NO319760B1 - Vannloselige azoler som bredspektrede antifungale midler, deres fremstilling og anvendelse samt farmasoytiske sammensetninger omfattende dem - Google Patents

Vannloselige azoler som bredspektrede antifungale midler, deres fremstilling og anvendelse samt farmasoytiske sammensetninger omfattende dem Download PDF

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Publication number
NO319760B1
NO319760B1 NO20005713A NO20005713A NO319760B1 NO 319760 B1 NO319760 B1 NO 319760B1 NO 20005713 A NO20005713 A NO 20005713A NO 20005713 A NO20005713 A NO 20005713A NO 319760 B1 NO319760 B1 NO 319760B1
Authority
NO
Norway
Prior art keywords
phenyl
triazol
amino
piperazinyl
formula
Prior art date
Application number
NO20005713A
Other languages
English (en)
Norwegian (no)
Other versions
NO20005713L (no
NO20005713D0 (no
Inventor
Jan Heeres
Louis Jozef Elisabeth Va Veken
Leo Jacobus Jozef Backx
Frank Christopher Odds
Lieven Meerpoel
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20005713D0 publication Critical patent/NO20005713D0/no
Publication of NO20005713L publication Critical patent/NO20005713L/no
Publication of NO319760B1 publication Critical patent/NO319760B1/no

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/101,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
NO20005713A 1998-05-14 2000-11-13 Vannloselige azoler som bredspektrede antifungale midler, deres fremstilling og anvendelse samt farmasoytiske sammensetninger omfattende dem NO319760B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201588A EP0957101A1 (en) 1998-05-14 1998-05-14 Water soluble azoles as broad-spectrum antifungals
PCT/EP1999/003243 WO1999058530A1 (en) 1998-05-14 1999-05-06 Water soluble azoles as broad-spectrum antifungals

Publications (3)

Publication Number Publication Date
NO20005713D0 NO20005713D0 (no) 2000-11-13
NO20005713L NO20005713L (no) 2001-01-11
NO319760B1 true NO319760B1 (no) 2005-09-12

Family

ID=8233724

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20005712A NO319851B1 (no) 1998-05-14 2000-11-13 Vannloselige azoler som bredspektrede antifungale midler
NO20005713A NO319760B1 (no) 1998-05-14 2000-11-13 Vannloselige azoler som bredspektrede antifungale midler, deres fremstilling og anvendelse samt farmasoytiske sammensetninger omfattende dem

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO20005712A NO319851B1 (no) 1998-05-14 2000-11-13 Vannloselige azoler som bredspektrede antifungale midler

Country Status (32)

