FR2831883B1 - Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant - Google Patents

Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant

Info

Publication number
FR2831883B1
FR2831883B1 FR0114579A FR0114579A FR2831883B1 FR 2831883 B1 FR2831883 B1 FR 2831883B1 FR 0114579 A FR0114579 A FR 0114579A FR 0114579 A FR0114579 A FR 0114579A FR 2831883 B1 FR2831883 B1 FR 2831883B1
Authority
FR
France
Prior art keywords
same
rimonabant
preparing
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0114579A
Other languages
English (en)
Other versions
FR2831883A1 (fr
Inventor
Alain Alcade
Archard Gilles Anne
Corinne Gavory
Olivier Monnier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Priority to FR0114579A priority Critical patent/FR2831883B1/fr
Priority to UA20040402974A priority patent/UA76776C2/uk
Priority to APAP/P/2004/003024A priority patent/AP1830A/en
Priority to JP2003542151A priority patent/JP4181994B2/ja
Priority to HU0402043A priority patent/HUP0402043A3/hu
Priority to KR1020047006969A priority patent/KR20050043774A/ko
Priority to MEP-219/08A priority patent/MEP21908A/xx
Priority to GE5606A priority patent/GEP20063894B/en
Priority to PCT/FR2002/003765 priority patent/WO2003040105A1/fr
Priority to CA002464145A priority patent/CA2464145A1/fr
Priority to MXPA04004394A priority patent/MXPA04004394A/es
Priority to EP02785580A priority patent/EP1446384A1/fr
Priority to PL02369372A priority patent/PL369372A1/xx
Priority to IL16153302A priority patent/IL161533A0/xx
Priority to OA1200400131A priority patent/OA12721A/fr
Priority to CNB028219686A priority patent/CN100412063C/zh
Priority to AU2002350869A priority patent/AU2002350869B2/en
Priority to NZ532369A priority patent/NZ532369A/en
Priority to EA200400491A priority patent/EA006771B1/ru
Priority to KR1020097016373A priority patent/KR20090089485A/ko
Priority to YU36904A priority patent/RS36904A/sr
Priority to BR0213931-6A priority patent/BR0213931A/pt
Priority to US10/494,211 priority patent/US20050043356A1/en
Priority to ARP020104228A priority patent/AR037253A1/es
Priority to TW091132763A priority patent/TW200302824A/zh
Publication of FR2831883A1 publication Critical patent/FR2831883A1/fr
Priority to IS7226A priority patent/IS7226A/is
Priority to ZA200402999A priority patent/ZA200402999B/en
Priority to IL161533A priority patent/IL161533A/en
Priority to EC2004005088A priority patent/ECSP045088A/es
Priority to MA27659A priority patent/MA27080A1/fr
Priority to CR7333A priority patent/CR7333A/es
Priority to CO04040840A priority patent/CO5580827A2/es
Priority to HR20040403A priority patent/HRP20040403A2/hr
Priority to NO20041879A priority patent/NO326648B1/no
Priority to TNP2004000079A priority patent/TNSN04079A1/fr
Application granted granted Critical
Publication of FR2831883B1 publication Critical patent/FR2831883B1/fr
Priority to JP2008181474A priority patent/JP4931874B2/ja
Priority to US12/259,701 priority patent/US20100190827A1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
FR0114579A 2001-11-08 2001-11-08 Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant Expired - Fee Related FR2831883B1 (fr)

Priority Applications (37)

