IL164324A0 - Quinolinone derivatives - Google Patents
Quinolinone derivativesInfo
- Publication number
- IL164324A0 IL164324A0 IL16432403A IL16432403A IL164324A0 IL 164324 A0 IL164324 A0 IL 164324A0 IL 16432403 A IL16432403 A IL 16432403A IL 16432403 A IL16432403 A IL 16432403A IL 164324 A0 IL164324 A0 IL 164324A0
- Authority
- IL
- Israel
- Prior art keywords
- quinolinone derivatives
- quinolinone
- derivatives
- Prior art date
Links
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/116,117 US20030028018A1 (en) | 2000-09-11 | 2002-04-05 | Quinolinone derivatives |
PCT/US2003/010463 WO2003087095A1 (fr) | 2002-04-05 | 2003-04-04 | Derives de quinolinone |
Publications (1)
Publication Number | Publication Date |
---|---|
IL164324A0 true IL164324A0 (en) | 2005-12-18 |
Family
ID=29248193
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL16432403A IL164324A0 (en) | 2002-04-05 | 2003-04-04 | Quinolinone derivatives |
IL164324A IL164324A (en) | 2002-04-05 | 2004-09-28 | Medicaments comprising quinolinone derivatives in combination with anti-cancer drugs |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL164324A IL164324A (en) | 2002-04-05 | 2004-09-28 | Medicaments comprising quinolinone derivatives in combination with anti-cancer drugs |
Country Status (25)
Country | Link |
---|---|
US (3) | US20030028018A1 (fr) |
EP (1) | EP1497287B1 (fr) |
JP (1) | JP2005527587A (fr) |
KR (1) | KR101035894B1 (fr) |
CN (1) | CN1659165A (fr) |
AP (1) | AP2070A (fr) |
AT (1) | ATE489092T1 (fr) |
AU (1) | AU2003226275B2 (fr) |
BR (1) | BR0308996A (fr) |
CA (1) | CA2481055C (fr) |
DE (1) | DE60335096D1 (fr) |
EA (1) | EA010393B1 (fr) |
EC (1) | ECSP045411A (fr) |
ES (1) | ES2357289T3 (fr) |
HK (1) | HK1067966A1 (fr) |
HR (1) | HRP20041031B1 (fr) |
IL (2) | IL164324A0 (fr) |
MA (1) | MA28122A1 (fr) |
MX (1) | MXPA04009739A (fr) |
NO (1) | NO331021B1 (fr) |
NZ (1) | NZ536068A (fr) |
PL (1) | PL209412B1 (fr) |
PT (1) | PT1497287E (fr) |
SG (1) | SG143985A1 (fr) |
WO (1) | WO2003087095A1 (fr) |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1313734E (pt) | 2000-09-01 | 2010-02-09 | Novartis Vaccines & Diagnostic | Derivados aza heterocíclicos e sua utilização terapêutica |
CA2421120C (fr) * | 2000-09-11 | 2008-07-15 | Chiron Corporation | Derives de quinolinone utilises comme inhibiteurs de la tyrosine kinase |
US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
US7642278B2 (en) * | 2001-07-03 | 2010-01-05 | Novartis Vaccines And Diagnostics, Inc. | Indazole benzimidazole compounds |
JP2004536113A (ja) * | 2001-07-03 | 2004-12-02 | カイロン コーポレイション | チロシンキナーゼおよびセリン/スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物 |
AU2002361577A1 (en) * | 2001-10-30 | 2003-05-12 | Merck And Co., Inc. | Tyrosine kinase inhibitors |
US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
CA2496164C (fr) * | 2002-08-23 | 2010-11-09 | Chiron Corporation | Quinolinones de benzimidazole et leurs utilisations |
US20050256157A1 (en) * | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
AU2003275282A1 (en) * | 2002-09-30 | 2004-04-23 | Bristol-Myers Squibb Company | Novel tyrosine kinase inhibitors |
KR20050075005A (ko) * | 2002-11-13 | 2005-07-19 | 카이론 코포레이션 | 암을 치료하는 방법 및 관련 방법 |
AU2004259012C1 (en) * | 2003-07-23 | 2012-08-02 | Exelixis, Inc. | Anaplastic lymphoma kinase modulators and methods of use |
EP1682529A4 (fr) * | 2003-11-07 | 2010-06-30 | Novartis Vaccines & Diagnostic | Methodes de synthese de composes de quinolinone |
US7767670B2 (en) * | 2003-11-13 | 2010-08-03 | Ambit Biosciences Corporation | Substituted 3-carboxamido isoxazoles as kinase modulators |
