B (en) 1981-07-29
SU1014472A3 (ru) 1983-04-23
UA5559A1 (uk) 1994-12-28
DK338580A (da) 1981-02-08
NO153220B (no) 1985-10-28
ATE7226T1 (de) 1984-05-15
FI70709B (fi) 1986-06-26
JPS5632463A (en) 1981-04-01
DE3067618D1 (en) 1984-05-30
DK630586A (da) 1986-12-29
JPS624387B2 (no) 1987-01-30
AU518569B2 (en) 1981-10-08
US4443466A (en) 1984-04-17
DK157491B (da) 1990-01-15
EP0024829A1 (en) 1981-03-11
FI802404A (fi) 1981-02-08
DD152548A1 (de) 1981-12-02
CA1154780A (en) 1983-10-04
IE50080B1 (en) 1986-02-05
IL60723A (en) 1985-02-28
EP0024829B1 (en) 1984-04-25
IE801626L (en) 1981-02-07
DK155794B (da) 1989-05-16
DK630586D0 (da) 1986-12-29
NZ194536A (en) 1983-06-17
HK68587A (en) 1987-10-02
FI70709C (fi) 1986-10-06
DK155794C (da) 1989-11-06
SU997607A3 (ru) 1983-02-15
NO153220C (no) 1986-02-05

Similar Documents

Publication Publication Date Title
NO802352L (no) Fremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater.
NO810478L (no) Fremgangsmaate for fremstilling av terapeutisk aktive substituerte imidazolderivater
NO155884C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazol-derivater.
NO158017C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazolderivater.
ATE2265T1 (de) Sekundaere amine, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen.
FI834800A (fi) Foerfarande foer framstaellning av dialkylaminoalkoxibensylalkohol-derivat.
NO803547L (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-fenylamino-imidazolin-derivater
NO794316L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 1,4-oksazepin-derivater