NO331021B1 - Medikament for behandling av kreft omfattende kinolonderivater i kombinasjon med 5-FU eller CPT-11 samt anvendelse av derivatene - Google Patents
Medikament for behandling av kreft omfattende kinolonderivater i kombinasjon med 5-FU eller CPT-11 samt anvendelse av derivateneInfo
- Publication number
- NO331021B1 NO331021B1 NO20044776A NO20044776A NO331021B1 NO 331021 B1 NO331021 B1 NO 331021B1 NO 20044776 A NO20044776 A NO 20044776A NO 20044776 A NO20044776 A NO 20044776A NO 331021 B1 NO331021 B1 NO 331021B1
- Authority
- NO
- Norway
- Prior art keywords
- derivatives
- cpt
- cancer
- treatment
- compound
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 title abstract 3
- 150000007660 quinolones Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 6
- 150000003839 salts Chemical class 0.000 abstract 4
- 239000002246 antineoplastic agent Substances 0.000 abstract 3
- 229940041181 antineoplastic drug Drugs 0.000 abstract 3
- 150000002894 organic compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/116,117 US20030028018A1 (en) | 2000-09-11 | 2002-04-05 | Quinolinone derivatives |
PCT/US2003/010463 WO2003087095A1 (fr) | 2002-04-05 | 2003-04-04 | Derives de quinolinone |
Publications (2)
Publication Number | Publication Date |
---|---|
NO20044776L NO20044776L (no) | 2004-12-07 |
NO331021B1 true NO331021B1 (no) | 2011-09-12 |
Family
ID=29248193
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20044776A NO331021B1 (no) | 2002-04-05 | 2004-11-03 | Medikament for behandling av kreft omfattende kinolonderivater i kombinasjon med 5-FU eller CPT-11 samt anvendelse av derivatene |
Country Status (25)
Country | Link |
---|---|
US (3) | US20030028018A1 (fr) |
EP (1) | EP1497287B1 (fr) |
JP (1) | JP2005527587A (fr) |
KR (1) | KR101035894B1 (fr) |
CN (1) | CN1659165A (fr) |
AP (1) | AP2070A (fr) |
AT (1) | ATE489092T1 (fr) |
AU (1) | AU2003226275B2 (fr) |
BR (1) | BR0308996A (fr) |
CA (1) | CA2481055C (fr) |
DE (1) | DE60335096D1 (fr) |
EA (1) | EA010393B1 (fr) |
EC (1) | ECSP045411A (fr) |
ES (1) | ES2357289T3 (fr) |
HK (1) | HK1067966A1 (fr) |
HR (1) | HRP20041031B1 (fr) |
IL (2) | IL164324A0 (fr) |
MA (1) | MA28122A1 (fr) |
MX (1) | MXPA04009739A (fr) |
NO (1) | NO331021B1 (fr) |
NZ (1) | NZ536068A (fr) |
PL (1) | PL209412B1 (fr) |
PT (1) | PT1497287E (fr) |
SG (1) | SG143985A1 (fr) |
WO (1) | WO2003087095A1 (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2334641T3 (es) * | 2000-09-01 | 2010-03-15 | Novartis Vaccines And Diagnostics, Inc. | Derivados aza heterociclicos y su uso terapeutico. |
ES2302106T3 (es) * | 2000-09-11 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Procedimiento de preparacion de derivados de bencimidazol-2-il quinolina. |
US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
US7064215B2 (en) * | 2001-07-03 | 2006-06-20 | Chiron Corporation | Indazole benzimidazole compounds |
US7642278B2 (en) * | 2001-07-03 | 2010-01-05 | Novartis Vaccines And Diagnostics, Inc. | Indazole benzimidazole compounds |
WO2003037252A2 (fr) * | 2001-10-30 | 2003-05-08 | Merck & Co., Inc. | Inhibiteurs de tyrosines kinases |
US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
US20050256157A1 (en) * | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
AU2003288899B2 (en) | 2002-08-23 | 2009-09-03 | Novartis Vaccines And Diagnostics, Inc. | Benzimidazole quinolinones and uses thereof |
AU2003275282A1 (en) * | 2002-09-30 | 2004-04-23 | Bristol-Myers Squibb Company | Novel tyrosine kinase inhibitors |
EP1565187A4 (fr) * | 2002-11-13 | 2010-02-17 | Novartis Vaccines & Diagnostic | Procedes de traitement du cancer et procedes connexes |
