NO324372B1 - Polypeptid, DNA-sekvens som koder for polypeptidet, ekspresjonsvektor og vertscelle som omfatter DNA-molekylet, samt kombinasjonspolypeptid, blanding og diagnostisk testsett som omfatter polypeptidet og farmasoytisk blanding og vaksine som omfatter polypeptidet, et DNA-molekyl som koder for polypeptidet eller et kombinasjonspolypeptid som omfatter polypeptidet. - Google Patents

Polypeptid, DNA-sekvens som koder for polypeptidet, ekspresjonsvektor og vertscelle som omfatter DNA-molekylet, samt kombinasjonspolypeptid, blanding og diagnostisk testsett som omfatter polypeptidet og farmasoytisk blanding og vaksine som omfatter polypeptidet, et DNA-molekyl som koder for polypeptidet eller et kombinasjonspolypeptid som omfatter polypeptidet. Download PDF

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Publication number
NO324372B1
NO324372B1 NO19980883A NO980883A NO324372B1 NO 324372 B1 NO324372 B1 NO 324372B1 NO 19980883 A NO19980883 A NO 19980883A NO 980883 A NO980883 A NO 980883A NO 324372 B1 NO324372 B1 NO 324372B1
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NO
Norway
Prior art keywords
polypeptide
seq
amino acid
tuberculosis
acid sequence
Prior art date
Application number
NO19980883A
Other languages
English (en)
Norwegian (no)
Other versions
NO980883L (no
NO980883D0 (no
Inventor
Daniel R Twardzik
Steven G Reed
Yasir A W Skeiky
David C Dillon
Antonio Campos-Neto
Raymond Houghton
Thomas H Vedvick
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27541835&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO324372(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of NO980883D0 publication Critical patent/NO980883D0/no
Publication of NO980883L publication Critical patent/NO980883L/no
Publication of NO324372B1 publication Critical patent/NO324372B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • A61P31/06Antibacterial agents for tuberculosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
NO19980883A 1995-09-01 1998-02-27 Polypeptid, DNA-sekvens som koder for polypeptidet, ekspresjonsvektor og vertscelle som omfatter DNA-molekylet, samt kombinasjonspolypeptid, blanding og diagnostisk testsett som omfatter polypeptidet og farmasoytisk blanding og vaksine som omfatter polypeptidet, et DNA-molekyl som koder for polypeptidet eller et kombinasjonspolypeptid som omfatter polypeptidet. NO324372B1 (no)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US52343695A 1995-09-01 1995-09-01
US53363495A 1995-09-22 1995-09-22
US62087496A 1996-03-22 1996-03-22
US65968396A 1996-06-05 1996-06-05
US68057496A 1996-07-12 1996-07-12
PCT/US1996/014674 WO1997009428A2 (fr) 1995-09-01 1996-08-30 Composes et methodes d'immunotherapie et de diagnostic de la tuberculose

Publications (3)

Publication Number Publication Date
NO980883D0 NO980883D0 (no) 1998-02-27
NO980883L NO980883L (no) 1998-04-27
NO324372B1 true NO324372B1 (no) 2007-10-01

Family

ID=27541835

Family Applications (4)

Application Number Title Priority Date Filing Date
NO19980883A NO324372B1 (no) 1995-09-01 1998-02-27 Polypeptid, DNA-sekvens som koder for polypeptidet, ekspresjonsvektor og vertscelle som omfatter DNA-molekylet, samt kombinasjonspolypeptid, blanding og diagnostisk testsett som omfatter polypeptidet og farmasoytisk blanding og vaksine som omfatter polypeptidet, et DNA-molekyl som koder for polypeptidet eller et kombinasjonspolypeptid som omfatter polypeptidet.
NO20070621A NO20070621L (no) 1995-09-01 2007-02-01 Forbindelser og fremgangsmater for immunterapi og diagnose av tuberkulose
NO20070618A NO336288B1 (no) 1995-09-01 2007-02-01 Polypeptid, DNA-molekyl, ekspresjonsvektor, vertscelle, fusjonsprotein, farmasøytisk blanding, vaksine, blanding og diagnostisk sett.
NO20070619A NO20070619L (no) 1995-09-01 2007-02-01 Forbindelser og fremgangsmater for immunterapi og diagnose av tuberkulose.

