NO330769B1 - Polypeptid isolert fra H. medicinalis, isolert polynukleotid, ekspresjonsvektor, vertscelle, ekspresjonssystem, fremgangsmate for fremstilling av et polypeptid, antistoff, farmasoytisk preparat, anvendelse av et polypeptid, fremstilling av et medikament for behandling av tromboemboliske sykdommer. - Google Patents
Polypeptid isolert fra H. medicinalis, isolert polynukleotid, ekspresjonsvektor, vertscelle, ekspresjonssystem, fremgangsmate for fremstilling av et polypeptid, antistoff, farmasoytisk preparat, anvendelse av et polypeptid, fremstilling av et medikament for behandling av tromboemboliske sykdommer. Download PDFInfo
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- NO330769B1 NO330769B1 NO20014506A NO20014506A NO330769B1 NO 330769 B1 NO330769 B1 NO 330769B1 NO 20014506 A NO20014506 A NO 20014506A NO 20014506 A NO20014506 A NO 20014506A NO 330769 B1 NO330769 B1 NO 330769B1
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- Prior art keywords
- polypeptide
- saratin
- protein
- isolated
- collagen
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- PHEDXBVPIONUQT-RGYGYFBISA-N phorbol 13-acetate 12-myristate Chemical compound C([C@]1(O)C(=O)C(C)=C[C@H]1[C@@]1(O)[C@H](C)[C@H]2OC(=O)CCCCCCCCCCCCC)C(CO)=C[C@H]1[C@H]1[C@]2(OC(C)=O)C1(C)C PHEDXBVPIONUQT-RGYGYFBISA-N 0.000 description 1
- 239000002644 phorbol ester Substances 0.000 description 1
- 230000006461 physiological response Effects 0.000 description 1
- 229940127126 plasminogen activator Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 description 1
- 210000004623 platelet-rich plasma Anatomy 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
- 239000001120 potassium sulphate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 229960004919 procaine Drugs 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 238000002331 protein detection Methods 0.000 description 1
- 238000000164 protein isolation Methods 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 239000013014 purified material Substances 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 210000003079 salivary gland Anatomy 0.000 description 1
- 230000002784 sclerotic effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000003998 snake venom Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000012209 synthetic fiber Substances 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 description 1
- PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
- 229960005001 ticlopidine Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000011830 transgenic mouse model Methods 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 108700026220 vif Genes Proteins 0.000 description 1
- 230000004304 visual acuity Effects 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99105530 | 1999-03-18 | ||
| EP99109503 | 1999-05-12 | ||
| PCT/EP2000/002117 WO2000056885A1 (en) | 1999-03-18 | 2000-03-10 | Protein for blocking platelet adhesion |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20014506D0 NO20014506D0 (no) | 2001-09-17 |
| NO20014506L NO20014506L (no) | 2001-11-16 |
| NO330769B1 true NO330769B1 (no) | 2011-07-11 |
Family
ID=26152935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20014506A NO330769B1 (no) | 1999-03-18 | 2001-09-17 | Polypeptid isolert fra H. medicinalis, isolert polynukleotid, ekspresjonsvektor, vertscelle, ekspresjonssystem, fremgangsmate for fremstilling av et polypeptid, antistoff, farmasoytisk preparat, anvendelse av et polypeptid, fremstilling av et medikament for behandling av tromboemboliske sykdommer. |
Country Status (27)
| Country | Link |
|---|---|
| US (3) | US6774107B1 (zh) |
| EP (1) | EP1161530B1 (zh) |
| JP (1) | JP4805461B2 (zh) |
| KR (1) | KR100788219B1 (zh) |
| CN (1) | CN1185344C (zh) |
| AR (1) | AR023099A1 (zh) |
| AT (1) | ATE295883T1 (zh) |
| AU (1) | AU767172B2 (zh) |
| BR (1) | BR0009074A (zh) |
| CA (1) | CA2367457C (zh) |
| CO (1) | CO5241328A1 (zh) |
| CZ (1) | CZ301524B6 (zh) |
| DE (1) | DE60020220T2 (zh) |
| DK (1) | DK1161530T3 (zh) |
| ES (1) | ES2240067T3 (zh) |
| HK (1) | HK1045330B (zh) |
| HU (1) | HU228068B1 (zh) |
| MX (1) | MXPA01009363A (zh) |
| MY (1) | MY123371A (zh) |