EP1648455A4 (fr) * | 2003-07-23 | 2009-03-04 | Exelixis Inc | Modulateurs de la proteine alk (anaplastic lymphoma kinase) et leurs methodes d'utilisation |
JP4724665B2 (ja) * | 2003-11-07 | 2011-07-13 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | キノリノン化合物を合成する方法 |
US7767670B2 (en) * | 2003-11-13 | 2010-08-03 | Ambit Biosciences Corporation | Substituted 3-carboxamido isoxazoles as kinase modulators |
CA2556872C (fr) * | 2004-02-20 | 2015-05-12 | Chiron Corporation | Modulation de processus inflammatoires et metastiques |
WO2006009734A1 (fr) * | 2004-06-17 | 2006-01-26 | Wyeth | Antagonistes de récepteurs de l'hormone de libération de gonadotrophines |
US7714130B2 (en) * | 2004-06-17 | 2010-05-11 | Wyeth | Processes for preparing gonadotropin releasing hormone receptor antagonists |
JP2008520732A (ja) * | 2004-11-23 | 2008-06-19 | ワイス | ゴナドトロピン放出ホルモン受容体アンタゴニスト |
ES2374570T3 (es) | 2005-01-27 | 2012-02-17 | Novartis Vaccines And Diagnostics, Inc. | Tratamiento de tumores metastalizados. |
US7538113B2 (en) * | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7534796B2 (en) * | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
US7582634B2 (en) * | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US20060189619A1 (en) * | 2005-02-24 | 2006-08-24 | Wyeth | 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds |
MX2007014206A (es) | 2005-05-13 | 2008-02-07 | Novartis Ag | Metodos para tratar cancer resistente a los farmacos. |
KR101324863B1 (ko) * | 2005-05-17 | 2013-11-01 | 노파르티스 아게 | 헤테로고리 화합물의 합성 방법 |
US7531542B2 (en) * | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
KR101368519B1 (ko) | 2005-05-23 | 2014-02-27 | 노파르티스 아게 | 결정형 및 기타 형태의 4-아미노-5-플루오로-3-[6-(4-메틸피페라진-1-일)-1h-벤즈이미다졸-2-일]-1h-퀴놀린-2-온 락트산염 |
US7582636B2 (en) * | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
CA2627544C (fr) | 2005-11-29 | 2015-07-07 | Novartis Ag | Formulations de quinolinones pour le traitement du cancer |
EP1960547A2 (fr) | 2005-12-08 | 2008-08-27 | Novartis AG | Effets d'inhibiteurs de fgfr3 sur la transcription genetique |
CN100488960C (zh) * | 2006-03-09 | 2009-05-20 | 中国药科大学 | 2-位取代的喹诺酮类化合物及其在制药中的应用 |
WO2008006051A2 (fr) * | 2006-07-07 | 2008-01-10 | Govek Steven P | Hétéroaryles bicycliques inhibiteurs de pde4 |
US8138205B2 (en) * | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
EP2555766A4 (fr) | 2010-04-06 | 2015-06-03 | Univ Brigham Young | Composés antimétastatiques |
CA2808841A1 (fr) * | 2010-08-24 | 2012-03-01 | Brigham Young University | Composes antimetastatiques |
WO2013063003A1 (fr) | 2011-10-28 | 2013-05-02 | Novartis Ag | Méthode de traitement des tumeurs stromales gastro-intestinales |
CN104093402A (zh) | 2012-01-31 | 2014-10-08 | 诺华股份有限公司 | Rtk抑制剂与抗雌激素的组合及其治疗癌症的应用 |
IN2014DN10801A (fr) | 2012-07-11 | 2015-09-04 | Novartis Ag | |
WO2014058785A1 (fr) | 2012-10-10 | 2014-04-17 | Novartis Ag | Polythérapie |
CN105636945B (zh) | 2013-10-14 | 2017-11-17 | 卫材R&D管理有限公司 | 选择性取代的喹啉化合物 |
AU2014334554B2 (en) | 2013-10-14 | 2018-12-06 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
PT3157566T (pt) | 2014-06-17 | 2019-07-11 | Vertex Pharma | Método para tratamento de cancro utilizando uma combinação de inibidores chk1 e atr |
EP2977374A1 (fr) * | 2014-07-21 | 2016-01-27 | Université de Strasbourg | Molécules présentant des propriétés d'émission double |
CA3000684A1 (fr) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Methode de traitement du cancer utilisant une association d'agents endommageant l'adn et d'inhibiteurs de l'atr |
CN108003150A (zh) * | 2016-10-31 | 2018-05-08 | 河南工业大学 | 4-杂芳基喹啉酮衍生物的制备方法及其应用 |
EP3645526A4 (fr) | 2017-06-27 | 2020-10-28 | Janssen Pharmaceutica NV | Nouveaux composés de quinoléinone |
CN111655690B (zh) | 2017-11-24 | 2023-01-10 | 詹森药业有限公司 | 吡唑并吡啶酮化合物 |
AU2018370904B2 (en) | 2017-11-24 | 2023-09-21 | Janssen Pharmaceutica Nv | Pyrazolopyridinone compounds |
CN108516973A (zh) * | 2018-03-30 | 2018-09-11 | 广西师范大学 | 3-苯并噻唑-1-(3-二甲氨基)丙基喹啉-4-酮衍生物及其制备方法和应用 |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6A (en) * | 1836-08-10 | Thomas blanghard | ||
US508800A (en) * | 1893-11-14 | Trustees | ||
US129025A (en) * | 1872-07-16 | Improvement in strainer-pipes | ||
US37650A (en) * | 1863-02-10 | Improvement in apparatus for obtaining profiles of submarine beds | ||
US155114A (en) * | 1874-09-15 | Improvement in methods of laying and forming cast-iron pipes | ||
US63A (en) * | 1836-10-20 | Kravxiig | ||
US162251A (en) * | 1875-04-20 | Improvement in interfering-pads for horses | ||
US290153A (en) * | 1883-12-11 | Beer-scale | ||
US128993A (en) * | 1872-07-16 | Improvement in furnaces for reducing iron ores | ||
US207883A (en) * | 1878-09-10 | Improvement in drafting-pencils | ||
US152904A (en) * | 1874-07-14 | Improvement in rotary pumps | ||
US7A (en) * | 1836-08-10 | Thomas blanchard | ||
US158224A (en) * | 1874-12-29 | Improvement in eye-cups | ||
US509717A (en) * | 1893-11-28 | beach | ||
US8A (en) * | 1836-08-10 | T Blanchard | Machine for cutting scores around ships' tackle blocks and dead eyes | |
US36256A (en) * | 1862-08-19 | Improvement in sewing-m ach ines | ||
US27379A (en) * | 1860-03-06 | Improvement in seeding-machines | ||
US102369A (en) * | 1870-04-26 | Improvement in pumps | ||
US162252A (en) * | 1875-04-20 | Improvement in safety-catches for elevators | ||
US232861A (en) * | 1880-10-05 | Machine for dressing millstones | ||
US747771A (en) * | 1903-04-16 | 1903-12-22 | Rudolf Richter | Machine for harvesting potatoes or similar root crops. |
US797376A (en) * | 1905-05-19 | 1905-08-15 | John P Schneider Sr | Vise. |
US1086705A (en) * | 1913-06-04 | 1914-02-10 | Frank O Havener | Cigar-moistener. |
US2363459A (en) * | 1944-02-19 | 1944-11-21 | Draper Corp | Picker stick checking mechanism |
US3663606A (en) * | 1966-06-21 | 1972-05-16 | Mitsui Toatsu Chemicals | Organic imino-compounds |
US4659657A (en) * | 1982-12-24 | 1987-04-21 | Bayer Aktiengesellschaft | Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases |
DE3634066A1 (de) * | 1986-10-07 | 1988-04-21 | Boehringer Mannheim Gmbh | Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel |
US5073492A (en) * | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
DE3932953A1 (de) * | 1989-10-03 | 1991-04-11 | Boehringer Mannheim Gmbh | Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5151360A (en) * | 1990-12-31 | 1992-09-29 | Biomembrane Institute | Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation |
US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
USRE37650E1 (en) * | 1991-05-10 | 2002-04-09 | Aventis Pharmacetical Products, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5856115A (en) * | 1991-05-24 | 1999-01-05 | Fred Hutchinson Cancer Research Center | Assay for identification therapeutic agents |
ATE239506T1 (de) * | 1992-03-05 | 2003-05-15 | Univ Texas | Verwendung von immunokonjugate zur diagnose und/oder therapie der vaskularisierten tumoren |
US5330992A (en) * | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
US5792771A (en) * | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
US5981569A (en) * | 1992-11-13 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease |
US5763441A (en) * | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
JP3441246B2 (ja) * | 1995-06-07 | 2003-08-25 | 富士写真フイルム株式会社 | 光重合性組成物 |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
US5942385A (en) * | 1996-03-21 | 1999-08-24 | Sugen, Inc. | Method for molecular diagnosis of tumor angiogenesis and metastasis |
CA2258728C (fr) * | 1996-06-19 | 2011-09-27 | Rhone Poulenc Rorer Limited | Composes azabicycliques substitues et leur utilisation en tant qu'inhibiteurs de la production de tnf et de la photodiesterase cyclique d'amp |
US6111110A (en) * | 1996-10-30 | 2000-08-29 | Eli Lilly And Company | Synthesis of benzo[f]quinolinones |
DE19756235A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
US6174912B1 (en) * | 1998-08-21 | 2001-01-16 | Dupont Pharmaceuticals Company | Nitrogen substituted imidazo[4,5-C]pyrazoles as corticotropin releasing hormone antagonists |
US20030087854A1 (en) * | 2001-09-10 | 2003-05-08 | Isis Pharmaceuticals Inc. | Antisense modulation of fibroblast growth factor receptor 3 expression |
ES2328269T3 (es) | 1999-05-21 | 2009-11-11 | Bristol-Myers Squibb Company | Pirrolotriazinas como inhibires de quinasas. |
KR100298572B1 (ko) * | 1999-08-19 | 2001-09-22 | 박찬구 | 카바아닐라이드로부터 4-니트로디페닐아민과 4-니트로소디페닐아민의 제조방법 |
TR200201051T2 (tr) * | 1999-10-19 | 2002-09-23 | Merck & Co., Inc. | Tirosin kinaz inhibitörleri. |
WO2001028993A2 (fr) * | 1999-10-19 | 2001-04-26 | Merck & Co. Inc. | Inhibiteurs tyrosine kinase |
US6420382B2 (en) * | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6313138B1 (en) * | 2000-02-25 | 2001-11-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
ES2334641T3 (es) * | 2000-09-01 | 2010-03-15 | Novartis Vaccines And Diagnostics, Inc. | Derivados aza heterociclicos y su uso terapeutico. |
EP1351946A2 (fr) * | 2000-09-01 | 2003-10-15 | Icos Corporation | Substances potentialisant un traitement anticancereux et methodes a cet effet |
ES2302106T3 (es) | 2000-09-11 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Procedimiento de preparacion de derivados de bencimidazol-2-il quinolina. |
US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
US7064215B2 (en) * | 2001-07-03 | 2006-06-20 | Chiron Corporation | Indazole benzimidazole compounds |
US20030159702A1 (en) * | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
US20050256157A1 (en) * | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
AU2003288899B2 (en) * | 2002-08-23 | 2009-09-03 | Novartis Vaccines And Diagnostics, Inc. | Benzimidazole quinolinones and uses thereof |
EP1565187A4 (fr) * | 2002-11-13 | 2010-02-17 | Novartis Vaccines & Diagnostic | Procedes de traitement du cancer et procedes connexes |
US6774327B1 (en) * | 2003-09-24 | 2004-08-10 | Agilent Technologies, Inc. | Hermetic seals for electronic components |
JP4724665B2 (ja) * | 2003-11-07 | 2011-07-13 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | キノリノン化合物を合成する方法 |
BRPI0613200A2 (pt) * | 2005-05-18 | 2012-01-03 | M & G Polimeri Italia Spa | composiÇço de poliÉster |
-
2002
- 2002-04-05 US US10/116,117 patent/US20030028018A1/en not_active Abandoned
-
2003
- 2003-04-04 WO PCT/US2003/010463 patent/WO2003087095A1/fr active Application Filing
- 2003-04-04 AU AU2003226275A patent/AU2003226275B2/en not_active Expired
- 2003-04-04 KR KR1020047015851A patent/KR101035894B1/ko not_active IP Right Cessation
- 2003-04-04 NZ NZ536068A patent/NZ536068A/en not_active IP Right Cessation
- 2003-04-04 PL PL372871A patent/PL209412B1/pl unknown
- 2003-04-04 IL IL16432403A patent/IL164324A0/xx unknown
- 2003-04-04 PT PT03746614T patent/PT1497287E/pt unknown
- 2003-04-04 AP APAP/P/2004/003166A patent/AP2070A/en active
- 2003-04-04 ES ES03746614T patent/ES2357289T3/es not_active Expired - Lifetime
- 2003-04-04 EA EA200401318A patent/EA010393B1/ru not_active IP Right Cessation
