NO329927B1 - Anvendelse av karboksamidiner for fremstilling av medikament for behandling av sykdom - Google Patents
Anvendelse av karboksamidiner for fremstilling av medikament for behandling av sykdom Download PDFInfo
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- NO329927B1 NO329927B1 NO20023855A NO20023855A NO329927B1 NO 329927 B1 NO329927 B1 NO 329927B1 NO 20023855 A NO20023855 A NO 20023855A NO 20023855 A NO20023855 A NO 20023855A NO 329927 B1 NO329927 B1 NO 329927B1
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- cells
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- compounds
- viramidin
- ribavirin
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18267600P | 2000-02-15 | 2000-02-15 | |
| US09/595,365 US6455508B1 (en) | 2000-02-15 | 2000-10-05 | Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides |
| PCT/US2001/040148 WO2001060379A1 (fr) | 2000-02-15 | 2001-02-15 | Analogues nucleosidiques comportant une base monocyclique de carboxamidine modifiee |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20023855D0 NO20023855D0 (no) | 2002-08-14 |
| NO20023855L NO20023855L (no) | 2002-10-08 |
| NO329927B1 true NO329927B1 (no) | 2011-01-24 |
Family
ID=26878297
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023855A NO329927B1 (no) | 2000-02-15 | 2002-08-14 | Anvendelse av karboksamidiner for fremstilling av medikament for behandling av sykdom |
| NO20023852A NO20023852L (no) | 2000-02-15 | 2002-08-14 | Nukleosidanaloger med karboksamidin-modifisert bisyklisk base |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20023852A NO20023852L (no) | 2000-02-15 | 2002-08-14 | Nukleosidanaloger med karboksamidin-modifisert bisyklisk base |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US6455508B1 (fr) |
| EP (3) | EP1257281B8 (fr) |
| JP (3) | JP4975930B2 (fr) |
| KR (2) | KR100811927B1 (fr) |
| CN (2) | CN1268335C (fr) |
| AT (1) | ATE377422T1 (fr) |
| AU (2) | AU783142B2 (fr) |
| BR (2) | BR0108401A (fr) |
| CA (2) | CA2399208C (fr) |
| CY (1) | CY1107103T1 (fr) |
| CZ (2) | CZ302327B6 (fr) |
| DE (1) | DE60131250T8 (fr) |
| DK (1) | DK1257281T3 (fr) |
| ES (2) | ES2295148T3 (fr) |
| HK (1) | HK1051149A1 (fr) |
| HR (2) | HRP20020583A2 (fr) |
| HU (2) | HU229480B1 (fr) |
| IL (3) | IL150555A0 (fr) |
| MX (2) | MXPA02007931A (fr) |
| NO (2) | NO329927B1 (fr) |
| NZ (2) | NZ520877A (fr) |
| PL (2) | PL365239A1 (fr) |
| PT (1) | PT1257281E (fr) |
| RS (1) | RS20090086A (fr) |
| RU (2) | RU2002120483A (fr) |
| SI (2) | SI21076A (fr) |
| SK (2) | SK11572002A3 (fr) |
| WO (2) | WO2001060381A1 (fr) |
| YU (1) | YU61502A (fr) |
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| US6831069B2 (en) * | 1999-08-27 | 2004-12-14 | Ribapharm Inc. | Pyrrolo[2,3-d]pyrimidine nucleoside analogs |
| US7638496B2 (en) * | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
| US7056895B2 (en) * | 2000-02-15 | 2006-06-06 | Valeant Pharmaceuticals International | Tirazole nucleoside analogs and methods for using same |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20030036189A (ko) * | 2000-05-26 | 2003-05-09 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| CN1267446C (zh) | 2001-01-22 | 2006-08-02 | 默克公司 | 作为依赖于rna的rna病毒聚合酶的抑制剂的核苷衍生物 |
| WO2003037908A1 (fr) * | 2001-10-31 | 2003-05-08 | Ribapharm Inc. | Therapie de combinaison antivirale et compositions |
| AU2003248748A1 (en) | 2002-06-28 | 2004-01-19 | Idenix (Cayman) Limited | 2'-c-methyl-3'-o-l-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections |
| CN101172993A (zh) | 2002-06-28 | 2008-05-07 | 埃迪尼克斯(开曼)有限公司 | 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷 |
| US7608600B2 (en) | 2002-06-28 | 2009-10-27 | Idenix Pharmaceuticals, Inc. | Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections |
| KR20050088079A (ko) | 2002-11-15 | 2005-09-01 | 이데닉스 (케이만) 리미티드 | 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이 |
| EP2319853B1 (fr) | 2002-12-12 | 2014-03-12 | IDENIX Pharmaceuticals, Inc. | Procédé de production de nucléosides ramifiés en 2' |
| RU2005133093A (ru) * | 2003-03-28 | 2006-07-27 | Фармассет, Инк. (Us) | Соединения для лечения флавивирусных инфекций |
| US20040197287A1 (en) * | 2003-04-04 | 2004-10-07 | The Procter & Gamble Company | Personal care composition containing an antidandruff component and a nonionic surfactant |
| US20040202636A1 (en) * | 2003-04-11 | 2004-10-14 | Kaczvinsky Joseph Robert | Personal care composition containing an antidandruff component and a nonionic surfactant |
| US20040197292A1 (en) * | 2003-04-04 | 2004-10-07 | The Procter & Gamble Company | Personal care composition containing an antidandruff component and a nonionic surfactant |
| US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
| US20050009848A1 (en) * | 2003-07-10 | 2005-01-13 | Icn Pharmaceuticals Switzerland Ltd. | Use of antivirals against inflammatory bowel diseases |
| WO2005018330A1 (fr) * | 2003-08-18 | 2005-03-03 | Pharmasset, Inc. | Regime de dosage pour therapie contre flaviviridae |
| US20050095218A1 (en) * | 2003-10-29 | 2005-05-05 | The Procter & Gamble Company | Personal care composition containing a detersive surfactant, an antidandruff component, and ketoamide surfactants |
| US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
| AU2005254057B2 (en) | 2004-06-15 | 2011-02-17 | Isis Pharmaceuticals, Inc. | C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase |
| JP4516863B2 (ja) * | 2005-03-11 | 2010-08-04 | 株式会社ケンウッド | 音声合成装置、音声合成方法及びプログラム |
| CA2606195C (fr) | 2005-05-02 | 2015-03-31 | Merck And Co., Inc. | Inhibiteurs de la protease ns3 du vhc |
| TWI387603B (zh) | 2005-07-20 | 2013-03-01 | Merck Sharp & Dohme | Ｈｃｖ ｎｓ３蛋白酶抑制劑 |
| US8278322B2 (en) | 2005-08-01 | 2012-10-02 | Merck Sharp & Dohme Corp. | HCV NS3 protease inhibitors |
| US7781576B2 (en) | 2005-12-23 | 2010-08-24 | Idenix Pharmaceuticals, Inc. | Process for preparing a synthetic intermediate for preparation of branched nucleosides |
| JP2009522281A (ja) * | 2005-12-28 | 2009-06-11 | トランスレーショナル セラピューティクス，インク． | 翻訳機能障害に基づく治療法 |
| US8497292B2 (en) | 2005-12-28 | 2013-07-30 | Translational Therapeutics, Inc. | Translational dysfunction based therapeutics |
| GB0609492D0 (en) | 2006-05-15 | 2006-06-21 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| GB0612423D0 (en) | 2006-06-23 | 2006-08-02 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| US7842672B2 (en) | 2006-07-07 | 2010-11-30 | Gilead Sciences, Inc. | Phosphonate inhibitors of HCV |
| CN101583372A (zh) | 2006-10-24 | 2009-11-18 | 默克公司 | Hcv ns3蛋白酶抑制剂 |
| CA2667165A1 (fr) | 2006-10-24 | 2008-05-02 | Merck & Co., Inc. | Inhibiteurs de la protease hcv ns3 |
| AU2007309544B2 (en) | 2006-10-24 | 2012-05-31 | Msd Italia S.R.L. | HCV NS3 protease inhibitors |
| KR101615500B1 (ko) | 2006-10-27 | 2016-04-27 | 머크 샤프 앤드 돔 코포레이션 | Ｈｃｖ ｎｓ3 프로테아제 억제제 |
| JP5352464B2 (ja) | 2006-10-27 | 2013-11-27 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｈｃｖｎｓ３プロテアーゼ阻害剤 |
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| GB0625349D0 (en) | 2006-12-20 | 2007-01-31 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
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| RU2466729C2 (ru) * | 2006-12-28 | 2012-11-20 | Айденикс Фармасьютикалз, Инк. | Соединения и фармацевтические композиции для лечения вирусных инфекций |
| CN101754970B (zh) | 2007-07-17 | 2013-07-10 | P.安杰莱蒂分子生物学研究所 | 用于治疗丙型肝炎的大环吲哚衍生物 |
| CA2699891C (fr) | 2007-07-19 | 2013-10-22 | Nigel Liverton | Composes macrocycliques servant d'agents antiviraux |
| JP2011518882A (ja) | 2008-04-28 | 2011-06-30 | メルク・シャープ・エンド・ドーム・コーポレイション | Ｈｃｖｎｓ３プロテアーゼ阻害剤 |
| DK2310095T3 (da) | 2008-07-22 | 2012-12-10 | Merck Sharp & Dohme | Makrocykliske quinoxalinforbindelser som hcv-ns3-protease-inhibitorer |
| WO2010082050A1 (fr) | 2009-01-16 | 2010-07-22 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Composés benzoxazocines substitués 7-aminoalkyle macrocycycliques destinés au traitement des infections par hépatite c |
| GB0900914D0 (en) | 2009-01-20 | 2009-03-04 | Angeletti P Ist Richerche Bio | Antiviral agents |
| EP2459582B1 (fr) | 2009-07-30 | 2015-05-27 | Merck Sharp & Dohme Corp. | Inhibiteurs de protéase ns3 du virus de l'hépatite c |
| EP2780026B1 (fr) | 2011-11-15 | 2019-10-23 | Merck Sharp & Dohme Corp. | Inhibiteurs de la protéase ns3 du vhc |
| US20140356325A1 (en) | 2012-01-12 | 2014-12-04 | Ligand Pharmaceuticals Incorporated | Novel 2'-c-methyl nucleoside derivative compounds |
| CN102978264B (zh) * | 2012-11-14 | 2014-12-10 | 广东肇庆星湖生物科技股份有限公司 | 一种他立韦林的制备方法 |
| WO2014121418A1 (fr) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tétracycliques et leurs méthodes d'utilisation pour le traitement de l'hépatite c |
| WO2014121417A1 (fr) | 2013-02-07 | 2014-08-14 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tétracycliques et leurs procédés d'utilisation pour le traitement de l'hépatite c |
| EP3105238A4 (fr) | 2014-02-13 | 2017-11-08 | Ligand Pharmaceuticals, Inc. | Composés de promédicaments et leurs utilisations |
| EP3164136A4 (fr) | 2014-07-02 | 2018-04-04 | Ligand Pharmaceuticals, Inc. | Composés de promédicaments et leurs utilisations |
| JP2018523665A (ja) | 2015-08-06 | 2018-08-23 | キメリックス インコーポレイテッド | 抗ウイルス剤として有用なピロロピリミジンヌクレオシドおよびその類縁体 |
| EP3684771A1 (fr) | 2017-09-21 | 2020-07-29 | Chimerix, Inc. | Formes morphiques de 4-amino-7-(3,4-dihydroxy-5-(hydroxyméthyle)tétrahydrofurane-2-yl)-2-méthyle-7 h-pyrrolo[2,3-d]pyrimidine-5-carboxamide et leurs utilisations |
| CN111788196A (zh) | 2018-01-09 | 2020-10-16 | 配体药物公司 | 缩醛化合物及其治疗用途 |
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| US3991078A (en) | 1971-06-01 | 1976-11-09 | Icn Pharmaceuticals, Inc. | N-substituted 1,2,4-triazoles |
| US3798209A (en) | 1971-06-01 | 1974-03-19 | Icn Pharmaceuticals | 1,2,4-triazole nucleosides |
| US3984396A (en) | 1971-06-01 | 1976-10-05 | Icn Pharmaceuticals, Inc. | 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters |
| USRE29835E (en) | 1971-06-01 | 1978-11-14 | Icn Pharmaceuticals | 1,2,4-Triazole nucleosides |
| US3962211A (en) * | 1975-01-13 | 1976-06-08 | The University Of Utah | 7-substituted nucleoside compounds |
| US4093624A (en) | 1977-01-31 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 1,2,4-Thiadiazolidine-3,5-dione |
| JPS6426593A (en) | 1987-07-21 | 1989-01-27 | Asahi Glass Co Ltd | Nucleoside derivative |
| US4892865A (en) * | 1987-12-01 | 1990-01-09 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents |
| US5767097A (en) * | 1996-01-23 | 1998-06-16 | Icn Pharmaceuticals, Inc. | Specific modulation of Th1/Th2 cytokine expression by ribavirin in activated T-lymphocytes |
| DE69712316T2 (de) * | 1996-01-23 | 2003-01-02 | Icn Pharmaceuticals | Modulation der th1/th2 cytokinexpression durch ribavirin in aktivierten t-lymphozyten |
| ATE238328T1 (de) * | 1996-10-16 | 2003-05-15 | Ribapharm Inc | Monozyklische l-nukleoside, analoga und ihre anwendungen |
| PL354094A1 (en) * | 1999-08-27 | 2003-12-29 | Icn Pharmaceuticals, Inc.Icn Pharmaceuticals, Inc. | Pyrrolo[2,3-d]pyrimidine nucleoside analogs |
-
2000
- 2000-10-05 US US09/595,365 patent/US6455508B1/en not_active Expired - Lifetime
-
2001
- 2001-02-15 CN CNB018077455A patent/CN1268335C/zh not_active Expired - Fee Related
- 2001-02-15 YU YU61502A patent/YU61502A/sh unknown
