NO329500B1 - Flytende farmasoytiske palonosetronformuleringer - Google Patents
Flytende farmasoytiske palonosetronformuleringer Download PDFInfo
- Publication number
- NO329500B1 NO329500B1 NO20053987A NO20053987A NO329500B1 NO 329500 B1 NO329500 B1 NO 329500B1 NO 20053987 A NO20053987 A NO 20053987A NO 20053987 A NO20053987 A NO 20053987A NO 329500 B1 NO329500 B1 NO 329500B1
- Authority
- NO
- Norway
- Prior art keywords
- palonosetron
- solution
- acid
- pharmaceutically acceptable
- mannitol
- Prior art date
Links
- 229960002131 palonosetron Drugs 0.000 title claims abstract description 43
- CPZBLNMUGSZIPR-NVXWUHKLSA-N palonosetron Chemical compound C1N(CC2)CCC2[C@@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@H]3C1 CPZBLNMUGSZIPR-NVXWUHKLSA-N 0.000 title claims abstract description 43
- 239000000203 mixture Substances 0.000 title abstract description 40
- 238000009472 formulation Methods 0.000 title abstract description 39
- 239000007788 liquid Substances 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 claims abstract description 24
- 206010047700 Vomiting Diseases 0.000 claims abstract description 22
- 238000001990 intravenous administration Methods 0.000 claims abstract description 9
- 239000000243 solution Substances 0.000 claims description 38
- OLDRWYVIKMSFFB-SSPJITILSA-N palonosetron hydrochloride Chemical compound Cl.C1N(CC2)CCC2[C@@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@H]3C1 OLDRWYVIKMSFFB-SSPJITILSA-N 0.000 claims description 30
- 229960003359 palonosetron hydrochloride Drugs 0.000 claims description 29
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 17
- 229930195725 Mannitol Natural products 0.000 claims description 17
- 239000000594 mannitol Substances 0.000 claims description 17
- 235000010355 mannitol Nutrition 0.000 claims description 17
- 239000003937 drug carrier Substances 0.000 claims description 15
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 14
- 239000007979 citrate buffer Substances 0.000 claims description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 239000002738 chelating agent Substances 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 10
- 239000011521 glass Substances 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000012458 free base Substances 0.000 claims description 2
- 229940102223 injectable solution Drugs 0.000 claims description 2
- 239000001509 sodium citrate Substances 0.000 claims description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 2
- 229940038773 trisodium citrate Drugs 0.000 claims description 2
- 229940079593 drug Drugs 0.000 abstract description 18
- 238000003860 storage Methods 0.000 abstract description 8
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- 239000000126 substance Substances 0.000 description 8
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- 238000000034 method Methods 0.000 description 7
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- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 description 6
- FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 5
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- 208000031649 Postoperative Nausea and Vomiting Diseases 0.000 description 4
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- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