Application Number Priority Date Filing Date Title
FR0114579A FR2831883B1 (fr) 2001-11-08 2001-11-08 Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
UA20040402974A UA76776C2 (uk) 2001-11-08 2002-04-11 Поліморфна форма римонабанту, спосіб її отримання та фармацевтична композиція, що її містить
CNB028219686A CN100412063C (zh) 2001-11-08 2002-11-04 多晶型利莫那班,其制备方法及含有它的药物组合物
HU0402043A HUP0402043A3 (en) 2001-11-08 2002-11-04 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
KR1020047006969A KR20050043774A (ko) 2001-11-08 2002-11-04 리모나반트의 다형체 형태, 그의 제조 방법 및 그를함유하는 제약 조성물
MEP-219/08A MEP21908A (en) 2001-11-08 2002-11-04 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
GE5606A GEP20063894B (en) 2001-11-08 2002-11-04 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
YU36904A RS36904A (en) 2001-11-08 2002-11-04 Polymorphous form or rimonabant,preparation method and pharmaceutical, compositions containing same
CA002464145A CA2464145A1 (fr) 2001-11-08 2002-11-04 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
MXPA04004394A MXPA04004394A (es) 2001-11-08 2002-11-04 Forma polimorfa de rimonabant, su metodo de preparacion y composiciones farmaceuticas que lo contienen.
EP02785580A EP1446384A1 (fr) 2001-11-08 2002-11-04 Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
PL02369372A PL369372A1 (en) 2001-11-08 2002-11-04 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
IL16153302A IL161533A0 (en) 2001-11-08 2002-11-04 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
OA1200400131A OA12721A (fr) 2001-11-08 2002-11-04 Forme polymorphe du rimonabant, son procédé de préparation et les compositions pharmaceutiques en contenant.
JP2003542151A JP4181994B2 (ja) 2001-11-08 2002-11-04 リモナバントの結晶多形、およびそれを含む医薬組成物
AU2002350869A AU2002350869B2 (en) 2001-11-08 2002-11-04 Polymorphous form of rimonabant, preperation method and pharmaceutical compositions containing same
NZ532369A NZ532369A (en) 2001-11-08 2002-11-04 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
EA200400491A EA006771B1 (ru) 2001-11-08 2002-11-04 Полиморфная форма римонабанта, способ её получения и содержащие её фармацевтические композиции
APAP/P/2004/003024A AP1830A (en) 2001-11-08 2002-11-04 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same.
PCT/FR2002/003765 WO2003040105A1 (fr) 2001-11-08 2002-11-04 Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
US10/494,211 US20050043356A1 (en) 2001-11-08 2002-11-04 Polymorphic form of rimonabant method for preparing it and pharmaceutical compositions containing it
KR1020097016373A KR20090089485A (ko) 2001-11-08 2002-11-04 리모나반트의 다형체 형태, 그의 제조 방법 및 그를 함유하는 제약 조성물
BR0213931-6A BR0213931A (pt) 2001-11-08 2002-11-04 Forma polimórfica de rimonabant, processo para sua preparação e composições farmacêuticas contendo-as
ARP020104228A AR037253A1 (es) 2001-11-08 2002-11-06 Forma polimorfa de rimonabant, su procedimiento de preparacion y composiciones farmaceuticas que la contienen
TW091132763A TW200302824A (en) 2001-11-08 2002-11-07 Polymorphic form of rimonabant, method for preparing it and pharmaceutical compositions containing it
IS7226A IS7226A (is) 2001-11-08 2004-04-19 Fjölbrigða form af rimonabant, framleiðsluaðferð og lyfjasamsetningar sem innihalda það
ZA200402999A ZA200402999B (en) 2001-11-08 2004-04-20 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same.
IL161533A IL161533A (en) 2001-11-08 2004-04-20 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
EC2004005088A ECSP045088A (es) 2001-11-08 2004-04-27 Forma polimorfica de rimonabant, su procedimiento de preparacion y composiciones farmaceuticas que la contienen
MA27659A MA27080A1 (fr) 2001-11-08 2004-04-28 Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
CR7333A CR7333A (es) 2001-11-08 2004-05-04 Forma poliforma de rimonabant, su procedimiento de preparacion y composiciones farmaceuticas que la contienen
CO04040840A CO5580827A2 (es) 2001-11-08 2004-05-04 Forma polimorfa de rimonabant, su procedimiento de preparacion y composiciones farmaceuticas que la contienen
HR20040403A HRP20040403A2 (en) 2001-11-08 2004-05-06 Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
NO20041879A NO326648B1 (no) 2001-11-08 2004-05-07 Polymorf form av rimonabant, fremgangsmate for fremstilling derav og farmasoytisk preparat inneholdende det samme.
TNP2004000079A TNSN04079A1 (fr) 2001-11-08 2004-05-07 Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
JP2008181474A JP4931874B2 (ja) 2001-11-08 2008-07-11 リモナバントの結晶多形の製造方法
US12/259,701 US20100190827A1 (en) 2001-11-08 2008-10-28 Polymorphic form of rimonabant, method for preparing it and pharmaceutical compositions containing it

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0114579A FR2831883B1 (fr) 2001-11-08 2001-11-08 Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant

Publications (2)

Publication Number Publication Date
FR2831883A1 FR2831883A1 (fr) 2003-05-09
FR2831883B1 true FR2831883B1 (fr) 2004-07-23

Family

ID=8869285

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0114579A Expired - Fee Related FR2831883B1 (fr) 2001-11-08 2001-11-08 Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant

Country Status (33)

