HK1049849B - 用作免疫抑制劑的縮肽及其同類物 - Google Patents
用作免疫抑制劑的縮肽及其同類物Info
- Publication number
- HK1049849B HK1049849B HK03101982.5A HK03101982A HK1049849B HK 1049849 B HK1049849 B HK 1049849B HK 03101982 A HK03101982 A HK 03101982A HK 1049849 B HK1049849 B HK 1049849B
- Authority
- HK
- Hong Kong
- Prior art keywords
- congeners
- immunosuppressants
- grant
- depsipeptide
- suffering
- Prior art date
Links
- 108010002156 Depsipeptides Proteins 0.000 title abstract 2
- 239000000039 congener Substances 0.000 title abstract 2
- 229960003444 immunosuppressant agent Drugs 0.000 title abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 title abstract 2
- OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- -1 FR901228 Chemical class 0.000 abstract 1
- 102000000588 Interleukin-2 Human genes 0.000 abstract 1
- 108010002350 Interleukin-2 Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000004698 lymphocyte Anatomy 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16973199P | 1999-12-08 | 1999-12-08 | |
US19358200P | 2000-03-30 | 2000-03-30 | |
PCT/US2000/033169 WO2001042282A1 (en) | 1999-12-08 | 2000-12-06 | Depsipeptide and congeners thereof for use as immunosuppressants |
Publications (2)
Publication Number | Publication Date |
---|---|
HK1049849A1 HK1049849A1 (en) | 2003-05-30 |
HK1049849B true HK1049849B (zh) | 2004-12-03 |
Family
ID=26865325
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK03101982.5A HK1049849B (zh) | 1999-12-08 | 2003-03-18 | 用作免疫抑制劑的縮肽及其同類物 |
HK05100599A HK1070268A1 (en) | 1999-12-08 | 2005-01-21 | Use of depsipeptide and congeners thereof as immunosuppressants for treating an infectious disease, an autoimmune disease, allergic reactions or a hyperproliferative skin disease |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05100599A HK1070268A1 (en) | 1999-12-08 | 2005-01-21 | Use of depsipeptide and congeners thereof as immunosuppressants for treating an infectious disease, an autoimmune disease, allergic reactions or a hyperproliferative skin disease |
Country Status (16)
Country | Link |
---|---|
US (2) | US6403555B1 (zh) |
EP (3) | EP1438966B1 (zh) |
JP (4) | JP4824890B2 (zh) |
KR (1) | KR20020062956A (zh) |
CN (1) | CN1414971A (zh) |
AT (3) | ATE470447T1 (zh) |
AU (1) | AU762525B2 (zh) |
BR (1) | BR0016154A (zh) |
CA (1) | CA2393682C (zh) |
DE (3) | DE60011678T2 (zh) |
DK (1) | DK1438966T3 (zh) |
ES (3) | ES2282751T3 (zh) |
HK (2) | HK1049849B (zh) |
IL (2) | IL149995A0 (zh) |
PT (1) | PT1438966E (zh) |
WO (1) | WO2001042282A1 (zh) |
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US6822267B1 (en) * | 1997-08-20 | 2004-11-23 | Advantest Corporation | Signal transmission circuit, CMOS semiconductor device, and circuit board |
US8119159B2 (en) | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
WO2002020817A1 (en) | 2000-09-01 | 2002-03-14 | Fujisawa Pharmaceutical Co., Ltd. | A method of producing fr901228 |
WO2002055017A2 (en) * | 2000-11-21 | 2002-07-18 | Wake Forest University | Method of treating autoimmune diseases |
US6632553B2 (en) * | 2001-03-27 | 2003-10-14 | Mti Microfuel Cells, Inc. | Methods and apparatuses for managing effluent products in a fuel cell system |
RU2298414C2 (ru) * | 2001-08-21 | 2007-05-10 | Астеллас Фарма Инк. | Медицинское применение ингибитора гистоновой дезацетилазы и способ оценки его противоопухолевого действия |
US8883148B2 (en) * | 2002-04-26 | 2014-11-11 | Asan Laboratories Company (Cayman), Limited | Prevention of joint destruction |
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US20060275370A1 (en) * | 2002-07-25 | 2006-12-07 | Yih-Lin Chung | Method and compositions for treatment of epithelial damage |
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US6809118B2 (en) * | 2002-07-25 | 2004-10-26 | Yih-Lin Chung | Methods for therapy of radiation cutaneous syndrome |
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US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
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ES2341771T3 (es) * | 2003-06-27 | 2010-06-28 | Astellas Pharma Inc. | Agente terapeutico contra el sarcoma de tejidos blandos. |
US20090285783A1 (en) * | 2003-07-09 | 2009-11-19 | Henry Ford Health System | Methods and compositions for cancer therapy using a novel adenovirus |
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US20050137234A1 (en) * | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
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US7951780B2 (en) * | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
US20050187148A1 (en) * | 2004-02-25 | 2005-08-25 | Yoshinori Naoe | Antitumor agent |
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WO2007011626A2 (en) | 2005-07-14 | 2007-01-25 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
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JP2009525955A (ja) * | 2006-01-13 | 2009-07-16 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
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US9539303B2 (en) | 2006-04-24 | 2017-01-10 | Celgene Corporation | Treatment of Ras-expressing tumors |
US8957027B2 (en) | 2006-06-08 | 2015-02-17 | Celgene Corporation | Deacetylase inhibitor therapy |
US20070292512A1 (en) * | 2006-06-09 | 2007-12-20 | Merrion Research Ii Limited | Solid Oral Dosage Form Containing an Enhancer |
US7883855B2 (en) | 2006-07-21 | 2011-02-08 | Abbott Laboratories | Immunosuppressant drug extraction reagent for immunoassays |
MX2009002893A (es) | 2006-09-18 | 2009-07-10 | Raptor Pharmaceutical Inc | Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap). |
AU2007323215B2 (en) * | 2006-11-22 | 2012-07-19 | Karus Therapeutics Limited | Depsipeptides and their therapeutic use |
GB0623388D0 (en) * | 2006-11-23 | 2007-01-03 | Univ Southampton | Chemical compounds |
CN101687010A (zh) | 2006-12-29 | 2010-03-31 | 格洛斯特制药公司 | 制备Romidepsin |
CN101801994A (zh) * | 2006-12-29 | 2010-08-11 | 格洛斯特制药公司 | 制备Romidepsin |
US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
WO2008151306A1 (en) * | 2007-06-05 | 2008-12-11 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University | Synthesis of cyclodepsipeptide compounds having antineoplastic and/or antimicrobial activity |
GB0715750D0 (en) * | 2007-08-13 | 2007-09-19 | Karus Therapeutics Ltd | Chemical compounds |
EP2232264B1 (en) * | 2007-12-19 | 2015-12-02 | Abbott Laboratories | Immunosuppressant drug extraction reagent for immunoassays |
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EP2293846B1 (en) * | 2008-05-22 | 2013-07-10 | Karus Therapeutics Limited | Depsipeptides and their therapeutic use |
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TWI412359B (zh) * | 2009-07-07 | 2013-10-21 | Asan Lab Co Ltd | 組織蛋白去乙醯酵素抑制劑在製備治療或減緩黏膜/皮膚或眼睛毒性或副作用之藥物的用途 |
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US8859502B2 (en) | 2010-09-13 | 2014-10-14 | Celgene Corporation | Therapy for MLL-rearranged leukemia |
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AU2012204213A1 (en) | 2011-01-07 | 2013-06-13 | Merrion Research Iii Limited | Pharmaceutical compositions of iron for oral administration |
US9963482B2 (en) | 2011-09-30 | 2018-05-08 | Tohoku University | Phosphatidylinositol-3-kinase inhibitor and pharmaceutical composition |
WO2013148260A1 (en) | 2012-03-30 | 2013-10-03 | Washington University | Methods for modulating tau expression for reducing seizure and modifying a neurodegenerative syndrome |
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TWI657819B (zh) | 2013-07-19 | 2019-05-01 | 美商Ionis製藥公司 | 用於調節τ蛋白表現之組合物 |
NZ630311A (en) | 2013-12-27 | 2016-03-31 | Celgene Corp | Romidepsin formulations and uses thereof |
KR20150140177A (ko) * | 2014-06-05 | 2015-12-15 | 한미약품 주식회사 | 단백질 및 펩타이드의 면역원성을 감소시키는 방법 |
JP7211704B2 (ja) | 2015-01-29 | 2023-01-24 | ノヴォ ノルディスク アー/エス | Glp-1アゴニスト及び腸溶コーティングを含む錠剤 |
CN110760564A (zh) * | 2019-10-16 | 2020-02-07 | 菲诺克生物科技(上海)有限公司 | 细胞周期检测方法及其所用试剂与试剂盒 |
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-
2000
- 2000-12-06 AT AT07002930T patent/ATE470447T1/de not_active IP Right Cessation
- 2000-12-06 EP EP04007814A patent/EP1438966B1/en not_active Expired - Lifetime
- 2000-12-06 CN CN00817856A patent/CN1414971A/zh active Pending
- 2000-12-06 WO PCT/US2000/033169 patent/WO2001042282A1/en active IP Right Grant
- 2000-12-06 DK DK04007814T patent/DK1438966T3/da active
- 2000-12-06 DE DE60011678T patent/DE60011678T2/de not_active Expired - Lifetime
- 2000-12-06 ES ES04007814T patent/ES2282751T3/es not_active Expired - Lifetime
- 2000-12-06 PT PT04007814T patent/PT1438966E/pt unknown
- 2000-12-06 JP JP2001543579A patent/JP4824890B2/ja not_active Expired - Fee Related
- 2000-12-06 ES ES07002930T patent/ES2347284T3/es not_active Expired - Lifetime
- 2000-12-06 DE DE60044542T patent/DE60044542D1/de not_active Expired - Lifetime
- 2000-12-06 AT AT04007814T patent/ATE353663T1/de not_active IP Right Cessation
- 2000-12-06 IL IL14999500A patent/IL149995A0/xx unknown
- 2000-12-06 DE DE60033453T patent/DE60033453T2/de not_active Expired - Lifetime
- 2000-12-06 EP EP00983997A patent/EP1246839B1/en not_active Revoked
- 2000-12-06 BR BR0016154-3A patent/BR0016154A/pt not_active Application Discontinuation
- 2000-12-06 AT AT00983997T patent/ATE269354T1/de not_active IP Right Cessation
- 2000-12-06 US US09/732,183 patent/US6403555B1/en not_active Expired - Lifetime
- 2000-12-06 AU AU20680/01A patent/AU762525B2/en not_active Ceased
- 2000-12-06 EP EP07002930A patent/EP1779859B1/en not_active Expired - Lifetime
- 2000-12-06 CA CA2393682A patent/CA2393682C/en not_active Expired - Fee Related
- 2000-12-06 KR KR1020027007258A patent/KR20020062956A/ko not_active Application Discontinuation
- 2000-12-06 ES ES00983997T patent/ES2225282T3/es not_active Expired - Lifetime
-
2002
- 2002-04-02 US US10/115,576 patent/US6548479B1/en not_active Expired - Lifetime
- 2002-06-03 IL IL149995A patent/IL149995A/en not_active IP Right Cessation
-
2003
- 2003-03-18 HK HK03101982.5A patent/HK1049849B/zh not_active IP Right Cessation
-
2005
- 2005-01-21 HK HK05100599A patent/HK1070268A1/xx not_active IP Right Cessation
-
2011
- 2011-01-28 JP JP2011017260A patent/JP2011084585A/ja not_active Withdrawn
-
2013
- 2013-03-06 JP JP2013043969A patent/JP2013107902A/ja not_active Withdrawn
-
2014
- 2014-07-31 JP JP2014155914A patent/JP2014205714A/ja not_active Withdrawn
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