TW369541B - Thrombin inhibitors - Google Patents

Thrombin inhibitors

Info

Publication number
TW369541B
TW369541B TW083107061A TW83107061A TW369541B TW 369541 B TW369541 B TW 369541B TW 083107061 A TW083107061 A TW 083107061A TW 83107061 A TW83107061 A TW 83107061A TW 369541 B TW369541 B TW 369541B
Authority
TW
Taiwan
Prior art keywords
thrombin inhibitors
polypeptides
leeches
secretions
tissues
Prior art date
Application number
TW083107061A
Other languages
English (en)
Inventor
Jurgen Hemberger
Roy Sawyer
Sabine Wolf
Johannes Dodt
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of TW369541B publication Critical patent/TW369541B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/815Protease inhibitors from leeches, e.g. hirudin, eglin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/855Proteins from animals other than mammals or birds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW083107061A 1993-05-07 1994-08-02 Thrombin inhibitors TW369541B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939309509A GB9309509D0 (en) 1993-05-07 1993-05-07 Thrombin inhibitors

Publications (1)

Publication Number Publication Date
TW369541B true TW369541B (en) 1999-09-11

Family

ID=10735154

Family Applications (1)

Application Number Title Priority Date Filing Date
TW083107061A TW369541B (en) 1993-05-07 1994-08-02 Thrombin inhibitors

Country Status (22)

Country Link
US (1) US5583111A (zh)
EP (1) EP0652900B1 (zh)
JP (1) JP3537437B2 (zh)
KR (1) KR100335536B1 (zh)
AT (1) ATE208793T1 (zh)
AU (1) AU682368B2 (zh)
CA (1) CA2139652C (zh)
CZ (1) CZ287794B6 (zh)
DE (1) DE69429062T2 (zh)
DK (1) DK0652900T3 (zh)
ES (1) ES2167364T3 (zh)
GB (1) GB9309509D0 (zh)
HU (1) HU226243B1 (zh)
NO (1) NO318017B1 (zh)
PL (1) PL179215B1 (zh)
PT (1) PT652900E (zh)
RU (1) RU2138275C1 (zh)
SK (1) SK282860B6 (zh)
TW (1) TW369541B (zh)
UA (1) UA43831C2 (zh)
WO (1) WO1994026777A1 (zh)
ZA (1) ZA943171B (zh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2380633A1 (en) * 1999-08-06 2001-02-15 Genentech, Inc. Peptide antagonists of factor viia
GB9930659D0 (en) * 1999-12-24 2000-02-16 Bio Discovery Ltd Inhibitors of complement activation
FR2834293B1 (fr) * 2002-01-03 2005-02-04 Ricarimpex Extraits de sangsues a effet psychosomatique
US7164002B2 (en) 2002-02-06 2007-01-16 Genentech, Inc. FVIIa antagonists
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
JP2009510105A (ja) * 2005-09-28 2009-03-12 バイオバスキュラー インコーポレーティッド 血小板および細胞の接着、細胞移動、および炎症を阻止するための方法および組成物
CN101095697A (zh) * 2006-06-28 2008-01-02 李振国 水蛭和/或地龙分子量5800道尔顿以下的提取物
TWI540132B (zh) * 2009-06-08 2016-07-01 亞培公司 Bcl-2族群抑制劑之口服醫藥劑型
RU2519741C2 (ru) * 2012-06-25 2014-06-20 Общество с ограниченной ответственностью Научно-внедренческая фирма "Гируд И.Н." (ООО НВФ "Гируд И.Н.") Фармацевтическая композиция, обладающая противотромботическим, тромболитическим, иммуномодулирующим, противовоспалительным действиями, нормализующая липидный и углеводный обмен
US8784896B2 (en) 2012-09-17 2014-07-22 Biopep Solutions, Inc Antioxidant therapy with a whole, leech saliva extract
CN108395475B (zh) * 2018-03-29 2021-09-10 苏州至汇生物科技有限公司 一种基于亲和层析的水蛭素分离纯化方法
CN116987181B (zh) * 2023-09-27 2023-12-08 北京元延医药科技股份有限公司 高生物学活性的天然水蛭素和高收率制备它们的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390630A (en) * 1980-10-28 1983-06-28 The Regents Of The University Of California Hementin--a fibrinolytic agent
DE3689525D1 (de) * 1985-07-17 1994-02-24 Hoechst Ag Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel.
GB8826428D0 (en) * 1988-11-11 1988-12-14 Biopharm Ltd Antithrombin
EP0487660B1 (en) * 1990-04-06 1997-08-20 MERCK PATENT GmbH Treatment of thrombotic events

Also Published As

Publication number Publication date
EP0652900B1 (en) 2001-11-14
PL307088A1 (en) 1995-05-02
US5583111A (en) 1996-12-10
UA43831C2 (uk) 2002-01-15
PL179215B1 (pl) 2000-08-31
DE69429062D1 (de) 2001-12-20
PT652900E (pt) 2002-05-31
SK895A3 (en) 1995-05-10
ZA943171B (en) 1995-01-11
EP0652900A1 (en) 1995-05-17
NO950075D0 (no) 1995-01-06
CA2139652C (en) 2003-03-18
HU226243B1 (en) 2008-07-28
NO318017B1 (no) 2005-01-24
ATE208793T1 (de) 2001-11-15
HUT70215A (en) 1995-09-28
AU682368B2 (en) 1997-10-02
SK282860B6 (sk) 2002-12-03
AU6795094A (en) 1994-12-12
DE69429062T2 (de) 2002-06-20
CZ287794B6 (en) 2001-02-14
CA2139652A1 (en) 1994-11-24
WO1994026777A1 (en) 1994-11-24
DK0652900T3 (da) 2002-02-25
ES2167364T3 (es) 2002-05-16
JP3537437B2 (ja) 2004-06-14
GB9309509D0 (en) 1993-06-23
JPH07508765A (ja) 1995-09-28
RU2138275C1 (ru) 1999-09-27
NO950075L (no) 1995-01-06
KR950702579A (ko) 1995-07-29
RU95105983A (ru) 1997-02-27
KR100335536B1 (ko) 2002-11-11
HU9500038D0 (en) 1995-03-28
CZ4295A3 (en) 1995-10-18

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees