NO326298B1 - Anvendelse av R'-Glu-Trp-R'' dipeptider i fremstilling av medikamenter - Google Patents
Anvendelse av R'-Glu-Trp-R'' dipeptider i fremstilling av medikamenter Download PDFInfo
- Publication number
- NO326298B1 NO326298B1 NO19981436A NO981436A NO326298B1 NO 326298 B1 NO326298 B1 NO 326298B1 NO 19981436 A NO19981436 A NO 19981436A NO 981436 A NO981436 A NO 981436A NO 326298 B1 NO326298 B1 NO 326298B1
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- Prior art keywords
- glu
- trp
- neovascularization
- dipeptide
- drug
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- 229940049964 oleate Drugs 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 229940039748 oxalate Drugs 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000000863 peptide conjugate Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920005990 polystyrene resin Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 150000003233 pyrroles Chemical class 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
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- 208000037921 secondary disease Diseases 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 238000011125 single therapy Methods 0.000 description 1
- 238000009097 single-agent therapy Methods 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 238000011287 therapeutic dose Methods 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 210000001541 thymus gland Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000007838 tissue remodeling Effects 0.000 description 1
- 230000037317 transdermal delivery Effects 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 238000011277 treatment modality Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000007556 vascular defect Effects 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 230000002227 vasoactive effect Effects 0.000 description 1
- 230000007998 vessel formation Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53870195A | 1995-10-03 | 1995-10-03 | |
| US08/614,764 US5902790A (en) | 1995-10-03 | 1996-03-13 | Pharmaceutical angiostatic dipeptide compositions and method of use thereof |
| PCT/US1996/015856 WO1997012625A1 (en) | 1995-10-03 | 1996-10-02 | Pharmaceutical angiostatic dipeptide compositions and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO981436D0 NO981436D0 (no) | 1998-03-30 |
| NO981436L NO981436L (no) | 1998-05-19 |
| NO326298B1 true NO326298B1 (no) | 2008-11-03 |
Family
ID=27065900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19981436A NO326298B1 (no) | 1995-10-03 | 1998-03-30 | Anvendelse av R'-Glu-Trp-R'' dipeptider i fremstilling av medikamenter |
Country Status (23)
| Country | Link |
|---|---|
| US (4) | US5902790A (cs) |
| EP (1) | EP0869808B1 (cs) |
| JP (2) | JP3679129B2 (cs) |
| KR (1) | KR100483779B1 (cs) |
| CN (1) | CN1128636C (cs) |
| AT (1) | ATE332702T1 (cs) |
| AU (1) | AU714846B2 (cs) |
| BR (1) | BR9610838A (cs) |
| CA (1) | CA2233457C (cs) |
| CZ (1) | CZ298345B6 (cs) |
| DE (1) | DE69636343T2 (cs) |
| DK (1) | DK0869808T3 (cs) |
| EA (1) | EA001146B1 (cs) |
| ES (1) | ES2268710T3 (cs) |
| HU (1) | HUP9902105A3 (cs) |
| IL (1) | IL123889A0 (cs) |
| MX (1) | MX9802564A (cs) |
| NO (1) | NO326298B1 (cs) |
| NZ (1) | NZ319907A (cs) |
| PL (1) | PL186123B1 (cs) |
| SK (1) | SK283677B6 (cs) |
| TR (1) | TR199800653T1 (cs) |
| WO (1) | WO1997012625A1 (cs) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5902790A (en) * | 1995-10-03 | 1999-05-11 | Cytran, Inc. | Pharmaceutical angiostatic dipeptide compositions and method of use thereof |
| US6060452A (en) * | 1996-03-13 | 2000-05-09 | Cytran, Inc. | Analogs of L-Glu-L-Trp having pharmacological activity |
| AU3467099A (en) * | 1998-04-03 | 1999-10-25 | Cytran Ltd. | Methods for production of therapeutic cytokines |
| US6555543B2 (en) | 2000-08-04 | 2003-04-29 | Dmi Biosciences, Inc. | Method of using diketopiperazines and composition containing them |
| CN100579582C (zh) * | 2001-01-02 | 2010-01-13 | Imtm股份有限公司 | 联合应用酶抑制剂及其药学组合物在制备治疗和预防动脉硬化、预防和治疗根据杰尔－库姆斯分类法分类的ⅰ型过敏反应以及治疗和预防与毛囊和表皮角化过度和角质细胞的过度增殖相关的皮肤疾病的药物中的用途 |
