NO332991B1 - Kalsiumreseptormodulerende forbindelse, farmasoytisk sammensetning og anvendelse derav - Google Patents
Kalsiumreseptormodulerende forbindelse, farmasoytisk sammensetning og anvendelse deravInfo
- Publication number
- NO332991B1 NO332991B1 NO20051328A NO20051328A NO332991B1 NO 332991 B1 NO332991 B1 NO 332991B1 NO 20051328 A NO20051328 A NO 20051328A NO 20051328 A NO20051328 A NO 20051328A NO 332991 B1 NO332991 B1 NO 332991B1
- Authority
- NO
- Norway
- Prior art keywords
- salt
- pyrimidine
- ethyl
- carboxamide
- propyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 109
- 102000013830 Calcium-Sensing Receptors Human genes 0.000 title claims abstract description 6
- 108010050543 Calcium-Sensing Receptors Proteins 0.000 title claims abstract description 6
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 6
- 150000003839 salts Chemical class 0.000 claims abstract description 76
- 239000011575 calcium Substances 0.000 claims description 49
- 239000000203 mixture Substances 0.000 claims description 24
- LPCQBTAOTIZGAE-UHFFFAOYSA-N 2h-pyrimidine-1-carboxamide Chemical compound NC(=O)N1CN=CC=C1 LPCQBTAOTIZGAE-UHFFFAOYSA-N 0.000 claims description 14
- 208000001132 Osteoporosis Diseases 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 208000020084 Bone disease Diseases 0.000 claims description 8
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 8
- 229910052791 calcium Inorganic materials 0.000 claims description 8
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- XMRIUEGHBZTNND-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine-3-carboxamide Chemical compound C1=CC=NC2=C(C(=O)N)C=NN21 XMRIUEGHBZTNND-UHFFFAOYSA-N 0.000 claims description 3
- 230000005856 abnormality Effects 0.000 claims description 2
- CJKTUXMCNPTCQS-UHFFFAOYSA-N (2,2-diethyl-4-fluoropyrrolidin-1-yl)-(7,7-dimethyl-5-phenyl-5,6-dihydro-4H-pyrazolo[1,5-a]pyrimidin-3-yl)methanone Chemical group CCC1(CC)CC(F)CN1C(=O)C1=C(NC(CC2(C)C)C=3C=CC=CC=3)N2N=C1 CJKTUXMCNPTCQS-UHFFFAOYSA-N 0.000 claims 1
- BXHRVRKLOIWLRF-UHFFFAOYSA-N (2,2-diethyl-4-methoxypyrrolidin-1-yl)-(7,7-dimethyl-5-phenyl-5,6-dihydro-4H-pyrazolo[1,5-a]pyrimidin-3-yl)methanone Chemical group CCC1(CC)CC(OC)CN1C(=O)C1=C(NC(CC2(C)C)C=3C=CC=CC=3)N2N=C1 BXHRVRKLOIWLRF-UHFFFAOYSA-N 0.000 claims 1
- GCAJUNZLLXNQQO-UHFFFAOYSA-N 1,2,3,3a-tetrahydropyrazolo[1,5-a]pyrimidine Chemical compound N1=CC=CN2NCCC21 GCAJUNZLLXNQQO-UHFFFAOYSA-N 0.000 claims 1
- KPGWORILVIXGJV-UHFFFAOYSA-N 2-[3-(4-methylphenyl)pentan-3-yl]-5-(2,7,7-trimethyl-5-phenyl-5,6-dihydro-4H-pyrazolo[1,5-a]pyrimidin-3-yl)-1,3,4-thiadiazole Chemical group C=1C=C(C)C=CC=1C(CC)(CC)C(S1)=NN=C1C=1C(C)=NN(C(C2)(C)C)C=1NC2C1=CC=CC=C1 KPGWORILVIXGJV-UHFFFAOYSA-N 0.000 claims 1
- HJFZVTDRWQVFDN-UHFFFAOYSA-N 4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine Chemical compound C1CCNC2=CC=NN21 HJFZVTDRWQVFDN-UHFFFAOYSA-N 0.000 claims 1
- RMLQZXDBDWLNLI-UHFFFAOYSA-N 5-(2-chlorophenyl)-2,7,7-trimethyl-N-[3-(4-methylphenyl)pentan-3-yl]-5,6-dihydro-4H-pyrazolo[1,5-a]pyrimidine-3-carboxamide Chemical group C=1C=C(C)C=CC=1C(CC)(CC)NC(=O)C=1C(C)=NN(C(C2)(C)C)C=1NC2C1=CC=CC=C1Cl RMLQZXDBDWLNLI-UHFFFAOYSA-N 0.000 claims 1
- HUZMHENQDRSAGB-UHFFFAOYSA-N chembl1687946 Chemical compound C=1C=C(C)C=CC=1C(CC)(CC)NC(=O)C=1C=NN(C(C2)(C)C)C=1NC2C1=CC=CC=C1 HUZMHENQDRSAGB-UHFFFAOYSA-N 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 abstract description 5
