NO322551B1 - Anvendelse av gelaterte komplekser som "blood-pool"-midler for kjernemagnetisk resonansdiagnostikk - Google Patents
Anvendelse av gelaterte komplekser som "blood-pool"-midler for kjernemagnetisk resonansdiagnostikk Download PDFInfo
- Publication number
- NO322551B1 NO322551B1 NO20013154A NO20013154A NO322551B1 NO 322551 B1 NO322551 B1 NO 322551B1 NO 20013154 A NO20013154 A NO 20013154A NO 20013154 A NO20013154 A NO 20013154A NO 322551 B1 NO322551 B1 NO 322551B1
- Authority
- NO
- Norway
- Prior art keywords
- amino
- bis
- acid
- carboxymethyl
- ethyl
- Prior art date
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- GFSTXYOTEVLASN-UHFFFAOYSA-K gadoteric acid Chemical compound [Gd+3].OC(=O)CN1CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC1 GFSTXYOTEVLASN-UHFFFAOYSA-K 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
- Y10S977/928—X-ray agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
- Y10S977/929—Ultrasound contrast agent
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/927—Diagnostic contrast agent
- Y10S977/93—MRI contrast agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1998MI002802A IT1304501B1 (it) | 1998-12-23 | 1998-12-23 | Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza |
| PCT/EP1999/010002 WO2000038738A1 (en) | 1998-12-23 | 1999-12-16 | Blood pool agents for nuclear magnetic resonance diagnostics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20013154D0 NO20013154D0 (no) | 2001-06-22 |
| NO20013154L NO20013154L (no) | 2001-08-23 |
| NO322551B1 true NO322551B1 (no) | 2006-10-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20013154A NO322551B1 (no) | 1998-12-23 | 2001-06-22 | Anvendelse av gelaterte komplekser som "blood-pool"-midler for kjernemagnetisk resonansdiagnostikk |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6461588B1 (ja) |
| EP (2) | EP1140209B1 (ja) |
| JP (1) | JP4733271B2 (ja) |
| KR (1) | KR100736298B1 (ja) |
| CN (2) | CN100450996C (ja) |
| AT (1) | ATE405296T1 (ja) |
| AU (1) | AU773876B2 (ja) |
| CA (1) | CA2355888C (ja) |
| CZ (1) | CZ302195B6 (ja) |
| DE (1) | DE69939398D1 (ja) |
| HK (1) | HK1042432B (ja) |
| HU (1) | HU228048B1 (ja) |
| IL (2) | IL143730A0 (ja) |
| IT (1) | IT1304501B1 (ja) |
| MX (1) | MXPA01006344A (ja) |
| NO (1) | NO322551B1 (ja) |
| PL (1) | PL196474B1 (ja) |
| RU (2) | RU2250765C2 (ja) |
| WO (1) | WO2000038738A1 (ja) |
| ZA (1) | ZA200104820B (ja) |
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| TW319763B (ja) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| HUP0101245A3 (en) | 1997-10-02 | 2003-10-28 | Epix Pharmaceuticals Inc Cambr | Contrast-enhanced diagnostic imaging method for monitoring interventional therapies |
| IT1317862B1 (it) * | 2000-02-29 | 2003-07-15 | Bracco Spa | Coniugati di acidi biliari con chelati complessi di ioni metallici eloro uso. |
| IT1318485B1 (it) * | 2000-04-21 | 2003-08-25 | Bracco Spa | Uso di derivati di acidi biliari coniugati con complessi di ionimetallici nella visualizzazione diagnostica di sistemi microvascolari |
| WO2002032376A2 (en) * | 2000-10-06 | 2002-04-25 | Xenoport, Inc. | Bile-acid conjugates for providing sustained systemic concentrations of drugs |
| EP1229041A1 (en) * | 2001-02-05 | 2002-08-07 | Bracco Imaging S.p.A. | A process for the preparation of 3-Glutamido bile ester derivatives using N-tBoc methyl pyroglutamate |
| US7053076B2 (en) | 2001-08-29 | 2006-05-30 | Xenoport, Inc. | Bile-acid derived compounds for enhancing oral absorption and systemic bioavailability of drugs |
| EP1302465A1 (en) * | 2001-10-11 | 2003-04-16 | BRACCO IMAGING S.p.A. | Enhanced substrate imaging by reversible binding to a paramagnetic complex |
| US7922998B2 (en) | 2003-01-13 | 2011-04-12 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US8420050B2 (en) * | 2003-01-13 | 2013-04-16 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7611692B2 (en) | 2003-01-13 | 2009-11-03 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| US7850947B2 (en) * | 2003-01-13 | 2010-12-14 | Bracco Imaging S.P.A. | Gastrin releasing peptide compounds |
| WO2004062574A2 (en) * | 2003-01-13 | 2004-07-29 | Bracco Imaging S.P.A. | Improved linkers for radiopharmaceutical compounds |
| US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| AU2004314112A1 (en) * | 2003-12-24 | 2005-07-28 | Bracco Imaging S.P.A. | Improved gastrin releasing peptide compounds |
| CN101827631B (zh) | 2007-07-11 | 2013-04-24 | 得克萨斯系统大学董事会 | 用于成像中的粒子和标记物 |
| CN101845112B (zh) * | 2010-06-02 | 2011-09-14 | 华东理工大学 | 一种基于高分子纳米粒子的高灵敏性核磁共振成像造影剂的制备方法 |
| MX356514B (es) | 2011-01-20 | 2018-05-30 | Univ Texas | Marcadores de formación de imagen por resonancia magnética, sistemas de suministro y extracción, y métodos de fabricación y uso de los mismos. |
| CN110841078A (zh) | 2012-03-05 | 2020-02-28 | 伯拉考成像股份公司 | 用于评价病理性组织内大分子转运的动态增强mri成像法和活性剂 |
| CN102766188B (zh) * | 2012-07-24 | 2016-01-13 | 上海交通大学 | 胆固醇衍生物、螯合物、重组高密度脂蛋白及其用途 |
| GB201421163D0 (en) * | 2014-11-28 | 2015-01-14 | Ge Healthcare As | Formulations of metal complexes |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| CN117603148A (zh) | 2017-05-05 | 2024-02-27 | 探针技术开发及商业化中心 | 双官能螯合物的药代动力学增强及其用途 |
| RU2019139434A (ru) | 2017-05-05 | 2021-06-07 | Сентр фор Проуб Девелопмент энд Коммерсиализэйшн | Моноклональные антитела против igf-1r и их применение |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1213029B (it) * | 1986-01-30 | 1989-12-07 | Bracco Ind Chimica Spa | Chelati di ioni metallici paramagnetici. |
| US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
| US5227474A (en) * | 1987-02-13 | 1993-07-13 | Abbott Laboratories | Bifunctional chelating agents |
| DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| NO940115D0 (no) * | 1994-01-13 | 1994-01-13 | Nycomed Imaging As | Kontrastmidler for roentgen- og magnettomografisk avbildning |
| CN1148813A (zh) * | 1994-04-20 | 1997-04-30 | 耐克麦德瑟鲁塔公司 | 造影剂 |
| IT1269839B (it) * | 1994-05-26 | 1997-04-15 | Bracco Spa | Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi |
| JPH11116542A (ja) * | 1997-10-06 | 1999-04-27 | Sogo Pharmaceut Co Ltd | γ−グルタミン酸アミド類の製造法 |
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