Country Link
US (2) US20050043356A1 (fr)
EP (1) EP1446384A1 (fr)
JP (2) JP4181994B2 (fr)
KR (2) KR20090089485A (fr)
CN (1) CN100412063C (fr)
AP (1) AP1830A (fr)
AR (1) AR037253A1 (fr)
AU (1) AU2002350869B2 (fr)
BR (1) BR0213931A (fr)
CA (1) CA2464145A1 (fr)
CO (1) CO5580827A2 (fr)
CR (1) CR7333A (fr)
EA (1) EA006771B1 (fr)
EC (1) ECSP045088A (fr)
FR (1) FR2831883B1 (fr)
GE (1) GEP20063894B (fr)
HR (1) HRP20040403A2 (fr)
HU (1) HUP0402043A3 (fr)
IL (2) IL161533A0 (fr)
IS (1) IS7226A (fr)
MA (1) MA27080A1 (fr)
ME (1) MEP21908A (fr)
MX (1) MXPA04004394A (fr)
NO (1) NO326648B1 (fr)
NZ (1) NZ532369A (fr)
OA (1) OA12721A (fr)
PL (1) PL369372A1 (fr)
RS (1) RS36904A (fr)
TN (1) TNSN04079A1 (fr)
TW (1) TW200302824A (fr)
UA (1) UA76776C2 (fr)
WO (1) WO2003040105A1 (fr)
ZA (1) ZA200402999B (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2831883B1 (fr) * 2001-11-08 2004-07-23 Sanofi Synthelabo Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
KR101228376B1 (ko) 2002-07-18 2013-01-31 사이토스 바이오테크놀로지 아게 합텐-캐리어 컨쥬게이트 및 그의 용도
FR2861992B1 (fr) * 2003-11-10 2007-07-20 Sanofi Synthelabo Composition pharmaceutique destinee a l'administration orale d'un derive de pyrazole-3-carboxamide.
WO2007003962A2 (fr) 2005-06-30 2007-01-11 Prosidion Limited Agonistes de gpcr
EP1816125A1 (fr) * 2006-02-02 2007-08-08 Ranbaxy Laboratories, Ltd. Formes cristallines d'un antagoniste du récepteur cannabinoïde CB1 et son procédé de préparation
FR2897060B1 (fr) * 2006-02-08 2008-07-25 Sanofi Aventis Sa Le monohydrate de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
AR061606A1 (es) * 2006-06-22 2008-09-10 Medichem Sa Formas solidas de rimonabant y procesos para su preparacion
AR062593A1 (es) * 2006-08-29 2008-11-19 Medichem Sa 1-{[5-(4-clorofenil)-1-(2,4-diclorofenil)-4-metil-1h-pirazol-3-il]carbonil}-piperidina y proceso para preparar dicho compuesto; proceso para analizar la pureza de rimonabant,proceso para preparar rimonabant,rimonabant que se obtiene mediante dicho proceso y formulaciones.
WO2008026219A2 (fr) * 2006-09-01 2008-03-06 Hetero Drugs Limited Nouveaux polymorphes de rimonabant
WO2008032330A2 (fr) * 2006-09-11 2008-03-20 Hetero Drugs Limited Procédé amélioré pour l'obtention de rimonabant
WO2008035023A1 (fr) * 2006-09-19 2008-03-27 Cipla Limited Formes polymorphes de rimonabant
WO2008056377A2 (fr) * 2006-11-06 2008-05-15 Cadila Healthcare Limited Nouvelles formes du rimonabant
WO2008064615A2 (fr) * 2006-12-01 2008-06-05 Zentiva, A.S. Formes cristallines et amorphes du rimonabant et procédés permettant d'obtenir ces formes
MX2009006214A (es) * 2006-12-18 2009-06-22 7Tm Pharma As Moduladores del receptor cb1.
CA2674360A1 (fr) 2007-01-04 2008-07-10 Prosidion Limited Agonistes de gpcr piperidiniques
CL2008000018A1 (es) 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
GB0700122D0 (en) 2007-01-04 2007-02-14 Prosidion Ltd GPCR agonists
RS52065B (en) 2007-01-04 2012-06-30 Prosidion Ltd PIPERIDINSKI GPCR AGONIST
CL2008000017A1 (es) 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
EP1944297A1 (fr) * 2007-01-09 2008-07-16 Miklós Vértessy Rimonabant solide et cristallin et procédés de préparation, ainsi que composition pharmaceutique correspondante
WO2008088900A2 (fr) * 2007-01-18 2008-07-24 Teva Pharmaceutical Industries Ltd. Formes polymorphes d'une base de rimonabant et procédés pour leur préparation
EP1953144A1 (fr) * 2007-01-30 2008-08-06 Sandoz AG Nouvelles formes polymorphes de N-pipéridino-5-(4-chlorophényl)-1-(2, 4-dichlorphényl)-4-méthyl-3-pyrazolecarboxamide
FR2919863A1 (fr) * 2007-08-06 2009-02-13 Sanofi Aventis Sa Le solvate de n-methylpyrrolidone de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
FR2919864A1 (fr) * 2007-08-06 2009-02-13 Sanofi Aventis Sa Le solvate de 1,4-dioxane de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
FR2919862A1 (fr) * 2007-08-06 2009-02-13 Sanofi Aventis Sa Le solvate de 3-methylbutan-1-ol de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
FR2919865A1 (fr) * 2007-08-06 2009-02-13 Sanofi Aventis Sa Le solvate de dmso de rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant
FR2919867A1 (fr) * 2007-08-06 2009-02-13 Sanofi Aventis Sa Le solvate de 2-methoxyethanol de rimonabant et son procede de preparation
GB0720390D0 (en) 2007-10-18 2007-11-28 Prosidion Ltd G-Protein coupled receptor agonists
GB0720389D0 (en) 2007-10-18 2008-11-12 Prosidion Ltd G-Protein Coupled Receptor Agonists
WO2009153804A1 (fr) * 2008-06-16 2009-12-23 Cadila Healthcare Limited Procédé de préparation de la forme 1 du rimonabant
WO2010079241A1 (fr) 2009-01-12 2010-07-15 Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion Utilisation d'antagonistes et/ou d'agonistes inverses des récepteurs cb1 pour la préparation de médicaments qui augmentent l'excitabilité des motoneurones
FR3008620A1 (fr) * 2013-07-22 2015-01-23 Sanofi Sa Formulation de comprime d'un inhibiteur de phosphatidylinositol 3-kinase
WO2021075494A1 (fr) * 2019-10-16 2021-04-22 大塚製薬株式会社 Procédé de production de la centanafadine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2692575B1 (fr) * 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2713225B1 (fr) * 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
US7109245B2 (en) * 2001-08-15 2006-09-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Vasoconstrictor cannabinoid analogs
FR2831883B1 (fr) * 2001-11-08 2004-07-23 Sanofi Synthelabo Forme polymorphe du rimonabant, son procede de preparation et les compositions pharmaceutiques en contenant