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940075993 receptor modulator Drugs 0.000 abstract 1
- 125000005750 substituted cyclic group Chemical group 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 description 53
- 238000006243 chemical reaction Methods 0.000 description 30
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- 102000005962 receptors Human genes 0.000 description 25
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- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 20
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 18
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- 238000000034 method Methods 0.000 description 14
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 102000003982 Parathyroid hormone Human genes 0.000 description 10
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- 239000000199 parathyroid hormone Substances 0.000 description 10
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 9
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- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
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- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 7
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 7
- 235000001465 calcium Nutrition 0.000 description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
- 239000002299 complementary DNA Substances 0.000 description 7
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- 230000028327 secretion Effects 0.000 description 7
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 6
- SJRJJKPEHAURKC-UHFFFAOYSA-N N-Methylmorpholine Chemical compound CN1CCOCC1 SJRJJKPEHAURKC-UHFFFAOYSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 6
- 229910052783 alkali metal Inorganic materials 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- 238000003379 elimination reaction Methods 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
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- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 5
- 235000001014 amino acid Nutrition 0.000 description 5
- 150000001413 amino acids Chemical class 0.000 description 5
- 230000027455 binding Effects 0.000 description 5
- 210000003169 central nervous system Anatomy 0.000 description 5
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- 238000003818 flash chromatography Methods 0.000 description 5
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- 229910052739 hydrogen Inorganic materials 0.000 description 5
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- 238000000746 purification Methods 0.000 description 5
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- 238000012360 testing method Methods 0.000 description 5
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 5
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- 239000003795 chemical substances by application Substances 0.000 description 4
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
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- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 4
- 150000007529 inorganic bases Chemical class 0.000 description 4
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40601202P | 2002-08-26 | 2002-08-26 | |
US46612903P | 2003-04-28 | 2003-04-28 | |
PCT/US2003/026317 WO2004017908A2 (en) | 2002-08-26 | 2003-08-21 | Calcium receptor modulating compound and use thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20051328L NO20051328L (no) | 2005-03-15 |