Family Applications After (3)

Application Number Title Priority Date Filing Date
NO20070621A NO20070621L (no) 1995-09-01 2007-02-01 Forbindelser og fremgangsmater for immunterapi og diagnose av tuberkulose
NO20070618A NO336288B1 (no) 1995-09-01 2007-02-01 Polypeptid, DNA-molekyl, ekspresjonsvektor, vertscelle, fusjonsprotein, farmasøytisk blanding, vaksine, blanding og diagnostisk sett.
NO20070619A NO20070619L (no) 1995-09-01 2007-02-01 Forbindelser og fremgangsmater for immunterapi og diagnose av tuberkulose.

Country Status (24)

Country Link
EP (5) EP1712628B1 (fr)
JP (5) JP4382160B2 (fr)
KR (1) KR100433750B1 (fr)
CN (1) CN1117149C (fr)
AT (5) ATE426025T1 (fr)
AU (1) AU727602B2 (fr)
BR (2) BR9610262B1 (fr)
CA (3) CA2230885C (fr)
CY (2) CY2570B1 (fr)
CZ (3) CZ297406B6 (fr)
DE (4) DE69636046T2 (fr)
DK (4) DK1203817T3 (fr)
ES (4) ES2262595T3 (fr)
HK (1) HK1059282A1 (fr)
HU (2) HU225979B1 (fr)
IL (1) IL123506A (fr)
MX (1) MX9801638A (fr)
NO (4) NO324372B1 (fr)
NZ (1) NZ319377A (fr)
PL (1) PL186774B1 (fr)
PT (4) PT1347055E (fr)
SI (1) SI0851927T1 (fr)
TR (5) TR200403064T2 (fr)
WO (1) WO1997009428A2 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6991797B2 (en) 1993-07-02 2006-01-31 Statens Serum Institut M. tuberculosis antigens
US6641814B1 (en) 1997-04-02 2003-11-04 Statens Serum Institut Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis
US6592877B1 (en) 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6290969B1 (en) * 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6458366B1 (en) 1995-09-01 2002-10-01 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
EP0934415A2 (fr) * 1996-10-11 1999-08-11 Corixa Corporation Composes et procedes pour diagnostiquer la tuberculose
US6350456B1 (en) 1997-03-13 2002-02-26 Corixa Corporation Compositions and methods for the prevention and treatment of M. tuberculosis infection
US6627198B2 (en) 1997-03-13 2003-09-30 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis antigens and their uses
US6544522B1 (en) 1998-12-30 2003-04-08 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
EP0972045A1 (fr) * 1997-04-02 2000-01-19 Statens Seruminstitut FRAGMENTS D'ACIDE NUCLEIQUE ET FRAGMENTS POLYPEPTIDIQUES DERIVES DE $i(M. TUBERCULOSIS)
US6982085B2 (en) 1997-04-02 2006-01-03 Statens Serum Institut TB diagnostic based on antigens from M. tuberculosis
US7037510B2 (en) 1997-04-18 2006-05-02 Statens Serum Institut Hybrids of M. tuberculosis antigens
US7087713B2 (en) 2000-02-25 2006-08-08 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
US6555653B2 (en) * 1997-05-20 2003-04-29 Corixa Corporation Compounds for diagnosis of tuberculosis and methods for their use
US6613881B1 (en) * 1997-05-20 2003-09-02 Corixa Corporation Compounds for immunotherapy and diagnosis of tuberculosis and methods of their use
AU8123898A (en) * 1997-07-16 1999-02-10 Institut Pasteur A polynucleotide functionally coding for the lhp protein from mycobacterium tuberculosis, its biologically active derivative fragments, as well as metho ds usingthe same
AU750173B2 (en) * 1997-11-10 2002-07-11 Statens Serum Institut Nucleic acid fragments and polypeptide fragments derived from M. tuberculosis
EP1484405A1 (fr) * 1997-11-10 2004-12-08 Statens Serum Institut Fragments d'acide nucléique et fragments polypeptidiques derivés de M. tuberculosis
CN1163602C (zh) * 1998-04-07 2004-08-25 科里克萨公司 结核杆菌抗原融合蛋白及其应用
GB9808720D0 (en) * 1998-04-23 1998-06-24 Smithkline Beecham Biolog Novel compounds
US7632646B1 (en) * 1998-11-04 2009-12-15 Isis Innovation Limited Tuberculosis diagnostic test
US6465633B1 (en) 1998-12-24 2002-10-15 Corixa Corporation Compositions and methods of their use in the treatment, prevention and diagnosis of tuberculosis
