NO318017B1 - Ekstrakt med trombininhibitoraktivitet, polypeptid erholdt fra ekstrakten, fremgangsmater for fremstilling av henholdsvis ekstrakten og polypeptider, farmasoytiske preparater og anvendelse av polypeptidet for fremstilling av preparatene, samt anvendelse av blodigler for fremstilling av trombininhibitorer - Google Patents
Ekstrakt med trombininhibitoraktivitet, polypeptid erholdt fra ekstrakten, fremgangsmater for fremstilling av henholdsvis ekstrakten og polypeptider, farmasoytiske preparater og anvendelse av polypeptidet for fremstilling av preparatene, samt anvendelse av blodigler for fremstilling av trombininhibitorer Download PDFInfo
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- NO318017B1 NO318017B1 NO19950075A NO950075A NO318017B1 NO 318017 B1 NO318017 B1 NO 318017B1 NO 19950075 A NO19950075 A NO 19950075A NO 950075 A NO950075 A NO 950075A NO 318017 B1 NO318017 B1 NO 318017B1
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- Prior art keywords
- thrombin
- extract
- polypeptide
- leeches
- polypeptide according
- Prior art date
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/855—Proteins from animals other than mammals or birds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939309509A GB9309509D0 (en) | 1993-05-07 | 1993-05-07 | Thrombin inhibitors |
| PCT/EP1994/001404 WO1994026777A1 (en) | 1993-05-07 | 1994-05-03 | Thrombin inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO950075D0 NO950075D0 (no) | 1995-01-06 |
| NO950075L NO950075L (no) | 1995-01-06 |
| NO318017B1 true NO318017B1 (no) | 2005-01-24 |
Family
ID=10735154
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19950075A NO318017B1 (no) | 1993-05-07 | 1995-01-06 | Ekstrakt med trombininhibitoraktivitet, polypeptid erholdt fra ekstrakten, fremgangsmater for fremstilling av henholdsvis ekstrakten og polypeptider, farmasoytiske preparater og anvendelse av polypeptidet for fremstilling av preparatene, samt anvendelse av blodigler for fremstilling av trombininhibitorer |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5583111A (da) |
| EP (1) | EP0652900B1 (da) |
| JP (1) | JP3537437B2 (da) |
| KR (1) | KR100335536B1 (da) |
| AT (1) | ATE208793T1 (da) |
| AU (1) | AU682368B2 (da) |
| CA (1) | CA2139652C (da) |
| CZ (1) | CZ287794B6 (da) |
| DE (1) | DE69429062T2 (da) |
| DK (1) | DK0652900T3 (da) |
| ES (1) | ES2167364T3 (da) |
| GB (1) | GB9309509D0 (da) |
| HU (1) | HU226243B1 (da) |
| NO (1) | NO318017B1 (da) |
| PL (1) | PL179215B1 (da) |
| PT (1) | PT652900E (da) |
| RU (1) | RU2138275C1 (da) |
| SK (1) | SK282860B6 (da) |
| TW (1) | TW369541B (da) |
| UA (1) | UA43831C2 (da) |
| WO (1) | WO1994026777A1 (da) |
| ZA (1) | ZA943171B (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU783087B2 (en) * | 1999-08-06 | 2005-09-22 | Genentech Inc. | Peptide antagonists of factor VIIA |
| GB9930659D0 (en) * | 1999-12-24 | 2000-02-16 | Bio Discovery Ltd | Inhibitors of complement activation |
| FR2834293B1 (fr) * | 2002-01-03 | 2005-02-04 | Ricarimpex | Extraits de sangsues a effet psychosomatique |
| US7164002B2 (en) | 2002-02-06 | 2007-01-16 | Genentech, Inc. | FVIIa antagonists |
| US20110034396A1 (en) * | 2005-09-28 | 2011-02-10 | Biovascular, Inc. | Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions |
| EP1931733A4 (en) | 2005-09-28 | 2009-11-25 | Biovascular Inc | METHOD AND COMPOSITIONS FOR BLOCKING THROMBOZYTE AND CELL ADHESION, CELL MIGRATION AND IGNITION |
| CN101095697A (zh) * | 2006-06-28 | 2008-01-02 | 李振国 | 水蛭和/或地龙分子量5800道尔顿以下的提取物 |
| TWI471321B (zh) * | 2009-06-08 | 2015-02-01 | Abbott Gmbh & Co Kg | Ｂｃｌ－２族群抑制劑之口服醫藥劑型 |
| RU2519741C2 (ru) * | 2012-06-25 | 2014-06-20 | Общество с ограниченной ответственностью Научно-внедренческая фирма "Гируд И.Н." (ООО НВФ "Гируд И.Н.") | Фармацевтическая композиция, обладающая противотромботическим, тромболитическим, иммуномодулирующим, противовоспалительным действиями, нормализующая липидный и углеводный обмен |