NO332991B1 true NO332991B1 (no) | 2013-02-11 |
Family
ID=31949909
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20051328A NO332991B1 (no) | 2002-08-26 | 2005-03-15 | Kalsiumreseptormodulerende forbindelse, farmasoytisk sammensetning og anvendelse derav |
Country Status (12)
Country | Link |
---|---|
US (3) | US7514441B2 (es) |
EP (1) | EP1572113B1 (es) |
JP (1) | JP4494205B2 (es) |
KR (1) | KR101050700B1 (es) |
AU (1) | AU2003265585B2 (es) |
BR (1) | BRPI0313880B8 (es) |
CA (1) | CA2494700C (es) |
ES (1) | ES2635838T3 (es) |
NO (1) | NO332991B1 (es) |
NZ (1) | NZ538223A (es) |
PL (1) | PL382706A1 (es) |
WO (1) | WO2004017908A2 (es) |
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ES2635838T3 (es) | 2002-08-26 | 2017-10-05 | Takeda Pharmaceutical Company Limited | Compuesto modulador de receptores de calcio y su uso |
US7453002B2 (en) | 2004-06-15 | 2008-11-18 | Bristol-Myers Squibb Company | Five-membered heterocycles useful as serine protease inhibitors |
US7361789B1 (en) | 2004-07-28 | 2008-04-22 | Amgen Inc. | Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis |
US7790770B2 (en) | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
JPWO2007102531A1 (ja) * | 2006-03-08 | 2009-07-23 | 武田薬品工業株式会社 | 併用薬 |
US8779004B2 (en) | 2006-04-20 | 2014-07-15 | Amgen, Inc. | Stable emulsion formulations |
EP1975165A1 (de) | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
ES2449340T3 (es) | 2007-03-30 | 2014-03-19 | Amgen Inc. | Compuestos calcimiméticos para su uso en el tratamiento de trastornos intestinales |
EP2156846B1 (en) * | 2007-05-08 | 2014-08-13 | Ajinomoto Co., Inc. | Prophylactic or therapeutic agent for diarrhea |
EP2197280B1 (en) | 2007-08-27 | 2013-06-19 | Basf Se | Pyrazole compounds for controlling invertebrate pests |
WO2009051244A1 (ja) * | 2007-10-18 | 2009-04-23 | Takeda Pharmaceutical Company Limited | 複素環化合物 |
ES2390645T3 (es) | 2008-06-05 | 2012-11-15 | Asahi Kasei Pharma Corporation | Compuesto de sulfonamida y su aplicación |
WO2009153179A1 (en) * | 2008-06-16 | 2009-12-23 | F. Hoffmann-La Roche Ag | Pyrrolidine derivatives as nk2 receptor antagonists |
EP2346335B1 (en) * | 2008-09-24 | 2018-11-14 | Basf Se | Pyrazole compounds for controlling invertebrate pests |
TWI607996B (zh) | 2008-09-24 | 2017-12-11 | 巴地斯顏料化工廠 | 控制無脊椎害蟲之吡唑化合物 |
WO2010096115A1 (en) | 2008-10-29 | 2010-08-26 | Apath, Llc | Compounds, compositions and methods for control of hepatitis c viral infections |
US8318759B2 (en) * | 2009-02-18 | 2012-11-27 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives as NK3 receptor antagonists |
WO2010104882A1 (en) | 2009-03-10 | 2010-09-16 | Amgen Inc. | Methods of modulating sperm motility |
ES2461618T3 (es) | 2009-07-06 | 2014-05-20 | Basf Se | Compuestos de piridacina para el control de plagas de invertebrados |
EP2451804B1 (en) | 2009-07-06 | 2014-04-30 | Basf Se | Pyridazine compounds for controlling invertebrate pests |
US9125414B2 (en) | 2009-07-24 | 2015-09-08 | Basf Se | Pyridine derivatives compounds for controlling invertebrate pests |
EP2608669B1 (en) | 2010-08-23 | 2016-06-22 | Merck Sharp & Dohme Corp. | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
WO2012143522A1 (en) * | 2011-04-20 | 2012-10-26 | Glaxo Group Limited | Tetrahydropyrazolo [1,5 -a] pyrimidine as anti -tuberculosis compounds |
JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
