BR0016154A - Depsipeptida e seus congêneres papa uso como imunossupressores - Google Patents

Depsipeptida e seus congêneres papa uso como imunossupressores

Info

Publication number
BR0016154A
BR0016154A BR0016154-3A BR0016154A BR0016154A BR 0016154 A BR0016154 A BR 0016154A BR 0016154 A BR0016154 A BR 0016154A BR 0016154 A BR0016154 A BR 0016154A
Authority
BR
Brazil
Prior art keywords
immunosuppressants
grant
depsipeptide
counterparts
suffering
Prior art date
Application number
BR0016154-3A
Other languages
English (en)
Inventor
Soren Skov
Original Assignee
Xcyte Therapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26865325&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0016154(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Xcyte Therapies Inc filed Critical Xcyte Therapies Inc
Publication of BR0016154A publication Critical patent/BR0016154A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"DEPSIPEPTIDA E SEUS CONGêNERES PARA USO COMO IMUNOSSUPRESSORES". Depsipeptidas e seus congêneres são revelados possuindo a estrutura (I) onde m, n, p, q, X, R~ 1~,R~ 2~ e R~ 3~ são como definidos aqui. Esses compostos, incluindo FR901228, possuem atividade como, por exemplo, imunodepressores, bem como para a prevenção ou tratamento de pacientes que sofrem ou em risco de sofrerem de doenças inflamatórias, doenças autoimuno ou doenças relacionadas ao imuno-sistema incluindo doença de enxerto-versus-hospedeiro e ao aprimoramento da sobrevivência enxerto/tecido em seguida a um transplante. Também são proporcionados métodos para inibir a ativação, proliferação e/ou supressão da segregação de IL-2 dos linfócitos.
BR0016154-3A 1999-12-08 2000-12-06 Depsipeptida e seus congêneres papa uso como imunossupressores BR0016154A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16973199P 1999-12-08 1999-12-08
US19358200P 2000-03-30 2000-03-30
PCT/US2000/033169 WO2001042282A1 (en) 1999-12-08 2000-12-06 Depsipeptide and congeners thereof for use as immunosuppressants

Publications (1)

Publication Number Publication Date
BR0016154A true BR0016154A (pt) 2003-02-25

Family

ID=26865325

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0016154-3A BR0016154A (pt) 1999-12-08 2000-12-06 Depsipeptida e seus congêneres papa uso como imunossupressores

Country Status (16)

Country Link
US (2) US6403555B1 (pt)
EP (3) EP1246839B1 (pt)
JP (4) JP4824890B2 (pt)
KR (1) KR20020062956A (pt)
CN (1) CN1414971A (pt)
AT (3) ATE269354T1 (pt)
AU (1) AU762525B2 (pt)
BR (1) BR0016154A (pt)
CA (1) CA2393682C (pt)
DE (3) DE60011678T2 (pt)
DK (1) DK1438966T3 (pt)
ES (3) ES2225282T3 (pt)
HK (2) HK1049849B (pt)
IL (2) IL149995A0 (pt)
PT (1) PT1438966E (pt)
WO (1) WO2001042282A1 (pt)

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Also Published As

Publication number Publication date
ATE470447T1 (de) 2010-06-15
EP1779859A3 (en) 2007-05-16
DE60033453D1 (de) 2007-03-29
CN1414971A (zh) 2003-04-30
AU762525B2 (en) 2003-06-26
WO2001042282A1 (en) 2001-06-14
DE60044542D1 (de) 2010-07-22
EP1438966A2 (en) 2004-07-21
CA2393682C (en) 2012-01-31
EP1438966B1 (en) 2007-02-14
AU2068001A (en) 2001-06-18
EP1246839A1 (en) 2002-10-09
US6403555B1 (en) 2002-06-11
US6548479B1 (en) 2003-04-15
ATE269354T1 (de) 2004-07-15
IL149995A (en) 2009-09-01
HK1049849B (zh) 2004-12-03
ES2347284T3 (es) 2010-10-27
EP1438966A3 (en) 2004-08-04
ATE353663T1 (de) 2007-03-15
US20020045575A1 (en) 2002-04-18
ES2225282T3 (es) 2005-03-16
DE60033453T2 (de) 2007-11-29
KR20020062956A (ko) 2002-07-31
DE60011678D1 (de) 2004-07-22
EP1779859A2 (en) 2007-05-02
EP1779859B1 (en) 2010-06-09
DK1438966T3 (da) 2007-06-11
JP2003516418A (ja) 2003-05-13
JP2014205714A (ja) 2014-10-30
HK1049849A1 (en) 2003-05-30
WO2001042282A9 (en) 2002-05-30
JP2013107902A (ja) 2013-06-06
DE60011678T2 (de) 2005-07-14
IL149995A0 (en) 2002-12-01
EP1246839B1 (en) 2004-06-16
ES2282751T3 (es) 2007-10-16
JP2011084585A (ja) 2011-04-28
HK1070268A1 (en) 2005-06-17
JP4824890B2 (ja) 2011-11-30
PT1438966E (pt) 2007-05-31
CA2393682A1 (en) 2001-06-14

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