- 2003-04-04 MX MXPA04009739A patent/MXPA04009739A/es active IP Right Grant
- 2003-04-04 CA CA2481055A patent/CA2481055C/fr not_active Expired - Lifetime
- 2003-04-04 BR BR0308996-7A patent/BR0308996A/pt not_active Application Discontinuation
- 2003-04-04 SG SG200606999-1A patent/SG143985A1/en unknown
- 2003-04-04 JP JP2003584051A patent/JP2005527587A/ja active Pending
- 2003-04-04 EP EP03746614A patent/EP1497287B1/fr not_active Expired - Lifetime
- 2003-04-04 DE DE60335096T patent/DE60335096D1/de not_active Expired - Lifetime
- 2003-04-04 CN CN038129094A patent/CN1659165A/zh active Pending
- 2003-04-04 AT AT03746614T patent/ATE489092T1/de active
-
2004
- 2004-09-28 IL IL164324A patent/IL164324A/en not_active IP Right Cessation
- 2004-10-04 MA MA27887A patent/MA28122A1/fr unknown
- 2004-11-03 HR HRP20041031AA patent/HRP20041031B1/hr not_active IP Right Cessation
- 2004-11-03 NO NO20044776A patent/NO331021B1/no not_active IP Right Cessation
- 2004-11-05 EC EC2004005411A patent/ECSP045411A/es unknown
-
2005
- 2005-02-22 HK HK05101490.8A patent/HK1067966A1/xx not_active IP Right Cessation
-
2007
- 2007-10-02 US US11/866,296 patent/US20080070906A1/en not_active Abandoned
-
2010
- 2010-01-04 US US12/651,612 patent/US20100184754A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO331021B1 (no) | Medikament for behandling av kreft omfattende kinolonderivater i kombinasjon med 5-FU eller CPT-11 samt anvendelse av derivatene | |
NO20090443L (no) | 2-metylmorfolin pyrido-, pyrazo- and pyrimido-pyrimidin derivater | |
DE602004017194D1 (de) | Pyridylpyrrol-derivate als wirksame kinase-hemmer | |
NO20092033L (no) | Nye forbindelser | |
NO20055891L (no) | Kinazolinderivater som aurorakinaseinhibitorer | |
MXPA05010899A (es) | Derivados de 2-aminopirimidina y su uso medico. | |
TW200505924A (en) | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | |
MXPA06000302A (es) | Derivados de pirazolil-indol activos como inhibidores de cinasa, procedimientos para su preparacion y composiciones farmaceuticas que los comprenden. | |
GB0022438D0 (en) | Organic Compounds | |
NO20085217L (no) | Effektive pyrimidinderivater i behandlingen av kreft | |
NO20061657L (no) | Pyrolderivater med antibakteriell aktivitet | |
NO20055421L (no) | Kinolinderivater som fosfodiestrase-inhibitorer | |
HUP0300798A2 (hu) | Szubsztituált triazolopirimidin-származékok és alkalmazásuk rákellenes hatóanyagként és ezeket tartalmazó gyógyszerkészítmények | |
HK1136292A1 (en) | Substituted pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors | |
MX2007003321A (es) | Derivados heterociclicos y su uso como agentes terapeuticos. | |
DK2324008T3 (da) | Diarylpyrazol som protein kinase inhibitorer | |
DE50311898D1 (de) | Fredericamycin-derivate als arzneimittel zur tumorbehandlung | |
BRPI0515991A (pt) | derivados de bisariluréia substituìda heterocìclica como inibidores de cinase | |
ATE378332T1 (de) | Benzofuranderivate,verfahren zu deren herstellung und zwischenprodukte davon | |
MX2007000028A (es) | Derivados de nicotinamida y su uso como agentes terapeuticos. | |
WO2007046867A3 (fr) | Derives de piperidine et leurs utilisations comme agents therapeutiques | |
NO20076425L (no) | Fremgangsmater for behandling av drug-resistent cancer | |
JO2449B1 (en) | Thiosol derivatives - benziazothiazole dioxide, methods of preparation and use. | |
BRPI0413438A (pt) | derivados de pirimidilpirrol ativos como inibidores de cinase | |
UA96304C2 (en) | 2-METHYLMORPHOLINE PYRIDO-, PYRAZO- AND PYRIMIDO-PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM1K | Lapsed by not paying the annual fees |