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- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
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- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
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Landscapes
- Health & Medical Sciences (AREA)
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- Otolaryngology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44435103P | 2003-01-30 | 2003-01-30 | |
| PCT/EP2004/000888 WO2004067005A1 (fr) | 2003-01-30 | 2004-01-30 | Formulations pharmaceutiques liquides de palonosetrone |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20053987L NO20053987L (no) | 2005-08-26 |
| NO329500B1 true NO329500B1 (no) | 2010-11-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| NO20053987A NO329500B1 (no) | 2003-01-30 | 2005-08-26 | Flytende farmasoytiske palonosetronformuleringer |
Country Status (41)
| Country | Link |
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| US (9) | US7947724B2 (fr) |
| EP (2) | EP2008659A1 (fr) |
| JP (2) | JP5461763B2 (fr) |
| KR (1) | KR101113084B1 (fr) |
| CN (2) | CN102813621A (fr) |
| AP (1) | AP2110A (fr) |
| AR (1) | AR042977A1 (fr) |
| AT (1) | ATE410167T1 (fr) |
| AU (1) | AU2004208505C1 (fr) |
| BR (1) | BRPI0407121B8 (fr) |
| CA (5) | CA2573363A1 (fr) |
| CR (1) | CR7921A (fr) |
| CY (1) | CY1108660T1 (fr) |
| DE (1) | DE602004016967D1 (fr) |
| DK (1) | DK1601359T3 (fr) |
| EA (1) | EA014066B1 (fr) |
| EC (1) | ECSP055938A (fr) |
| ES (1) | ES2315635T3 (fr) |
| GE (1) | GEP20084445B (fr) |
| HK (1) | HK1076401A1 (fr) |
| HR (1) | HRP20050676B1 (fr) |
| IL (1) | IL169859A (fr) |
| IS (1) | IS7984A (fr) |
| JO (1) | JO2735B1 (fr) |
| MA (1) | MA27710A1 (fr) |
| MX (1) | MXPA05008028A (fr) |
| MY (1) | MY144036A (fr) |
| NO (1) | NO329500B1 (fr) |
| NZ (1) | NZ541533A (fr) |
| PA (1) | PA8594801A1 (fr) |
| PE (1) | PE20050066A1 (fr) |
| PL (1) | PL378398A1 (fr) |
| PT (1) | PT1601359E (fr) |
| RS (1) | RS20050578A (fr) |
| SI (1) | SI1601359T1 (fr) |
| TN (1) | TNSN05180A1 (fr) |
| TW (1) | TWI342212B (fr) |
| UA (1) | UA90449C2 (fr) |
| UY (1) | UY28175A1 (fr) |
| WO (1) | WO2004067005A1 (fr) |
| ZA (1) | ZA200506917B (fr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003302072A1 (en) * | 2002-11-15 | 2004-06-15 | Helsinn Healthcare Sa | Palonosetron for the treatment of chemotherapy-induced emesis |
| JO2735B1 (en) | 2003-01-30 | 2013-09-15 | هيلسين هيلث كير أس ايه. | Liquid pharmaceutical formations of balloonosterone |
| US8598219B2 (en) | 2003-01-30 | 2013-12-03 | Helsinn Healthcare Sa | Liquid pharmaceutical formulations of palonosetron |
| MY143789A (en) * | 2003-02-18 | 2011-07-15 | Helsinn Healthcare Sa | Use of palonosetron treating post- operative nausea and vomiting |
| CN100336508C (zh) * | 2005-02-23 | 2007-09-12 | 重庆医药工业研究院有限责任公司 | 一种稳定的帕洛诺司琼注射液 |
| CN100455286C (zh) * | 2006-11-21 | 2009-01-28 | 深圳海创医药科技发展有限公司 | 帕洛诺司琼注射液及其制备方法 |
| US9061076B2 (en) | 2007-05-25 | 2015-06-23 | North Carolina State University | Viral nanoparticle cell-targeted delivery platform |
| US20100048607A1 (en) * | 2008-08-25 | 2010-02-25 | Chandrashekhar Kocherlakota | Formulations comprising palonosetron |
| WO2010077669A2 (fr) | 2008-12-08 | 2010-07-08 | Teva Pharmaceutical Industries Ltd. | Formulation de palonosétron |