| US8790711B2 (en) | 2012-09-17 | 2014-07-29 | Biopep Solutions, Inc. | Treating diabetes with a whole, leech saliva extract |
| CN108395475B (zh) * | 2018-03-29 | 2021-09-10 | 苏州至汇生物科技有限公司 | 一种基于亲和层析的水蛭素分离纯化方法 |
| CN116987181B (zh) * | 2023-09-27 | 2023-12-08 | 北京元延医药科技股份有限公司 | 高生物学活性的天然水蛭素和高收率制备它们的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4390630A (en) * | 1980-10-28 | 1983-06-28 | The Regents Of The University Of California | Hementin--a fibrinolytic agent |
| EP0209061B1 (de) * | 1985-07-17 | 1994-01-12 | Hoechst Aktiengesellschaft | Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel |
| GB8826428D0 (en) * | 1988-11-11 | 1988-12-14 | Biopharm Ltd | Antithrombin |
| DE69127346T2 (de) * | 1990-04-06 | 1998-02-26 | Merck Patent Gmbh, 64293 Darmstadt | Behandlung thrombotischer ereignisse |
-
1993
- 1993-05-07 GB GB939309509A patent/GB9309509D0/en active Pending
-
1994
- 1994-03-05 UA UA95018001A patent/UA43831C2/uk unknown
- 1994-05-03 AU AU67950/94A patent/AU682368B2/en not_active Ceased
- 1994-05-03 CZ CZ199542A patent/CZ287794B6/cs not_active IP Right Cessation
- 1994-05-03 CA CA002139652A patent/CA2139652C/en not_active Expired - Fee Related
- 1994-05-03 EP EP94916187A patent/EP0652900B1/en not_active Expired - Lifetime
- 1994-05-03 US US08/362,567 patent/US5583111A/en not_active Expired - Lifetime
- 1994-05-03 KR KR1019950700039A patent/KR100335536B1/ko not_active IP Right Cessation
- 1994-05-03 RU RU95105983A patent/RU2138275C1/ru not_active IP Right Cessation
- 1994-05-03 HU HU9500038A patent/HU226243B1/hu not_active IP Right Cessation
- 1994-05-03 SK SK8-95A patent/SK282860B6/sk not_active IP Right Cessation
- 1994-05-03 ES ES94916187T patent/ES2167364T3/es not_active Expired - Lifetime
- 1994-05-03 AT AT94916187T patent/ATE208793T1/de not_active IP Right Cessation
- 1994-05-03 DK DK94916187T patent/DK0652900T3/da active
- 1994-05-03 PL PL94307088A patent/PL179215B1/pl not_active IP Right Cessation
- 1994-05-03 PT PT94916187T patent/PT652900E/pt unknown
- 1994-05-03 JP JP52489694A patent/JP3537437B2/ja not_active Expired - Fee Related
- 1994-05-03 DE DE69429062T patent/DE69429062T2/de not_active Expired - Lifetime
- 1994-05-03 WO PCT/EP1994/001404 patent/WO1994026777A1/en active IP Right Grant
- 1994-05-06 ZA ZA943171A patent/ZA943171B/xx unknown
- 1994-08-02 TW TW083107061A patent/TW369541B/zh not_active IP Right Cessation
-
1995
- 1995-01-06 NO NO19950075A patent/NO318017B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| HU9500038D0 (en) | 1995-03-28 |
| US5583111A (en) | 1996-12-10 |
| HU226243B1 (en) | 2008-07-28 |
| SK282860B6 (sk) | 2002-12-03 |
| RU95105983A (ru) | 1997-02-27 |
| PT652900E (pt) | 2002-05-31 |
| DE69429062T2 (de) | 2002-06-20 |
| PL307088A1 (en) | 1995-05-02 |
| DE69429062D1 (de) | 2001-12-20 |
| UA43831C2 (uk) | 2002-01-15 |
| AU682368B2 (en) | 1997-10-02 |
| DK0652900T3 (da) | 2002-02-25 |
| CZ4295A3 (en) | 1995-10-18 |
| KR100335536B1 (ko) | 2002-11-11 |
| EP0652900B1 (en) | 2001-11-14 |
| RU2138275C1 (ru) | 1999-09-27 |
| WO1994026777A1 (en) | 1994-11-24 |
| PL179215B1 (pl) | 2000-08-31 |
| GB9309509D0 (en) | 1993-06-23 |
| ZA943171B (en) | 1995-01-11 |
| CA2139652C (en) | 2003-03-18 |
| ATE208793T1 (de) | 2001-11-15 |
| HUT70215A (en) | 1995-09-28 |
| AU6795094A (en) | 1994-12-12 |
| TW369541B (en) | 1999-09-11 |
| JPH07508765A (ja) | 1995-09-28 |
| CZ287794B6 (en) | 2001-02-14 |
| NO950075D0 (no) | 1995-01-06 |
| JP3537437B2 (ja) | 2004-06-14 |
| SK895A3 (en) | 1995-05-10 |
| ES2167364T3 (es) | 2002-05-16 |
| EP0652900A1 (en) | 1995-05-17 |
| CA2139652A1 (en) | 1994-11-24 |
| KR950702579A (ko) | 1995-07-29 |
| NO950075L (no) | 1995-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |