AR023099A1 - Constructos de adn que codifican saratina y sus usos. - Google Patents
Constructos de adn que codifican saratina y sus usos.Info
- Publication number
- AR023099A1 AR023099A1 ARP000101192A ARP000101192A AR023099A1 AR 023099 A1 AR023099 A1 AR 023099A1 AR P000101192 A ARP000101192 A AR P000101192A AR P000101192 A ARP000101192 A AR P000101192A AR 023099 A1 AR023099 A1 AR 023099A1
- Authority
- AR
- Argentina
- Prior art keywords
- collagen
- natural
- protein
- cells
- saratina
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se describe una proteína natural aislada de la saliva de la sanguijuela medicinal Hirudo medicinalis que se une fuertemente al colágeno, actuando de estamanera como un inhibidor de la adherencia natural de las plaquetas al colágeno. La proteína tieneun peso molecular de aproximadamente 12000, un puntoisoeléctrico ácido y contiene seis cisteínas. La proteína fue secuenciada y el gen fue clonado a partir de la biblioteca de ADNc de H. Medicinalis. También sedan a conocer procedimientos para producir tal polipéptido por medio de técnicas recombinantes. Tanto las proteínas naturales como las quiméricas soninhibidores potentes de la adherencia de plaquetas dependiente del colágeno y, por lo tanto, pueden ser utilizadas para el tratamiento terapéutico de diversascondiciones relacionadas con la enfermedad cardíaca y las enfermedades del sistema circulatorio. Además, la proteína también es apropiada para recubrirsuperficies naturales o artificiales de colágeno con el fin de volverlas no adhesivas para las células y de esta manera prevenir la activacion de células.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99105530 | 1999-03-18 | ||
EP99109503 | 1999-05-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR023099A1 true AR023099A1 (es) | 2002-09-04 |
Family
ID=26152935
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP000101192A AR023099A1 (es) | 1999-03-18 | 2000-03-17 | Constructos de adn que codifican saratina y sus usos. |
Country Status (27)
Country | Link |
---|---|
US (3) | US6774107B1 (es) |
EP (1) | EP1161530B1 (es) |
JP (1) | JP4805461B2 (es) |
KR (1) | KR100788219B1 (es) |
CN (1) | CN1185344C (es) |
AR (1) | AR023099A1 (es) |
AT (1) | ATE295883T1 (es) |
AU (1) | AU767172B2 (es) |
BR (1) | BR0009074A (es) |
CA (1) | CA2367457C (es) |
CO (1) | CO5241328A1 (es) |
CZ (1) | CZ301524B6 (es) |
DE (1) | DE60020220T2 (es) |
DK (1) | DK1161530T3 (es) |
ES (1) | ES2240067T3 (es) |
HK (1) | HK1045330B (es) |
HU (1) | HU228068B1 (es) |
MX (1) | MXPA01009363A (es) |
MY (1) | MY123371A (es) |
NO (1) | NO330769B1 (es) |
PL (1) | PL200384B1 (es) |
PT (1) | PT1161530E (es) |
RU (1) | RU2292351C2 (es) |
SI (1) | SI1161530T1 (es) |
SK (1) | SK287496B6 (es) |
TR (1) | TR200102729T2 (es) |
WO (1) | WO2000056885A1 (es) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000056885A1 (en) | 1999-03-18 | 2000-09-28 | Merck Patent Gmbh | Protein for blocking platelet adhesion |
MY128992A (en) * | 2000-08-25 | 2007-03-30 | Merck Patent Gmbh | Saratin for inhibiting platelet adhesion to collagen |
CA2453986A1 (en) * | 2001-07-18 | 2003-01-30 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Glycoprotein vi fusion proteins |
US7053051B2 (en) | 2003-10-28 | 2006-05-30 | Medtronic, Inc. | Methods of preparing crosslinked materials and bioprosthetic devices |
US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
KR101340580B1 (ko) * | 2004-10-12 | 2013-12-11 | 보드 오브 트러스티즈 오브 미시건 스테이트 유니버시티 | 플로로글루시놀의 생합성 및 이로부터1,3-디하이드록시벤젠의 합성 |
US8999370B2 (en) * | 2005-05-26 | 2015-04-07 | Thomas Jefferson University | Method to treat and prevent posterior capsule opacification |