Also Published As

Publication number Publication date
CA2464145A1 (fr) 2003-05-15
HUP0402043A3 (en) 2009-07-28
RS36904A (en) 2006-10-27
HRP20040403A2 (en) 2004-08-31
CR7333A (es) 2008-09-23
EA200400491A1 (ru) 2004-12-30
CN1582278A (zh) 2005-02-16
JP2009035547A (ja) 2009-02-19
TW200302824A (en) 2003-08-16
ZA200402999B (en) 2005-04-20
IS7226A (is) 2004-04-19
JP4931874B2 (ja) 2012-05-16
CN100412063C (zh) 2008-08-20
NO20041879D0 (no) 2004-05-07
BR0213931A (pt) 2004-09-08
JP2005508383A (ja) 2005-03-31
US20050043356A1 (en) 2005-02-24
AP1830A (en) 2008-02-22
TNSN04079A1 (fr) 2006-06-01
MXPA04004394A (es) 2004-08-11
IL161533A (en) 2010-05-31
WO2003040105A1 (fr) 2003-05-15
MEP21908A (en) 2010-06-10
GEP20063894B (en) 2006-08-10
AR037253A1 (es) 2004-11-03
EP1446384A1 (fr) 2004-08-18
ECSP045088A (es) 2004-06-28
UA76776C2 (uk) 2006-09-15
OA12721A (fr) 2006-06-27
PL369372A1 (en) 2005-04-18
AP2004003024A0 (en) 2004-06-30
US20100190827A1 (en) 2010-07-29
CO5580827A2 (es) 2005-11-30
AU2002350869B2 (en) 2007-07-26
NO326648B1 (no) 2009-01-26
KR20090089485A (ko) 2009-08-21
EA006771B1 (ru) 2006-04-28
NZ532369A (en) 2005-10-28
KR20050043774A (ko) 2005-05-11
NO20041879L (no) 2004-06-08
HUP0402043A2 (hu) 2005-01-28
MA27080A1 (fr) 2004-12-20
JP4181994B2 (ja) 2008-11-19
IL161533A0 (en) 2004-09-27
FR2831883A1 (fr) 2003-05-09

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