NO326882B1 - Inhibitorer for interleukin-1 konverterende enzym - Google Patents
Inhibitorer for interleukin-1 konverterende enzymInfo
- Publication number
- NO326882B1 NO326882B1 NO19982597A NO982597A NO326882B1 NO 326882 B1 NO326882 B1 NO 326882B1 NO 19982597 A NO19982597 A NO 19982597A NO 982597 A NO982597 A NO 982597A NO 326882 B1 NO326882 B1 NO 326882B1
- Authority
- NO
- Norway
- Prior art keywords
- interleukin
- inhibitors
- converting enzyme
- enzyme
- converting
- Prior art date
Links
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- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines
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- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/575,641 US6008217A (en) | 1995-12-20 | 1995-12-20 | Inhibitors of interleukin-1β converting enzyme |
US08/598,332 US5874424A (en) | 1995-12-20 | 1996-02-08 | Inhibitors of interleukin-1β converting enzyme |
US08/712,878 US5985863A (en) | 1996-09-12 | 1996-09-12 | Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor |
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US08/761,483 US6204261B1 (en) | 1995-12-20 | 1996-12-06 | Inhibitors of interleukin-1β Converting enzyme inhibitors |
PCT/US1996/020843 WO1997022619A2 (en) | 1995-12-20 | 1996-12-20 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
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EP (3) | EP2295442A3 (cs) |
JP (3) | JP4205762B2 (cs) |
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AP (4) | AP2002002540A0 (cs) |
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BR (2) | BRPI9612258B8 (cs) |
CA (1) | CA2239904C (cs) |
CZ (2) | CZ298171B6 (cs) |
GE (1) | GEP20022638B (cs) |
IL (2) | IL124850A0 (cs) |
IN (1) | IN182290B (cs) |
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MX (1) | MX9805016A (cs) |
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TR (3) | TR200201216T2 (cs) |
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Families Citing this family (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US6420522B1 (en) * | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US6531467B2 (en) | 1996-09-12 | 2003-03-11 | Idun Pharmaceuticals, Inc. | Inhibition of inflammation using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
US6610683B2 (en) * | 1996-09-12 | 2003-08-26 | Idun Pharmaceuticals, Inc. | Treatment of infectious disease using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
US6200969B1 (en) | 1996-09-12 | 2001-03-13 | Idun Pharmaceuticals, Inc. | Inhibition of apoptosis using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors |
KR20000049050A (ko) * | 1996-10-11 | 2000-07-25 | 로즈 암스트롱, 크리스틴 에이. 트러트웨인 | 술폰아미드 치환된 아스파르트산 인터루킨-1β 전환 효소 억제제 |
JP2001508404A (ja) | 1996-10-11 | 2001-06-26 | ワーナー―ランバート・コンパニー | スルホンアミドインターロイキン―1β変換酵素阻害剤 |
US5919790A (en) * | 1996-10-11 | 1999-07-06 | Warner-Lambert Company | Hydroxamate inhibitors of interleukin-1β converting enzyme |
WO1998024804A2 (en) * | 1996-12-06 | 1998-06-11 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
EP1466921A1 (en) * | 1996-12-06 | 2004-10-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1 beta converting enzyme |
FR2766188B1 (fr) * | 1997-07-15 | 2000-02-11 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes |
DE69925581T2 (de) | 1998-03-09 | 2006-04-27 | Vertex Pharmaceuticals Inc., Cambridge | 1,2-diazepanderivate als inhibitoren des interleukin-1beta umwandelnden enzyms |