RU2377988C2 (ru) * | 2004-02-20 | 2010-01-10 | Новартис Вэксинес Энд Дайэгностикс, Инк. | Модуляция воспалительных и метастатических процессов |
EP1756093A1 (fr) * | 2004-06-17 | 2007-02-28 | Wyeth | Procedes pour la preparation d'antagonistes du recepteur de la gonadoliberine |
KR20070027584A (ko) * | 2004-06-17 | 2007-03-09 | 와이어쓰 | 고나도트로핀 방출 호르몬 수용체 길항제 |
MX2007005765A (es) * | 2004-11-23 | 2007-07-19 | Wyeth Corp | Antagonistas del receptor de la hormona que libera gonadotropina. |
CA2596084A1 (fr) | 2005-01-27 | 2006-08-03 | Novartis Vaccines And Diagnostics Inc. | Traitement de tumeurs metastatiques a l'aide de composes de benzimidazole-quinolinone |
US7534796B2 (en) * | 2005-02-18 | 2009-05-19 | Wyeth | Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor |
US7538113B2 (en) * | 2005-02-18 | 2009-05-26 | Wyeth | 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US7582634B2 (en) * | 2005-02-18 | 2009-09-01 | Wyeth | 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor |
US20060189619A1 (en) * | 2005-02-24 | 2006-08-24 | Wyeth | 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds |
WO2006124413A2 (fr) | 2005-05-13 | 2006-11-23 | Novartis Ag | Procedes pour traiter un cancer pharmacoresistant |
RU2437878C2 (ru) | 2005-05-17 | 2011-12-27 | Новартис Аг | Способы получения гетероциклических соединений |
US7531542B2 (en) * | 2005-05-18 | 2009-05-12 | Wyeth | Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor |
AU2006249847B2 (en) * | 2005-05-23 | 2012-12-20 | Novartis Ag | Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one lactic acid salts |
US7582636B2 (en) * | 2005-05-26 | 2009-09-01 | Wyeth | Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor |
CA2627544C (fr) | 2005-11-29 | 2015-07-07 | Novartis Ag | Formulations de quinolinones pour le traitement du cancer |
CA2630597A1 (fr) | 2005-12-08 | 2007-06-14 | Novartis Ag | Effets d'inhibiteurs de fgfr3 sur la transcription genetique |
CN100488960C (zh) * | 2006-03-09 | 2009-05-20 | 中国药科大学 | 2-位取代的喹诺酮类化合物及其在制药中的应用 |
US20090291950A1 (en) * | 2006-07-07 | 2009-11-26 | Kalypsys, Inc. | Bicyclic heteroaryl inhibitors of pde4 |
US8138205B2 (en) * | 2006-07-07 | 2012-03-20 | Kalypsys, Inc. | Heteroarylalkoxy-substituted quinolone inhibitors of PDE4 |
EP2555766A4 (fr) | 2010-04-06 | 2015-06-03 | Univ Brigham Young | Composés antimétastatiques |
AU2011293449A1 (en) * | 2010-08-24 | 2013-02-28 | Brigham Young University | Antimetastatic compounds |
WO2013063003A1 (fr) | 2011-10-28 | 2013-05-02 | Novartis Ag | Méthode de traitement des tumeurs stromales gastro-intestinales |
RU2014135436A (ru) | 2012-01-31 | 2016-03-27 | Новартис Аг | Комбинация ингибитора rtk с антиэстрогеном и ее применение для лечения рака |
EP2872142A1 (fr) | 2012-07-11 | 2015-05-20 | Novartis AG | Méthode de traitement de tumeurs stromales gastro-intestinales |
WO2014058785A1 (fr) | 2012-10-10 | 2014-04-17 | Novartis Ag | Polythérapie |
PL3057964T3 (pl) | 2013-10-14 | 2020-05-18 | Eisai R&D Management Co., Ltd. | Selektywnie podstawione związki chinolinowe |
KR102365952B1 (ko) | 2013-10-14 | 2022-02-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 선택적으로 치환된 퀴놀린 화합물 |
SI3157566T1 (sl) | 2014-06-17 | 2019-08-30 | Vertex Pharmaceuticals Incorporated | Postopek za zdravljenje raka z uporabo kombinacije inhibitorjev CHK1 in ATR |
EP2977374A1 (fr) | 2014-07-21 | 2016-01-27 | Université de Strasbourg | Molécules présentant des propriétés d'émission double |
WO2017059357A1 (fr) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Méthode de traitement du cancer utilisant une association d'agents endommageant l'adn et d'inhibiteurs de l'atr |
CN108003150A (zh) * | 2016-10-31 | 2018-05-08 | 河南工业大学 | 4-杂芳基喹啉酮衍生物的制备方法及其应用 |
US11384075B2 (en) | 2017-06-27 | 2022-07-12 | Janssen Pharmaceutica Nv | Quinolinone compounds |
CN111655689B (zh) | 2017-11-24 | 2023-01-06 | 詹森药业有限公司 | 吡唑并吡啶酮化合物 |
US11691970B2 (en) | 2017-11-24 | 2023-07-04 | Janssen Pharmaceutica Nv | Pyrazolopyridinone compounds |
CN108516973A (zh) * | 2018-03-30 | 2018-09-11 | 广西师范大学 | 3-苯并噻唑-1-(3-二甲氨基)丙基喹啉-4-酮衍生物及其制备方法和应用 |
Family Cites Families (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US162251A (en) * | 1875-04-20 | Improvement in interfering-pads for horses | ||
US508800A (en) * | 1893-11-14 | Trustees | ||
US290153A (en) * | 1883-12-11 | Beer-scale | ||
US129025A (en) * | 1872-07-16 | Improvement in strainer-pipes | ||
US162252A (en) * | 1875-04-20 | Improvement in safety-catches for elevators | ||
US207883A (en) * | 1878-09-10 | Improvement in drafting-pencils | ||
US36256A (en) * | 1862-08-19 | Improvement in sewing-m ach ines | ||
US102369A (en) * | 1870-04-26 | Improvement in pumps | ||
US155114A (en) * | 1874-09-15 | Improvement in methods of laying and forming cast-iron pipes | ||
US8A (en) * | 1836-08-10 | T Blanchard | Machine for cutting scores around ships' tackle blocks and dead eyes | |
US128993A (en) * | 1872-07-16 | Improvement in furnaces for reducing iron ores | ||
US27379A (en) * | 1860-03-06 | Improvement in seeding-machines | ||
US152904A (en) * | 1874-07-14 | Improvement in rotary pumps | ||
US232861A (en) * | 1880-10-05 | Machine for dressing millstones | ||
US37650A (en) * | 1863-02-10 | Improvement in apparatus for obtaining profiles of submarine beds | ||
US7A (en) * | 1836-08-10 | Thomas blanchard | ||
US158224A (en) * | 1874-12-29 | Improvement in eye-cups | ||
US509717A (en) * | 1893-11-28 | beach | ||
US6A (en) * | 1836-08-10 | Thomas blanghard | ||
US63A (en) * | 1836-10-20 | Kravxiig | ||
US747771A (en) * | 1903-04-16 | 1903-12-22 | Rudolf Richter | Machine for harvesting potatoes or similar root crops. |
US797376A (en) * | 1905-05-19 | 1905-08-15 | John P Schneider Sr | Vise. |
US1086705A (en) * | 1913-06-04 | 1914-02-10 | Frank O Havener | Cigar-moistener. |
US2363459A (en) * | 1944-02-19 | 1944-11-21 | Draper Corp | Picker stick checking mechanism |
US3663606A (en) * | 1966-06-21 | 1972-05-16 | Mitsui Toatsu Chemicals | Organic imino-compounds |
US4659657A (en) * | 1982-12-24 | 1987-04-21 | Bayer Aktiengesellschaft | Chromogenic and fluorogenic esters for photometric or fluorimetric determination of phosphatases or sulphatases |
DE3634066A1 (de) * | 1986-10-07 | 1988-04-21 | Boehringer Mannheim Gmbh | Neue 5-alkylbenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel |
US5073492A (en) * | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
DE3932953A1 (de) * | 1989-10-03 | 1991-04-11 | Boehringer Mannheim Gmbh | Neue 2-bicyclo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
US5151360A (en) * | 1990-12-31 | 1992-09-29 | Biomembrane Institute | Effect of n,n,n-trimethylsphingosine on protein kinase-c activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation |
USRE37650E1 (en) * | 1991-05-10 | 2002-04-09 | Aventis Pharmacetical Products, Inc. | Aryl and heteroaryl quinazoline compounds which inhibit CSF-1R receptor tyrosine kinase |
US5710158A (en) * | 1991-05-10 | 1998-01-20 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Aryl and heteroaryl quinazoline compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5480883A (en) * | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