AU2594500A (en) * 1998-12-24 2000-07-31 Corixa Corporation Methods for using mycobacterium tuberculosis molecules as immunological adjuvants
EP1214088B1 (fr) * 1999-05-04 2009-04-22 The University of Medicine and Dentistry of New Jersey Proteines exprimees par mycobacterium tuberculosis et non par bcg et employees en tant que vaccins et reactifs de diagnostic
US7009042B1 (en) * 1999-10-07 2006-03-07 Corixa Corporation Methods of using a Mycobacterium tuberculosis coding sequence to facilitate stable and high yield expression of the heterologous proteins
US6316205B1 (en) 2000-01-28 2001-11-13 Genelabs Diagnostics Pte Ltd. Assay devices and methods of analyte detection
DE60139963D1 (de) 2000-06-20 2009-10-29 Corixa Corp Fusionsproteine aus mycobakterium tuberculosis
US7026465B2 (en) 2002-02-15 2006-04-11 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis
ITRM20040091A1 (it) 2004-02-19 2004-05-19 Istituto Naz Per Le Malattie Test immunologico rapido per la diagnosi ed il monitoraggio dell'infezione tubercolare.
FI119445B (fi) * 2004-10-29 2008-11-14 Waertsilae Finland Oy Polttomoottorin polttoaineen syöttöjärjestelmän paineen värähtelyn vaimennin
EP1812580B1 (fr) 2004-11-16 2014-12-17 Crucell Holland B.V. Vaccin polyvalent comprenant des vecteurs viraux recombinants.
NZ562729A (en) 2005-04-29 2009-10-30 Infectious Disease Res Inst Id Novel method for preventing or treating M tuberculosis infection using Mtb72f fusion proteins
FR2952058B1 (fr) * 2009-10-29 2013-10-04 Centre Nat Rech Scient Procede de ligation native de polypeptides
EP2528621B1 (fr) 2010-01-27 2016-09-21 GlaxoSmithKline Biologicals S.A. Antigènes modifiés de la tuberculose
BR112013014599A2 (pt) 2010-12-14 2016-09-27 Glaxosmithkline Biolog Sa composição imunogênica, uso de uma composição imunogênica, processo para preparar uma composição imunogênica, método para a fabricação de uma composição imunogênca estável, e, kit
FR2971509B1 (fr) * 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
CN103290030A (zh) * 2012-02-23 2013-09-11 上海交通大学 一种结核分枝杆菌标志物HtdY的重组蛋白及其制备方法和临床应用
JP6434905B2 (ja) * 2012-05-04 2018-12-05 ファイザー・インク 前立腺関連抗原およびワクチンに基づく免疫療法レジメン
US20170121377A1 (en) * 2014-04-04 2017-05-04 Vestaron Corporation Artificially activated toxic peptides
GB201513176D0 (en) 2015-07-27 2015-09-09 Glaxosmithkline Biolog Sa Novel methods for inducing an immune response
FR3048286B1 (fr) * 2016-02-26 2021-01-22 Omunis Peptides immunogenes et leur utilisation
CN107304231B (zh) * 2016-04-18 2021-01-01 华中农业大学 一种结核分枝杆菌融合蛋白及应用
GB201614485D0 (en) * 2016-08-25 2016-10-12 Univ Oxford Innovation Ltd Immunogenic composition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244539A1 (en) * 1973-07-13 1975-04-18 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
FR2265402A1 (en) * 1974-03-29 1975-10-24 Mitsui Pharmaceuticals Tuberculin active proteins and peptides prepn - from tubercle bacillus
US4876089A (en) * 1984-09-06 1989-10-24 Chiron Corporation Feline leukemia virus protein vaccines
US4751180A (en) 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
US4935233A (en) 1985-12-02 1990-06-19 G. D. Searle And Company Covalently linked polypeptide cell modulators
US5075109A (en) 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US4897268A (en) 1987-08-03 1990-01-30 Southern Research Institute Drug delivery system and method of making the same
FR2677365B1 (fr) * 1991-06-07 1995-08-04 Pasteur Institut Proteines de mycobacterium et applications.
US5330754A (en) * 1992-06-29 1994-07-19 Archana Kapoor Membrane-associated immunogens of mycobacteria
DK79893D0 (da) * 1993-07-02 1993-07-02 Statens Seruminstitut New vaccine
DK79793D0 (da) * 1993-07-02 1993-07-02 Statens Seruminstitut Diagnostic test

