NO326648B1 - Polymorf form av rimonabant, fremgangsmate for fremstilling derav og farmasoytisk preparat inneholdende det samme. - Google Patents
Polymorf form av rimonabant, fremgangsmate for fremstilling derav og farmasoytisk preparat inneholdende det samme. Download PDFInfo
- Publication number
- NO326648B1 NO326648B1 NO20041879A NO20041879A NO326648B1 NO 326648 B1 NO326648 B1 NO 326648B1 NO 20041879 A NO20041879 A NO 20041879A NO 20041879 A NO20041879 A NO 20041879A NO 326648 B1 NO326648 B1 NO 326648B1
- Authority
- NO
- Norway
- Prior art keywords
- temperature
- rimonabant
- methylcyclohexane
- medium
- stated
- Prior art date
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- JZCPYUJPEARBJL-UHFFFAOYSA-N rimonabant Chemical compound CC=1C(C(=O)NN2CCCCC2)=NN(C=2C(=CC(Cl)=CC=2)Cl)C=1C1=CC=C(Cl)C=C1 JZCPYUJPEARBJL-UHFFFAOYSA-N 0.000 title claims description 81
- 229960003015 rimonabant Drugs 0.000 title claims description 67
- 238000000034 method Methods 0.000 title claims description 29
- 238000002360 preparation method Methods 0.000 title description 13
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- UAEPNZWRGJTJPN-UHFFFAOYSA-N methylcyclohexane Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 claims description 84
- GYNNXHKOJHMOHS-UHFFFAOYSA-N methyl-cycloheptane Natural products CC1CCCCCC1 GYNNXHKOJHMOHS-UHFFFAOYSA-N 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 31
- 239000013078 crystal Substances 0.000 claims description 28
- 239000002904 solvent Substances 0.000 claims description 24
- 239000004480 active ingredient Substances 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 15
- 238000010438 heat treatment Methods 0.000 claims description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 12
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims description 12
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims description 11
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 claims description 11
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- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 6
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- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
- 229940029284 trichlorofluoromethane Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0114579A FR2831883B1 (fr) | 2001-11-08 | 2001-11-08 | Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
| PCT/FR2002/003765 WO2003040105A1 (fr) | 2001-11-08 | 2002-11-04 | Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20041879D0 NO20041879D0 (no) | 2004-05-07 |
| NO20041879L NO20041879L (no) | 2004-06-08 |
| NO326648B1 true NO326648B1 (no) | 2009-01-26 |
Family
ID=8869285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20041879A NO326648B1 (no) | 2001-11-08 | 2004-05-07 | Polymorf form av rimonabant, fremgangsmate for fremstilling derav og farmasoytisk preparat inneholdende det samme. |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US20050043356A1 (fr) |
| EP (1) | EP1446384A1 (fr) |
| JP (2) | JP4181994B2 (fr) |
| KR (2) | KR20090089485A (fr) |
| CN (1) | CN100412063C (fr) |
| AP (1) | AP1830A (fr) |
| AR (1) | AR037253A1 (fr) |
| AU (1) | AU2002350869B2 (fr) |
| BR (1) | BR0213931A (fr) |
| CA (1) | CA2464145A1 (fr) |
| CO (1) | CO5580827A2 (fr) |
| CR (1) | CR7333A (fr) |
| EA (1) | EA006771B1 (fr) |
| EC (1) | ECSP045088A (fr) |
| FR (1) | FR2831883B1 (fr) |
| GE (1) | GEP20063894B (fr) |
| HR (1) | HRP20040403A2 (fr) |
| HU (1) | HUP0402043A3 (fr) |
| IL (2) | IL161533A0 (fr) |
| IS (1) | IS7226A (fr) |
| MA (1) | MA27080A1 (fr) |
| ME (1) | MEP21908A (fr) |
| MX (1) | MXPA04004394A (fr) |
| NO (1) | NO326648B1 (fr) |
| NZ (1) | NZ532369A (fr) |
| OA (1) | OA12721A (fr) |
| PL (1) | PL369372A1 (fr) |
| RS (1) | RS36904A (fr) |
| TN (1) | TNSN04079A1 (fr) |
