NO322744B1 - Anvendelse av Lymfotoksin-alfa/beta-komplekser til fremstilling av medikamenter mot neoplasia samt anti-lymfotoksin-beta-reseptor-antistoff som anti-svukstmidler. - Google Patents

Anvendelse av Lymfotoksin-alfa/beta-komplekser til fremstilling av medikamenter mot neoplasia samt anti-lymfotoksin-beta-reseptor-antistoff som anti-svukstmidler. Download PDF

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Publication number
NO322744B1
NO322744B1 NO19973385A NO973385A NO322744B1 NO 322744 B1 NO322744 B1 NO 322744B1 NO 19973385 A NO19973385 A NO 19973385A NO 973385 A NO973385 A NO 973385A NO 322744 B1 NO322744 B1 NO 322744B1
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NO
Norway
Prior art keywords
antibody
pharmaceutical composition
ifn
cells
cross
Prior art date
Application number
NO19973385A
Other languages
English (en)
Norwegian (no)
Other versions
NO973385D0 (no
NO973385L (no
Inventor
Christopher D Benjamin
Jeffrey L Browning
Werner Meier
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of NO973385D0 publication Critical patent/NO973385D0/no
Publication of NO973385L publication Critical patent/NO973385L/no
Publication of NO322744B1 publication Critical patent/NO322744B1/no

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/191Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/525Tumour necrosis factor [TNF]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74Inducing cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
NO19973385A 1995-01-26 1997-07-22 Anvendelse av Lymfotoksin-alfa/beta-komplekser til fremstilling av medikamenter mot neoplasia samt anti-lymfotoksin-beta-reseptor-antistoff som anti-svukstmidler. NO322744B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37896895A 1995-01-26 1995-01-26
PCT/US1996/001386 WO1996022788A1 (en) 1995-01-26 1996-01-26 LYMPHOTOXIN-α/β COMPLEXES AND ANTI-LYMPHOTOXIN-BETA RECEPTOR ANTIBODIES AS ANTI-TUMOR AGENTS

Publications (3)

Publication Number Publication Date
NO973385D0 NO973385D0 (no) 1997-07-22
NO973385L NO973385L (no) 1997-09-25
NO322744B1 true NO322744B1 (no) 2006-12-04

Family

ID=23495285

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19973385A NO322744B1 (no) 1995-01-26 1997-07-22 Anvendelse av Lymfotoksin-alfa/beta-komplekser til fremstilling av medikamenter mot neoplasia samt anti-lymfotoksin-beta-reseptor-antistoff som anti-svukstmidler.

Country Status (24)