- 2001-02-15 JP JP2001559475A patent/JP4975930B2/ja not_active Expired - Fee Related
- 2001-02-15 EP EP01920996A patent/EP1257281B8/fr not_active Expired - Lifetime
- 2001-02-15 WO PCT/US2001/005172 patent/WO2001060381A1/fr active Search and Examination
- 2001-02-15 DE DE60131250T patent/DE60131250T8/de active Active
- 2001-02-15 CN CN01805036A patent/CN1420779A/zh active Pending
- 2001-02-15 ES ES01920996T patent/ES2295148T3/es not_active Expired - Lifetime
- 2001-02-15 SK SK1157-2002A patent/SK11572002A3/sk unknown
- 2001-02-15 CZ CZ20022798A patent/CZ302327B6/cs not_active IP Right Cessation
- 2001-02-15 KR KR1020027010417A patent/KR100811927B1/ko not_active IP Right Cessation
- 2001-02-15 KR KR1020027010593A patent/KR20030005190A/ko not_active Application Discontinuation
- 2001-02-15 MX MXPA02007931A patent/MXPA02007931A/es active IP Right Grant
- 2001-02-15 AU AU47988/01A patent/AU783142B2/en not_active Ceased
- 2001-02-15 HU HU0300027A patent/HU229480B1/hu unknown
- 2001-02-15 CA CA2399208A patent/CA2399208C/fr not_active Expired - Fee Related
- 2001-02-15 WO PCT/US2001/040148 patent/WO2001060379A1/fr active Search and Examination
- 2001-02-15 MX MXPA02007932A patent/MXPA02007932A/es unknown
- 2001-02-15 SK SK1149-2002A patent/SK287765B6/sk not_active IP Right Cessation
- 2001-02-15 JP JP2001559477A patent/JP2004510691A/ja active Pending
- 2001-02-15 PT PT01920996T patent/PT1257281E/pt unknown
- 2001-02-15 EP EP07107588.1A patent/EP1813278B9/fr not_active Expired - Lifetime
- 2001-02-15 RU RU2002120483/14A patent/RU2002120483A/ru not_active Application Discontinuation
- 2001-02-15 RS RSP-2009/0086A patent/RS20090086A/sr unknown
- 2001-02-15 IL IL15055501A patent/IL150555A0/xx unknown
- 2001-02-15 NZ NZ52087701A patent/NZ520877A/xx not_active IP Right Cessation
- 2001-02-15 PL PL01365239A patent/PL365239A1/xx unknown
- 2001-02-15 SI SI200120010A patent/SI21076A/sl not_active IP Right Cessation
- 2001-02-15 BR BR0108401-1A patent/BR0108401A/pt not_active IP Right Cessation
- 2001-02-15 SI SI200120011A patent/SI21077A/sl not_active IP Right Cessation
- 2001-02-15 RU RU2002120922/15A patent/RU2259831C2/ru active
- 2001-02-15 DK DK01920996T patent/DK1257281T3/da active
- 2001-02-15 HU HU0300912A patent/HUP0300912A2/hu unknown
- 2001-02-15 EP EP01910892A patent/EP1278528A4/fr not_active Withdrawn
- 2001-02-15 PL PL357945A patent/PL200140B1/pl unknown
- 2001-02-15 CZ CZ20022799A patent/CZ20022799A3/cs unknown
- 2001-02-15 AU AU38450/01A patent/AU3845001A/en not_active Abandoned
- 2001-02-15 BR BR0108402-0A patent/BR0108402A/pt not_active Application Discontinuation
- 2001-02-15 AT AT01920996T patent/ATE377422T1/de active
- 2001-02-15 NZ NZ521390A patent/NZ521390A/en unknown
- 2001-02-15 CA CA002395854A patent/CA2395854A1/fr not_active Abandoned
- 2001-02-15 ES ES07107588.1T patent/ES2528429T3/es not_active Expired - Lifetime
- 2001-02-15 IL IL15099001A patent/IL150990A0/xx unknown
-
2002
- 2002-07-08 HR HR20020583A patent/HRP20020583A2/xx not_active Application Discontinuation
- 2002-07-30 IL IL150990A patent/IL150990A/en not_active IP Right Cessation
- 2002-08-07 HR HR20020657A patent/HRP20020657A2/hr not_active Application Discontinuation
- 2002-08-14 NO NO20023855A patent/NO329927B1/no not_active IP Right Cessation
- 2002-08-14 NO NO20023852A patent/NO20023852L/no not_active Application Discontinuation
-
2003
- 2003-05-19 HK HK03103531A patent/HK1051149A1/xx not_active IP Right Cessation
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2007
- 2007-12-19 CY CY20071101614T patent/CY1107103T1/el unknown
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2009
- 2009-01-29 JP JP2009018382A patent/JP5253204B2/ja not_active Expired - Fee Related
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