Also Published As

Publication number Publication date
ES2324529T3 (es) 2009-08-10
DK1203817T3 (da) 2006-08-14
NO20070621L (no) 1998-04-27
CN1200147A (zh) 1998-11-25
NO20070619L (no) 1998-04-27
ES2271449T3 (es) 2007-04-16
EP1712628A2 (fr) 2006-10-18
EP1398379B1 (fr) 2006-08-23
ES2210392T3 (es) 2004-07-01
DE69636046D1 (de) 2006-05-24
KR100433750B1 (ko) 2004-09-01
JP4324596B2 (ja) 2009-09-02
EP1398379A3 (fr) 2004-07-14
IL123506A (en) 2004-12-15
CY2612B2 (en) 2010-12-22
IL123506A0 (en) 1998-10-30
EP1347055B1 (fr) 2009-03-18
JP2006149406A (ja) 2006-06-15
AU727602B2 (en) 2000-12-14
DE69630457T2 (de) 2004-11-25
CA2684425A1 (fr) 1997-03-13
BR9610262B1 (pt) 2013-11-26
JP4324597B2 (ja) 2009-09-02
EP1347055A3 (fr) 2003-11-26
ES2262595T3 (es) 2006-12-01
HU225979B1 (en) 2008-02-28
EP0851927A2 (fr) 1998-07-08
EP1712628A3 (fr) 2007-05-23
CZ300953B6 (cs) 2009-09-23
PL325373A1 (en) 1998-07-20
EP1203817A2 (fr) 2002-05-08
PT1398379E (pt) 2007-01-31
TR199800411T1 (xx) 1998-05-21
TR200403064T2 (tr) 2005-08-22
NO336288B1 (no) 2015-07-13
ATE513915T1 (de) 2011-07-15
EP1203817B9 (fr) 2006-08-16
JP4324618B2 (ja) 2009-09-02
HUP9900902A2 (hu) 1999-07-28
CZ297406B6 (cs) 2006-12-13
DE69636487T2 (de) 2007-05-03
PT1347055E (pt) 2009-06-19
NZ319377A (en) 2000-01-28
CA2653566A1 (fr) 1997-03-13
JP4382160B2 (ja) 2009-12-09
ATE252640T1 (de) 2003-11-15
DE69637879D1 (de) 2009-04-30
SI0851927T1 (en) 2004-02-29
BR9610262A (pt) 1999-07-06
PL186774B1 (pl) 2004-02-27
DK0851927T3 (da) 2004-01-26
PT851927E (pt) 2004-03-31
DE69636487D1 (de) 2006-10-05
CN1117149C (zh) 2003-08-06
JP2006187292A (ja) 2006-07-20
ATE426025T1 (de) 2009-04-15
CZ62898A3 (cs) 1999-10-13
CY2570B1 (en) 2008-07-02
TR200806259T2 (tr) 2008-10-21
DK1347055T3 (da) 2009-06-29
EP1398379A2 (fr) 2004-03-17
CA2230885A1 (fr) 1997-03-13
MX9801638A (es) 1998-05-31
DE69630457D1 (de) 2003-11-27
CA2653566C (fr) 2013-06-25
EP1203817A3 (fr) 2003-01-29
TR200901109T1 (tr) 2012-02-21
NO980883L (no) 1998-04-27
JP2009159982A (ja) 2009-07-23
EP1347055A2 (fr) 2003-09-24
NO980883D0 (no) 1998-02-27
CA2230885C (fr) 2010-02-02
HU227778B1 (en) 2012-02-28
JP2001517069A (ja) 2001-10-02
EP1203817B1 (fr) 2006-04-12
AU7158696A (en) 1997-03-27
HUP9900902A3 (en) 2001-03-28
WO1997009428A3 (fr) 1997-07-17
ATE323165T1 (de) 2006-04-15
NO20070618L (no) 1998-04-27
JP2007228972A (ja) 2007-09-13
DK1398379T3 (da) 2007-01-08
TR200806258T2 (tr) 2008-10-21
KR19990044347A (ko) 1999-06-25
PT1203817E (pt) 2006-08-31
ATE337399T1 (de) 2006-09-15
BR9612997B1 (pt) 2012-01-10
CZ300688B6 (cs) 2009-07-15
EP0851927B1 (fr) 2003-10-22
DE69636046T2 (de) 2006-11-23
HK1059282A1 (en) 2004-06-25
EP1712628B1 (fr) 2011-06-22
WO1997009428A2 (fr) 1997-03-13

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