US5856115A (en) * | 1991-05-24 | 1999-01-05 | Fred Hutchinson Cancer Research Center | Assay for identification therapeutic agents |
US6004554A (en) * | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for targeting the vasculature of solid tumors |
US5330992A (en) * | 1992-10-23 | 1994-07-19 | Sterling Winthrop Inc. | 1-cyclopropyl-4-pyridyl-quinolinones |
US5981569A (en) * | 1992-11-13 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease |
US5792771A (en) * | 1992-11-13 | 1998-08-11 | Sugen, Inc. | Quinazoline compounds and compositions thereof for the treatment of disease |
US5763441A (en) * | 1992-11-13 | 1998-06-09 | Sugen, Inc. | Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis |
JP3441246B2 (ja) * | 1995-06-07 | 2003-08-25 | 富士写真フイルム株式会社 | 光重合性組成物 |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
US5942385A (en) * | 1996-03-21 | 1999-08-24 | Sugen, Inc. | Method for molecular diagnosis of tumor angiogenesis and metastasis |
AU3102697A (en) * | 1996-06-19 | 1998-01-07 | Rhone-Poulenc Rorer Limited | Substituted azabicylic compounds and their use as inhibitors of the production of tnf and cyclic amp phosphodiesterase |
US6111110A (en) * | 1996-10-30 | 2000-08-29 | Eli Lilly And Company | Synthesis of benzo[f]quinolinones |
DE19756235A1 (de) * | 1997-12-17 | 1999-07-01 | Klinge Co Chem Pharm Fab | Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide |
US6174912B1 (en) * | 1998-08-21 | 2001-01-16 | Dupont Pharmaceuticals Company | Nitrogen substituted imidazo[4,5-C]pyrazoles as corticotropin releasing hormone antagonists |
US20030087854A1 (en) * | 2001-09-10 | 2003-05-08 | Isis Pharmaceuticals Inc. | Antisense modulation of fibroblast growth factor receptor 3 expression |
PL204437B1 (pl) | 1999-05-21 | 2010-01-29 | Bristol Myers Squibb Co | Pochodna pirolotriazyny i jej zastosowanie oraz kompozycja farmaceutyczna i jej zastosowanie |
KR100298572B1 (ko) * | 1999-08-19 | 2001-09-22 | 박찬구 | 카바아닐라이드로부터 4-니트로디페닐아민과 4-니트로소디페닐아민의 제조방법 |
WO2001028993A2 (fr) * | 1999-10-19 | 2001-04-26 | Merck & Co. Inc. | Inhibiteurs tyrosine kinase |
DE60017179T2 (de) * | 1999-10-19 | 2006-01-05 | Merck & Co., Inc. | Tyrosin kinaseinhibitoren |
US6420382B2 (en) * | 2000-02-25 | 2002-07-16 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
US6313138B1 (en) * | 2000-02-25 | 2001-11-06 | Merck & Co., Inc. | Tyrosine kinase inhibitors |
PT1313734E (pt) * | 2000-09-01 | 2010-02-09 | Novartis Vaccines & Diagnostic | Derivados aza heterocíclicos e sua utilização terapêutica |
AU2001288432A1 (en) * | 2000-09-01 | 2002-03-22 | Icos Corporation | Materials and methods to potentiate cancer treatment |
CA2421120C (fr) * | 2000-09-11 | 2008-07-15 | Chiron Corporation | Derives de quinolinone utilises comme inhibiteurs de la tyrosine kinase |
US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
JP2004536113A (ja) * | 2001-07-03 | 2004-12-02 | カイロン コーポレイション | チロシンキナーゼおよびセリン/スレオニンキナーゼのインヒビターとしてのインダゾールベンズイミダゾール化合物 |
US20030159702A1 (en) * | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
US20050256157A1 (en) * | 2002-08-23 | 2005-11-17 | Chiron Corporation | Combination therapy with CHK1 inhibitors |
US7825132B2 (en) * | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
CA2496164C (fr) * | 2002-08-23 | 2010-11-09 | Chiron Corporation | Quinolinones de benzimidazole et leurs utilisations |
KR20050075005A (ko) * | 2002-11-13 | 2005-07-19 | 카이론 코포레이션 | 암을 치료하는 방법 및 관련 방법 |
US6774327B1 (en) * | 2003-09-24 | 2004-08-10 | Agilent Technologies, Inc. | Hermetic seals for electronic components |
EP1682529A4 (fr) * | 2003-11-07 | 2010-06-30 | Novartis Vaccines & Diagnostic | Methodes de synthese de composes de quinolinone |