| DE10100052A1 (de) * | 2001-01-02 | 2002-07-11 | Inst Medizintechnologie Magdeb | Kombinierte Verwendung von Enzyminhibitoren und pharmazeutischen Zubereitungen daraus zur Therapie und Prophylaxe der Atheriosklerose |
| US20030087830A1 (en) * | 2001-06-12 | 2003-05-08 | Eric Dupont | Low molecular weight components of cartilage, complexes of metals with amino acids, DI-peptides and analogs thereof; processes for preparation and therapeutic uses thereof |
| KR20150080004A (ko) | 2003-05-15 | 2015-07-08 | 앰피오 파마슈티컬스 인코퍼레이티드 | Ｔ-세포 매개성 질환의 치료 방법 |
| WO2005016326A2 (en) * | 2003-07-11 | 2005-02-24 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Analogs of thalidomide as potential angiogenesis inhibitors |
| CA2808646C (en) | 2003-09-17 | 2016-08-23 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Thalidomide analogs as tnf-alpha modulators |
| US8952895B2 (en) | 2011-06-03 | 2015-02-10 | Apple Inc. | Motion-based device operations |
| EP1848541A4 (en) * | 2005-02-07 | 2013-01-16 | Pharmalight Inc | METHOD AND DEVICE FOR OPHTHALMIC DELIVERY OF PHARMACEUTICALLY ACTIVE INGREDIENTS |
| CA2569204A1 (en) * | 2006-11-28 | 2008-05-28 | Apotex Technologies Inc. | Crystalline d-isoglutamyl-d-tryptophan and the mono ammonium salt of d-isoglutamyl-d-tryptophan |
| CA2571645A1 (en) * | 2006-12-19 | 2008-06-19 | Apotex Technologies Inc. | Pharmaceutically acceptable salts of thymodepressin and processes for their manufacture |
| US7906486B2 (en) * | 2007-02-13 | 2011-03-15 | Sciclone Pharmaceuticals, Inc. | Method of treating or preventing tissue deterioration, injury or damage due to disease of mucosa |
| CA2579119C (en) * | 2007-02-16 | 2013-03-05 | Apotex Technologies Inc. | Crystalline forms of the mono-sodium salt of d-isoglutamyl-d-tryptophan |
| NZ584065A (en) * | 2007-08-23 | 2012-03-30 | Sciclone Pharmaceuticals Inc | Treatment of lung cancer with scv-07 |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ，インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| DE102008032828A1 (de) * | 2008-07-02 | 2010-01-07 | Technische Universität Dresden | Tryptophanhaltige Peptide aus alpha-Lactalbumin mit blutdrucksenkender und vasoprotektiver Wirkung für biofunktionelle Lebensmittel |
| CA2810844C (en) | 2010-09-07 | 2017-03-21 | Dmi Acquisition Corp. | Diketopiperazine compositions for the treatment of metabolic syndrome and related conditions |
| MY172699A (en) | 2011-10-10 | 2019-12-10 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
| WO2013055734A1 (en) | 2011-10-10 | 2013-04-18 | Ampio Pharmaceuticals, Inc. | Treatment of degenerative joint disease |
| MX355446B (es) | 2011-10-28 | 2018-04-18 | Ampio Pharmaceuticals Inc | Tratamiento de rinitis. |
| US8927725B2 (en) | 2011-12-02 | 2015-01-06 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Thio compounds |
| CN102631464B (zh) * | 2012-05-18 | 2013-07-31 | 崔新明 | 一种治疗婴幼儿血管瘤的中药膏剂及其制备方法 |
| EP2968315B1 (en) | 2013-03-15 | 2020-06-03 | Ampio Pharmaceuticals, Inc. | Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same |
| WO2016028790A1 (en) | 2014-08-18 | 2016-02-25 | Ampio Pharmaceuticals, Inc. | Treatment of joint conditions |
| US9744209B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9925233B2 (en) | 2015-01-30 | 2018-03-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9750785B2 (en) | 2015-01-30 | 2017-09-05 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9937223B2 (en) | 2015-01-30 | 2018-04-10 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9687526B2 (en) | 2015-01-30 | 2017-06-27 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US9744239B2 (en) | 2015-01-30 | 2017-08-29 | Par Pharmaceutical, Inc. | Vasopressin formulations for use in treatment of hypotension |
| US11389512B2 (en) | 2015-06-22 | 2022-07-19 | Ampio Pharmaceuticals, Inc. | Use of low molecular weight fractions of human serum albumin in treating diseases |
| SG11202001595SA (en) | 2017-08-31 | 2020-03-30 | Singapore Health Serv Pte Ltd | Angio-3 for treatment of retinal angiogenic diseases |
| CN116874557A (zh) * | 2023-08-01 | 2023-10-13 | 首都医科大学 | 2-Trp-AA-四氢咔啉-3-羧酸类化合物及其PAF抑制剂的应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3997516A (en) * | 1974-07-04 | 1976-12-14 | Takeda Chemical Industries, Ltd. | Method for protecting guanidino group and restoring the same |