Country Link
EP (2) EP1407781A1 (cs)
JP (2) JPH10513161A (cs)
KR (2) KR100475492B1 (cs)
CN (3) CN1589902A (cs)
AT (1) ATE268604T1 (cs)
AU (1) AU725351B2 (cs)
BG (1) BG62599B1 (cs)
BR (1) BR9606808A (cs)
CA (1) CA2211443A1 (cs)
CZ (1) CZ298711B6 (cs)
DE (1) DE69632681T2 (cs)
DK (1) DK0809510T3 (cs)
EA (1) EA000096B1 (cs)
EE (1) EE04453B1 (cs)
ES (1) ES2220972T3 (cs)
FI (1) FI119359B (cs)
HU (1) HUP9801746A3 (cs)
NO (1) NO322744B1 (cs)
NZ (1) NZ303405A (cs)
PL (1) PL185364B1 (cs)
PT (1) PT809510E (cs)
RO (1) RO118634B1 (cs)
SK (1) SK286497B6 (cs)
WO (1) WO1996022788A1 (cs)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925351A (en) 1995-07-21 1999-07-20 Biogen, Inc. Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6140467A (en) * 1997-07-07 2000-10-31 La Jolla Institute For Allergy And Immunology Ligand for herpes simplex virus entry mediator and methods of use
US7118742B2 (en) 1997-07-07 2006-10-10 La Jolla Institute For Allergy And Immunology Ligand for herpes simplex virus entry mediator and methods of use
US7060667B1 (en) 1998-01-30 2006-06-13 Biogen Idec Ma, Inc. Treatment of follicular lymphomas using inhibitors of the LT pathway
DE69931944T2 (de) 1998-10-09 2007-02-08 Biogen Idec Ma Inc., Cambridge Umkehr des viral-induzierten systemischen schocks und des atemnotsyndroms durch blockierung des lymphotoxin-beta- aktivierungsweges
IL155340A0 (en) * 2000-10-13 2003-11-23 Biogen Inc HUMANIZED ANTI LYMPHOTOXIN-beta-RECEPTOR ANTIBODIES
JP2005532051A (ja) * 2002-07-01 2005-10-27 バイオジェン, インコーポレイテッド ヒト化抗リンホトキシンβレセプター抗体
WO2004058191A2 (en) * 2002-12-20 2004-07-15 Biogen Idec Ma Inc. Multivalent lymphotoxin beta receptor agonists and therapeutic uses thereof
AU2003303339A1 (en) * 2002-12-20 2004-07-22 Biogen Idec Ma Inc. Lymphotoxin beta receptor agents in combination with chemotherapeutic agents
EP1641827A2 (en) 2003-06-27 2006-04-05 Biogen Idec MA Inc. Use of hydrophobic-interaction-chromatography or hinge-region modifications for the production of homogeneous antibody-solutions
CN1980957A (zh) 2004-03-23 2007-06-13 比奥根艾迪克Ma公司 受体偶联剂及其治疗用途
WO2006074399A2 (en) 2005-01-05 2006-07-13 Biogen Idec Ma Inc. Multispecific binding molecules comprising connecting peptides
EP1764371A1 (de) * 2005-04-25 2007-03-21 Xantos Biomedicine AG Agonistische Antikörper, welche an den LT-Beta-Rezeptor binden und dadurch Adipositas assoziierte Phänotypen modulieren, und deren Verwendung in der Therapie
CN101073665B (zh) * 2006-05-17 2014-11-26 上海复旦张江生物医药股份有限公司 淋巴毒素在制备增加化疗药物敏感性的药物中的应用
WO2008042436A2 (en) 2006-10-03 2008-04-10 Biogen Idec Ma Inc. Biomarkers and assays for the treatment of cancer
JP2010506955A (ja) 2006-10-20 2010-03-04 バイオジェン・アイデック・エムエイ・インコーポレイテッド 可溶性リンホトキシンβレセプターによる脱髄障害の処置
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
JP2012504245A (ja) * 2008-09-30 2012-02-16 ジェネンテック, インコーポレイテッド リンホトキシンアンタゴニストに対する関節リウマチの応答性を予測する生物学的マーカー
HK1203309A1 (zh) * 2011-12-05 2015-10-30 Igenica Biotherapeutics, Inc. 抗體-藥物綴合物以及相關化合物、組合物和方法
US10689449B2 (en) 2015-01-20 2020-06-23 Igm Biosciences, Inc. Multimeric death domain-containing receptor-5 (DR5) antibodies and uses thereof
WO2022117569A1 (en) 2020-12-02 2022-06-09 Oncurious Nv A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer
EP4255929A2 (en) 2020-12-02 2023-10-11 Vib Vzw An ltbr agonist in combination therapy against cancer
US20250235534A1 (en) 2022-04-13 2025-07-24 Vib Vzw An LTBR Agonist In Combination Therapy Against Cancer
WO2025113643A1 (en) 2023-12-01 2025-06-05 Gilead Sciences Inc. Anti-fap-light fusion protein and use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6124599A (ja) * 1984-07-11 1986-02-03 Kyowa Hakko Kogyo Co Ltd 新規ヒトインタ−フエロン−rポリペプチド誘導体
JPS61277628A (ja) * 1985-06-04 1986-12-08 Asahi Chem Ind Co Ltd 癌治療用白血球刺激材
US4770995A (en) * 1985-08-29 1988-09-13 New York Blood Center, Inc Detection of the sensitivity of cells to the effects of tumor necrosis factor and lymphotoxin
DK0536299T3 (da) * 1990-06-27 2001-07-09 Univ California Overfladekompleksbundet lymfotolksin
JPH08507201A (ja) * 1992-12-04 1996-08-06 バイオジェン,インコーポレイテッド リンホトキシン‐β、リンホトキシン‐β複合体、それらの薬学的な調製物および治療への使用

Also Published As

Publication number Publication date
CZ298711B6 (cs) 2008-01-02
HK1006356A1 (en) 1999-02-26
NO973385D0 (no) 1997-07-22
EA000096B1 (ru) 1998-08-27
BG101855A (en) 1998-04-30
FI973118A0 (fi) 1997-07-25
CN1900116A (zh) 2007-01-24
KR20040102364A (ko) 2004-12-04
DE69632681T2 (de) 2005-06-09
BR9606808A (pt) 1997-12-30
KR100470739B1 (ko) 2005-09-02
HUP9801746A2 (hu) 1998-11-30
PL321758A1 (en) 1997-12-22
SK98697A3 (en) 2000-02-14
KR19980701816A (ko) 1998-06-25
WO1996022788A1 (en) 1996-08-01
DE69632681D1 (de) 2004-07-15
EP0809510B1 (en) 2004-06-09
EE9700255A (et) 1998-04-15
NO973385L (no) 1997-09-25
ATE268604T1 (de) 2004-06-15
PT809510E (pt) 2004-09-30
MX9705629A (es) 1997-10-31
CN1589902A (zh) 2005-03-09
JPH10513161A (ja) 1998-12-15
AU4970496A (en) 1996-08-14
CN1146442C (zh) 2004-04-21
ES2220972T3 (es) 2004-12-16
FI973118A7 (fi) 1997-09-25
DK0809510T3 (da) 2004-10-04
CN1177302A (zh) 1998-03-25
EP0809510A1 (en) 1997-12-03
SK286497B6 (sk) 2008-11-06
EE04453B1 (et) 2005-04-15
CZ236197A3 (cs) 1998-02-18
CA2211443A1 (en) 1996-08-01
AU725351B2 (en) 2000-10-12
KR100475492B1 (ko) 2005-03-14
RO118634B1 (ro) 2003-08-29
PL185364B1 (pl) 2003-04-30
NZ303405A (en) 2000-02-28
FI119359B (fi) 2008-10-31
HUP9801746A3 (en) 2000-11-28
EP1407781A1 (en) 2004-04-14
BG62599B1 (bg) 2000-03-31
EA199700144A1 (ru) 1997-12-30
JP2007169296A (ja) 2007-07-05

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