NO330130B1 - N-aryldiazaspiracykliske forbindelser og farmasoytisk sammensetning - Google Patents
N-aryldiazaspiracykliske forbindelser og farmasoytisk sammensetning Download PDFInfo
- Publication number
- NO330130B1 NO330130B1 NO20050012A NO20050012A NO330130B1 NO 330130 B1 NO330130 B1 NO 330130B1 NO 20050012 A NO20050012 A NO 20050012A NO 20050012 A NO20050012 A NO 20050012A NO 330130 B1 NO330130 B1 NO 330130B1
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- diazaspiro
- nonane
- disorders
- pyridyl
- Prior art date
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- 150000001875 compounds Chemical class 0.000 title claims abstract description 205
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 21
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000001424 substituent group Chemical group 0.000 claims description 11
- NXIPMBQVNTWEEX-UHFFFAOYSA-N 7-pyridin-3-yl-1,7-diazaspiro[4.4]nonane Chemical compound C1CCNC21CN(C=1C=NC=CC=1)CC2 NXIPMBQVNTWEEX-UHFFFAOYSA-N 0.000 claims description 9
- BKIMMITUMNQMOS-UHFFFAOYSA-N nonane Chemical compound CCCCCCCCC BKIMMITUMNQMOS-UHFFFAOYSA-N 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- NYXIDUKKGAMMGZ-UHFFFAOYSA-N 7-(5-phenoxypyridin-3-yl)-1,7-diazaspiro[4.4]nonane Chemical compound C1CCNC21CN(C=1C=C(OC=3C=CC=CC=3)C=NC=1)CC2 NYXIDUKKGAMMGZ-UHFFFAOYSA-N 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- DHAJUFYBSWNDLJ-UHFFFAOYSA-N 7-pyrimidin-5-yl-1,7-diazaspiro[4.4]nonane Chemical compound C1CCNC21CN(C=1C=NC=NC=1)CC2 DHAJUFYBSWNDLJ-UHFFFAOYSA-N 0.000 claims description 3
- AVILZJWTGCBUAV-UHFFFAOYSA-N 4-[5-(1,7-diazaspiro[4.4]nonan-7-yl)pyridin-3-yl]oxyphenol Chemical compound C1=CC(O)=CC=C1OC1=CN=CC(N2CC3(NCCC3)CC2)=C1 AVILZJWTGCBUAV-UHFFFAOYSA-N 0.000 claims description 2
- YMBNXPNQYNMPAK-UHFFFAOYSA-N 5-(1,7-diazaspiro[4.4]nonan-7-yl)-1,2-oxazole Chemical compound C1CCNC21CN(C=1ON=CC=1)CC2 YMBNXPNQYNMPAK-UHFFFAOYSA-N 0.000 claims description 2
- HUDDCCGNQQQGEE-UHFFFAOYSA-N 7-(5-ethynylpyridin-3-yl)-1,7-diazaspiro[4.4]nonane Chemical compound C#CC1=CN=CC(N2CC3(NCCC3)CC2)=C1 HUDDCCGNQQQGEE-UHFFFAOYSA-N 0.000 claims description 2
- UGDSYGHDYFSOJQ-UHFFFAOYSA-N 7-(5-methoxypyridin-3-yl)-1,7-diazaspiro[4.4]nonane Chemical compound COC1=CN=CC(N2CC3(NCCC3)CC2)=C1 UGDSYGHDYFSOJQ-UHFFFAOYSA-N 0.000 claims description 2
- IQMOKOUVFKGBSZ-UHFFFAOYSA-N 7-(6-chloropyridin-3-yl)-1,7-diazaspiro[4.4]nonane Chemical compound C1=NC(Cl)=CC=C1N1CC2(NCCC2)CC1 IQMOKOUVFKGBSZ-UHFFFAOYSA-N 0.000 claims description 2
- QSSIQJNDVNWZIP-UHFFFAOYSA-N 7-(6-methoxypyridazin-3-yl)-1,7-diazaspiro[4.4]nonane Chemical compound N1=NC(OC)=CC=C1N1CC2(NCCC2)CC1 QSSIQJNDVNWZIP-UHFFFAOYSA-N 0.000 claims description 2
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- DEUMPRMCEZXKOS-UHFFFAOYSA-N 7-pyridazin-3-yl-1,7-diazaspiro[4.4]nonane Chemical compound C1CCNC21CN(C=1N=NC=CC=1)CC2 DEUMPRMCEZXKOS-UHFFFAOYSA-N 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000004076 pyridyl group Chemical group 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 88
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 12
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Classifications
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39433702P | 2002-07-05 | 2002-07-05 | |
| PCT/US2003/020524 WO2004005293A2 (en) | 2002-07-05 | 2003-06-27 | N-aryl diazaspiracyclic compounds and methods of preparation and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20050012L NO20050012L (no) | 2005-04-01 |
| NO330130B1 true NO330130B1 (no) | 2011-02-21 |
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Family Applications (1)
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| EP (2) | EP2078718A1 (pt) |
| JP (2) | JP4749715B2 (pt) |
| KR (1) | KR101052287B1 (pt) |
| CN (1) | CN100564381C (pt) |
| AT (1) | ATE451373T1 (pt) |
| AU (1) | AU2003245753B2 (pt) |
| BR (1) | BR0312414A (pt) |
| CA (1) | CA2491506C (pt) |
| CY (1) | CY1110291T1 (pt) |
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| DK (1) | DK1519939T5 (pt) |
| EA (1) | EA009789B1 (pt) |
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| MX (1) | MXPA05000370A (pt) |
| NO (1) | NO330130B1 (pt) |
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| PL (1) | PL374434A1 (pt) |
| PT (1) | PT1519939E (pt) |
| SI (1) | SI1519939T1 (pt) |
| WO (1) | WO2004005293A2 (pt) |
| ZA (1) | ZA200500070B (pt) |
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