NO327420B1 - N-formylhydroksylaminforbindelser, fremgangsmate til fremstilling derav, farmasoytiske sammensetninger og celledyrkningsmedium inneholdende slike forbindelser, samt anvendelse derav som legemiddel. - Google Patents
N-formylhydroksylaminforbindelser, fremgangsmate til fremstilling derav, farmasoytiske sammensetninger og celledyrkningsmedium inneholdende slike forbindelser, samt anvendelse derav som legemiddel. Download PDFInfo
- Publication number
- NO327420B1 NO327420B1 NO20035571A NO20035571A NO327420B1 NO 327420 B1 NO327420 B1 NO 327420B1 NO 20035571 A NO20035571 A NO 20035571A NO 20035571 A NO20035571 A NO 20035571A NO 327420 B1 NO327420 B1 NO 327420B1
- Authority
- NO
- Norway
- Prior art keywords
- pyrrolidine
- pyridin
- carboxylic acid
- compound
- amide
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29841901P | 2001-06-15 | 2001-06-15 | |
| US36031302P | 2002-02-27 | 2002-02-27 | |
| PCT/EP2002/006604 WO2002102790A1 (en) | 2001-06-15 | 2002-06-14 | N-formyl hydroxylamine compounds as inhibitors of pdf |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20035571D0 NO20035571D0 (no) | 2003-12-12 |
| NO20035571L NO20035571L (no) | 2004-02-16 |
| NO327420B1 true NO327420B1 (no) | 2009-06-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20035571A NO327420B1 (no) | 2001-06-15 | 2003-12-12 | N-formylhydroksylaminforbindelser, fremgangsmate til fremstilling derav, farmasoytiske sammensetninger og celledyrkningsmedium inneholdende slike forbindelser, samt anvendelse derav som legemiddel. |
Country Status (31)
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| US (1) | US7148242B2 (ko) |
| EP (1) | EP1401828B1 (ko) |
| JP (1) | JP4361365B2 (ko) |
| KR (2) | KR20060014083A (ko) |
| CN (1) | CN1511152A (ko) |
| AR (1) | AR036053A1 (ko) |
| AT (1) | ATE323081T1 (ko) |
| AU (1) | AU2002321062B2 (ko) |
| BR (1) | BR0210377A (ko) |
| CA (1) | CA2448526A1 (ko) |
| CO (1) | CO5640131A2 (ko) |
| CY (1) | CY1105085T1 (ko) |
| CZ (1) | CZ20033388A3 (ko) |
| DE (1) | DE60210612T2 (ko) |
| DK (1) | DK1401828T3 (ko) |
| ES (1) | ES2262824T3 (ko) |
| HK (1) | HK1064370A1 (ko) |
| HU (1) | HUP0400208A3 (ko) |
| IL (1) | IL158770A0 (ko) |
| MX (1) | MXPA03011628A (ko) |
| MY (1) | MY138619A (ko) |
| NO (1) | NO327420B1 (ko) |
| NZ (1) | NZ529489A (ko) |
| PE (1) | PE20030100A1 (ko) |
| PL (1) | PL364476A1 (ko) |
| PT (1) | PT1401828E (ko) |
| RU (1) | RU2325386C2 (ko) |
| SI (1) | SI1401828T1 (ko) |
| SK (1) | SK15242003A3 (ko) |
| WO (1) | WO2002102790A1 (ko) |
| ZA (1) | ZA200308379B (ko) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2283589T3 (es) * | 2001-06-15 | 2007-11-01 | Vicuron Pharmaceuticals, Inc. | Compuestos biciclicos de pirrolidina. |
| GB0208579D0 (en) * | 2002-04-13 | 2002-05-22 | British Biotech Pharm | Antibacterial agents |
| PL374961A1 (en) * | 2002-09-19 | 2005-11-14 | Novartis Ag | Process for preparing intermediates |
| WO2004076053A2 (en) * | 2003-02-21 | 2004-09-10 | Novartis Ag | Chemical process for the preparation of intermediates to obtain n-formyl hydroxylamine compounds |
| TW200427458A (en) * | 2003-04-02 | 2004-12-16 | Novartis Ag | Crystalline N-formyl hydroxylamine compounds |
| US20070060753A1 (en) * | 2003-06-26 | 2007-03-15 | Joel Slade | Process for preparing intermediates useful to prepare certain antibacterial n-formyl hydroxylamines |
| KR100527624B1 (ko) * | 2003-08-21 | 2005-11-22 | 한기종 | 질소에 포밀기를 갖는 아민유도체의 새로운 제조방법 |
| CN1976703A (zh) * | 2004-06-30 | 2007-06-06 | 诺瓦提斯公司 | 通过使用外排泵抑制剂增加肽脱甲酰基酶抑制剂敏感性的方法 |
| JP2008520686A (ja) | 2004-11-17 | 2008-06-19 | スミスクライン・ビーチャム・コーポレイション | 新規な抗菌化合物の使用 |
| GT200600196A (es) * | 2005-05-23 | 2007-01-15 | Compuestos n-formil de hidroxilamina | |
| DE102005026231A1 (de) * | 2005-06-07 | 2006-12-14 | Origenis Ag | Peptid-Deformylase (PDF) Inhibitoren 3 |
| CN101184728B (zh) * | 2005-06-07 | 2011-08-17 | 诺瓦提斯公司 | 肽脱甲酰基酶（pdf）抑制剂4 |
| SG133452A1 (en) * | 2005-12-30 | 2007-07-30 | Novartis Ag | Peptide deformylase inhibitors for treatment of mycobacterial and other parasitic diseases |
| CN101395148A (zh) * | 2006-03-03 | 2009-03-25 | 诺瓦提斯公司 | N-甲酰基羟胺化合物 |
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