GB201217330D0 (en) | 2012-09-28 | 2012-11-14 | Univ Cardiff | Therapeutic for treating inflammatory lung disorders |
CA2889919C (en) | 2012-11-16 | 2021-08-17 | University Health Network | Pyrazolopyrimidine compounds |
BR112015022545A2 (pt) | 2013-03-13 | 2017-07-18 | Constellation Pharmaceuticals Inc | compostos de pirazolo e os usos disso |
EA028756B1 (ru) | 2013-04-25 | 2017-12-29 | Бэйджин, Лтд. | Конденсированные гетероциклические соединения в качестве ингибиторов протеинкиназы |
TW201602062A (zh) | 2013-08-12 | 2016-01-16 | 魯賓有限公司 | 取代聯苯基化合物作為鈣敏感受體調節劑 |
JP6623353B2 (ja) | 2013-09-13 | 2019-12-25 | ベイジーン スウィッツァーランド ゲーエムベーハー | 抗pd−1抗体並びにその治療及び診断のための使用 |
AU2015238298B2 (en) | 2014-03-27 | 2019-04-18 | Janssen Pharmaceutica Nv | Substituted 4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrimidine derivatives and 2,3-dihydro-1H-imidazo[1,2-b]pyrazole derivatives as ROS1 inhibitors |
CN106164076B (zh) | 2014-03-27 | 2019-03-26 | 詹森药业有限公司 | 作为ros1抑制剂的化合物 |
WO2015162538A1 (en) | 2014-04-21 | 2015-10-29 | Lupin Limited | Heterocyclic compounds as calcium sensing receptor modulators for the treatment of hyperparathyroidism, chronic renal failure and chronic kidney disease |
TWI687438B (zh) | 2014-07-03 | 2020-03-11 | 英屬開曼群島商百濟神州生物科技有限公司 | 抗pd-l1抗體及其作為治療及診斷之用途 |
WO2017037616A1 (en) | 2015-08-31 | 2017-03-09 | Lupin Limited | Arylalkylamine compounds as calcium sensing receptor modulators |
EP3156405A1 (en) * | 2015-10-13 | 2017-04-19 | Boehringer Ingelheim International GmbH | Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide |
BR112018007664B1 (pt) | 2015-10-16 | 2023-12-19 | Eisai R&D Management Co., Ltd | Compostos antagonistas de ep4, composição compreendendo o composto e uso dos mesmos para tratar câncer |
WO2017110881A1 (ja) * | 2015-12-25 | 2017-06-29 | 武田薬品工業株式会社 | 医薬 |
CN109069510A (zh) * | 2016-03-28 | 2018-12-21 | 武田药品工业株式会社 | 药物 |
EP3481393B1 (en) | 2016-07-05 | 2021-04-14 | Beigene, Ltd. | Combination of a pd-1 antagonist and a raf inhibitor for treating cancer |
TWI760356B (zh) | 2016-08-16 | 2022-04-11 | 英屬開曼群島商百濟神州有限公司 | (s)-7-(1-丙烯醯基六氫吡啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氫吡唑並[1,5-a]嘧啶-3-甲醯胺的晶型、其製備和用途 |
TWI739887B (zh) | 2016-08-19 | 2021-09-21 | 英屬開曼群島商百濟神州有限公司 | 使用包含btk抑制劑的組合產品治療癌症 |
CA3034705C (en) | 2016-08-31 | 2021-08-03 | Agios Pharmaceuticals, Inc. | Inhibitors of cellular metabolic processes |
JOP20190060A1 (ar) * | 2016-09-26 | 2019-03-26 | Chugai Pharmaceutical Co Ltd | مشتق بيرازولو بيريدين له تأثير مساعد لمستقبل glp-1 |
CN110023313B (zh) * | 2016-12-02 | 2022-10-25 | 豪夫迈·罗氏有限公司 | 二环酰胺化合物及其使用方法 |
CN110461847B (zh) | 2017-01-25 | 2022-06-07 | 百济神州有限公司 | (S)-7-(1-(丁-2-炔酰基)哌啶-4-基)-2-(4-苯氧基苯基)-4,5,6,7-四氢吡唑并[1,5-a]嘧啶-3-甲酰胺的结晶形式、其制备及用途 |
EP3617208A4 (en) * | 2017-04-27 | 2020-08-26 | Takeda Pharmaceutical Company Limited | HETEROCYCLIC CONNECTION |
IL270155B (en) | 2017-04-27 | 2022-07-01 | Takeda Pharmaceuticals Co | Heterocyclic compound |
CN110799543A (zh) | 2017-06-26 | 2020-02-14 | 百济神州有限公司 | 肝细胞癌的免疫治疗 |
RS65308B1 (sr) | 2017-07-14 | 2024-04-30 | Hoffmann La Roche | Biciklična ketonska jedinjenja i postupci za njihovu upotrebu |
CN110997677A (zh) | 2017-08-12 | 2020-04-10 | 百济神州有限公司 | 具有改进的双重选择性的Btk抑制剂 |
SG11202002877RA (en) | 2017-10-31 | 2020-04-29 | Hoffmann La Roche | Bicyclic sulfones and sulfoxides and methods of use thereof |