| TW (1) | TW200302824A (fr) |
| UA (1) | UA76776C2 (fr) |
| WO (1) | WO2003040105A1 (fr) |
| ZA (1) | ZA200402999B (fr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2831883B1 (fr) * | 2001-11-08 | 2004-07-23 | Sanofi Synthelabo | Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
| IN2008CN05409A (fr) | 2002-07-18 | 2015-10-02 | Cytos Biotechnology Ag | |
| FR2861992B1 (fr) * | 2003-11-10 | 2007-07-20 | Sanofi Synthelabo | Composition pharmaceutique destinee a l'administration orale d'un derive de pyrazole-3-carboxamide. |
| WO2007003962A2 (fr) | 2005-06-30 | 2007-01-11 | Prosidion Limited | Agonistes de gpcr |
| EP1816125A1 (fr) * | 2006-02-02 | 2007-08-08 | Ranbaxy Laboratories, Ltd. | Formes cristallines d'un antagoniste du récepteur cannabinoïde CB1 et son procédé de préparation |
| FR2897060B1 (fr) * | 2006-02-08 | 2008-07-25 | Sanofi Aventis Sa | Le monohydrate de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
| WO2008038143A2 (fr) * | 2006-06-22 | 2008-04-03 | Medichem, S.A. | Nouvelles formes solides du rimonabant et procédés de synthèse pour la préparation de celles-ci |
| WO2008044153A2 (fr) * | 2006-08-29 | 2008-04-17 | Medichem, S.A. | Procédé de synthèse amélioré de rimonabant |
| EP2057144A4 (fr) * | 2006-09-01 | 2010-06-02 | Hetero Drugs Ltd | Nouveaux polymorphes de rimonabant |
| EP2061783A2 (fr) * | 2006-09-11 | 2009-05-27 | Hetero Drugs Limited | Procédé amélioré pour l'obtention de rimonabant |
| WO2008035023A1 (fr) * | 2006-09-19 | 2008-03-27 | Cipla Limited | Formes polymorphes de rimonabant |
| WO2008056377A2 (fr) * | 2006-11-06 | 2008-05-15 | Cadila Healthcare Limited | Nouvelles formes du rimonabant |
| WO2008064615A2 (fr) * | 2006-12-01 | 2008-06-05 | Zentiva, A.S. | Formes cristallines et amorphes du rimonabant et procédés permettant d'obtenir ces formes |
| EP2121617B1 (fr) * | 2006-12-18 | 2014-01-22 | 7TM Pharma A/S | Modulateurs de récepteur cb1 |
| AR064735A1 (es) | 2007-01-04 | 2009-04-22 | Prosidion Ltd | Agonistas de gpcr y composicion farmaceutica en base al compuesto |
| GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
| JP2010514832A (ja) | 2007-01-04 | 2010-05-06 | プロシディオン・リミテッド | ピペリジンｇｐｃｒアゴニスト |
| RS52065B (en) | 2007-01-04 | 2012-06-30 | Prosidion Ltd | PIPERIDINSKI GPCR AGONIST |
| CL2008000017A1 (es) | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
| EP1944297A1 (fr) * | 2007-01-09 | 2008-07-16 | Miklós Vértessy | Rimonabant solide et cristallin et procédés de préparation, ainsi que composition pharmaceutique correspondante |
| WO2008088900A2 (fr) * | 2007-01-18 | 2008-07-24 | Teva Pharmaceutical Industries Ltd. | Formes polymorphes d'une base de rimonabant et procédés pour leur préparation |
| EP1953144A1 (fr) * | 2007-01-30 | 2008-08-06 | Sandoz AG | Nouvelles formes polymorphes de N-pipéridino-5-(4-chlorophényl)-1-(2, 4-dichlorphényl)-4-méthyl-3-pyrazolecarboxamide |
| FR2919865A1 (fr) * | 2007-08-06 | 2009-02-13 | Sanofi Aventis Sa | Le solvate de dmso de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
| FR2919867A1 (fr) * | 2007-08-06 | 2009-02-13 | Sanofi Aventis Sa | Le solvate de 2-methoxyethanol de rimonabant et son procede de preparation |
| FR2919864A1 (fr) * | 2007-08-06 | 2009-02-13 | Sanofi Aventis Sa | Le solvate de 1,4-dioxane de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
| FR2919862A1 (fr) * | 2007-08-06 | 2009-02-13 | Sanofi Aventis Sa | Le solvate de 3-methylbutan-1-ol de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
| FR2919863A1 (fr) * | 2007-08-06 | 2009-02-13 | Sanofi Aventis Sa | Le solvate de n-methylpyrrolidone de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
| GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| WO2009153804A1 (fr) * | 2008-06-16 | 2009-12-23 | Cadila Healthcare Limited | Procédé de préparation de la forme 1 du rimonabant |