AP2000001919A0 (en) | 1998-03-19 | 2000-09-30 | Vertex Pharma | Inhibitors of caspases. |
FR2777279B1 (fr) * | 1998-04-08 | 2004-08-13 | Hoechst Marion Roussel Inc | Nouvelles formes cristallines du 1s-[1alpha(2s*,3r*), 9 alpha] 6,10-dioxo-n-(2-ethoxy-5-oxo-tetrahydro-3-furanyl) -9[[(1-isoquinolyl)carbonyl]amino]octohydro-6h-pyridazino [1,2-a][1,2]diazepine-1-carboxamide |
FR2777889B1 (fr) * | 1998-04-27 | 2004-07-09 | Hoechst Marion Roussel Inc | Nouveaux derives de l'acide octahydro-6,10-dioxo-6h- pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de composes therapeutiquement actifs |
FR2777888B1 (fr) * | 1998-04-27 | 2004-07-16 | Hoechst Marion Roussel Inc | Nouveaux derives de l'acide (3,4,7,8,9,10-hexahydro-6,10- dioxo-6h-pyridazino[1,2-a][1,2]diazepine-1-carboxylique, leur procede de preparation et leur application a la preparation de medicaments |
US6197750B1 (en) * | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6544951B2 (en) | 1998-07-02 | 2003-04-08 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US7053056B2 (en) | 1998-07-02 | 2006-05-30 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
US6703500B2 (en) * | 1998-08-19 | 2004-03-09 | Vertex Pharmaceuticals, Incorporated | Method of preparing bicyclic intermediates from piperazic acid or an ester thereof useful in the manufacture of caspase inhibitors |
US6559304B1 (en) * | 1998-08-19 | 2003-05-06 | Vertex Pharmaceuticals Incorporated | Method for synthesizing caspase inhibitors |
US6177565B1 (en) | 1998-08-19 | 2001-01-23 | Vertex Pharmaceuticals Inc. | Process for synthesizing piperazic acid |
US6201118B1 (en) | 1998-08-19 | 2001-03-13 | Vertex Pharmaceuticals Inc. | Process for forming an N-acylated, N,N-containing bicyclic ring from piperazic acid or an ester thereof especially useful as an intermediate in the manufacture of a caspase inhibitor |
EP1159273A1 (en) | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cathepsin s |
TW200404789A (en) * | 1999-03-15 | 2004-04-01 | Axys Pharm Inc | Novel compounds and compositions as protease inhibitors |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
AR026748A1 (es) | 1999-12-08 | 2003-02-26 | Vertex Pharma | Un compuesto inhibidor de caspasas, una composicion farmaceutica que lo comprende, un metodo para la sintesis del mismo y un compuesto intermediario paradicha sintesis |
FR2802927B1 (fr) * | 1999-12-28 | 2002-03-01 | Hoechst Marion Roussel Inc | Nouveaux derives de diazepine carboxamide, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et leur nouvelle utilisation |
US6515173B1 (en) | 2000-01-13 | 2003-02-04 | Idun Pharmaceuticals, Inc. | Inhibitors of the ICE/ced-3 family of cysteine proteases |
US6790989B2 (en) | 2000-01-13 | 2004-09-14 | Idun Pharmaceuticals, Inc. | Inhibitors of the ICE/ced-3 family of cysteine proteases |
AU2001259758A1 (en) | 2000-05-12 | 2001-11-26 | Immunex Corporation | Interleukin-1 inhibitors in the treatment of diseases |
PE20011350A1 (es) * | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
ATE437234T1 (de) * | 2000-06-15 | 2009-08-15 | Smithkline Beecham Corp | Verfahren zur herstellung eines physiologisch aktiven il-18 polypeptids |
DE10037310A1 (de) * | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
CN100396680C (zh) * | 2000-12-28 | 2008-06-25 | 第一制药株式会社 | 极迟抗原-4抑制剂 |
EP1346982B1 (en) * | 2000-12-28 | 2011-09-14 | Daiichi Pharmaceutical Co., Ltd. | Vla-4 inhibitors |