MX2007014612A (es) * | 2005-05-18 | 2008-01-17 | M & G Polimeri Italia Spa | Composicion de poliester. |
-
2002
- 2002-04-05 US US10/116,117 patent/US20030028018A1/en not_active Abandoned
-
2003
- 2003-04-04 IL IL16432403A patent/IL164324A0/xx unknown
- 2003-04-04 JP JP2003584051A patent/JP2005527587A/ja active Pending
- 2003-04-04 MX MXPA04009739A patent/MXPA04009739A/es active IP Right Grant
- 2003-04-04 CA CA2481055A patent/CA2481055C/fr not_active Expired - Lifetime
- 2003-04-04 EP EP03746614A patent/EP1497287B1/fr not_active Expired - Lifetime
- 2003-04-04 BR BR0308996-7A patent/BR0308996A/pt not_active Application Discontinuation
- 2003-04-04 WO PCT/US2003/010463 patent/WO2003087095A1/fr active Application Filing
- 2003-04-04 NZ NZ536068A patent/NZ536068A/en not_active IP Right Cessation
- 2003-04-04 AT AT03746614T patent/ATE489092T1/de active
- 2003-04-04 AU AU2003226275A patent/AU2003226275B2/en not_active Expired
- 2003-04-04 KR KR1020047015851A patent/KR101035894B1/ko not_active IP Right Cessation
- 2003-04-04 CN CN038129094A patent/CN1659165A/zh active Pending
- 2003-04-04 SG SG200606999-1A patent/SG143985A1/en unknown
- 2003-04-04 PT PT03746614T patent/PT1497287E/pt unknown
- 2003-04-04 PL PL372871A patent/PL209412B1/pl unknown
- 2003-04-04 ES ES03746614T patent/ES2357289T3/es not_active Expired - Lifetime
- 2003-04-04 EA EA200401318A patent/EA010393B1/ru not_active IP Right Cessation
- 2003-04-04 AP APAP/P/2004/003166A patent/AP2070A/en active
- 2003-04-04 DE DE60335096T patent/DE60335096D1/de not_active Expired - Lifetime
-
2004
- 2004-09-28 IL IL164324A patent/IL164324A/en not_active IP Right Cessation
- 2004-10-04 MA MA27887A patent/MA28122A1/fr unknown
- 2004-11-03 NO NO20044776A patent/NO331021B1/no not_active IP Right Cessation
- 2004-11-03 HR HRP20041031AA patent/HRP20041031B1/hr not_active IP Right Cessation
- 2004-11-05 EC EC2004005411A patent/ECSP045411A/es unknown
-
2005
- 2005-02-22 HK HK05101490.8A patent/HK1067966A1/xx not_active IP Right Cessation
-
2007
- 2007-10-02 US US11/866,296 patent/US20080070906A1/en not_active Abandoned
-
2010
- 2010-01-04 US US12/651,612 patent/US20100184754A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL164324A0 (en) | Quinolinone derivatives | |
AP1850A (en) | Spiroindolineplperidine derivatives | |
EG24050A (en) | Heterocylocarboxamide derivatives | |
ZA200603657B (en) | Novel quinoline derivatives | |
HK1077068A1 (en) | Azolidinone-vinyl fused-benzene derivatives | |
IL166121A0 (en) | Indole-3-sulphur derivatives | |
EP1522540A4 (fr) | Derives d'azaarene | |
PL376475A1 (en) | N-substituted-2-oxodihydropyridine derivatives | |
ZA200500471B (en) | N-biarylmethyl aminocycloalkanecarboxamide derivatives | |
HK1080836A1 (en) | Isoquinoline derivatives | |
PL376997A1 (pl) | Pochodne tetrahydrochinoliny | |
PL377318A1 (pl) | Pochodne tetrahydrochinoliny | |
HK1071364A1 (en) | Quinoline derivatives | |
AU2003222659A8 (en) | 23-o-substituted 5-o-mycaminosyltylonide derivatives | |
PL371216A1 (en) | Isoquinoline derivatives | |
AU2003274551A1 (en) | Quinoline derivatives | |
AU2003252333A1 (en) | Novel tetrahydroquinoline derivatives | |
EP1531854A4 (fr) | Derives de nocathiacine o-derivatises | |
GB0213488D0 (en) | 2-Naphthamide derivatives | |
AU2003243397A8 (en) | Homo-camptothecin derivatives | |
HK1077577A1 (en) | Tetrahydroquinoline derivatives | |
AU2003285777A8 (en) | 3-substituted-4-pyrimidone derivatives | |
GB0221143D0 (en) | Dihydropyridinone derivatives | |
GB0210512D0 (en) | Tetrahydro-napthalene derivatives | |
HK1081943A1 (en) | N-hydroxyformamidine derivative |