TR200102729T2 - Platelet yapışmasını bloke etme amaçlı protein - Google Patents

Platelet yapışmasını bloke etme amaçlı protein

Info

Publication number
TR200102729T2
TR200102729T2 TR2001/02729T TR200102729T TR200102729T2 TR 200102729 T2 TR200102729 T2 TR 200102729T2 TR 2001/02729 T TR2001/02729 T TR 2001/02729T TR 200102729 T TR200102729 T TR 200102729T TR 200102729 T2 TR200102729 T2 TR 200102729T2
Authority
TR
Turkey
Prior art keywords
protein
collagen
cells
platelet adhesion
naturally occurring
Prior art date
Application number
TR2001/02729T
Other languages
English (en)
Inventor
Strittmatter Wolfgang
G�Ssow Dettlef
Hofmann Uwe
Hemberger J�Rgen
Fotev Zisi
Scheuble Bernhard
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of TR200102729T2 publication Critical patent/TR200102729T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Tibbi sülük Hirudo medicinalis'in tükürügünden izole edilen, dogal yoldan olusan ve güçlü sekilde kolajene baglanan ve böylelikle kalojene dogal platelet yapismasini önleyici olarak hareket eden protein tarif edilir.Protein, yaklasik 12000 moleküler agirliga, bir asidik izoelektrik noktaya sahiptir ve alti sistein içerir. Protein sekanslandi ve gen, H.medicinalis cDNA-kütüphanesinden klonlandi. Yeniden birlestirici tekniklerle böyle polipeptidin üretilmesi prosedürü açiklanir. Yeniden birlestirici ve dogal yoldan olusan proteinler, kolajene bagimli platelet yapismasinin güçlü önleyicileridir ve bu nedenle kalp hastaliklari ve dolasim sistemi hastaliklariyla ilgili çesitli durumlarin terapötik tedavisinde yararlidirlar. Ayrica protein, dogal veya suni kolajen yüzeylerin hücreler için yapiskan olmamalarini saglamak ve hücrelerin aktiflestirlmesini önlemek amaciyla bu yüzeylerin kaplanmasinda yaralidir.
TR2001/02729T 1999-03-18 2000-03-10 Platelet yapışmasını bloke etme amaçlı protein TR200102729T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99105530 1999-03-18
EP99109503 1999-05-12

Publications (1)

Publication Number Publication Date
TR200102729T2 true TR200102729T2 (tr) 2002-04-22

Family

ID=26152935

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02729T TR200102729T2 (tr) 1999-03-18 2000-03-10 Platelet yapışmasını bloke etme amaçlı protein

Country Status (27)