| NO (1) | NO330769B1 (zh) |
| PL (1) | PL200384B1 (zh) |
| PT (1) | PT1161530E (zh) |
| RU (1) | RU2292351C2 (zh) |
| SI (1) | SI1161530T1 (zh) |
| SK (1) | SK287496B6 (zh) |
| TR (1) | TR200102729T2 (zh) |
| WO (1) | WO2000056885A1 (zh) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774107B1 (en) | 1999-03-18 | 2004-08-10 | Merck Patent Gmbh | Protein for blocking platelet adhesion |
| MY128992A (en) | 2000-08-25 | 2007-03-30 | Merck Patent Gmbh | Saratin for inhibiting platelet adhesion to collagen |
| JP2005511005A (ja) * | 2001-07-18 | 2005-04-28 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 糖タンパク質ｖｉ融合タンパク質 |
| WO2005042043A2 (en) | 2003-10-28 | 2005-05-12 | Medtronic, Inc. | Methods of preparing crosslinked materials and bioprosthetic devices |
| US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
| WO2006044290A2 (en) * | 2004-10-12 | 2006-04-27 | Board Of Trustees Of Michigan State University | Biosynthesis of philoroglucinol and preparation of 1,3-dihydroxybenzene therefrom |
| CA2611102A1 (en) * | 2005-05-26 | 2006-11-30 | Thomas Jefferson University | Method to treat and prevent posterior capsule opacification |
| US7691839B2 (en) * | 2005-09-28 | 2010-04-06 | Biovascular, Inc. | Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation |
| US20110034396A1 (en) * | 2005-09-28 | 2011-02-10 | Biovascular, Inc. | Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions |
| US20080015145A1 (en) | 2006-07-11 | 2008-01-17 | Maria Gyongyossy-Issa | Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions |
| GB2460915B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor |
| EP3335715A3 (en) | 2008-10-15 | 2018-08-08 | Ionis Pharmaceuticals, Inc. | Modulation of factor 11 expression |
| WO2012003461A2 (en) | 2010-07-02 | 2012-01-05 | Draths Corporation | Phloroglucinol synthases and methods of making and using the same |
| WO2012006245A1 (en) | 2010-07-06 | 2012-01-12 | Draths Corporation | Phloroglucinol reductase and methods of making and using the same |
| WO2012006244A1 (en) | 2010-07-06 | 2012-01-12 | Draths Corporation | Method for producing phloroglucinol and dihydrophloroglucinol |
| RS63063B1 (sr) | 2010-08-19 | 2022-04-29 | Zoetis Belgium S A | Anti-ngf antitela i njihova upotreba |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| DE202012012998U1 (de) | 2011-08-31 | 2014-06-13 | Daniel Elias | Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels |
| WO2013184871A1 (en) | 2012-06-06 | 2013-12-12 | Zoetis Llc | Caninized anti-ngf antibodies and methods thereof |
| MX2015000789A (es) | 2012-07-19 | 2015-05-07 | Zoetis Llc | Composiciones de virus de la gripe bovina. |
| AU2013295770A1 (en) | 2012-07-27 | 2015-01-29 | Zoetis Services Llc | Tick toxin compositions |
| EP3500292B1 (en) | 2016-08-17 | 2024-10-16 | Pharmaq AS | Sea lice vaccine |
| BR102017005783A2 (pt) * | 2017-03-21 | 2018-10-02 | Fund Butantan | processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos |
| WO2019177690A1 (en) | 2018-03-12 | 2019-09-19 | Zoetis Services Llc | Anti-ngf antibodies and methods thereof |
| BR112020017715A2 (pt) | 2018-03-16 | 2020-12-29 | Zoetis Services Llc | Vacinas de peptídeo contra interleucina-31 |
| EP3765500A2 (en) | 2018-03-16 | 2021-01-20 | Zoetis Services LLC | Interleukin-31 monoclonal antibodies for veterinary use |
| JOP20200280A1 (ar) | 2018-05-09 | 2020-11-05 | Ionis Pharmaceuticals Inc | مركبات وطرق لتقليل التعبير الوراثي عن fxi |
| US11464849B2 (en) | 2019-09-11 | 2022-10-11 | Zoetis Services Llc | Recombinant herpesvirus of turkey vectors expressing antigens of avian pathogens and uses thereof |
| US20220119513A1 (en) | 2020-06-08 | 2022-04-21 | Zoetis Services Llc | Anti-tgfb antibodies and therapeutic uses thereof |
| US20210386854A1 (en) | 2020-06-15 | 2021-12-16 | Zoetis Services Llc | Cell Line for Production of Marek's Disease Virus Vaccine and Methods of Making and Using the Same |
| MX2023004020A (es) | 2020-10-07 | 2023-07-07 | Zoetis Services Llc | Anticuerpos anti-ngf y métodos para su uso. |
| TW202221039A (zh) | 2020-10-19 | 2022-06-01 | 美商碩騰服務公司 | 犬及貓抑瘤素Ｍ受體β之抗體及其用途 |