Country Link
US (2) US6448244B1 (et)
EP (3) EP0957101A1 (et)
JP (2) JP2002514646A (et)
KR (2) KR100575147B1 (et)
CN (2) CN1135229C (et)
AR (2) AR016482A1 (et)
AT (2) ATE221884T1 (et)
AU (2) AU751135B2 (et)
BG (2) BG64388B1 (et)
BR (2) BR9911057A (et)
CA (2) CA2331141C (et)
CO (1) CO5021227A1 (et)
CZ (2) CZ298702B6 (et)
DE (2) DE69907171T2 (et)
DK (1) DK1077976T3 (et)
EE (2) EE04311B1 (et)
ES (2) ES2198915T3 (et)
HK (2) HK1032781A1 (et)
HR (2) HRP20000741B1 (et)
HU (2) HUP0103536A3 (et)
IL (2) IL139647A0 (et)
MY (2) MY120248A (et)
NO (2) NO319851B1 (et)
NZ (2) NZ507965A (et)
PL (2) PL194085B1 (et)
PT (1) PT1077976E (et)
SI (1) SI1077976T1 (et)
SK (2) SK285763B6 (et)
TR (2) TR200003323T2 (et)
TW (2) TWI259835B (et)
WO (2) WO1999058530A1 (et)
ZA (2) ZA200007173B (et)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals
WO2001066551A2 (en) * 2000-03-07 2001-09-13 Ranbaxy Laboratories Limited Azole compounds as therapeutic agents for fungal infections
EP1413301A1 (fr) * 2002-10-24 2004-04-28 Bayer CropScience SA Médicaments antifongiques à base de dérivés d'arylamidine
ITMI20032020A1 (it) * 2003-10-17 2005-04-18 Italfarmaco Spa Nuovi agenti antifungini azolici con diminuita interazione con i citocromi metabolici
AR052342A1 (es) * 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
CN102906087B (zh) * 2010-05-19 2016-03-23 桑多斯股份公司 制备手性三唑酮的方法
US9346791B2 (en) 2011-09-07 2016-05-24 The Johns Hopkins University Itraconazole analogs and use thereof
US11028078B2 (en) 2011-09-07 2021-06-08 The Johns Hopkins University Itraconazole analogs and use thereof
KR102240329B1 (ko) * 2013-06-07 2021-04-14 더 스크립스 리서치 인스티튜트 섬유증의 소분자 억제제
DK3227277T3 (da) 2014-12-05 2020-04-27 Pulmocide Ltd Antimykotisk forbindelse
AU2015360583B2 (en) * 2014-12-10 2020-01-23 The Scripps Research Institute Small molecule inhibitors of fibrosis
MX2017014814A (es) 2015-05-21 2018-02-15 Pulmocide Ltd 4-(4-(4-(((3r,5r)-5-((1h-1,2,4-triazol-1-il)metil)-5-(2,4-difluor ofenil)tetrahidrofuran-3-il)metoxi)-3-metilfenil)piperazin-1-il)- n-(2-hidroxiciclohexil) benzamida antifungica, o una sal farmaceuticamente aceptable de la misma.
CN105237392B (zh) * 2015-11-24 2017-12-12 辽宁渤大化工有限公司 芳烷基水杨酸及其衍生物的制备方法
WO2019040363A1 (en) * 2017-08-20 2019-02-28 University Of Connecticut AZOLE-TYPE COMPOUND ANALOGUES AND METHODS OF USE
CN111138421A (zh) * 2019-12-26 2020-05-12 上海英诺富成生物科技有限公司 抗真菌水溶性化合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218458A (en) * 1978-06-23 1980-08-19 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxy-methyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
CZ286619B6 (cs) * 1992-03-18 2000-05-17 Janssen Pharmaceutica N. V. Stereoisomerické formy itrakonazolu a saperkonazolu, způsob jejich výroby, jejich komplexy, způsob výroby těchto komplexů, farmaceutické přípravky a způsob jejich výroby
ATE204875T1 (de) * 1993-12-21 2001-09-15 Schering Corp Fungizide tetrahydrofurane
ES2141329T3 (es) * 1994-01-24 2000-03-16 Janssen Pharmaceutica Nv Antifungicos azolicos solubles en agua.
FI98688C (fi) * 1994-07-20 1997-07-25 Nokia Telecommunications Oy Menetelmä lyhytsanomalähetyksen käynnistämiseksi solukkoradiojärjestelmässä, solukkoradiojärjestelmä sekä solukkoradiojärjestelmän tilaajarekisteri
SK27097A3 (en) * 1995-06-02 1997-09-10 Schering Corp Tetrahydrofuran antifungals
MX9710270A (es) * 1995-06-19 1998-08-30 Schering Corp Fungicidas de tetrahidrofurano.
KR100509171B1 (ko) 1997-02-11 2005-08-22 얀센 파마슈티카 엔.브이. 아미노산 에스테르를 포함하는 아졸 항진균제
EP0957101A1 (en) * 1998-05-14 1999-11-17 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals

Also Published As

Publication number Publication date
NZ507966A (en) 2002-10-25
DK1077976T3 (da) 2002-12-02
US6448244B1 (en) 2002-09-10
CN1137118C (zh) 2004-02-04
EP1077976A1 (en) 2001-02-28
EE200000657A (et) 2002-04-15
BG64388B1 (bg) 2004-12-30
SK16822000A3 (sk) 2001-07-10
BR9910448A (pt) 2001-01-02
PL344047A1 (en) 2001-09-24
BG104717A (en) 2001-07-31
AU4141799A (en) 1999-11-29
ATE238296T1 (de) 2003-05-15
CZ299481B6 (cs) 2008-08-13
ZA200007173B (en) 2002-03-04
CZ298702B6 (cs) 2007-12-27
AR016482A1 (es) 2001-07-04
TW572899B (en) 2004-01-21
BG64954B1 (bg) 2006-10-31
ZA200007459B (en) 2002-09-13
IL139647A0 (en) 2002-02-10
PL194085B1 (pl) 2007-04-30
KR100593395B1 (ko) 2006-06-28
EE04346B1 (et) 2004-08-16
TR200003323T2 (tr) 2001-02-21
CA2331141A1 (en) 1999-11-18
HRP20000741B1 (en) 2009-02-28
WO1999058530A1 (en) 1999-11-18
CA2331141C (en) 2008-10-28
TR200003322T2 (tr) 2001-02-21
SK285763B6 (sk) 2007-07-06
CA2331187A1 (en) 1999-11-18
DE69902461T2 (de) 2003-04-10
SK286156B6 (sk) 2008-04-07
SI1077976T1 (en) 2003-02-28
HK1033312A1 (en) 2001-08-24
BG104933A (en) 2001-10-31
ES2198915T3 (es) 2004-02-01
DE69902461D1 (de) 2002-09-12
EP1077976B1 (en) 2002-08-07
CN1300287A (zh) 2001-06-20
NO20005713L (no) 2001-01-11
EP1077975A1 (en) 2001-02-28
SK16812000A3 (sk) 2001-08-06
NO319851B1 (no) 2005-09-19
EP1077975B1 (en) 2003-04-23
PL194086B1 (pl) 2007-04-30
KR100575147B1 (ko) 2006-05-03
NO20005713D0 (no) 2000-11-13
KR20010041480A (ko) 2001-05-25
AU4361599A (en) 1999-11-29
KR20010042852A (ko) 2001-05-25
HUP0102031A2 (hu) 2002-05-29
ES2182531T3 (es) 2003-03-01
CN1135229C (zh) 2004-01-21
BR9911057A (pt) 2001-02-06
DE69907171D1 (de) 2003-05-28
CZ20004109A3 (en) 2001-05-16
TWI259835B (en) 2006-08-11
CN1300288A (zh) 2001-06-20
HRP20000740B1 (en) 2003-12-31
EP0957101A1 (en) 1999-11-17
AR016480A1 (es) 2001-07-04
NO20005712D0 (no) 2000-11-13
ATE221884T1 (de) 2002-08-15
AU751135B2 (en) 2002-08-08
HRP20000741A2 (en) 2001-06-30
HRP20000740A2 (en) 2001-10-31
US6384030B1 (en) 2002-05-07
NZ507965A (en) 2002-05-31
PL344037A1 (en) 2001-09-24
NO20005712L (no) 2000-12-07
AU758876B2 (en) 2003-04-03
DE69907171T2 (de) 2004-02-05
IL139649A0 (en) 2002-02-10
MY122147A (en) 2006-03-31
PT1077976E (pt) 2002-12-31
IL139649A (en) 2004-09-27
CA2331187C (en) 2008-11-18
EE04311B1 (et) 2004-06-15
MY120248A (en) 2005-09-30
JP2002514646A (ja) 2002-05-21
CZ20004108A3 (en) 2001-05-16
HUP0103536A2 (hu) 2002-07-29
HUP0103536A3 (en) 2002-08-28
JP2002514645A (ja) 2002-05-21
HUP0102031A3 (en) 2002-10-28
CO5021227A1 (es) 2001-03-27
HK1032781A1 (en) 2001-08-03
EE200000651A (et) 2002-04-15
WO1999058529A1 (en) 1999-11-18

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