Country Link
US (3) US6774107B1 (tr)
EP (1) EP1161530B1 (tr)
JP (1) JP4805461B2 (tr)
KR (1) KR100788219B1 (tr)
CN (1) CN1185344C (tr)
AR (1) AR023099A1 (tr)
AT (1) ATE295883T1 (tr)
AU (1) AU767172B2 (tr)
BR (1) BR0009074A (tr)
CA (1) CA2367457C (tr)
CO (1) CO5241328A1 (tr)
CZ (1) CZ301524B6 (tr)
DE (1) DE60020220T2 (tr)
DK (1) DK1161530T3 (tr)
ES (1) ES2240067T3 (tr)
HK (1) HK1045330B (tr)
HU (1) HU228068B1 (tr)
MX (1) MXPA01009363A (tr)
MY (1) MY123371A (tr)
NO (1) NO330769B1 (tr)
PL (1) PL200384B1 (tr)
PT (1) PT1161530E (tr)
RU (1) RU2292351C2 (tr)
SI (1) SI1161530T1 (tr)
SK (1) SK287496B6 (tr)
TR (1) TR200102729T2 (tr)
WO (1) WO2000056885A1 (tr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6774107B1 (en) * 1999-03-18 2004-08-10 Merck Patent Gmbh Protein for blocking platelet adhesion
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen
JP2005511005A (ja) * 2001-07-18 2005-04-28 メルク　パテント　ゲゼルシャフト　ミット　ベシュレンクテル　ハフトング 糖タンパク質ｖｉ融合タンパク質
WO2005042043A2 (en) 2003-10-28 2005-05-12 Medtronic, Inc. Methods of preparing crosslinked materials and bioprosthetic devices
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
KR101340580B1 (ko) * 2004-10-12 2013-12-11 보드 오브 트러스티즈 오브 미시건 스테이트 유니버시티 플로로글루시놀의 생합성 및 이로부터1,3-디하이드록시벤젠의 합성
CA2611102A1 (en) * 2005-05-26 2006-11-30 Thomas Jefferson University Method to treat and prevent posterior capsule opacification
CA2623565A1 (en) * 2005-09-28 2007-04-05 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US20080015145A1 (en) * 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
AU2009305636A1 (en) 2008-10-15 2010-04-22 Ionis Pharmaceuticals, Inc. Modulation of Factor 11 expression
WO2012003461A2 (en) 2010-07-02 2012-01-05 Draths Corporation Phloroglucinol synthases and methods of making and using the same
WO2012006244A1 (en) 2010-07-06 2012-01-12 Draths Corporation Method for producing phloroglucinol and dihydrophloroglucinol
WO2012006245A1 (en) 2010-07-06 2012-01-12 Draths Corporation Phloroglucinol reductase and methods of making and using the same
PL3333188T3 (pl) 2010-08-19 2022-05-09 Zoetis Belgium S.A. Przeciwciała anty-ngf i ich zastosowanie
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
DE202012012998U1 (de) 2011-08-31 2014-06-13 Daniel Elias Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels
JP6629069B2 (ja) 2012-06-06 2020-01-15 ゾエティス・エルエルシー イヌ化抗ｎｇｆ抗体およびその方法
US20150190499A1 (en) 2012-07-19 2015-07-09 Zoetis Llc Bovine influenza c virus compositions
AU2013295770A1 (en) 2012-07-27 2015-01-29 Zoetis Services Llc Tick toxin compositions
CA3033759C (en) 2016-08-17 2022-06-14 Pharmaq As Sea lice vaccine
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
EP3765499A1 (en) 2018-03-12 2021-01-20 Zoetis Services LLC Anti-ngf antibodies and methods thereof
MA52011A (fr) 2018-03-16 2021-01-20 Zoetis Services Llc Vaccins peptidiques contre l'interleukine-31
KR20230145511A (ko) 2018-03-16 2023-10-17 조에티스 서비시즈 엘엘씨 수의학적 용도를 위한 인터류킨-31 단클론성 항체
BR112020020957B1 (pt) 2018-05-09 2022-05-10 Ionis Pharmaceuticals, Inc Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos
CN114616325A (zh) 2019-09-11 2022-06-10 硕腾服务有限责任公司 表达禽病原体抗原的重组火鸡疱疹病毒载体和其用途
US20220119513A1 (en) 2020-06-08 2022-04-21 Zoetis Services Llc Anti-tgfb antibodies and therapeutic uses thereof
US20210386854A1 (en) 2020-06-15 2021-12-16 Zoetis Services Llc Cell Line for Production of Marek's Disease Virus Vaccine and Methods of Making and Using the Same
CA3198362A1 (en) 2020-10-07 2022-04-14 Zoetis Services Llc Anti-ngf antibodies and methods of use thereof
TW202221039A (zh) 2020-10-19 2022-06-01 美商碩騰服務公司 犬及貓抑瘤素Ｍ受體β之抗體及其用途
WO2023049917A1 (en) 2021-09-27 2023-03-30 Zoetis Services Llc ANTI- TGFβ1,2,3 ANTIBODIES AND THERAPEUTIC USES THEREOF

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705355A (en) * 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
US4898734A (en) 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
IL86857A (en) * 1988-06-24 1994-04-12 Yissum Res Dev Co Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
CA2052486A1 (en) * 1990-10-09 1992-04-10 Thomas M. Connolly Protein for inhibiting collagen-stimulated platelet aggregation
GB9022040D0 (en) * 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
DE4136513A1 (de) * 1991-11-06 1993-05-13 Basf Ag Neues thrombininhibitorisches protein aus raubwanzen
SK282961B6 (sk) * 1993-07-01 2003-01-09 Merck Patent Gesellschaft Mit Beschr�Nkter Haftung Purifikovaný proteín, spôsob jeho výroby a použitia a farmaceutický prostriedok na jeho báze
DE69434598T3 (de) 1993-07-29 2010-07-29 The United States Of America Represented By The Secretary, Department Of Health And Human Services Verwendung von Paclitaxel und seinen Derivaten zur Herstellung eines Medikaments für die Behandlung von Restenose
RO117971B1 (ro) * 1994-09-12 2002-11-29 Schering Ag Procedeu de obtinere a unei proteine asp pallidipin recombinanta, proteina obtinuta si compozitie farmaceutica cu aceasta
ATE211765T1 (de) * 1994-10-28 2002-01-15 Vitaleech Bioscience N V Neue familie von proteaseinhibitoren und andere biologisch aktive substanzen
US6774107B1 (en) * 1999-03-18 2004-08-10 Merck Patent Gmbh Protein for blocking platelet adhesion
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen

Also Published As

Publication number Publication date
JP2002539788A (ja) 2002-11-26
WO2000056885A1 (en) 2000-09-28
CN1344318A (zh) 2002-04-10
DK1161530T3 (da) 2005-08-08
US7090986B2 (en) 2006-08-15
PL200384B1 (pl) 2008-12-31
CZ20013341A3 (cs) 2002-01-16
EP1161530A1 (en) 2001-12-12
CA2367457C (en) 2010-09-21
HUP0200353A3 (en) 2003-12-29
EP1161530B1 (en) 2005-05-18
AU3166200A (en) 2000-10-09
US20050065084A1 (en) 2005-03-24
HK1045330B (zh) 2005-09-09
MY123371A (en) 2006-05-31
CN1185344C (zh) 2005-01-19
ES2240067T3 (es) 2005-10-16
AU767172B2 (en) 2003-11-06
NO330769B1 (no) 2011-07-11
DE60020220T2 (de) 2006-05-24
HK1045330A1 (en) 2002-11-22
AR023099A1 (es) 2002-09-04
NO20014506D0 (no) 2001-09-17
CO5241328A1 (es) 2003-01-31
RU2292351C2 (ru) 2007-01-27
MXPA01009363A (es) 2002-06-04
PT1161530E (pt) 2005-09-30
HU228068B1 (en) 2012-09-28
PL350147A1 (en) 2002-11-04
JP4805461B2 (ja) 2011-11-02
KR20020008131A (ko) 2002-01-29
US6962801B2 (en) 2005-11-08
SK287496B6 (sk) 2010-12-07
CZ301524B6 (cs) 2010-03-31
SK12902001A3 (sk) 2002-03-05
DE60020220D1 (de) 2005-06-23
HUP0200353A2 (hu) 2002-05-29
CA2367457A1 (en) 2000-09-28
BR0009074A (pt) 2002-01-02
US20060094079A1 (en) 2006-05-04
ATE295883T1 (de) 2005-06-15
KR100788219B1 (ko) 2007-12-26
SI1161530T1 (en) 2005-10-31
US6774107B1 (en) 2004-08-10
NO20014506L (no) 2001-11-16

Similar Documents

Publication Publication Date Title
TR200102729T2 (tr) Platelet yapışmasını bloke etme amaçlı protein
ES2306483T5 (es) Prote�?na inhibidora de la ruta de señalización de wnt.
AR002024A1 (es) Proteinas utiles para el tratamiento de la obesidad, composiciones farmaceuticas que incluyen dichas proteinas para tratamientos anti-obesidady procedimiento para prepararlas.
JP2010155859A (ja) 生物活性ケラチンタンパク質
DE69434538D1 (de) Vaskularer endothelialer wachstumsfaktor 2
NZ279963A (en) Human tissue inhibitor of metalloproteinase-4 (timp-4) and dna (rna) encoding polypeptide which may be derived from atcc 75946
WO1997015598A1 (en) Novel peptide
CN1659184B (zh) 活化凝血酶原的蛋白
KR970701724A (ko) 스타니어스 단백질인 스타니오칼신의 소체(Corpuscles of stannius protein, stanniocalcin)
AU630132B2 (en) Anticoagulant peptides
KR100718589B1 (ko) 세포 부착 및 퍼짐을 촉진하는 펩티드, 그의 단편 및 그의유도체
MY109158A (en) Modified platelet factor-4.
NO980300L (no) Nye höymolekylære humane MP52 proteiner
Mao et al. SM50 repeat-polypeptides self-assemble into discrete matrix subunits and promote appositional calcium carbonate crystal growth during sea urchin tooth biomineralization
TNSN95068A1 (fr) Oligonucleotides pour inhiber le role des isoprenyl proteine transferases
BG105682A (en) Bone stimulating factor
DE69712182D1 (de) Peptide und ihre verwendung in der therapie von krankheiten des zöliakie-formenkreises
US6103691A (en) Utilisation of angiogenin and/or α1 -microglobulin and/or complement factor D in order to inhibit the secretion of proteins
US5232912A (en) Anticoagulant peptides
WO1997012036A3 (en) Bone stimulating factor
KR950703993A (ko) 치주 조직 질환 치료제(periodonal disease remedy)
PT789761E (pt) Scf humano, uma respectiva variante de processamento, sua utilizacao farmaceutica
ATE417061T1 (de) Scorpionpeptid als blutdrucksenkendes mittel
JPH0474132A (ja) 歯根膜ならびに歯槽骨組織再生修復促進剤
ECSP003383A (es) Proteina para bloquear la adherencia plaquetaria