| WO2023049917A1 (en) | 2021-09-27 | 2023-03-30 | Zoetis Services Llc | ANTI- TGFβ1,2,3 ANTIBODIES AND THERAPEUTIC USES THEREOF |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705355A (en) * | 1984-03-27 | 1998-01-06 | Transgene, S.A. | Hirudin, pharmaceutical compositions comprising it and their use |
| US4898734A (en) | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
| IL86857A (en) * | 1988-06-24 | 1994-04-12 | Yissum Res Dev Co | Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same |
| US5182260A (en) * | 1989-01-27 | 1993-01-26 | Biogen, Inc. | Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them |
| CA2052486A1 (en) * | 1990-10-09 | 1992-04-10 | Thomas M. Connolly | Protein for inhibiting collagen-stimulated platelet aggregation |
| GB9022040D0 (en) * | 1990-10-10 | 1990-11-21 | Biopharm Ltd | Platelet adhesion inhibitor |
| DE4136513A1 (de) * | 1991-11-06 | 1993-05-13 | Basf Ag | Neues thrombininhibitorisches protein aus raubwanzen |
| JP3742429B2 (ja) * | 1993-07-01 | 2006-02-01 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | コラーゲン刺激血小板凝集の阻害剤 |
| EP1118325B2 (en) | 1993-07-29 | 2010-01-06 | The United States of America, represented by the Secretary, Department of Health and Human Services | Use of Paclitaxel and its derivatives in the manufacture of a medicament for treating restenosis. |
| CZ76297A3 (cs) * | 1994-09-12 | 1998-01-14 | Schering Aktiengesellschaft | Způsob výroby modifikovaného pallidipinu - inhibitoru agregace krevních destiček vyvolané kolagenem |
| ATE211765T1 (de) * | 1994-10-28 | 2002-01-15 | Vitaleech Bioscience N V | Neue familie von proteaseinhibitoren und andere biologisch aktive substanzen |
| US6774107B1 (en) * | 1999-03-18 | 2004-08-10 | Merck Patent Gmbh | Protein for blocking platelet adhesion |
| MY128992A (en) * | 2000-08-25 | 2007-03-30 | Merck Patent Gmbh | Saratin for inhibiting platelet adhesion to collagen |
-
2000
- 2000-03-10 US US09/936,737 patent/US6774107B1/en not_active Expired - Fee Related
- 2000-03-10 SK SK1290-2001A patent/SK287496B6/sk not_active IP Right Cessation
- 2000-03-10 CN CNB008052115A patent/CN1185344C/zh not_active Expired - Fee Related
- 2000-03-10 SI SI200030723T patent/SI1161530T1/xx unknown
- 2000-03-10 RU RU2001126921/13A patent/RU2292351C2/ru not_active IP Right Cessation
- 2000-03-10 ES ES00909351T patent/ES2240067T3/es not_active Expired - Lifetime
- 2000-03-10 CZ CZ20013341A patent/CZ301524B6/cs not_active IP Right Cessation
- 2000-03-10 EP EP00909351A patent/EP1161530B1/en not_active Expired - Lifetime
- 2000-03-10 JP JP2000606744A patent/JP4805461B2/ja not_active Expired - Fee Related
- 2000-03-10 CA CA2367457A patent/CA2367457C/en not_active Expired - Fee Related
- 2000-03-10 PL PL350147A patent/PL200384B1/pl not_active IP Right Cessation
- 2000-03-10 WO PCT/EP2000/002117 patent/WO2000056885A1/en active Search and Examination
- 2000-03-10 TR TR2001/02729T patent/TR200102729T2/xx unknown
- 2000-03-10 MX MXPA01009363A patent/MXPA01009363A/es active IP Right Grant
- 2000-03-10 KR KR1020017011881A patent/KR100788219B1/ko not_active IP Right Cessation
- 2000-03-10 HU HU0200353A patent/HU228068B1/hu not_active IP Right Cessation
- 2000-03-10 PT PT00909351T patent/PT1161530E/pt unknown
- 2000-03-10 DE DE60020220T patent/DE60020220T2/de not_active Expired - Lifetime
- 2000-03-10 BR BR0009074-3A patent/BR0009074A/pt not_active IP Right Cessation
- 2000-03-10 AT AT00909351T patent/ATE295883T1/de active
- 2000-03-10 AU AU31662/00A patent/AU767172B2/en not_active Ceased
- 2000-03-10 DK DK00909351T patent/DK1161530T3/da active
- 2000-03-14 MY MYPI20000991A patent/MY123371A/en unknown
- 2000-03-17 AR ARP000101192A patent/AR023099A1/es active IP Right Grant
- 2000-03-17 CO CO00019687A patent/CO5241328A1/es not_active Application Discontinuation
-
2001
- 2001-09-17 NO NO20014506A patent/NO330769B1/no not_active IP Right Cessation
-
2002
- 2002-09-16 HK HK02106777.4A patent/HK1045330B/zh not_active IP Right Cessation
-
2004
- 2004-05-17 US US10/846,668 patent/US6962801B2/en not_active Expired - Fee Related
-
2005
- 2005-06-16 US US11/153,433 patent/US7090986B2/en not_active Expired - Fee Related
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