NO20050162L - Nye antagonister av CXCR3-bindene CXC-kjemokiner - Google Patents

Nye antagonister av CXCR3-bindene CXC-kjemokiner

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Publication number
NO20050162L
NO20050162L NO20050162A NO20050162A NO20050162L NO 20050162 L NO20050162 L NO 20050162L NO 20050162 A NO20050162 A NO 20050162A NO 20050162 A NO20050162 A NO 20050162A NO 20050162 L NO20050162 L NO 20050162L
Authority
NO
Norway
Prior art keywords
cxcr3
cxc chemokines
chemokines
binding
binding cxc
Prior art date
Application number
NO20050162A
Other languages
English (en)
Other versions
NO332309B1 (no
Inventor
Amanda Proudfoot
Marie Kosco-Vilbois
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO20050162L publication Critical patent/NO20050162L/no
Publication of NO332309B1 publication Critical patent/NO332309B1/no

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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)

Abstract

Nye antagonister av CXCR3-bindende CXCkjemokiner og spesielt humant CXCLI I kan oppnås gjennom dannelsen av mutanter av slike kjemokiner hvori bindingen til glykosaminoglykaner (GAG'er) er svekket som følge av ikke-konservative substitusjoner av aminosyrer involvert i denne interaksjonen. Forbindelser fremstilt i henhold til den foreliggende oppfinnelse kan anvendes for å blokkere aktiviteten til CXCR3-bindende CXCkjemokiner på CXCR3-uttrykkende celler og derved tilveiebringe terapeutiske preparater for anvendelse i behandlingen eller forebyggingen av sykdommer relatert til overdreven aktivert T-cellemigrering, slik som ved transplantatavstøtning og autoimmune sykdommer, og av sykdommer med behov for økt vaskularisering, slik som ischemisk hjertesykdom.
NO20050162A 2002-06-12 2005-01-12 Antagonister av CXCRX3-bindene CXC-kjemokiner, samt fremgangsmate for fremstilling derav, DNA molekyler kodende for nevnte antagonister, ekspresjonsvektor, vertcelle, farmasoytisk preparat og anvendelse av nevnte antagonister. NO332309B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02100697 2002-06-12
PCT/EP2003/050211 WO2003106488A2 (en) 2002-06-12 2003-06-03 Novel antagonists of cxcr3-binding cxc chemokines

Publications (2)

Publication Number Publication Date
NO20050162L true NO20050162L (no) 2005-01-12
NO332309B1 NO332309B1 (no) 2012-08-20

Family

ID=29724537

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20050162A NO332309B1 (no) 2002-06-12 2005-01-12 Antagonister av CXCRX3-bindene CXC-kjemokiner, samt fremgangsmate for fremstilling derav, DNA molekyler kodende for nevnte antagonister, ekspresjonsvektor, vertcelle, farmasoytisk preparat og anvendelse av nevnte antagonister.

Country Status (16)

Country Link
US (1) US7541435B2 (no)
EP (1) EP1515990B1 (no)
JP (1) JP4394569B2 (no)
AR (1) AR040200A1 (no)
AT (1) ATE359297T1 (no)
AU (1) AU2003255505B2 (no)
CA (1) CA2489298C (no)
CY (1) CY1106799T1 (no)
DE (1) DE60313168T2 (no)
DK (1) DK1515990T3 (no)
ES (1) ES2282666T3 (no)
IL (1) IL165727A (no)
NO (1) NO332309B1 (no)
PT (1) PT1515990E (no)
SI (1) SI1515990T1 (no)
WO (1) WO2003106488A2 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004045525A2 (en) * 2002-11-15 2004-06-03 Morehouse School Of Medicine Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation.
US20090208486A1 (en) * 2004-03-09 2009-08-20 Makoto Taketo Pharmaceutical composition comprising cxcr3 inhibitor
ITFI20040243A1 (it) * 2004-11-25 2005-02-25 Paola Romagnani Metodo diagnostico per la previsione di rigetto di organo trapiantato
WO2006069449A1 (en) * 2004-12-29 2006-07-06 The University Of British Columbia Chemokine receptor-independent immunomodulatory and anti-proliferative activity
WO2006125077A2 (en) * 2005-05-18 2006-11-23 Intermune, Inc. Non-natural chemokine receptor ligands and methods of use thereof
EP2136832B1 (en) 2007-03-26 2015-09-02 General Regeneratives Limited Methods for promoting protection and regeneration of bone marrow using cxcl9 and anti-cxcl9 antibodies
WO2008149354A2 (en) * 2007-06-04 2008-12-11 Rappaport Family Institute For Research In The Medical Sciences Agents for the treatment of inflammatory diseases and methods of using same
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
US10983128B2 (en) 2015-02-05 2021-04-20 Bristol-Myers Squibb Company CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy
WO2016176583A1 (en) * 2015-04-29 2016-11-03 Sanford-Burnham Medical Research Institute Modulation of immune response using btla agonist antibodies
US20180206726A1 (en) 2016-12-07 2018-07-26 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
CA3045310A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
WO2020106754A1 (en) 2018-11-19 2020-05-28 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
WO2021119482A1 (en) 2019-12-13 2021-06-17 Progenity, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
GB202214951D0 (en) * 2022-10-11 2022-11-23 Univ London Queen Mary CXC receptor ligands

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5739103A (en) * 1993-11-12 1998-04-14 Dana-Farber Cancer Institute Chemokine N-terminal deletion mutations
US5656724A (en) 1994-10-26 1997-08-12 Repligen Corporation Chemokine-like proteins and methods of use
US5707829A (en) 1995-08-11 1998-01-13 Genetics Institute, Inc. DNA sequences and secreted proteins encoded thereby
US6140064A (en) 1996-09-10 2000-10-31 Theodor-Kocher Institute Method of detecting or identifying ligands, inhibitors or promoters of CXC chemokine receptor 3
US5977334A (en) 1997-09-11 1999-11-02 The Cleveland Clinic Foundation DNA encoding a chemokine, Beta R1, comprising the Beta R1 promoter
WO2001078708A1 (en) 2000-04-14 2001-10-25 Millennium Pharmaceuticals, Inc. Treating graft rejection with cxcr3 inhibitors
AU2002218769A1 (en) 2000-07-12 2002-01-21 Gryphon Therapeutics, Inc. Chemokine receptor modulators, production and use
US20020111290A1 (en) * 2000-12-01 2002-08-15 Bernhard Homey Uses of mammalian genes and related reagents

Also Published As

Publication number Publication date
CA2489298A1 (en) 2003-12-24
US7541435B2 (en) 2009-06-02
IL165727A0 (en) 2006-01-15
AU2003255505A1 (en) 2003-12-31
WO2003106488A3 (en) 2004-04-15
EP1515990A2 (en) 2005-03-23
WO2003106488A2 (en) 2003-12-24
PT1515990E (pt) 2007-05-31
IL165727A (en) 2010-05-17
SI1515990T1 (sl) 2007-08-31
US20060204498A1 (en) 2006-09-14
EP1515990B1 (en) 2007-04-11
AU2003255505B2 (en) 2009-01-08
JP4394569B2 (ja) 2010-01-06
ES2282666T3 (es) 2007-10-16
NO332309B1 (no) 2012-08-20
DE60313168D1 (de) 2007-05-24
DK1515990T3 (da) 2007-06-11
ATE359297T1 (de) 2007-05-15
CY1106799T1 (el) 2012-10-24
JP2006511200A (ja) 2006-04-06
CA2489298C (en) 2012-09-11
AR040200A1 (es) 2005-03-16
DE60313168T2 (de) 2007-12-20

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