NO326780B1 - Insulinformulering med forbedret stabilitet samt fremgangsmate for fremstilling av slike - Google Patents
Insulinformulering med forbedret stabilitet samt fremgangsmate for fremstilling av slike Download PDFInfo
- Publication number
- NO326780B1 NO326780B1 NO20034125A NO20034125A NO326780B1 NO 326780 B1 NO326780 B1 NO 326780B1 NO 20034125 A NO20034125 A NO 20034125A NO 20034125 A NO20034125 A NO 20034125A NO 326780 B1 NO326780 B1 NO 326780B1
- Authority
- NO
- Norway
- Prior art keywords
- insulin
- pharmaceutical formulation
- formulation according
- zinc
- concentration
- Prior art date
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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Landscapes
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Diabetes (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10114178A DE10114178A1 (de) | 2001-03-23 | 2001-03-23 | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| PCT/EP2002/002625 WO2002076495A1 (de) | 2001-03-23 | 2002-03-09 | Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität |
Publications (3)
| Publication Number | Publication Date |
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| NO20034125D0 NO20034125D0 (no) | 2003-09-16 |
| NO20034125L NO20034125L (no) | 2003-11-11 |
| NO326780B1 true NO326780B1 (no) | 2009-02-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| NO20034125A NO326780B1 (no) | 2001-03-23 | 2003-09-16 | Insulinformulering med forbedret stabilitet samt fremgangsmate for fremstilling av slike |
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| EP (2) | EP1381385B1 (zh) |
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| CN (1) | CN1273187C (zh) |
| AR (2) | AR033059A1 (zh) |
| AT (1) | ATE497777T1 (zh) |
| AU (1) | AU2002302409B2 (zh) |
| BR (1) | BRPI0208210B8 (zh) |
| CA (1) | CA2441260C (zh) |
| CY (2) | CY1111413T1 (zh) |
| DE (2) | DE10114178A1 (zh) |
| DK (2) | DK1381385T3 (zh) |
| ES (2) | ES2393180T3 (zh) |
| HK (1) | HK1061521A1 (zh) |
| HR (1) | HRP20030765B1 (zh) |
| HU (1) | HU228847B1 (zh) |
| IL (2) | IL158057A0 (zh) |
| ME (1) | ME00408B (zh) |
| MX (1) | MXPA03007942A (zh) |
| MY (1) | MY129417A (zh) |
| NO (1) | NO326780B1 (zh) |
| NZ (1) | NZ528335A (zh) |
| PE (1) | PE20020968A1 (zh) |
| PL (1) | PL205465B1 (zh) |
| PT (2) | PT1381385E (zh) |
| RS (1) | RS51579B (zh) |
| RU (1) | RU2311922C2 (zh) |
| SI (1) | SI1381385T1 (zh) |
| TW (1) | TWI301761B (zh) |
| WO (1) | WO2002076495A1 (zh) |
| ZA (1) | ZA200306637B (zh) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL131796A0 (en) * | 1997-03-20 | 2001-03-19 | Novo Nordisk As | Zinc free insulin crystals for use in pulmonary compositions |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| US20050250676A1 (en) * | 2001-11-19 | 2005-11-10 | Aventis Pharma Deutschland Gmbh | Method of activating insulin receptor substrate-2 to stimulate insulin production |
| DE10227232A1 (de) * | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| US7193035B2 (en) | 2002-10-29 | 2007-03-20 | Sanofi-Aventis Deutschland Gmbh | Crystals of insulin analogs and processes for their preparation |
| DE10250297A1 (de) * | 2002-10-29 | 2004-05-19 | Aventis Pharma Deutschland Gmbh | Kristalle von Insulinanaloga und Verfahren zu ihrer Herstellung |
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2001
- 2001-03-23 DE DE10114178A patent/DE10114178A1/de not_active Ceased
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2002
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