EA006767B1 (ru) * | 2001-01-29 | 2006-04-28 | Апплайд Резеч Системз Арс Холдинг Н.В. | Применение ингибитора il-18 для приготовления лекарственного средства для лечения и/или профилактики заболевания сердца |
US20030096737A1 (en) | 2001-04-19 | 2003-05-22 | Anita Diu-Hercend | Caspase inhibitors and uses thereof |
ES2278078T3 (es) * | 2001-10-04 | 2007-08-01 | Ortho Mcneil Pharmaceutical, Inc. | Derivados de triazepina como agentes neurotroficos. |
US6821993B1 (en) | 2001-10-04 | 2004-11-23 | Ortho-Mcneil Pharmaceutical, Inc. | Triazepine derivatives as neurotrophic agents |
AU2003238948A1 (en) * | 2002-06-05 | 2003-12-22 | Sunesis Pharmaceuticals, Inc. | Caspase-1 inhibitors and methods for their use |
CA2493646A1 (en) | 2002-06-28 | 2004-01-08 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
AU2003297570A1 (en) * | 2002-11-26 | 2004-06-18 | Advanced Biotherapy, Inc. | Treatment of skin diseases |
EP1581501A1 (en) | 2002-12-20 | 2005-10-05 | Vertex Pharmaceuticals Incorporated | 4-oxo-3-(1-oxo-1h-isoquinolin-2-ylacetylamino)-pentanoic acid ester and amide derivatives and their use as caspase inhibitors |
PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
CA2770493A1 (en) | 2003-07-24 | 2005-02-03 | Daiichi Pharmaceutical Co., Ltd. | Cyclohexanecarboxylic acid compound |
US20050124684A1 (en) * | 2003-08-29 | 2005-06-09 | Ying Du | 5-(hydroxymethyl) furfural and derivatives as inhibitors of TNFalpha and IL-1beta production |
WO2005030083A2 (en) * | 2003-09-25 | 2005-04-07 | Dmi Biosciences Inc. | Methods and products which utilize n-acyl-l-aspartic acid |
AU2005249503B2 (en) * | 2003-11-10 | 2011-08-25 | Vertex Pharmaceuticals Incorporated | ICE inhibitors for the treatment of autoinflammatory diseases |
JP2007513092A (ja) * | 2003-12-01 | 2007-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | Ice阻害剤を使用する感染性疾患の処置 |
CN100441186C (zh) * | 2003-12-03 | 2008-12-10 | 和记黄埔医药企业有限公司 | 伪石蒜碱的医药用途 |
US7615212B2 (en) | 2004-02-26 | 2009-11-10 | Baylor Research Institute | Compositions and methods for the systemic treatment of arthritis |
CN102161656B (zh) * | 2004-02-27 | 2013-02-20 | 沃泰克斯药物股份有限公司 | 天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途 |
SG150546A1 (en) | 2004-03-12 | 2009-03-30 | Vertex Pharma | Processes and intermediates |
CN1946700A (zh) * | 2004-04-22 | 2007-04-11 | 宝洁公司 | 作为细胞因子抑制剂的三取代尿素 |
JP4848367B2 (ja) * | 2004-05-15 | 2011-12-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | Iceインヒビターを使用した発作の処置 |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
GB0515323D0 (en) * | 2005-07-26 | 2005-08-31 | Electrophoretics Ltd | Mass labels |
DE102005048293A1 (de) * | 2005-10-08 | 2007-04-12 | Sanofi-Aventis Deutschland Gmbh | Retardformulierung für Pralnacasan |
EP1826199A1 (en) * | 2006-02-27 | 2007-08-29 | Technische Universität Wien | Modified amino acids |
WO2008034095A2 (en) * | 2006-09-15 | 2008-03-20 | University Of Utah Research Foundation | Protected enantiopure trifluorothreonines and methods of making and using same |
EP2185721B1 (en) | 2007-08-03 | 2014-04-02 | Sanofi | Caspase imaging probes |
WO2009128932A1 (en) * | 2008-04-15 | 2009-10-22 | Sarcode Corporation | Delivery of lfa-1 antagonists to the gastrointestinal system |
US9365612B2 (en) | 2010-01-29 | 2016-06-14 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Caspase inhibitors |
US9116157B2 (en) | 2010-11-05 | 2015-08-25 | Brandeis University | Ice-cleaved alpha-synuclein as a biomarker |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
EP2848696A1 (en) | 2013-09-13 | 2015-03-18 | Sanofi-Aventis Deutschland GmbH | Caspase-1 imaging probes |
MX2016005759A (es) * | 2013-11-06 | 2016-07-18 | Squibb Bristol Myers Co | Derivados de piridina sustituidos, utiles como inhibidores de glucogeno sintasa cinasa 3 (gsk-3). |
TWI698436B (zh) | 2014-12-30 | 2020-07-11 | 美商佛瑪治療公司 | 作為泛素特異性蛋白酶7抑制劑之吡咯并及吡唑并嘧啶 |
MA41291A (fr) | 2014-12-30 | 2017-11-07 | Forma Therapeutics Inc | Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer |
EP3253738A1 (en) | 2015-02-05 | 2017-12-13 | Forma Therapeutics, Inc. | Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors |
US9938300B2 (en) | 2015-02-05 | 2018-04-10 | Forma Therapeutics, Inc. | Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors |
JP2018504431A (ja) | 2015-02-05 | 2018-02-15 | フォーマ セラピューティクス,インコーポレイテッド | ユビキチン特異的プロテアーゼ7阻害物質としてのチエノピリミジノン |
EP3330256B1 (en) | 2015-07-07 | 2021-06-16 | Shionogi & Co., Ltd. | HETEROCYCLIC DERIVATIVE HAVING TrkA-INHIBITING ACTIVITY |
SG10201913587WA (en) | 2016-02-05 | 2020-02-27 | Denali Therapeutics Inc | Inhibitors of receptor-interacting protein kinase 1 |
RS63203B1 (sr) | 2016-12-09 | 2022-06-30 | Denali Therapeutics Inc | Jedinjenja korisna kao inhibitori ripk1 |
US11952365B2 (en) | 2020-06-10 | 2024-04-09 | Aligos Therapeutics, Inc. | Anti-viral compounds |
AU2021377248A1 (en) | 2020-11-13 | 2023-06-22 | Inipharm, Inc. | Dichlorophenol hsd17b13 inhibitors and uses thereof |
WO2023283256A1 (en) | 2021-07-09 | 2023-01-12 | Aligos Therapeutics, Inc. | Anti-viral compounds |
WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
KR20240132504A (ko) | 2022-01-12 | 2024-09-03 | 데날리 테라퓨틱스 인크. | (s)-5-벤질-n-(5-메틸-4-옥소-2,3,4,5-테트라하이드로피리도 [3,2-b][1,4]옥사제핀-3-일)-4h-1,2,4-트리아졸-3-카복사미드의 결정질 형태 |
Family Cites Families (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US6008217A (en) * | 1995-12-20 | 1999-12-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5985863A (en) * | 1996-09-12 | 1999-11-16 | Vertex Pharmaceuticals, Inc. | Compositions and methods for decreasing IGIF and IFN-γ production by administering an ICE inhibitor |
US5874424A (en) * | 1995-12-20 | 1999-02-23 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US4276298A (en) | 1978-03-24 | 1981-06-30 | Merck & Co., Inc. | 2-Aryl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
US4337346A (en) * | 1978-11-02 | 1982-06-29 | Sumitomo Chemical Company, Limited | α-Hydroxyaldehyde and a process for preparing the same |
US4369183A (en) | 1979-09-06 | 1983-01-18 | Merck & Co., Inc. | 2-Pyridyl-1,2-benzisothiazolinone-1,1-dioxides and their use as selective protease inhibitors |
US4584397A (en) | 1983-05-09 | 1986-04-22 | G. D. Searle & Co. | Protease inhibitors |
US4499295A (en) | 1983-05-09 | 1985-02-12 | G. D. Searle & Co. | Protease inhibitors |
IL72523A (en) * | 1983-08-12 | 1988-06-30 | Takeda Chemical Industries Ltd | 3-amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine derivatives,their production and pharmaceutical compositions containing them |
US4551279A (en) | 1984-01-09 | 1985-11-05 | G. D. Searle & Co. | Protease inhibitors |
US5055451A (en) | 1986-12-22 | 1991-10-08 | Syntex Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
US5158936A (en) | 1986-12-22 | 1992-10-27 | Syntex (U.S.A.) Inc. | Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors |
NZ223148A (en) | 1987-01-16 | 1989-10-27 | Merrell Dow Pharma | Peptide derivatives having peptidase inhibition activity |
US5081228A (en) | 1988-02-25 | 1992-01-14 | Immunex Corporation | Interleukin-1 receptors |
US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
WO1989004838A1 (en) | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
US5008245A (en) | 1988-10-27 | 1991-04-16 | University Of Kentucky Research Foundation | Novel peptidyl carbamate inhibitors of the enzyme elastase |
WO1990013549A1 (en) | 1989-05-04 | 1990-11-15 | Sterling Winthrop Inc. | Saccharin derivatives useful as proteolytic enzyme inhibitors and preparation thereof |
ZA905737B (en) | 1989-07-26 | 1991-05-29 | Merrell Dow Pharma | Novel peptidase inhibitors |
NZ235155A (en) | 1989-09-11 | 1993-04-28 | Merrell Dow Pharma | Peptidase substrates in which the carboxy terminal group has been replaced by a tricarbonyl radical |
AU6712790A (en) | 1989-10-05 | 1991-05-16 | Board Of Trustees Of The Leland Stanford Junior University | Catheter device with insertion stop means |
AU7775991A (en) | 1990-04-04 | 1991-10-30 | Immunex Corporation | Interleukin 1beta protease |
US5416013A (en) | 1990-04-04 | 1995-05-16 | Sterling Winthrop Inc. | Interleukin 1β protease and interleukin 1β protease inhibitors |
AU7891891A (en) | 1990-05-25 | 1991-12-31 | Fujisawa Pharmaceutical Co., Ltd. | Pyrrolopyridazine compounds |
US5199980A (en) | 1990-09-21 | 1993-04-06 | Multicolor Specialties, Inc. | Polyurethane-based water-in-water multicolor paint and method for making |
IL99527A (en) | 1990-09-28 | 1997-08-14 | Lilly Co Eli | Tripeptide antithrombotic agents |
EP0504938A3 (en) | 1991-03-22 | 1993-04-14 | Suntory Limited | Prophylactic and therapeutic agent for bone diseases comprising di- or tripeptide derivative as active ingredient |
EP0519748B1 (en) | 1991-06-21 | 1998-09-02 | Merck & Co. Inc. | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme |
JP3190431B2 (ja) | 1991-07-01 | 2001-07-23 | 三菱化学株式会社 | ケトン誘導体 |
EP0533226A3 (en) | 1991-08-16 | 1993-08-18 | Merck & Co. Inc. | Novel chromophore containing compounds |
EP0533350B1 (en) | 1991-08-16 | 1999-05-26 | Merck & Co. Inc. | DNA encoding precursor interleukin 1B converting enzyme |
US5278061A (en) | 1991-08-16 | 1994-01-11 | Merck & Co., Inc. | Affinity chromatography matrix useful in purifying interleukin-1β converting enzyme |
US6348570B1 (en) | 1991-08-16 | 2002-02-19 | Merck & Co., Inc. | Chromophore containing compounds and their use in determining interleukin-1β convertase activity |
AU657701B2 (en) | 1991-08-30 | 1995-03-23 | Vertex Pharmaceuticals Incorporated | Interleukin 1beta protease and interleukin 1beta protease inhibitors |
GB9123326D0 (en) | 1991-11-04 | 1991-12-18 | Sandoz Ltd | Improvements in or relating to organic compounds |
EP0547699A1 (en) | 1991-12-19 | 1993-06-23 | Merck & Co. Inc. | Peptidyl derivatives as inhibitors of interleukin-1B converting enzyme |
WO1993014777A1 (en) | 1992-01-31 | 1993-08-05 | Merck & Co., Inc. | PEPTIDYL DERIVATIVES AS INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
ATE169224T1 (de) | 1992-02-21 | 1998-08-15 | Merck & Co Inc | Peptidylderivate und inhibitoren des interleukin- 1-g(b)-konvertierenden enzyms |
WO1993025685A1 (en) | 1992-06-12 | 1993-12-23 | Massachusetts Institute Of Technology | Cloning and characterization of the cell death genes ced-3 and ced-4 |
WO1993025683A1 (en) | 1992-06-12 | 1993-12-23 | Massachusetts Institute Of Technology | A gene which prevents programmed cell death |
EP0672151A1 (en) | 1992-06-12 | 1995-09-20 | Massachusetts Institute Of Technology | Inhibitors of ced-3 and related proteins |
JPH08500242A (ja) | 1992-06-24 | 1996-01-16 | メルク エンド カンパニー インコーポレーテッド | インターロイキン1β前駆体の転換酵素をコードするDNA |
JP2602181B2 (ja) | 1992-07-31 | 1997-04-23 | ファイザー・インク. | 消炎薬としてのペプチジル4−アミノ−2,2−ジフルオロ−3−オクソ−1,6−ヘキサン二酸誘導体 |
US5374623A (en) | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
CA2109646C (en) | 1992-11-24 | 2000-03-07 | Gaston O. Daumy | Para-nitroanilide peptides |
EP0618223A3 (en) | 1993-03-08 | 1996-06-12 | Sandoz Ltd | Peptides, the release of Interleukin 1-Bêta, useful as anti-inflammatory agents. |
CA2122227A1 (en) | 1993-04-29 | 1994-10-30 | Roland E. Dolle | Peptide analogs as irreversible interleukin-1.beta. protease inhibitors |
US5462939A (en) | 1993-05-07 | 1995-10-31 | Sterling Winthrop Inc. | Peptidic ketones as interleukin-1β-converting enzyme inhibitors |
US5411985A (en) | 1993-05-17 | 1995-05-02 | Merck & Co., Inc. | Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 β inventory enzyme |
JPH0789951A (ja) | 1993-06-03 | 1995-04-04 | Sterling Winthrop Inc | インターロイキン−1β転換酵素阻害剤 |
ATE170868T1 (de) | 1993-06-04 | 1998-09-15 | Vertex Pharma | Peptid-phosphinyloxymethyl-ketonen als inhibitoren von interleukin-1 beta- konvertierenden enzymen |
DE69408598T2 (de) | 1993-06-08 | 1998-09-17 | Vertex Pharmaceuticals Inc Cam | Pyridazine als Interleukin-1-beta Verwandlungsenzym Inhibitoren |
EP0711174A4 (en) | 1993-06-24 | 1997-11-12 | Gen Hospital Corp | GENES FOR PROGRAMMED CELL DEATH AND PROTEINS |
US5866545A (en) | 1993-08-13 | 1999-02-02 | Merck & Co., Inc. | Substituted ketone derivatives as inhibitors of interleukin-1β converting enzyme |
US5486623A (en) | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
US5508262A (en) | 1993-12-15 | 1996-04-16 | University Of South Florida | Interleukin-1 receptor antagonist decreases severity of acute pancreatitis |
CN1118458C (zh) | 1994-03-31 | 2003-08-20 | 弗特克斯药品有限公司 | 作为白细胞介素抑制剂的嘧啶基衍生物 |
WO1995029672A1 (en) | 1994-04-29 | 1995-11-09 | Sanofi Winthrop, Inc. | HALOMETHYL AMIDES AS IL-1β PROTEASE INHIBITORS |
CH688319A5 (fr) | 1994-06-03 | 1997-07-31 | Marcham Trading & Investment L | Procédé pour la préparation du céfixime trihydraté. |
US5552400A (en) | 1994-06-08 | 1996-09-03 | Sterling Winthrop Inc. | Fused-bicyclic lactams as interleukin-1β converting enzyme inhibitors |
US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US5716929A (en) | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
US6420522B1 (en) * | 1995-06-05 | 2002-07-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
US5565430A (en) | 1994-08-02 | 1996-10-15 | Sterling Winthrop Inc. | Azaaspartic acid analogs as interleukin-1β converting enzyme inhibitors |
JP2882756B2 (ja) | 1994-10-12 | 1999-04-12 | 昭和高分子株式会社 | 脂肪族ポリエステル組成物からなる延伸中空成形体 |
US5498616A (en) | 1994-11-04 | 1996-03-12 | Cephalon, Inc. | Cysteine protease and serine protease inhibitors |
TW394764B (en) | 1995-02-14 | 2000-06-21 | Mitsubishi Chemcal Corp | Oxygen-containing heterocyclic derivatives |
US6184244B1 (en) * | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
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1996
- 1996-12-06 US US08/761,483 patent/US6204261B1/en not_active Expired - Lifetime
- 1996-12-18 IN IN2188CA1996 patent/IN182290B/en unknown
- 1996-12-20 CZ CZ0190698A patent/CZ298171B6/cs not_active IP Right Cessation
- 1996-12-20 AP AP2002002540A patent/AP2002002540A0/xx unknown
- 1996-12-20 EP EP10010860A patent/EP2295442A3/en not_active Withdrawn
- 1996-12-20 CA CA002239904A patent/CA2239904C/en not_active Expired - Fee Related
- 1996-12-20 UA UA98073924A patent/UA66337C2/uk unknown
- 1996-12-20 NZ NZ518094A patent/NZ518094A/en not_active IP Right Cessation
- 1996-12-20 AP APAP/P/2002/002540A patent/AP0202540A0/en unknown
- 1996-12-20 CZ CZ20030411A patent/CZ300171B6/cs not_active IP Right Cessation
- 1996-12-20 NZ NZ326610A patent/NZ326610A/xx not_active IP Right Cessation
- 1996-12-20 AU AU15222/97A patent/AU735075B2/en not_active Ceased
- 1996-12-20 KR KR1020047011964A patent/KR100561504B1/ko not_active Expired - Fee Related
- 1996-12-20 JP JP52309897A patent/JP4205762B2/ja not_active Expired - Fee Related
- 1996-12-20 WO PCT/US1996/020843 patent/WO1997022619A2/en active Search and Examination
- 1996-12-20 BR BRPI9612258A patent/BRPI9612258B8/pt unknown
- 1996-12-20 GE GEAP19964412A patent/GEP20022638B/en unknown
- 1996-12-20 CN CN96199828A patent/CN1229412A/zh active Pending
- 1996-12-20 BR BRPI9612258-7A patent/BR9612258B1/pt not_active IP Right Cessation
- 1996-12-20 EP EP96945318A patent/EP0869967A2/en not_active Withdrawn
- 1996-12-20 SK SK842-98A patent/SK287195B6/sk not_active IP Right Cessation
- 1996-12-20 EP EP09004786A patent/EP2083014A3/en not_active Withdrawn
- 1996-12-20 TR TR2002/01216T patent/TR200201216T2/xx unknown
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- 1996-12-20 IL IL12485096A patent/IL124850A0/xx unknown
- 1996-12-20 TR TR2002/01218T patent/TR200201218T2/xx unknown
- 1996-12-20 AP APAP/P/2002/002539A patent/AP0202539A0/en unknown
- 1996-12-20 AP APAP/P/2002/002538A patent/AP0202538A0/en unknown
- 1996-12-20 PL PL96328527A patent/PL190736B1/pl not_active IP Right Cessation
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1998
- 1998-06-05 NO NO19982597A patent/NO326882B1/no not_active IP Right Cessation
- 1998-06-11 IL IL124850A patent/IL124850A/en not_active IP Right Cessation
- 1998-06-12 IS IS4771A patent/IS4771A/is unknown
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- 1998-07-13 BG BG102624A patent/BG64465B1/bg unknown
- 1998-07-13 BG BG108927A patent/BG108927A/en unknown
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1999
- 1999-09-21 US US09/400,639 patent/US6258948B1/en not_active Expired - Fee Related
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2001
- 2001-01-31 US US09/773,477 patent/US6423840B1/en not_active Expired - Fee Related
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2002
- 2002-01-28 US US10/058,522 patent/US20030225269A1/en not_active Abandoned
- 2002-10-21 JP JP2002306094A patent/JP2003137896A/ja not_active Withdrawn
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2004
- 2004-11-29 US US10/999,865 patent/US20050143436A1/en not_active Abandoned
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2007
- 2007-01-18 US US11/655,938 patent/US7790713B2/en not_active Expired - Fee Related
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2008
- 2008-06-18 JP JP2008159803A patent/JP2008285493A/ja not_active Withdrawn
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2010
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