HUP0200353A2 - Fehérje, vérlemezkék tapadásának gátlására - Google Patents

Fehérje, vérlemezkék tapadásának gátlására

Info

Publication number
HUP0200353A2
HUP0200353A2 HU0200353A HUP0200353A HUP0200353A2 HU P0200353 A2 HUP0200353 A2 HU P0200353A2 HU 0200353 A HU0200353 A HU 0200353A HU P0200353 A HUP0200353 A HU P0200353A HU P0200353 A2 HUP0200353 A2 HU P0200353A2
Authority
HU
Hungary
Prior art keywords
protein
collagen
natural
platelet adhesion
adhesion
Prior art date
Application number
HU0200353A
Other languages
English (en)
Inventor
Zisi Fotev
Detlef Güssow
Jürgen Hemberger
Uwe Hofmann
Bernhard Scheuble
Wolfgang Strittmatter
Original Assignee
Merck Patent Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh. filed Critical Merck Patent Gmbh.
Publication of HUP0200353A2 publication Critical patent/HUP0200353A2/hu
Publication of HUP0200353A3 publication Critical patent/HUP0200353A3/hu
Publication of HU228068B1 publication Critical patent/HU228068B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Az orvosi pióca (Hirudo medicinalis) nyálából izolált, természetbenelőforduló fehérjét tárnak fel, amely erősen kötődik kollagénhez,ezáltal a vérlemezkék kollagénhez való természetes tapadásánakinhibitoraként hat. A fehérje molekulatömege körülbelül 12000,izoelektromos pontja savas, és hat ciszteint tartalmaz. A fehérjétmegszekvenálták és klónozták H. medicinalis cDNS-könyvtárból.Apolipeptid előállítására szolgáló rekombináns eljárásokat isfeltárnak. A rekombináns és természetes fehérje hatásos inhibitora akollagénfüggő vérlemezke-tapadásnak, és ezáltal alkalmas különböző,szívbetegséggel és a keringési rendszer betegségeivel kapcsolatosállapotok terápiás kezelésére. Ezenkívül a fehérje alkalmastermészetes és mesterséges kollagénfelületek bevonására annakérdekében, hogy azokat sejtek számára nem tapadóvá tegye, ésmegakadályozza a sejtek aktiválását. Ó
HU0200353A 1999-03-18 2000-03-10 Protein for blocking platelet adhesion HU228068B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99105530 1999-03-18
EP99109503 1999-05-12
PCT/EP2000/002117 WO2000056885A1 (en) 1999-03-18 2000-03-10 Protein for blocking platelet adhesion

Publications (3)

Publication Number Publication Date
HUP0200353A2 true HUP0200353A2 (hu) 2002-05-29
HUP0200353A3 HUP0200353A3 (en) 2003-12-29
HU228068B1 HU228068B1 (en) 2012-09-28

Family

ID=26152935

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0200353A HU228068B1 (en) 1999-03-18 2000-03-10 Protein for blocking platelet adhesion

Country Status (27)

Country Link
US (3) US6774107B1 (hu)
EP (1) EP1161530B1 (hu)
JP (1) JP4805461B2 (hu)
KR (1) KR100788219B1 (hu)
CN (1) CN1185344C (hu)
AR (1) AR023099A1 (hu)
AT (1) ATE295883T1 (hu)
AU (1) AU767172B2 (hu)
BR (1) BR0009074A (hu)
CA (1) CA2367457C (hu)
CO (1) CO5241328A1 (hu)
CZ (1) CZ301524B6 (hu)
DE (1) DE60020220T2 (hu)
DK (1) DK1161530T3 (hu)
ES (1) ES2240067T3 (hu)
HK (1) HK1045330B (hu)
HU (1) HU228068B1 (hu)
MX (1) MXPA01009363A (hu)
MY (1) MY123371A (hu)
NO (1) NO330769B1 (hu)
PL (1) PL200384B1 (hu)
PT (1) PT1161530E (hu)
RU (1) RU2292351C2 (hu)
SI (1) SI1161530T1 (hu)
SK (1) SK287496B6 (hu)
TR (1) TR200102729T2 (hu)
WO (1) WO2000056885A1 (hu)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228068B1 (en) * 1999-03-18 2012-09-28 Merck Patent Gmbh Protein for blocking platelet adhesion
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen
EP1406929A2 (en) * 2001-07-18 2004-04-14 MERCK PATENT GmbH Glycoprotein vi fusion proteins
ATE430593T1 (de) 2003-10-28 2009-05-15 Medtronic Inc Verfahren zur herstellung von vernetzten materialien und bioprothetischen vorrichtungen
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
WO2006044290A2 (en) * 2004-10-12 2006-04-27 Board Of Trustees Of Michigan State University Biosynthesis of philoroglucinol and preparation of 1,3-dihydroxybenzene therefrom
CA2611102A1 (en) * 2005-05-26 2006-11-30 Thomas Jefferson University Method to treat and prevent posterior capsule opacification
US7691839B2 (en) * 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US20080015145A1 (en) * 2006-07-11 2008-01-17 Maria Gyongyossy-Issa Mimotope receptors and inhibitors for platelet-platelet and platelet-endothelium interactions
GB2460915B (en) 2008-06-16 2011-05-25 Biovascular Inc Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor
NO2379084T3 (hu) 2008-10-15 2018-04-21
WO2012003461A2 (en) 2010-07-02 2012-01-05 Draths Corporation Phloroglucinol synthases and methods of making and using the same
WO2012006244A1 (en) 2010-07-06 2012-01-12 Draths Corporation Method for producing phloroglucinol and dihydrophloroglucinol
WO2012006245A1 (en) 2010-07-06 2012-01-12 Draths Corporation Phloroglucinol reductase and methods of making and using the same
ES2910305T3 (es) 2010-08-19 2022-05-12 Zoetis Belgium S A Anticuerpos anti-NGF y su uso
US8790651B2 (en) 2011-07-21 2014-07-29 Zoetis Llc Interleukin-31 monoclonal antibody
DE102012016127A1 (de) 2011-08-31 2013-02-28 Daniel Elias Bioaktive, regenerative Mischung zur Herstellung eines Ergänzungsnahrungsmittels
EP2859018B1 (en) 2012-06-06 2021-09-22 Zoetis Services LLC Caninized anti-ngf antibodies and methods thereof
CN104854128A (zh) 2012-07-19 2015-08-19 硕腾有限责任公司 牛流感病毒组合物
AU2013295770A1 (en) 2012-07-27 2015-01-29 Zoetis Services Llc Tick toxin compositions
CA3033759C (en) 2016-08-17 2022-06-14 Pharmaq As Sea lice vaccine
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
AU2019234213A1 (en) 2018-03-12 2020-09-03 Zoetis Services Llc Anti-NGF antibodies and methods thereof
US11433139B2 (en) 2018-03-16 2022-09-06 Zoetis Services Llc Peptide vaccines against interleukin-31
BR112020017703A2 (pt) 2018-03-16 2021-03-09 Zoetis Services Llc Anticorpos monoclonais de interleucina-31 para uso veterinário
US20210355497A1 (en) 2018-05-09 2021-11-18 Ionis Pharmaceuticals, Inc. Compounds and methods for reducing fxi expression
US11464849B2 (en) 2019-09-11 2022-10-11 Zoetis Services Llc Recombinant herpesvirus of turkey vectors expressing antigens of avian pathogens and uses thereof
US20220119513A1 (en) 2020-06-08 2022-04-21 Zoetis Services Llc Anti-tgfb antibodies and therapeutic uses thereof
US20210386854A1 (en) 2020-06-15 2021-12-16 Zoetis Services Llc Cell Line for Production of Marek's Disease Virus Vaccine and Methods of Making and Using the Same
EP4225788A2 (en) 2020-10-07 2023-08-16 Zoetis Services LLC Anti-ngf antibodies and methods of use thereof
TW202221039A (zh) 2020-10-19 2022-06-01 美商碩騰服務公司 犬及貓抑瘤素Ｍ受體β之抗體及其用途
CA3232382A1 (en) 2021-09-27 2023-03-30 Zoetis Services Llc Anti- tgf.beta.1,2,3 antibodies and therapeutic uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705355A (en) * 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
IL86857A (en) * 1988-06-24 1994-04-12 Yissum Res Dev Co Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
US5182260A (en) * 1989-01-27 1993-01-26 Biogen, Inc. Dna sequences encoding snake venom inhibitors of platelet activation processes for producing those inhibitors and compositions using them
CA2052486A1 (en) * 1990-10-09 1992-04-10 Thomas M. Connolly Protein for inhibiting collagen-stimulated platelet aggregation
GB9022040D0 (en) * 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
DE4136513A1 (de) * 1991-11-06 1993-05-13 Basf Ag Neues thrombininhibitorisches protein aus raubwanzen
CA2143416C (en) * 1993-07-01 2003-06-10 Jurgen Hemberger Inhibitor of collagen-stimulated platelet aggregation
PT1118325E (pt) * 1993-07-29 2006-05-31 Us Health Utilizacao de paclitaxel e seus derivados na preparacao de um medicamento para o tratamento de restenose
NZ293261A (en) * 1994-09-12 1998-11-25 Schering Ag Recombinant pallidipin protein, asp-pallidipin, which inhibits collagen induced platelet aggregation inhibitor
WO1996013585A1 (en) * 1994-10-28 1996-05-09 Clodica S.A. A novel family of protease inhibitors, and other biologic active substances
HU228068B1 (en) * 1999-03-18 2012-09-28 Merck Patent Gmbh Protein for blocking platelet adhesion
MY128992A (en) * 2000-08-25 2007-03-30 Merck Patent Gmbh Saratin for inhibiting platelet adhesion to collagen