| US4191753A (en) * | 1978-11-06 | 1980-03-04 | University Of Miami | Anti-hypertensive peptide analogs |
| US5728680A (en) * | 1987-12-30 | 1998-03-17 | Cytoven J.V. | Methods for normalizing numbers of lymphocytes |
| JP2511159B2 (ja) * | 1987-12-30 | 1996-06-26 | オブシェストボ エス オグラニチェンノイ オトベツベンノスチュ “ツィトメド―ペプトス” | 免疫欠損状態の治療のための医薬製剤 |
| GR1000608B (el) * | 1988-07-21 | 1992-08-31 | Erba Carlo Spa | Μεθοδος για την παρασκευη ανταγωνιστων bombesin. |
| SU1642398A1 (ru) * | 1988-12-21 | 1991-04-15 | Ростовский медицинский институт | Способ лечени синуитов у детей |
| US5902790A (en) * | 1995-10-03 | 1999-05-11 | Cytran, Inc. | Pharmaceutical angiostatic dipeptide compositions and method of use thereof |
| US5770576A (en) * | 1989-08-30 | 1998-06-23 | Cytran, Inc. | Pharmaceutical dipeptide compositions and methods of use thereof: systemic toxicity |
| RU1827255C (ru) * | 1990-10-22 | 1993-07-15 | Киевский государственный институт усовершенствования врачей | Способ лечени туберкулеза легких |
| JP3068656B2 (ja) * | 1991-03-07 | 2000-07-24 | アピ株式会社 | 新規なペプチド及びアンジオテンシン変換酵素阻害ペプチド並びにそれらを含有する経口摂食組成物 |
| CA2107460A1 (en) * | 1991-04-01 | 1992-10-02 | Vladimir K. Khavinson | Pharmaceutical dipeptide compositions and methods of use thereof |
| RU2014063C1 (ru) * | 1991-04-23 | 1994-06-15 | Сочинский научно-исследовательский институт курортологии и физиотерапии | Способ лечения подострых воспалительных заболеваний гениталий |
| ATE188219T1 (de) * | 1991-10-28 | 2000-01-15 | Cytran Ltd | Pharmazeutische dipeptid zusammensetzungen und verwendungsmethoden. |
| WO1995003067A1 (en) * | 1993-07-21 | 1995-02-02 | Khavinson Vladimir Khatskelevi | Pharmaceutical with immunomodulating activity |
| JPH09503205A (ja) * | 1993-09-24 | 1997-03-31 | ザ ユニバーシティ オブ サザーン カリフォルニア | 組織修復におけるアンギオテンシン▲ｉｉ▼類似体の使用 |
-
1996
- 1996-03-13 US US08/614,764 patent/US5902790A/en not_active Expired - Lifetime
- 1996-10-02 IL IL12388996A patent/IL123889A0/xx unknown
- 1996-10-02 BR BR9610838-0A patent/BR9610838A/pt not_active Application Discontinuation
- 1996-10-02 AT AT96934021T patent/ATE332702T1/de not_active IP Right Cessation
- 1996-10-02 HU HU9902105A patent/HUP9902105A3/hu unknown
- 1996-10-02 CZ CZ0091398A patent/CZ298345B6/cs not_active IP Right Cessation
- 1996-10-02 TR TR1998/00653T patent/TR199800653T1/xx unknown
- 1996-10-02 SK SK423-98A patent/SK283677B6/sk not_active IP Right Cessation
- 1996-10-02 ES ES96934021T patent/ES2268710T3/es not_active Expired - Lifetime
- 1996-10-02 NZ NZ319907A patent/NZ319907A/xx not_active IP Right Cessation
- 1996-10-02 EP EP96934021A patent/EP0869808B1/en not_active Expired - Lifetime
- 1996-10-02 EA EA199800357A patent/EA001146B1/ru not_active IP Right Cessation
- 1996-10-02 DK DK96934021T patent/DK0869808T3/da active
- 1996-10-02 PL PL96326149A patent/PL186123B1/pl unknown
- 1996-10-02 KR KR1019980702431A patent/KR100483779B1/ko not_active IP Right Cessation
- 1996-10-02 WO PCT/US1996/015856 patent/WO1997012625A1/en active IP Right Grant
- 1996-10-02 JP JP51441597A patent/JP3679129B2/ja not_active Expired - Lifetime
- 1996-10-02 CN CN96197430A patent/CN1128636C/zh not_active Expired - Lifetime
- 1996-10-02 CA CA002233457A patent/CA2233457C/en not_active Expired - Lifetime
- 1996-10-02 DE DE69636343T patent/DE69636343T2/de not_active Expired - Lifetime
- 1996-10-02 AU AU72540/96A patent/AU714846B2/en not_active Expired
-
1998
- 1998-03-30 NO NO19981436A patent/NO326298B1/no not_active IP Right Cessation
- 1998-04-01 MX MX9802564A patent/MX9802564A/es unknown
-
1999
- 1999-03-01 US US09/260,190 patent/US6096713A/en not_active Expired - Lifetime
-
2000
- 2000-02-17 US US09/506,430 patent/US6911431B1/en not_active Expired - Fee Related
-
2005
- 2005-03-15 JP JP2005074079A patent/JP2005194287A/ja not_active Withdrawn
- 2005-05-16 US US11/129,367 patent/US20060094665A1/en not_active Abandoned
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| Date | Code | Title | Description |
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| MK1K | Patent expired |