US20110034396A1 (en) * | 2005-09-28 | 2011-02-10 | Biovascular, Inc. | Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions |
US7691839B2 (en) | 2005-09-28 | 2010-04-06 | Biovascular, Inc. | Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation |
US20080015145A1 (en) * | 2006-07-11 | 2008-01-17 | Maria Gyongyossy-Issa | Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions |
GB2462022B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods thereof |
HUE035888T2 (en) | 2008-10-15 | 2018-05-28 | Ionis Pharmaceuticals Inc | Modulation of Factor 11 Expression |
WO2012003461A2 (en) | 2010-07-02 | 2012-01-05 | Draths Corporation | Phloroglucinol synthases and methods of making and using the same |
WO2012006244A1 (en) | 2010-07-06 | 2012-01-12 | Draths Corporation | Method for producing phloroglucinol and dihydrophloroglucinol |
WO2012006245A1 (en) | 2010-07-06 | 2012-01-12 | Draths Corporation | Phloroglucinol reductase and methods of making and using the same |
DK3333188T3 (da) | 2010-08-19 | 2022-03-07 | Zoetis Belgium S A | Anti-NGF-antistoffer og deres anvendelse |
US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
DE202012012998U1 (de) | 2011-08-31 | 2014-06-13 | Daniel Elias | Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels |
ES2894852T3 (es) | 2012-06-06 | 2022-02-16 | Zoetis Services Llc | Anticuerpos anti-NGF caninizados y métodos de los mismos |
CA2879443A1 (en) | 2012-07-19 | 2014-01-23 | Zoetis Llc | Bovine influenza virus compositions |
AU2013295770A1 (en) | 2012-07-27 | 2015-01-29 | Zoetis Services Llc | Tick toxin compositions |
CA3033759C (en) | 2016-08-17 | 2022-06-14 | Pharmaq As | Sea lice vaccine |
BR102017005783A2 (pt) * | 2017-03-21 | 2018-10-02 | Fund Butantan | processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos |
EP3765499A1 (en) | 2018-03-12 | 2021-01-20 | Zoetis Services LLC | Anti-ngf antibodies and methods thereof |
JP7449234B2 (ja) | 2018-03-16 | 2024-03-13 | ゾエティス・サービシーズ・エルエルシー | 獣医学使用のためのインターロイキン31モノクローナル抗体 |
KR102672548B1 (ko) | 2018-03-16 | 2024-06-04 | 조에티스 서비시즈 엘엘씨 | 인터루킨-31에 대한 펩티드 백신 |
SG11202010012PA (en) | 2018-05-09 | 2020-11-27 | Ionis Pharmaceuticals Inc | Compounds and methods for reducing fxi expression |
MX2022002994A (es) | 2019-09-11 | 2022-06-14 | Zoetis Services Llc | Vectores de herpesvirus de los pavos recombinante que expresan antígenos de patógenos aviares y usos de estos. |
US20220119513A1 (en) | 2020-06-08 | 2022-04-21 | Zoetis Services Llc | Anti-tgfb antibodies and therapeutic uses thereof |
US20210386854A1 (en) | 2020-06-15 | 2021-12-16 | Zoetis Services Llc | Cell Line for Production of Marek's Disease Virus Vaccine and Methods of Making and Using the Same |
CA3198362A1 (en) | 2020-10-07 | 2022-04-14 | Zoetis Services Llc | Anti-ngf antibodies and methods of use thereof |
TW202221039A (zh) | 2020-10-19 | 2022-06-01 | 美商碩騰服務公司 | 犬及貓抑瘤素M受體β之抗體及其用途 |
WO2023049917A1 (en) | 2021-09-27 | 2023-03-30 | Zoetis Services Llc | ANTI- TGFβ1,2,3 ANTIBODIES AND THERAPEUTIC USES THEREOF |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5705355A (en) * | 1984-03-27 | 1998-01-06 | Transgene, S.A. | Hirudin, pharmaceutical compositions comprising it and their use |
US4898734A (en) | 1988-02-29 | 1990-02-06 | Massachusetts Institute Of Technology | Polymer composite for controlled release or membrane formation |
IL86857A (en) * | 1988-06-24 | 1994-04-12 | Yissum Res Dev Co | Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same |
US5182260A (en) * | 1989-01-27 | 1993-01-26 | Biogen, Inc. | Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them |
