HUP0303596A2 - Cinkmentes és cinkben szegény, javított stabilitású inzulinkészítmények - Google Patents

Cinkmentes és cinkben szegény, javított stabilitású inzulinkészítmények

Info

Publication number
HUP0303596A2
HUP0303596A2 HU0303596A HUP0303596A HUP0303596A2 HU P0303596 A2 HUP0303596 A2 HU P0303596A2 HU 0303596 A HU0303596 A HU 0303596A HU P0303596 A HUP0303596 A HU P0303596A HU P0303596 A2 HUP0303596 A2 HU P0303596A2
Authority
HU
Hungary
Prior art keywords
zinc
insulin
contain
small quantity
improved stability
Prior art date
Application number
HU0303596A
Other languages
English (en)
Inventor
Peter Boderke
Original Assignee
Aventis Pharma Deutschland Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh filed Critical Aventis Pharma Deutschland Gmbh
Publication of HUP0303596A2 publication Critical patent/HUP0303596A2/hu
Publication of HUP0303596A3 publication Critical patent/HUP0303596A3/hu
Publication of HU228847B1 publication Critical patent/HU228847B1/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

A találmány stabilizált gyógyászati készítményekre vonatkozik, amelyekinzulint, például humán inzulint, szarvasmarha- vagy sertésinzulint,inzulinanalógot, inzulinszármazékot, aktív inzulinmetabolitot vagy afelsoroltak kombinációját tartalmazzák. Stabilizátorként akészítmények tenzidet tartalmaznak. Az így stabilizált készítményfőleg mechanikai és hőbehatásokkal szemben ellenálló, nem zavarosodik. Ó
HU0303596A 2001-03-23 2002-03-09 Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability HU228847B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10114178A DE10114178A1 (de) 2001-03-23 2001-03-23 Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
PCT/EP2002/002625 WO2002076495A1 (de) 2001-03-23 2002-03-09 Zinkfreie und zinkarme insulinzubereitungen mit verbesserter stabilität

Publications (3)

Publication Number Publication Date
HUP0303596A2 true HUP0303596A2 (hu) 2004-01-28
HUP0303596A3 HUP0303596A3 (en) 2005-11-28
HU228847B1 HU228847B1 (en) 2013-06-28

Family

ID=7678654

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303596A HU228847B1 (en) 2001-03-23 2002-03-09 Insulin preparations, which do not contain any zinc or only a small quantity of zinc and which have an improved stability

Country Status (32)

Country Link
US (5) US6960561B2 (hu)
EP (2) EP2289539B1 (hu)
JP (1) JP4231292B2 (hu)
KR (2) KR20100061868A (hu)
CN (1) CN1273187C (hu)
AR (2) AR033059A1 (hu)
AT (1) ATE497777T1 (hu)
AU (1) AU2002302409B2 (hu)
BR (1) BRPI0208210B8 (hu)
CA (1) CA2441260C (hu)
CY (2) CY1111413T1 (hu)
DE (2) DE10114178A1 (hu)
DK (2) DK2289539T3 (hu)
ES (2) ES2393180T3 (hu)
HK (1) HK1061521A1 (hu)
HR (1) HRP20030765B1 (hu)
HU (1) HU228847B1 (hu)
IL (2) IL158057A0 (hu)
ME (1) ME00408B (hu)
MX (1) MXPA03007942A (hu)
MY (1) MY129417A (hu)
NO (1) NO326780B1 (hu)
NZ (1) NZ528335A (hu)
PE (1) PE20020968A1 (hu)
PL (1) PL205465B1 (hu)
PT (2) PT1381385E (hu)
RS (1) RS51579B (hu)
RU (1) RU2311922C2 (hu)
SI (1) SI1381385T1 (hu)
TW (1) TWI301761B (hu)
WO (1) WO2002076495A1 (hu)
ZA (1) ZA200306637B (hu)

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