| US20130213393A1 (en) | 2009-12-22 | 2013-08-22 | Evoke Pharma, Inc. | Nasal formulations of metoclopramide |
| EP2499137A1 (fr) | 2009-11-13 | 2012-09-19 | Helsinn Healthcare S.A. | Metabolites de palonosetron |
| ES2623503T3 (es) | 2009-11-18 | 2017-07-11 | Helsinn Healthcare Sa | Composiciones para tratar náuseas y vómitos mediados centralmente |
| EP2722045B1 (fr) | 2009-11-18 | 2016-07-06 | Helsinn Healthcare SA | Compositions pour traiter les nausées et vomissements à médiation centrale |
| KR101368587B1 (ko) * | 2010-12-27 | 2014-03-05 | 주식회사 삼양바이오팜 | 오심 또는 구토 방지용 조성물 |
| EP2759298B1 (fr) | 2011-10-18 | 2018-01-17 | Helsinn Healthcare SA | Combinaisons thérapeutiques comprenant netupitant et palonosetron |
| CN105934247A (zh) | 2013-12-23 | 2016-09-07 | 株式会社三养生物制药 | 包含帕洛诺司琼的药物组合物 |
| CN104784107A (zh) * | 2014-01-17 | 2015-07-22 | 南京瑞尔医药有限公司 | 一种盐酸托烷司琼口服液的制备方法 |
| KR20160128573A (ko) * | 2015-04-29 | 2016-11-08 | 주식회사 삼양바이오팜 | 약제학적 패키지 |
| LT3435980T (lt) * | 2016-06-06 | 2020-02-25 | Helsinn Healthcare Sa | Fiziologiškai subalansuotos injekcinės fosnetupitanto kompozicijos |
| JP6768404B2 (ja) * | 2016-08-12 | 2020-10-14 | 武田テバファーマ株式会社 | パロノセトロン又はその薬学的に許容される塩を含む医薬組成物 |
| JP6705348B2 (ja) * | 2016-09-23 | 2020-06-03 | ニプロ株式会社 | 液体製剤、及び、パロノセトロンの安定性を向上する方法 |
| JP6642377B2 (ja) * | 2016-10-25 | 2020-02-05 | ニプロ株式会社 | 液体製剤、及び、パロノセトロンの安定性を向上する方法 |
| KR101802183B1 (ko) * | 2016-11-16 | 2017-11-28 | 주식회사 유영제약 | 팔로노세트론을 활성성분으로 함유하는 약제학적 조성물 |
| EP3672964A4 (fr) | 2017-08-21 | 2021-05-26 | Leiutis Pharmaceuticals Pvt. Ltd. | Nouvelles formulations à triple combinaison pour une thérapie antiémétique |
| HUE062180T2 (hu) * | 2018-01-12 | 2023-09-28 | Orion Corp | Palonosetron szemcsepp a hányinger és a hányás kezelésére vagy megelõzésére |
| JP7090845B2 (ja) * | 2018-08-03 | 2022-06-27 | 高田製薬株式会社 | パロノセトロン含有液体組成物 |
| JP7438802B2 (ja) * | 2020-03-23 | 2024-02-27 | シオノギファーマ株式会社 | パロノセトロン含有組成物 |
| WO2024147073A1 (fr) * | 2023-01-03 | 2024-07-11 | Helsinn Healthcare Sa | Formulations orales liquides de nétupitant et de palonosétron |
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| JPS599539B2 (ja) * | 1979-11-13 | 1984-03-03 | 日本化薬株式会社 | ニトログリセリン水溶液及びその製造法 |
| US4695578A (en) | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
| EP0200444B1 (fr) | 1985-04-27 | 1992-11-11 | Beecham Group Plc | Azabicyclononyl-indazole carboxamide ayant une activité antagoniste de la 5-HT |
| US4937247A (en) | 1985-04-27 | 1990-06-26 | Beecham Group P.L.C. | 1-acyl indazoles |
| GB8516083D0 (en) | 1985-06-25 | 1985-07-31 | Glaxo Group Ltd | Heterocyclic compounds |
| US5578628A (en) | 1985-06-25 | 1996-11-26 | Glaxo Group Limited | Medicaments for the treatment of nausea and vomiting |
| US5240954A (en) | 1985-06-25 | 1993-08-31 | Glaxo Group Limited | Medicaments |
| US4906755A (en) | 1986-11-03 | 1990-03-06 | Merrell Dow Pharmaceuticals Inc. | Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds |
| US5360800A (en) | 1987-09-03 | 1994-11-01 | Glaxo Group Limited | Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives |
| US5011846A (en) | 1988-02-23 | 1991-04-30 | Merrell Dow Pharmaceuticals Inc. | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof |
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