Also Published As

Publication number Publication date
SK287496B6 (sk) 2010-12-07
PL350147A1 (en) 2002-11-04
CO5241328A1 (es) 2003-01-31
AR023099A1 (es) 2002-09-04
CN1344318A (zh) 2002-04-10
EP1161530A1 (en) 2001-12-12
EP1161530B1 (en) 2005-05-18
WO2000056885A1 (en) 2000-09-28
NO330769B1 (no) 2011-07-11
JP2002539788A (ja) 2002-11-26
KR20020008131A (ko) 2002-01-29
DE60020220D1 (de) 2005-06-23
MY123371A (en) 2006-05-31
SK12902001A3 (sk) 2002-03-05
CZ301524B6 (cs) 2010-03-31
NO20014506D0 (no) 2001-09-17
ES2240067T3 (es) 2005-10-16
PT1161530E (pt) 2005-09-30
CA2367457C (en) 2010-09-21
CZ20013341A3 (cs) 2002-01-16
HU228068B1 (en) 2012-09-28
HUP0200353A3 (en) 2003-12-29
AU3166200A (en) 2000-10-09
US20060094079A1 (en) 2006-05-04
US6962801B2 (en) 2005-11-08
JP4805461B2 (ja) 2011-11-02
CA2367457A1 (en) 2000-09-28
DE60020220T2 (de) 2006-05-24
TR200102729T2 (tr) 2002-04-22
DK1161530T3 (da) 2005-08-08
MXPA01009363A (es) 2002-06-04
PL200384B1 (pl) 2008-12-31
US6774107B1 (en) 2004-08-10
KR100788219B1 (ko) 2007-12-26
US7090986B2 (en) 2006-08-15
BR0009074A (pt) 2002-01-02
HK1045330B (zh) 2005-09-09
NO20014506L (no) 2001-11-16
AU767172B2 (en) 2003-11-06
SI1161530T1 (en) 2005-10-31
ATE295883T1 (de) 2005-06-15
RU2292351C2 (ru) 2007-01-27
CN1185344C (zh) 2005-01-19
HK1045330A1 (en) 2002-11-22
US20050065084A1 (en) 2005-03-24

Similar Documents

Publication Publication Date Title
HUP0200353A2 (hu) Fehérje, vérlemezkék tapadásának gátlására
AU2003210722B2 (en) Bioactive keratin peptides
BR0109494A (pt) Produção de fatores recombinantes de coagulação do sangue em linhas celulares humanas
HUP9902698A2 (hu) Humán bikunin
NO20050162L (no) Nye antagonister av CXCR3-bindene CXC-kjemokiner
DE10299044I1 (de) n-Terminal chemisch modifizierte Protein-Zusammensetzungen und Methoden
DE69128779D1 (de) Epitheline: neue cystein-reiche, den wachstum modulierende proteine
ATE194658T1 (de) Das dorsalgewebe beeinflussender faktor
EP0372670A3 (en) Hirudin peptides for inhibiting platelet aggregation
FI912240A0 (fi) Antitrombiner.
DE60226323D1 (de) Peptid und dessen kosmetische oder dermatologische verwendung zur verbesserung der haftung zwischen hautzellen
CN101260150B (zh) 犬钩虫抗凝肽及其制备和应用
CN1659184B (zh) 活化凝血酶原的蛋白
ECSP003383A (es) Proteina para bloquear la adherencia plaquetaria
US5847084A (en) Process for obtaining platelet factor-4
HUP0402246A2 (hu) Leukocitaintegrinek új peptidligandjai
PT789761E (pt) Scf humano, uma respectiva variante de processamento, sua utilizacao farmaceutica
WO1997043309A1 (en) Tsetse thrombin inhibitor
ATE139702T1 (de) Die freisetzung des histamin hemmenden faktors sowie diesen enthaltende präparate
DK1556488T3 (da) Human chondroosteomodulin (TIG2), fremstilling og anvendelse heraf til behandling eller diagnose af knoglesygdomme, brusksygdomme, fedme samt inflammatoriske sygdomme og hudsygdomme
JPH03291238A (ja) 角膜障害治療剤
TH34900A (th) โปรตีนยับยั้งความอ้วน
KR20050016333A (ko) 프로트롬빈 활성화 단백질
CN102617722A (zh) 犬钩虫抗凝肽及其制备和应用

Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees