AU4634993A - Dna encoding precursor interleukin 1beta converting enzyme - Google Patents

Dna encoding precursor interleukin 1beta converting enzyme

Info

Publication number
AU4634993A
AU4634993A AU46349/93A AU4634993A AU4634993A AU 4634993 A AU4634993 A AU 4634993A AU 46349/93 A AU46349/93 A AU 46349/93A AU 4634993 A AU4634993 A AU 4634993A AU 4634993 A AU4634993 A AU 4634993A
Authority
AU
Australia
Prior art keywords
dna encoding
converting enzyme
encoding precursor
precursor interleukin
interleukin 1beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU46349/93A
Inventor
Jimmy R. Calaycay
Andrew D Howard
Douglas K Miller
Susan M Molineaux
Michael J Tocci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of AU4634993A publication Critical patent/AU4634993A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AU46349/93A 1992-06-24 1993-06-14 Dna encoding precursor interleukin 1beta converting enzyme Abandoned AU4634993A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90639292A 1992-06-24 1992-06-24
US906392 1992-06-24
PCT/US1993/005687 WO1994000154A1 (en) 1992-06-24 1993-06-14 DNA ENCODING PRECURSOR INTERLEUKIN 1β CONVERTING ENZYME

Publications (1)

Publication Number Publication Date
AU4634993A true AU4634993A (en) 1994-01-24

Family

ID=25422367

Family Applications (1)

Application Number Title Priority Date Filing Date
AU46349/93A Abandoned AU4634993A (en) 1992-06-24 1993-06-14 Dna encoding precursor interleukin 1beta converting enzyme

Country Status (5)

Country Link
EP (1) EP0648128A4 (en)
JP (1) JPH08500242A (en)
AU (1) AU4634993A (en)
CA (1) CA2136981A1 (en)
WO (1) WO1994000154A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008217A (en) * 1995-12-20 1999-12-28 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US5874424A (en) * 1995-12-20 1999-02-23 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
US6204261B1 (en) 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5847135A (en) * 1994-06-17 1998-12-08 Vertex Pharmaceuticals, Incorporated Inhibitors of interleukin-1β converting enzyme
US5756466A (en) * 1994-06-17 1998-05-26 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme
US6057119A (en) * 1994-06-17 2000-05-02 Vertex Pharmaceuticals, Incorporated Crystal structure and mutants of interleukin-1β converting enzyme
AU733479B2 (en) * 1994-06-17 2001-05-17 Vertex Pharmaceuticals Incorporated Crystal structure and mutants of interleukin-1beta converting enzyme
US6420522B1 (en) 1995-06-05 2002-07-16 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β converting enzyme
WO1996012025A1 (en) * 1994-10-14 1996-04-25 Basf Aktiengesellschaft TRANSGENIC NONHUMAN ANIMAL HAVING FUNCTIONALLY DISRUPTED INTERLEUKIN-1β CONVERTING ENZYME GENE
WO1996026280A1 (en) * 1995-02-21 1996-08-29 Basf Aktiengesellschaft NOVEL CYSTEINE PROTEASE RELATED TO INTERLEUKIN-1β CONVERTING ENZYME
US5869315A (en) 1995-12-18 1999-02-09 Basf Aktiengesellschaft Modified interleukin-1β converting enzyme with increased stability
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme
US6288037B1 (en) 1996-01-29 2001-09-11 Basf Aktiengesellschaft Substrates and inhibitors for cysteine protease ICH-1
US6180402B1 (en) * 1996-11-20 2001-01-30 Qlt Inc. Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor
GB2324529A (en) * 1997-02-21 1998-10-28 Merck & Co Inc A combinatorial library based on a tetrapeptide substituted with aminomethylcoumarin for characterizing proteases
ATE296812T1 (en) 1998-03-09 2005-06-15 Vertex Pharma 1,2-DIAZEPAN DERIVATIVES AS INHIBITORS OF THE INTERLEUKIN-1BETA CONVERTING ENZYME
EP1064298B1 (en) 1998-03-19 2008-10-08 Vertex Pharmaceuticals Incorporated Inhibitors of caspases
PE20011350A1 (en) 2000-05-19 2002-01-15 Vertex Pharma PROPHARMAC OF AN INHIBITOR OF INTERLEUKIN-1ß CONVERTER ENZYME (ICE)
CA2383392A1 (en) * 2001-04-27 2002-10-27 Matsushita Electric Industrial Co., Ltd. Bio-device, and quantitative measurement apparatus and method using the same
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
CN1980658A (en) 2004-05-27 2007-06-13 沃泰克斯药物股份有限公司 Treatment of diseases using ICE inhibitors
WO2019226649A1 (en) * 2018-05-22 2019-11-28 Nantkwest, Inc. Optimization of nk-92 cell growth using poloxamer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (en) * 1978-11-24 1982-12-04 Hoffmann La Roche
DE69229252T2 (en) * 1991-08-16 1999-12-16 Merck & Co Inc DNA encoding the interleukin-1B precursor converting enzyme

Also Published As

Publication number Publication date
EP0648128A4 (en) 1995-07-26
EP0648128A1 (en) 1995-04-19
WO1994000154A1 (en) 1994-01-06
CA2136981A1 (en) 1994-01-06
JPH08500242A (en) 1996-01-16

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