CA2052486A1 (en) * | 1990-10-09 | 1992-04-10 | Thomas M. Connolly | Protein for inhibiting collagen-stimulated platelet aggregation |
GB9022040D0 (en) * | 1990-10-10 | 1990-11-21 | Biopharm Ltd | Platelet adhesion inhibitor |
DE4136513A1 (de) * | 1991-11-06 | 1993-05-13 | Basf Ag | Neues thrombininhibitorisches protein aus raubwanzen |
JP3742429B2 (ja) * | 1993-07-01 | 2006-02-01 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | コラーゲン刺激血小板凝集の阻害剤 |
EP1118325B2 (en) | 1993-07-29 | 2010-01-06 | The United States of America, represented by the Secretary, Department of Health and Human Services | Use of Paclitaxel and its derivatives in the manufacture of a medicament for treating restenosis. |
HU222398B1 (hu) * | 1994-09-12 | 2003-06-28 | Schering Aktiengesellschaft | Eljárás pallidipin, egy módosított, kollagénindukált vérlemezke-aggregációt gátló vegyület előállítására |
WO1996013585A1 (en) * | 1994-10-28 | 1996-05-09 | Clodica S.A. | A novel family of protease inhibitors, and other biologic active substances |
WO2000056885A1 (en) | 1999-03-18 | 2000-09-28 | Merck Patent Gmbh | Protein for blocking platelet adhesion |
MY128992A (en) * | 2000-08-25 | 2007-03-30 | Merck Patent Gmbh | Saratin for inhibiting platelet adhesion to collagen |
-
2000
- 2000-03-10 WO PCT/EP2000/002117 patent/WO2000056885A1/en active Search and Examination
- 2000-03-10 ES ES00909351T patent/ES2240067T3/es not_active Expired - Lifetime
- 2000-03-10 MX MXPA01009363A patent/MXPA01009363A/es active IP Right Grant
- 2000-03-10 AT AT00909351T patent/ATE295883T1/de active
- 2000-03-10 AU AU31662/00A patent/AU767172B2/en not_active Ceased
- 2000-03-10 US US09/936,737 patent/US6774107B1/en not_active Expired - Fee Related
- 2000-03-10 SI SI200030723T patent/SI1161530T1/xx unknown
- 2000-03-10 CA CA2367457A patent/CA2367457C/en not_active Expired - Fee Related
- 2000-03-10 PT PT00909351T patent/PT1161530E/pt unknown
- 2000-03-10 EP EP00909351A patent/EP1161530B1/en not_active Expired - Lifetime
- 2000-03-10 CZ CZ20013341A patent/CZ301524B6/cs not_active IP Right Cessation
- 2000-03-10 HU HU0200353A patent/HU228068B1/hu not_active IP Right Cessation
- 2000-03-10 KR KR1020017011881A patent/KR100788219B1/ko not_active IP Right Cessation
- 2000-03-10 CN CNB008052115A patent/CN1185344C/zh not_active Expired - Fee Related
- 2000-03-10 BR BR0009074-3A patent/BR0009074A/pt not_active IP Right Cessation
- 2000-03-10 SK SK1290-2001A patent/SK287496B6/sk not_active IP Right Cessation
- 2000-03-10 PL PL350147A patent/PL200384B1/pl not_active IP Right Cessation
- 2000-03-10 JP JP2000606744A patent/JP4805461B2/ja not_active Expired - Fee Related
- 2000-03-10 TR TR2001/02729T patent/TR200102729T2/xx unknown
- 2000-03-10 RU RU2001126921/13A patent/RU2292351C2/ru not_active IP Right Cessation
- 2000-03-10 DK DK00909351T patent/DK1161530T3/da active
- 2000-03-10 DE DE60020220T patent/DE60020220T2/de not_active Expired - Lifetime
- 2000-03-14 MY MYPI20000991A patent/MY123371A/en unknown
- 2000-03-17 CO CO00019687A patent/CO5241328A1/es not_active Application Discontinuation
- 2000-03-17 AR ARP000101192A patent/AR023099A1/es active IP Right Grant
-
2001
- 2001-09-17 NO NO20014506A patent/NO330769B1/no not_active IP Right Cessation
-
2002
- 2002-09-16 HK HK02106777.4A patent/HK1045330B/zh not_active IP Right Cessation
-
2004
- 2004-05-17 US US10/846,668 patent/US6962801B2/en not_active Expired - Fee Related
-
2005
- 2005-06-16 US US11/153,433 patent/US7090986B2/en not_active Expired - Fee Related
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