US11786529B2 (en) | 2017-11-29 | 2023-10-17 | Beigene Switzerland Gmbh | Treatment of indolent or aggressive B-cell lymphomas using a combination comprising BTK inhibitors |
JP7461104B2 (ja) * | 2017-11-29 | 2024-04-03 | 中外製薬株式会社 | Glp-1受容体アゴニスト作用を持つピラゾロピリジン誘導体を含有する医薬組成物 |
US11786531B1 (en) | 2022-06-08 | 2023-10-17 | Beigene Switzerland Gmbh | Methods of treating B-cell proliferative disorder |
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US4918074A (en) * | 1984-03-12 | 1990-04-17 | Yoshitomi Pharmaceutical Industries, Ltd. | Polyazaheterocycle compounds |
EP0217142A3 (en) * | 1985-09-30 | 1988-01-07 | Yoshitomi Pharmaceutical Industries, Ltd. | A polyazaheterocyclic compound |
US4746656A (en) * | 1986-07-21 | 1988-05-24 | E. R. Squibb & Sons, Inc. | 1,2,4,7-tetrahydro-2-oxopyrazolo[1,5-a]pyrimidine derivatives |
GB9303993D0 (en) * | 1993-02-26 | 1993-04-14 | Fujisawa Pharmaceutical Co | New heterocyclic derivatives |
WO2001016138A1 (en) | 1999-08-27 | 2001-03-08 | Abbott Laboratories | Sulfonylphenylpyrazole compounds useful as cox-2 inhibitors |
WO2001053266A1 (en) | 2000-01-24 | 2001-07-26 | Kinacia Pty Ltd. | Therapeutic morpholino-substituted compounds |
IL157895A0 (en) * | 2001-03-14 | 2004-03-28 | Gruenenthal Chemie | Substituted pyrazolopyrimidines and thiazolopyrimidines |
ES2635838T3 (es) * | 2002-08-26 | 2017-10-05 | Takeda Pharmaceutical Company Limited | Compuesto modulador de receptores de calcio y su uso |
-
2003
- 2003-08-21 ES ES03793273.8T patent/ES2635838T3/es not_active Expired - Lifetime
- 2003-08-21 AU AU2003265585A patent/AU2003265585B2/en not_active Ceased
- 2003-08-21 PL PL382706A patent/PL382706A1/pl not_active Application Discontinuation
- 2003-08-21 CA CA2494700A patent/CA2494700C/en not_active Expired - Lifetime
- 2003-08-21 WO PCT/US2003/026317 patent/WO2004017908A2/en active Search and Examination
- 2003-08-21 US US10/525,158 patent/US7514441B2/en active Active
- 2003-08-21 NZ NZ538223A patent/NZ538223A/en not_active IP Right Cessation
- 2003-08-21 EP EP03793273.8A patent/EP1572113B1/en not_active Expired - Lifetime
- 2003-08-21 JP JP2004529835A patent/JP4494205B2/ja not_active Expired - Lifetime
- 2003-08-21 BR BRPI0313880A patent/BRPI0313880B8/pt not_active IP Right Cessation
- 2003-08-21 KR KR1020057003335A patent/KR101050700B1/ko not_active IP Right Cessation
-
2005
- 2005-03-15 NO NO20051328A patent/NO332991B1/no not_active IP Right Cessation
-
2008
- 2008-10-31 US US12/263,426 patent/US20090215746A1/en not_active Abandoned
-
2013
- 2013-11-25 US US14/089,747 patent/US9447100B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2635838T3 (es) | 2017-10-05 |
US20060079536A1 (en) | 2006-04-13 |
NZ538223A (en) | 2008-03-28 |
WO2004017908A3 (en) | 2006-01-05 |
NO20051328L (no) | 2005-03-15 |
AU2003265585B2 (en) | 2008-07-03 |
KR20050038641A (ko) | 2005-04-27 |
CA2494700C (en) | 2011-06-28 |
BRPI0313880B1 (pt) | 2016-09-27 |
WO2004017908A2 (en) | 2004-03-04 |
PL382706A1 (pl) | 2007-11-26 |
EP1572113A2 (en) | 2005-09-14 |
US20090215746A1 (en) | 2009-08-27 |
EP1572113A4 (en) | 2006-11-22 |
AU2003265585A1 (en) | 2004-03-11 |
BR0313880A (pt) | 2007-11-06 |
CA2494700A1 (en) | 2004-03-04 |
EP1572113B1 (en) | 2017-05-17 |
KR101050700B1 (ko) | 2011-07-20 |
US7514441B2 (en) | 2009-04-07 |
US9447100B2 (en) | 2016-09-20 |
US20140155416A1 (en) | 2014-06-05 |
BRPI0313880B8 (pt) | 2021-05-25 |
JP4494205B2 (ja) | 2010-06-30 |
JP2006510582A (ja) | 2006-03-30 |
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