| WO2010079241A1 (fr) | 2009-01-12 | 2010-07-15 | Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion | Utilisation d'antagonistes et/ou d'agonistes inverses des récepteurs cb1 pour la préparation de médicaments qui augmentent l'excitabilité des motoneurones |
| FR3008620A1 (fr) * | 2013-07-22 | 2015-01-23 | Sanofi Sa | Formulation de comprime d'un inhibiteur de phosphatidylinositol 3-kinase |
| WO2021075494A1 (fr) * | 2019-10-16 | 2021-04-22 | 大塚製薬株式会社 | Procédé de production de la centanafadine |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| FR2713225B1 (fr) * | 1993-12-02 | 1996-03-01 | Sanofi Sa | N-pipéridino-3-pyrazolecarboxamide substitué. |
| AU2002331595A1 (en) * | 2001-08-15 | 2003-03-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Novel vasoconstrictor cannabinoid analogs |
| FR2831883B1 (fr) * | 2001-11-08 | 2004-07-23 | Sanofi Synthelabo | Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant |
-
2001
- 2001-11-08 FR FR0114579A patent/FR2831883B1/fr not_active Expired - Fee Related
-
2002
- 2002-04-11 UA UA20040402974A patent/UA76776C2/uk unknown
- 2002-11-04 PL PL02369372A patent/PL369372A1/xx not_active Application Discontinuation
- 2002-11-04 RS YU36904A patent/RS36904A/sr unknown
- 2002-11-04 WO PCT/FR2002/003765 patent/WO2003040105A1/fr active Application Filing
- 2002-11-04 JP JP2003542151A patent/JP4181994B2/ja not_active Expired - Fee Related
- 2002-11-04 US US10/494,211 patent/US20050043356A1/en not_active Abandoned
- 2002-11-04 GE GE5606A patent/GEP20063894B/en unknown
- 2002-11-04 OA OA1200400131A patent/OA12721A/fr unknown
- 2002-11-04 AP APAP/P/2004/003024A patent/AP1830A/en active
- 2002-11-04 MX MXPA04004394A patent/MXPA04004394A/es unknown
- 2002-11-04 KR KR1020097016373A patent/KR20090089485A/ko not_active Application Discontinuation
- 2002-11-04 KR KR1020047006969A patent/KR20050043774A/ko not_active Application Discontinuation
- 2002-11-04 EA EA200400491A patent/EA006771B1/ru not_active IP Right Cessation
- 2002-11-04 ME MEP-219/08A patent/MEP21908A/xx unknown
- 2002-11-04 AU AU2002350869A patent/AU2002350869B2/en not_active Ceased
- 2002-11-04 CN CNB028219686A patent/CN100412063C/zh not_active Expired - Fee Related
- 2002-11-04 CA CA002464145A patent/CA2464145A1/fr not_active Abandoned
- 2002-11-04 HU HU0402043A patent/HUP0402043A3/hu unknown
- 2002-11-04 EP EP02785580A patent/EP1446384A1/fr not_active Withdrawn
- 2002-11-04 NZ NZ532369A patent/NZ532369A/en not_active IP Right Cessation
- 2002-11-04 BR BR0213931-6A patent/BR0213931A/pt not_active IP Right Cessation
- 2002-11-04 IL IL16153302A patent/IL161533A0/xx unknown
- 2002-11-06 AR ARP020104228A patent/AR037253A1/es unknown
- 2002-11-07 TW TW091132763A patent/TW200302824A/zh unknown
-
2004
- 2004-04-19 IS IS7226A patent/IS7226A/is unknown
- 2004-04-20 IL IL161533A patent/IL161533A/en not_active IP Right Cessation
- 2004-04-20 ZA ZA200402999A patent/ZA200402999B/en unknown
- 2004-04-27 EC EC2004005088A patent/ECSP045088A/es unknown
- 2004-04-28 MA MA27659A patent/MA27080A1/fr unknown
- 2004-05-04 CR CR7333A patent/CR7333A/es unknown
- 2004-05-04 CO CO04040840A patent/CO5580827A2/es not_active Application Discontinuation
- 2004-05-06 HR HR20040403A patent/HRP20040403A2/hr not_active Application Discontinuation
- 2004-05-07 TN TNP2004000079A patent/TNSN04079A1/fr unknown
- 2004-05-07 NO NO20041879A patent/NO326648B1/no not_active IP Right Cessation
-
2008
- 2008-07-11 JP JP2008181474A patent/JP4931874B2/ja not_active Expired - Fee Related
- 2008-10-28 US US12/259,701 patent/US20100190827A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
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| MM1K | Lapsed by not paying the annual fees |